DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tbrd-1 and brd2b

DIOPT Version :9

Sequence 1:	NP_001369030.1	Gene:	tbrd-1 / 42823	FlyBaseID:	FBgn0039124	Length:	513	Species:	Drosophila melanogaster
Sequence 2:	NP_001103994.1	Gene:	brd2b / 569354	ZFINID:	ZDB-GENE-070220-1	Length:	276	Species:	Danio rerio

Alignment Length:	237	Identity:	87/237 - (36%)
Similarity:	115/237 - (48%)	Gaps:	27/237 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 ELQSNSNQPPPRNEPYLQPVNGIVQPPVIPPPNRPGRRTNILEELKSVL-NCLWRNRFSYHFRHP 66
            |..|..:.|||...|.|       |||| ..|:|.||.||.|:.|..|| ..|||:.|::.|..|
Zfish    42 ESPSLPHAPPPGPPPPL-------QPPV-RDPSRQGRATNQLQFLHKVLVKALWRHHFAWPFHEP 98

  Fly    67 VDSVSLGVPDYHAVVKHPMDLSTIRKRLHNKYYWQASEALEDFKLIFDNCLLYNLEGSPVYQAGK 131
            ||:..|.:||||.::|.|||:.||:|||.|.||..|||.|:||..:|.||.:||.....:....:
Zfish    99 VDATRLNLPDYHKIIKQPMDMGTIKKRLENNYYRGASECLQDFNTMFTNCYIYNKPADDIVLMAQ 163

  Fly   132 LLMEAFYMRMESIDLSTEVELKPKSEKRKR-----KATESLDQASTS-FSAPRASNN-YSRQWLS 189
            .|.:.|..::..:. ..|:|| |....|.|     ||.:|...:.|| ...|..|:: ||.....
Zfish   164 SLEKVFLQKVAQMP-QDEIEL-PSPTPRGRGNKSVKARKSRGGSVTSAHQVPAVSHSAYSPSSPE 226

  Fly   190 SSSSWLCPPPMPGGVSSFNPSFRNFVGPSLI--PSFMPDSLV 229
            :..|....||.....||..|       ||||  |...|.:.|
Zfish   227 TPDSQFSTPPQTLLSSSGPP-------PSLITPPHTQPTAKV 261

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tbrd-1	NP_001369030.1	Bromodomain	39..143	CDD:413371	45/104 (43%)
tbrd-1	NP_001369030.1	Bromodomain	328..423	CDD:413371
brd2b	NP_001103994.1	Bromo_Brdt_I_like	70..176	CDD:99929	45/105 (43%)
brd2b	NP_001103994.1	Pol_alpha_B_N	<161..>248	CDD:285602	23/95 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170586809
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	149	1.000	Inparanoid score	I4352
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000322
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100249
Panther	1	1.100	-	-	O	PTHR22880
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.890