DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tbrd-1 and bet-1

DIOPT Version :9

Sequence 1:	NP_001369030.1	Gene:	tbrd-1 / 42823	FlyBaseID:	FBgn0039124	Length:	513	Species:	Drosophila melanogaster
Sequence 2:	NP_001366626.1	Gene:	bet-1 / 172054	WormBaseID:	WBGene00022473	Length:	857	Species:	Caenorhabditis elegans

Alignment Length:	439	Identity:	109/439 - (24%)
Similarity:	171/439 - (38%)	Gaps:	94/439 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MNELQSNSNQPPPRNEPYLQPVNGIVQPPVIPPPNRPGRRTNILEE-LKSVLNCLWRNRFSYHFR 64
            |:|...:.:|..|...|..||:.|||||.|:||..:|.|.||.|:. :.:||....:::..:.|:
Worm     1 MSEGSGDQSQQRPWASPRQQPIKGIVQPRVLPPFGKPTRHTNKLDYIMTTVLKEAGKHKHVWPFQ 65

  Fly    65 HPVDSVSLGVPDYHAVVKHPMDLSTIRKRLHNKYYWQASEALEDFKLIFDNCLLYNLEGSPVYQA 129
            .|||:|:|.:|.||..|..||||.||..||.:.||..|.|.::|.:.:|.||..:|
Worm    66 KPVDAVALCIPLYHERVARPMDLKTIENRLKSTYYTCAQECIDDIETVFQNCYTFN--------- 121

  Fly   130 GKLLMEAFYMRMESIDLSTEVELKPKSEKRKRKATESLDQASTSFSAPRASNNYSRQWLSSSSSW 194
            ||                 |.::...::.......:||:|      |||..::....|..:...
Worm   122 GK-----------------EDDVTIMAQNVHEVIKKSLEQ------APREEHDMDVYWGKNKKK- 162

  Fly   195 LCPPPMPGGVSSFNPSFRNFVGPSLIPSFMPDSLVNPMQSMHPMSSMMNPIFKNNWETNEAMDPP 259
              |....||..|.:....:..|||..||          ::...:||:         .|..|..|.
Worm   163 --PAKSDGGSKSSSSKKNDARGPSEAPS----------EAGSEVSSV---------TTASAAAPT 206

  Fly   260 PSEPISY---------------RPLDSLAAPLPSPPMEPMTLPWPTPAPVESPASSP-PPAPNPP 308
            .||..|.               |..:|.....|.|......:     |.|:.....| .|:..|
Worm   207 VSESASVAAKPERKVAGKKTGKRKAESEDDEKPEPLRAKREV-----AVVKKEVHQPLLPSMKP- 265

  Fly   309 IIICYKSLDRMIEKSHSDHLLKSMVKRKRKQVTWAFNQADYWRRYSQNPDYDHDREEKLDWKILQ 373
               |.|             ||.....:|.::..|.||:.....:...: ||....:|.:|.|.::
Worm   266 ---CLK-------------LLNDFSTKKYQEFAWPFNEPVDAEQLGLH-DYHKIIKEPMDLKSMK 313

  Fly   374 ERLDSDNFESFDGFVSSVRKMFQNALRCFPEDGLVKVSVKKTNEIFEKR 422
            .:::|..::....|...||.|.:|.....|....|.....:..|:|::|
Worm   314 AKMESGAYKEPSDFEHDVRLMLRNCFLYNPVGDPVHSFGLRFQEVFDRR 362

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tbrd-1	NP_001369030.1	Bromodomain	39..143	CDD:413371	35/104 (34%)
tbrd-1	NP_001369030.1	Bromodomain	328..423	CDD:413371	22/95 (23%)
bet-1	NP_001366626.1	Bromo_Brdt_I_like	39..145	CDD:99929	39/137 (28%)
		PLN02967	95..>240	CDD:215521	39/198 (20%)
		Bromo_Brdt_II_like	262..363	CDD:99930	25/119 (21%)
		Ribosomal_P1_P2_L12p	<371..416	CDD:419700
		BET	526..592	CDD:407211
		DMRT-like	<684..730	CDD:374115
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000322
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100249
Panther	1	1.100	-	-	O	PTHR22880
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.910