DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tbrd-1 and ep300b

DIOPT Version :9

Sequence 1:	NP_001369030.1	Gene:	tbrd-1 / 42823	FlyBaseID:	FBgn0039124	Length:	513	Species:	Drosophila melanogaster
Sequence 2:	XP_009297682.1	Gene:	ep300b / 565612	ZFINID:	ZDB-GENE-080403-15	Length:	2646	Species:	Danio rerio

Alignment Length:	616	Identity:	130/616 - (21%)
Similarity:	223/616 - (36%)	Gaps:	163/616 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MNELQSNSNQPPPRNEPYLQPVNGIVQPPVIPPPNRPGRRTNILEE-LKSVLNCLWR-NRFSYHF 63
            |....:...:|..:.||..:.|.|....|......:...:.:.|.: |...|..|:| :..|..|
Zfish   984 METSTAEDKKPEVKTEPKEEEVAGANSTPANTQSKKKEFKPDELRQALMPTLEALYRQDPESLPF 1048

  Fly    64 RHPVDSVSLGVP-----------DYHAVVKHPMDLSTIRKRLHNKYYWQASEALEDFKLIFDNCL 117
            |.|||...||:|           ||..:||:|:|||||:::|....|.:..:.::|..|:|:|..
Zfish  1049 RQPVDPQLLGIPVRIRTSNKTNLDYFDIVKNPIDLSTIKRKLDTGQYQEPWQYVDDVWLMFNNAW 1113

  Fly   118 LYNLEGSPVYQAGKLLMEAFYMRMESIDLSTEVELKPKSEKRKRKATESLDQASTSFSAPRASNN 182
            |||.:.|.||:....|.|.|           |.|:.|..::........|:
Zfish  1114 LYNRKTSRVYKYCSKLAEVF-----------EQEIDPVMQELGYCCGRKLE-------------- 1153

  Fly   183 YSRQWLSSSSSWLCPPPMPGGVSSFNPS-----------------FRNFVGPSLI----PSFMPD 226
            :|.|.|......||..|......|:..|                 |....|.::.    |: .|.
Zfish  1154 FSPQTLCCYGKQLCTIPRDAAYFSYQNSSPKYGLLADRYHFCEKCFNEIQGENVSLGDDPT-QPQ 1217

  Fly   227 SLVNPMQSMHPMSSMMNP-----------------IFKNN--WETNEAMDPPPSEPISYRPLDSL 272
            :.:|..|.....:..::|                 :..|.  |.:....|....:..|.|..:..
Zfish  1218 TSINKDQFQRKKNDTLDPELLLECGDCGRKMHQICVLHNETIWPSGFICDGCLKKSNSTRKENKY 1282

  Fly   273 AAP-LPSPPMEPMTLPWPTPAPVESPASSPPPAPNPP------IIICYKSLDRMIE-----KSH- 324
            ||. ||...:...         :|:..:......|.|      |.:.:.| |:::|     ||.
Zfish  1283 AAKRLPQTKLGNF---------LETRVNDYLKRQNHPESGEVTIRVVHIS-DKVVEVKPGMKSRF 1337

  Fly   325 --SDHLLKSMVKRKRKQVTWAFNQAD-----YWRRYSQNPDYDHDREEKLDWKILQERLDSDNF- 381
              |..:.:|...|.:  ..:||.:.|     ::..:.|  :|..|.......::....|||.:|
Zfish  1338 VDSGEMSESFPYRTK--ALFAFEEIDGTDVCFFGMHVQ--EYGSDCPPPNQRRVYISYLDSVHFF 1398

  Fly   382 -----------ESFDGFVSSVRKM---FQNALRCFPEDGLVKVSVKKTNEIF-----EKRLPKYR 427
                       |...|::..|:||   ..:...|.|.:|        .:.||     ::::||.:
Zfish  1399 QPRHLRTGVYHEILIGYLEYVKKMGFVMGHIWACPPSEG--------DDYIFHCHPSDQKIPKPK 1455

  Fly   428 ELIATAKEKGRQLVASR-EQDFRDSQNLLIKQENANK--------NFKG--WVPKPFIIKTESLF 481
            .|....|:...:.|..| ..|::|    :.||...::        .|:|  |   |.::: ||:.
Zfish  1456 RLQEWYKKMLDKAVTERIVHDYKD----IFKQATEDRLTSAKELPYFEGDFW---PNVLE-ESIK 1512

  Fly   482 VQEQRVYKMEPQDVQEFSPGTEPLDDQTYDS 512
            ..||   :.|.:..:|.:..:|.:|....||
Zfish  1513 ELEQ---EEEERKREENNTSSESIDATNGDS 1540

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tbrd-1	NP_001369030.1	Bromodomain	39..143	CDD:413371	39/116 (34%)
tbrd-1	NP_001369030.1	Bromodomain	328..423	CDD:413371	22/119 (18%)
ep300b	XP_009297682.1	zf-TAZ	318..385	CDD:280324
		KIX	534..614	CDD:280354
		Bromo_cbp_like	1024..1142	CDD:99927	42/128 (33%)
		RING_CBP-p300	1154..1236	CDD:276805	14/82 (17%)
		PHD_SF	1237..1271	CDD:304600	3/33 (9%)
		HAT_KAT11	1300..1607	CDD:285432	55/265 (21%)
		ZZ_CBP	1663..1703	CDD:239077
		ZnF_TAZ	1724..1802	CDD:214717
		Creb_binding	<2164..2231	CDD:286163
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5076
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.900