Protein Alignment tbrd-1 and CREBBP

DIOPT Version :9

• Sequence 1: NP_001369030.1
• Gene: tbrd-1 / 42823
• FlyBaseID: FBgn0039124
• Length: 513
• Species: Drosophila melanogaster
• Sequence 2: NP_004371.2
• Gene: CREBBP / 1387
• HGNCID: 2348
• Length: 2442
• Species: Homo sapiens
• Alignment Length: 270
• Identity: 72/270 - (26%)
• Similarity: 110/270 - (40%)
• Gaps: 64/270 - (23%)

  Fly     3 ELQSNSNQPPPRNEPYLQPVNGIVQPPVIPPPNRPGRRTNILEELKS----VLNCLWR-NRFSYH 62
            |.:|:||....::....||...|.:|                |||:.    .|..|:| :..|..
Human  1062 EEESSSNGTASQSTSPSQPRKKIFKP----------------EELRQALMPTLEALYRQDPESLP 1110

  Fly    63 FRHPVDSVSLGVPDYHAVVKHPMDLSTIRKRLHNKYYWQASEALEDFKLIFDNCLLYNLEGSPVY 127
            ||.|||...||:|||..:||:|||||||:::|....|.:..:.::|..|:|:|..|||.:.|.||
Human  1111 FRQPVDPQLLGIPDYFDIVKNPMDLSTIKRKLDTGQYQEPWQYVDDVWLMFNNAWLYNRKTSRVY 1175

  Fly   128 QAGKLLMEAFYMRMESIDLSTEVELKPKSEKRKRKATESLDQASTSFSAPRASNNYSRQWLSSSS 192
            :....|.|.|           |.|:.|..:             |..:...| ...:|.|.|....
Human  1176 KFCSKLAEVF-----------EQEIDPVMQ-------------SLGYCCGR-KYEFSPQTLCCYG 1215

  Fly   193 SWLCPPPMPGGVSSF-------NPSFRNFVGPSLIPSFMPDSLVNPMQSMHPMSSMMNPIFKNNW 250
            ..||..|......|:       ...|....|.::.   :.|   :|.|   |.:::....|:.
Human  1216 KQLCTIPRDAAYYSYQNRYHFCEKCFTEIQGENVT---LGD---DPSQ---PQTTISKDQFEK-- 1269

  Fly   251 ETNEAMDPPP 260
            :.|:.:||.|
Human  1270 KKNDTLDPEP 1279

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
tbrd-1	NP_001369030.1	Bromodomain	39..143	CDD:413371	41/108 (38%)
		Bromodomain	328..423	CDD:413371
CREBBP	NP_004371.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..41
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	74..179
		Interaction with SRCAP. /evidence=ECO:0000269|PubMed:10347196	227..410
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	266..290
		zf-TAZ	363..430	CDD:280324
		KIX	587..667	CDD:280354
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	794..1083		6/20 (30%)
		Bromo_cbp_like	1087..1194	CDD:99927	45/133 (34%)
		Interaction with histone. /evidence=ECO:0000269|PubMed:24361270	1124..1170		20/45 (44%)
		Interaction with ASF1A. /evidence=ECO:0000269|PubMed:24616510	1162..1180		7/17 (41%)
		RING_CBP-p300	1206..1278	CDD:276805	16/82 (20%)
		PHD_CBP_p300	1280..1311	CDD:277032	72/270 (27%)
		HAT_KAT11	1342..1649	CDD:285432
		Interaction with histone. /evidence=ECO:0000250|UniProtKB:Q09472	1433..1435
		Acetyl-CoA binding. /evidence=ECO:0000250|UniProtKB:Q09472	1434..1436
		Acetyl-CoA binding. /evidence=ECO:0000250|UniProtKB:Q09472	1446..1447
		Interaction with TRERF1. /evidence=ECO:0000269|PubMed:11349124	1460..1891
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1556..1615
		ZZ_CBP	1705..1745	CDD:239077
		ZnF_TAZ	1766..1844	CDD:214717
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1874..1959
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1977..2028
		Med15	1986..>2413	CDD:255446
		Creb_binding	2034..2111	CDD:286163
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2112..2263
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2294..2433

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5076
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900