DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tbrd-1 and Crebbp

DIOPT Version :9

Sequence 1:	NP_001369030.1	Gene:	tbrd-1 / 42823	FlyBaseID:	FBgn0039124	Length:	513	Species:	Drosophila melanogaster
Sequence 2:	XP_006521814.1	Gene:	Crebbp / 12914	MGIID:	1098280	Length:	2451	Species:	Mus musculus

Alignment Length:	621	Identity:	131/621 - (21%)
Similarity:	217/621 - (34%)	Gaps:	201/621 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 ELQSNSNQPPPRNEPYLQPVNGIVQPPVIPPPNRPGRRTNILEELKS----VLNCLWR-NRFSYH 62
            |.:::||....::....||...|.:|                |||:.    .|..|:| :..|..
Mouse  1063 EEENSSNDTASQSTSPSQPRKKIFKP----------------EELRQALMPTLEALYRQDPESLP 1111

  Fly    63 FRHPVDSVSLGVPDYHAVVKHPMDLSTIRKRLHNKYYWQASEALEDFKLIFDNCLLYNLEGSPVY 127
            ||.|||...||:|||..:||:|||||||:::|....|.:..:.::|..|:|:|..|||.:.|.||
Mouse  1112 FRQPVDPQLLGIPDYFDIVKNPMDLSTIKRKLDTGQYQEPWQYVDDVWLMFNNAWLYNRKTSRVY 1176

  Fly   128 QAGKLLMEAFYMRMESIDLSTEVELKPKSEKRKRKATESLDQASTSFSAPRASNNYSRQWLSSSS 192
            :....|.|.|           |.|:.|..:             |..:...| ...:|.|.|....
Mouse  1177 KFCSKLAEVF-----------EQEIDPVMQ-------------SLGYCCGR-KYEFSPQTLCCYG 1216

  Fly   193 SWLCPPPMPGGVSSFNPS-----------------FRNFVGPSLIPSFMPDSLVNPMQSMHPMSS 240
            ..||..|......|:..|                 |....|.::.   :.|   :|.|   |.::
Mouse  1217 KQLCTIPRDAAYYSYQNSSPKYGLLADRYHFCEKCFTEIQGENVT---LGD---DPSQ---PQTT 1272

  Fly   241 MMNPIFKNNWETNEAMDPPP----------SEPISYRPLDSLAAPLPSPPMEPMTLPWP------ 289
            :....|:.  :.|:.:||.|          ...|.....|.:               ||
Mouse  1273 ISKDQFEK--KKNDTLDPEPFVDCKECGRKMHQICVLHYDII---------------WPSGFVCD 1320

  Fly   290 -----TPAPVESPASSPP------------------------PAPNPPIIICYKSLDRMIE---- 321
                 |..|.:....|..                        |......:....|.|:.:|
Mouse  1321 NCLKKTGRPRKENKFSAKRLQTTRLGNHLEDRVNKFLRRQNHPEAGEVFVRVVASSDKTVEVKPG 1385

  Fly   322 -KSH---SDHLLKSMVKRKRKQVTWAFNQAD-----YWRRYSQNPDYDHDREEKLDWKILQERLD 377
             ||.   |..:.:|...|.:  ..:||.:.|     ::..:.|  :|..|.......::....||
Mouse  1386 MKSRFVDSGEMSESFPYRTK--ALFAFEEIDGVDVCFFGMHVQ--EYGSDCPPPNTRRVYISYLD 1446

  Fly   378 SDNF------------ESFDGFVSSVRKM---FQNALRCFPEDGLVKVSVKKTNEIF-----EKR 422
            |.:|            |...|::..|:|:   ..:...|.|.:|        .:.||     :::
Mouse  1447 SIHFFRPRCLRTAVYHEILIGYLEYVKKLGYVTGHIWACPPSEG--------DDYIFHCHPPDQK 1503

  Fly   423 LPKYRELIATAKEKGRQLVASR-EQDFRDSQNLLIKQENANK--------NFKG--WVPKPFIIK 476
            :||.:.|....|:...:..|.| ..|::|    :.||.|.::        .|:|  |   |.:::
Mouse  1504 IPKPKRLQEWYKKMLDKAFAERIINDYKD----IFKQANEDRLTSAKELPYFEGDFW---PNVLE 1561

  Fly   477 TESLFVQEQRVYKMEPQDVQEFSPGTEPLDDQTYDS 512
             ||:...||   :.|.:..:|.:..:|..:....||
Mouse  1562 -ESIKELEQ---EEEERKKEESTAASETPEGSQGDS 1593

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tbrd-1	NP_001369030.1	Bromodomain	39..143	CDD:413371	41/108 (38%)
tbrd-1	NP_001369030.1	Bromodomain	328..423	CDD:413371	21/119 (18%)
Crebbp	XP_006521814.1	zf-TAZ	362..429	CDD:366931
		KIX	586..666	CDD:366953
		PHA03247	<687..1037	CDD:223021
		COG5076	942..>1194	CDD:227408	51/157 (32%)
		Bromo_cbp_like	1088..1195	CDD:99927	45/133 (34%)
		RING_CBP-p300	1207..1289	CDD:276805	17/92 (18%)
		PHD_CBP_p300	1291..1322	CDD:277032	4/45 (9%)
		HAT_KAT11	1353..>1564	CDD:369758	44/230 (19%)
		ZZ_CBP	1716..1756	CDD:239077
		ZnF_TAZ	1777..1855	CDD:214717
		Med15	1971..>2422	CDD:312941
		Creb_binding	2045..2125	CDD:370251
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5076
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900