DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tbrd-1 and Crebbp

DIOPT Version :9

Sequence 1:	NP_001369030.1	Gene:	tbrd-1 / 42823	FlyBaseID:	FBgn0039124	Length:	513	Species:	Drosophila melanogaster
Sequence 2:	XP_038942595.1	Gene:	Crebbp / 54244	RGDID:	2401	Length:	2454	Species:	Rattus norvegicus

Alignment Length:	590	Identity:	126/590 - (21%)
Similarity:	210/590 - (35%)	Gaps:	185/590 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 PNRPGRRTNILEELKS----VLNCLWR-NRFSYHFRHPVDSVSLGVPDYHAVVKHPMDLSTIRKR 93
            |::|.::....|||:.    .|..|:| :..|..||.|||...||:|||..:||:|||||||:::
  Rat  1078 PSQPRKKIFKPEELRQALMPTLEALYRQDPESLPFRQPVDPQLLGIPDYFDIVKNPMDLSTIKRK 1142

  Fly    94 LHNKYYWQASEALEDFKLIFDNCLLYNLEGSPVYQAGKLLMEAFYMRMESIDLSTEVELKPKSEK 158
            |....|.:..:.::|..|:|:|..|||.:.|.||:....|.|.|           |.|:.|..:
  Rat  1143 LDTGQYQEPWQYVDDVWLMFNNAWLYNRKTSRVYKFCSKLAEVF-----------EQEIDPVMQ- 1195

  Fly   159 RKRKATESLDQASTSFSAPRASNNYSRQWLSSSSSWLCPPPMPGGVSSFNPS------------- 210
                        |..:...| ...:|.|.|......||..|......|:..|
  Rat  1196 ------------SLGYCCGR-KYEFSPQTLCCYGKQLCTIPRDAAYYSYQNSSPKYGLLADRYHF 1247

  Fly   211 ----FRNFVGPSLIPSFMPDSLVNPMQSMHPMSSMMNPIFKNNWETNEAMDPPP----------S 261
                |....|.::.   :.|   :|.|   |.:::....|:.  :.|:.:||.|          .
  Rat  1248 CEKCFTEIQGENVT---LGD---DPSQ---PQTTISKDQFEK--KKNDTLDPEPFVDCKECGRKM 1301

  Fly   262 EPISYRPLDSLAAPLPSPPMEPMTLPWP-----------TPAPVESPASSPP------------- 302
            ..|.....|.:               ||           |..|.:....|..
  Rat  1302 HQICVLHYDII---------------WPSGFVCDNCLKKTGRPRKENKFSAKRLQTTRLGNHLED 1351

  Fly   303 -----------PAPNPPIIICYKSLDRMIE-----KSH---SDHLLKSMVKRKRKQVTWAFNQAD 348
                       |......:....|.|:.:|     ||.   |..:.:|...|.:  ..:||.:.|
  Rat  1352 RVNKFLRRQNHPEAGEVFVRVVASSDKTVEVKPGMKSRFVDSGEMSESFPYRTK--ALFAFEEID 1414

  Fly   349 -----YWRRYSQNPDYDHDREEKLDWKILQERLDSDNF------------ESFDGFVSSVRKM-- 394
                 ::..:.|  :|..|.......::....|||.:|            |...|::..|:|:
  Rat  1415 GVDVCFFGMHVQ--EYGSDCPPPNTRRVYISYLDSIHFFRPRCLRTAVYHEILIGYLEYVKKLGY 1477

  Fly   395 -FQNALRCFPEDGLVKVSVKKTNEIF-----EKRLPKYRELIATAKEKGRQLVASR-EQDFRDSQ 452
             ..:...|.|.:|        .:.||     ::::||.:.|....|:...:..|.| ..|::|
  Rat  1478 VTGHIWACPPSEG--------DDYIFHCHPPDQKIPKPKRLQEWYKKMLDKAFAERIINDYKD-- 1532

  Fly   453 NLLIKQENANK--------NFKG--WVPKPFIIKTESLFVQEQRVYKMEPQDVQEFSPGTEPLDD 507
              :.||.|.::        .|:|  |   |.::: ||:...||   :.|.:..:|.:..:|..:.
  Rat  1533 --IFKQANEDRLTSAKELPYFEGDFW---PNVLE-ESIKELEQ---EEEERKKEESTAASETPEG 1588

  Fly   508 QTYDS 512
            ...||
  Rat  1589 SQGDS 1593

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tbrd-1	NP_001369030.1	Bromodomain	39..143	CDD:413371	41/108 (38%)
tbrd-1	NP_001369030.1	Bromodomain	328..423	CDD:413371	21/119 (18%)
Crebbp	XP_038942595.1	zf-TAZ	362..429	CDD:396624
		KIX	586..666	CDD:366953
		PHA03247	<682..1098	CDD:223021	5/19 (26%)
		COG5076	942..>1194	CDD:227408	46/126 (37%)
		Bromo_cbp_like	1088..1195	CDD:99927	44/117 (38%)
		RING_CBP-p300	1207..1289	CDD:276805	17/92 (18%)
		PHD_CBP_p300	1291..1322	CDD:277032	4/45 (9%)
		HAT_KAT11	1353..1660	CDD:400497	52/264 (20%)
		ZZ_CBP	1716..1756	CDD:239077
		zf-TAZ	1783..1851	CDD:396624
		Med15	1971..>2425	CDD:312941
		Creb_binding	2045..2123	CDD:401102
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5076
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900