Protein Alignment tbrd-1 and BRD2

DIOPT Version :10

• Sequence 1: NP_651190.1
• Gene: tbrd-1 / 42823
• FlyBaseID: FBgn0039124
• Length: 513
• Species: Drosophila melanogaster
• Sequence 2: NP_001186384.1
• Gene: BRD2 / 6046
• HGNCID: 1103
• Length: 836
• Species: Homo sapiens
• Alignment Length: 569
• Identity: 139/569 - (24%)
• Similarity: 232/569 - (40%)
• Gaps: 157/569 - (27%)

  Fly     4 LQSNSNQPPPRNEPYLQPVNGIVQPPVIPPPNRPGRRTNILEEL-KSVLNCLWRNRFSYHFRHPV 67
            |......|...:.|.||.......||.:..|.:|||.||.|:.| |.|:..||:::|::.||.||
Human    39 LYEGFESPTMASVPALQLTPANPPPPEVSNPKKPGRVTNQLQYLHKVVMKALWKHQFAWPFRQPV 103

  Fly    68 DSVSLGVPDYHAVVKHPMDLSTIRKRLHNKYYWQASEALEDFKLIFDNCLLYNLEGSPVYQAGKL 132
            |:|.||:||||.::|.|||:.||::||.|.|||.|||.::||..:|.||.:||.....:....:.
Human   104 DAVKLGLPDYHKIIKQPMDMGTIKRRLENNYYWAASECMQDFNTMFTNCYIYNKPTDDIVLMAQT 168

  Fly   133 LMEAFYMRMESIDLSTEVELK---PKSEKRKRKATESLDQASTS-FSAPRASNNYSRQWLSSSSS 193
            |.:.|..::.|:. ..|.||.   ||:..:|.....:|..:.|| ...|..|:      :|.::.
Human   169 LEKIFLQKVASMP-QEEQELVVTIPKNSHKKGAKLAALQGSVTSAHQVPAVSS------VSHTAL 226

  Fly   194 WLCPPPMPGGVSSFNPSFRNFVGPSLIPSFMPDSLVNPMQSMHPMSSMMNPIFKNNWETNEAMDP 258
            :..||.:|..|       .|...||:|.|.:       ::|:|                  :..|
Human   227 YTPPPEIPTTV-------LNIPHPSVISSPL-------LKSLH------------------SAGP 259

  Fly   259 PPSEPISYRPLDSLAAPLPSPPMEPMT----------LPWPTPAPVESPAS--SPPPAPNP---- 307
            |            |.|...:||.:|:.          ...|||..:.:|.|  |||.:..|
Human   260 P------------LLAVTAAPPAQPLAKKKGVKRKADTTTPTPTAILAPGSPASPPGSLEPKAAR 312

  Fly   308 ----------PIIICYKSL------------DRMIEK-SHSDHLLKSMVKRKRKQVTWAFNQA-- 347
                      ||....|.|            .::.|: .|.:.:||.::.:|.....|.|.:.
Human   313 LPPMRRESGRPIKPPRKDLPDSQQQHQSSKKGKLSEQLKHCNGILKELLSKKHAAYAWPFYKPVD 377

  Fly   348 -------DYWRRYSQNPDYDHD-REEKLDWKILQERLDSDNFESFDGFVSSVRKMFQNALRCFPE 404
                   ||           || .:..:|...::.::::.::.....|.:.||.||.|..:..|.
Human   378 ASALGLHDY-----------HDIIKHPMDLSTVKRKMENRDYRDAQEFAADVRLMFSNCYKYNPP 431

  Fly   405 DGLVKVSVKKTNEIFEKRLPKYRE--------LIATA-------------KEKGRQLVASREQDF 448
            |..|....:|..::||.|..|..:        .::||             .|:.....:|.|::.
Human   432 DHDVVAMARKLQDVFEFRYAKMPDEPLEPGPLPVSTAMPPGLAKSSSESSSEESSSESSSEEEEE 496

  Fly   449 RDSQNLLIKQENANKNFKGWVPKPFIIKTESLFVQEQRVYKMEPQDVQE 497
            .|.::   ::|.               ::||...:|:|.:::  .::||
Human   497 EDEED---EEEE---------------ESESSDSEEERAHRL--AELQE 525

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
tbrd-1	NP_651190.1	Bromodomain	39..143	CDD:445827	46/104 (44%)
		Mucin15	139..>291	CDD:406167	32/165 (19%)
		Bromodomain	328..423	CDD:445827	22/104 (21%)
BRD2	NP_001186384.1	Bromo_Brdt_I_like	74..180	CDD:99929	46/105 (44%)
		PHA03247	<216..333	CDD:223021	34/166 (20%)
		Bromo_Brdt_II_like	349..450	CDD:99930	23/111 (21%)
		BET	676..738	CDD:435704