Protein Alignment tbrd-1 and brd2a

DIOPT Version :10

• Sequence 1: NP_651190.1
• Gene: tbrd-1 / 42823
• FlyBaseID: FBgn0039124
• Length: 513
• Species: Drosophila melanogaster
• Sequence 2: NP_571275.2
• Gene: brd2a / 30445
• ZFINID: ZDB-GENE-990415-248
• Length: 836
• Species: Danio rerio
• Alignment Length: 494
• Identity: 114/494 - (23%)
• Similarity: 179/494 - (36%)
• Gaps: 166/494 - (33%)

  Fly    29 PVIPPPNRPGRRTNILEEL-KSVLNCLWRNRFSYHFRHPVDSVSLGVPDYHAVVKHPMDLSTIRK 92
            |.:..|:|.||.||.|:.| |:::..|||:.|::.|..|||:..|.:|||:.::|.|||:.||:|
Zfish    62 PAVRDPSRQGRMTNQLQFLQKALVKTLWRHHFAWPFHEPVDAAKLNLPDYYNIIKQPMDMGTIKK 126

  Fly    93 RLHNKYYWQASEALEDFKLIFDNCLLYNLEGSPVYQAGKLLMEAFYMRMESIDLSTEVELK---- 153
            ||.|.||..|||.::||..:|.||.:||.....:....:.|.:||   ::.:....|||.:
Zfish   127 RLENNYYRSASECMQDFNTMFTNCYIYNKPTDDIVLMAQSLEKAF---LQKVAQMPEVEEEIPAP 188

  Fly   154 -PKSEKRKRKATESLDQA--STSFSAPRASNNYSRQWLSSSSSWLCPPPMPGGVSSFNPSFRNFV 215
             |:.::.|.|..:.|...  :|:...|.         :||.|.....||.|.
Zfish   189 VPRGKQSKPKKGQKLFSGGITTAHQVPA---------ISSLSQLAYSPPTPD------------- 231

  Fly   216 GPSLIPSFMPDSLVN-PMQSMHPMSSMMNPIFKNNWETNEAMDPPPSEPISYRPLDSLAAPLPSP 279
                    .|||::: |.|::         |.||        .|||       ||.|..|.|..|
Zfish   232 --------TPDSVLSTPPQTL---------ITKN--------FPPP-------PLHSTPALLGLP 264

  Fly   280 PMEP------------------------------------------------------------- 283
            |.:|
Zfish   265 PTQPTAKKKGVKRKADTTTPTTTVMPLTLGVGGMGMGMGMGMSMGMGMGMGLGGDSPLTLSNMGM 329

  Fly   284 -----------MTLPWPTPA-------PVESPASSPPPAPNPPIIICYKSLDRMIEKSHSDHLLK 330
                       |:|....||       |::.|....|.:.|....:....|.:.:.  :...:||
Zfish   330 DSKQSLSLSLGMSLEDKVPARRGGSGRPIKPPRKDLPDSQNQHQPVRRGKLSQQLR--YCSTILK 392

  Fly   331 SMVKRKRKQVTWAFNQA---------DYWRRYSQNPDYDHDREEKLDWKILQERLDSDNFESFDG 386
            .::.:|.....|.|.:.         ||         ||... ..:|...::.::|...:.....
Zfish   393 ELLSKKHTAYAWPFYKPVDVSSLGLHDY---------YDIIM-YPMDLSTIKRKMDHREYRDALQ 447

  Fly   387 FVSSVRKMFQNALRCFPEDGLVKVSVKKTNEIFEKRLPK 425
            |.:.||.||.|..:..|.|..|....::..::||.|..|
Zfish   448 FAADVRLMFSNCYKYNPPDHDVVAMARRLQDVFEFRFAK 486

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
tbrd-1	NP_651190.1	Bromodomain	39..143	CDD:445827	43/104 (41%)
		Mucin15	139..>291	CDD:406167	36/231 (16%)
		Bromodomain	328..423	CDD:445827	22/103 (21%)
brd2a	NP_571275.2	Bromo_Brdt_I_like	72..178	CDD:99929	43/108 (40%)
		Bromo_Brdt_II_like	383..484	CDD:99930	22/112 (20%)
		BET	676..740	CDD:435704