DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tbrd-1 and Brd2

DIOPT Version :9

Sequence 1:	NP_001369030.1	Gene:	tbrd-1 / 42823	FlyBaseID:	FBgn0039124	Length:	513	Species:	Drosophila melanogaster
Sequence 2:	NP_001191902.1	Gene:	Brd2 / 14312	MGIID:	99495	Length:	798	Species:	Mus musculus

Alignment Length:	559	Identity:	139/559 - (24%)
Similarity:	234/559 - (41%)	Gaps:	138/559 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 LQSNSNQPPPRNEPYLQPVNGIVQPPVIPPPNRPGRRTNILEEL-KSVLNCLWRNRFSYHFRHPV 67
            |......|...:.|.||.......||.:..|.:|||.||.|:.| |.|:..||:::|::.||.||
Mouse    38 LYEGFESPTMASVPALQLAPANPPPPEVSNPKKPGRVTNQLQYLHKVVMKALWKHQFAWPFRQPV 102

  Fly    68 DSVSLGVPDYHAVVKHPMDLSTIRKRLHNKYYWQASEALEDFKLIFDNCLLYNLEGSPVYQAGKL 132
            |:|.||:||||.::|.|||:.||::||.|.|||.|||.::||..:|.||.:||.....:....:.
Mouse   103 DAVKLGLPDYHKIIKQPMDMGTIKRRLENNYYWAASECMQDFNTMFTNCYIYNKPTDDIVLMAQT 167

  Fly   133 LMEAFYMRMESIDLSTEVELK---PKSEKRKRKATESLDQASTS-FSAPRASNNYSRQWLSSSSS 193
            |.:.|..::.|:. ..|.||.   ||:..:|.....:|..:.|| ...|..|:      :|.::.
Mouse   168 LEKIFLQKVASMP-QEEQELVVTIPKNSHKKGAKLAALQGSITSAHQVPAVSS------VSHTAL 225

  Fly   194 WLCPPPMPGGVSSFNPSFRNFVGPSLIPSFMPDSLVNPMQSMHPMSSMMNPIFKNNWETNEAMDP 258
            :..||.:|..|       .|...||:|.|.:       ::|:|                  :..|
Mouse   226 YTPPPEIPTTV-------LNIPHPSVISSPL-------LKSLH------------------SAGP 258

  Fly   259 PPSEPISYRPLDSLAAPLPSPPMEPMT----------LPWPTPAPVESPAS--SPPPAPNP---- 307
            |            |.|...:||.:|:.          ...|||..:.:|.|  |||.:..|
Mouse   259 P------------LLAVSAAPPAQPLAKKKGVKRKADTTTPTPTAILAPGSPASPPGSLEPKAAR 311

  Fly   308 ----------PIIICYKSL------------DRMIEK-SHSDHLLKSMVKRKRKQVTWAFNQA-- 347
                      ||....|.|            .::.|: .|.:.:||.::.:|.....|.|.:.
Mouse   312 LPPMRRESGRPIKPPRKDLPDSQQQHQSSKKGKLSEQLKHCNGILKELLSKKHAAYAWPFYKPVD 376

  Fly   348 -------DYWRRYSQNPDYDHD-REEKLDWKILQERLDSDNFESFDGFVSSVRKMFQNALRCFPE 404
                   ||           || .:..:|...::.::::.::.....|.:.||.||.|..:..|.
Mouse   377 ASALGLHDY-----------HDIIKHPMDLSTVKRKMENRDYRDAQEFAADVRLMFSNCYKYNPP 430

  Fly   405 DGLVKVSVKKTNEIFEKRLPKYRE--------LIATAKEKG---RQLVASREQDFRDSQNLLIKQ 458
            |..|....:|..::||.|..|..:        .::||...|   ....:|.|:...:|.:...::
Mouse   431 DHDVVAMARKLQDVFEFRYAKMPDEPLEPGPLPVSTALPPGLTKSSSESSSEESSSESSSEEEEE 495

  Fly   459 ENANKNFKGWVPKPFIIKTESLFVQEQRVYKMEPQDVQE 497
            |..:::.:         ::||...:|:|.:::  .::||
Mouse   496 EEEDEDEE---------ESESSDSEEERAHRL--AELQE 523

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tbrd-1	NP_001369030.1	Bromodomain	39..143	CDD:413371	46/104 (44%)
tbrd-1	NP_001369030.1	Bromodomain	328..423	CDD:413371	22/104 (21%)
Brd2	NP_001191902.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..21
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	53..72		5/18 (28%)
		Bromo_Brdt_I_like	73..179	CDD:99929	46/105 (44%)
		PHA03247	<215..332	CDD:223021	34/166 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	267..348		16/80 (20%)
		Bromo_Brdt_II_like	348..449	CDD:99930	23/111 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	454..645		13/81 (16%)
		Nuclear localization signal. /evidence=ECO:0000255	553..557
		BET	639..701	CDD:407211
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	736..798
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167842379
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5076
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	153	1.000	Inparanoid score	I4316
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000322
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100249
Panther	1	1.100	-	-	O	PTHR22880
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	8	7.750