DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tbrd-1 and ep300a

DIOPT Version :9

Sequence 1:	NP_001369030.1	Gene:	tbrd-1 / 42823	FlyBaseID:	FBgn0039124	Length:	513	Species:	Drosophila melanogaster
Sequence 2:	XP_009304968.1	Gene:	ep300a / 559273	ZFINID:	ZDB-GENE-080403-16	Length:	2682	Species:	Danio rerio

Alignment Length:	494	Identity:	107/494 - (21%)
Similarity:	164/494 - (33%)	Gaps:	167/494 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 EELKS----VLNCLWR-NRFSYHFRHPVDSVSLGVPDYHAVVKHPMDLSTIRKRLHNKYYWQASE 104
            |||:.    .|..|:| :..|..||.|||...||:|||..:||:|||||||:::|....|.:..:
Zfish  1057 EELRQALMPTLESLYRQDPESLPFRQPVDPSLLGIPDYFDIVKNPMDLSTIKRKLDTGQYQEPWQ 1121

  Fly   105 ALEDFKLIFDNCLLYNLEGSPVYQAGKLLMEAFYMRMESIDLSTEVELKPKSEKRKRKATESLDQ 169
            .::|..|:|:|..|||.:.|.||:....|.|.|           |.|:.|..:
Zfish  1122 YVDDIWLMFNNAWLYNRKTSRVYKYCSKLAEVF-----------EQEIDPVMQ------------ 1163

  Fly   170 ASTSFSAPRASNNYSRQWLSSSSSWLCPPPMPGGVSSFNPSFRNFVGPSLIPSFMPDSLVNPMQS 234
             |..:...| ...:|.|.|......||..|......|:..|...:       ..:.|       .
Zfish  1164 -SLGYCCGR-KLEFSPQTLCCYGKQLCTIPRDAAYFSYQNSSPKY-------GLLAD-------R 1212

  Fly   235 MHPMSSMMNPIFKNNWETNEAMDPPPSEPISYRPLDSLAAPLPSPPMEPMTLPWPTPAPVESPAS 299
            .|......|.|              ..|.:|          |...|.:|.|
Zfish  1213 YHFCEKCFNEI--------------QGETVS----------LGDDPSQPQT-------------- 1239

  Fly   300 SPPPAPNPPIIICYKSLDRMIEKSHSDHLLKSMVKRKRKQVTWAFNQADYWRRYSQNPDYDHDRE 364
                      ...:.::.|.|.|.                                  .::..:.
Zfish  1240 ----------ATIFLNISRSINKD----------------------------------QFEKKKN 1260

  Fly   365 EKLDWKILQERLDSDNFESFDGFVSSVRKMFQNAL----RCFPE----DGLVKVS--VKKTNEIF 419
            :.||.::..|.:|..            |||.|..:    ..:|.    ||.:|.|  .:|.|:..
Zfish  1261 DTLDPELFVECMDCG------------RKMHQICVLHNETIWPSGFVCDGCLKKSNKTRKENKYA 1313

  Fly   420 EKRLPK-----YRELIATAKEKGRQLVASREQDFR---DSQNLLIKQENANKNF--KGWVPKPFI 474
            .||||:     :.|....|..|.:....|.|...|   .|:.::..:......|  .|.:.:.|.
Zfish  1314 AKRLPQTKLGNFLETRVNAYLKRQNHPESGEVTVRVVHVSEKMVEVKPGMKSRFVDSGEMSESFP 1378

  Fly   475 IKTESLFVQEQRVYKMEPQDVQEFSPGTEPLDDQTYDSD 513
            .|:::||..|:    ::..||..|.     :..|.|.||
Zfish  1379 YKSKALFAFEE----IDGVDVCFFG-----MHVQEYGSD 1408

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tbrd-1	NP_001369030.1	Bromodomain	39..143	CDD:413371	41/102 (40%)
tbrd-1	NP_001369030.1	Bromodomain	328..423	CDD:413371	16/104 (15%)
ep300a	XP_009304968.1	zf-TAZ	362..429	CDD:280324
		Med15	439..>907	CDD:255446
		KIX	571..649	CDD:280354
		Bromo_cbp_like	1056..1163	CDD:99927	44/116 (38%)
		RING_CBP-p300	1175..1266	CDD:276805	23/186 (12%)
		PHD_p300	1267..1301	CDD:277116	9/45 (20%)
		HAT_KAT11	1330..1637	CDD:285432	20/88 (23%)
		ZZ_CBP	1693..1733	CDD:239077
		ZnF_TAZ	1754..1832	CDD:214717
		Creb_binding	2141..2246	CDD:286163
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.000