DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tbrd-1 and Brdt

DIOPT Version :9

Sequence 1:	NP_001369030.1	Gene:	tbrd-1 / 42823	FlyBaseID:	FBgn0039124	Length:	513	Species:	Drosophila melanogaster
Sequence 2:	NP_001012031.1	Gene:	Brdt / 305123	RGDID:	1306678	Length:	326	Species:	Rattus norvegicus

Alignment Length:	352	Identity:	97/352 - (27%)
Similarity:	150/352 - (42%)	Gaps:	90/352 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 IVQPPVIPP----PNRPGRRTNILEEL-KSVLNCLWRNRFSYHFRHPVDSVSLGVPDYHAVVKHP 84
            ||.||  ||    ..:.||.||.|:.| :.||..||::.||:.|:.|||:..|.:|||:.:::.|
  Rat    10 IVNPP--PPEYINAKKTGRLTNQLQFLQRVVLKALWKHSFSWPFQQPVDAAKLKLPDYYTIIETP 72

  Fly    85 MDLSTIRKRLHNKYYWQASEALEDFKLIFDNCLLYNLEGSPVYQAGKLLMEAFYMRMESIDLSTE 149
            ||||||:|||.|:||.:|||.:.||..:|.||.|||..|..:....:.|.:.|..::..:....:
  Rat    73 MDLSTIKKRLENRYYEKASECVGDFNTMFSNCYLYNKPGDDIVVMAQALEKLFMQKLSQMPQEEQ 137

  Fly   150 V---ELKPKSEKRKRKATESLDQASTSFSAPRASNNYSRQWLSSSSSWLCPPPMPGGVSSFNPSF 211
            :   :.:.|.:.:::.|..|..:.:.|.|   |.|.:.||
  Rat   138 IVGGKERMKKDIQQKTAVSSAKEQTPSKS---AENVFKRQ------------------------- 174

  Fly   212 RNFVGPSLIPSFMPDSLVNPMQSMHPMSSMMNPIFKNNWETNEAMDPPP---SEPI--------- 264
                   .||:..||..::|:                    |.|.:.||   |:.:
  Rat   175 -------EIPAGFPDVCLSPL--------------------NMAQEAPPTCDSQTVVQITKGVKR 212

  Fly   265 ---SYRPLDSLA-APLPSPPMEPMTLPWPTPAPV-ESPASS--PPPAPNPPIIICYKSLDRMIEK 322
               :..|..|.| |...|||  |:....|..||| |:...|  |.......::...|..:::
  Rat   213 RADTTTPTTSSAKASSESPP--PLREAKPANAPVKENTVKSVLPDSQQQHRVLKTVKVTEQL--- 272

  Fly   323 SHSDHLLKSMVKRKRKQVTWAF-NQAD 348
            .|...:||.|:.:|.....|.| |..|
  Rat   273 KHCSEILKEMLAKKHLPYAWPFYNPVD 299

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tbrd-1	NP_001369030.1	Bromodomain	39..143	CDD:413371	46/104 (44%)
tbrd-1	NP_001369030.1	Bromodomain	328..423	CDD:413371	8/22 (36%)
Brdt	NP_001012031.1	Bromo_Brdt_I_like	26..132	CDD:99929	46/105 (44%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	141..168		5/29 (17%)
		Nuclear localization signal. /evidence=ECO:0000250\|UniProtKB:Q58F21	208..219		0/10 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	209..257		15/49 (31%)
		Bromodomain	271..>322	CDD:295360	9/32 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	153	1.000	Inparanoid score	I4244
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000322
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100249
Panther	1	1.100	-	-	O	PTHR22880
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.960