DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tbrd-1 and brdt

DIOPT Version :9

Sequence 1:	NP_001369030.1	Gene:	tbrd-1 / 42823	FlyBaseID:	FBgn0039124	Length:	513	Species:	Drosophila melanogaster
Sequence 2:	XP_012817895.2	Gene:	brdt / 100144959	XenbaseID:	XB-GENE-983868	Length:	1013	Species:	Xenopus tropicalis

Alignment Length:	477	Identity:	127/477 - (26%)
Similarity:	199/477 - (41%)	Gaps:	83/477 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 NGIVQPPVIPPP----NRPGRRTNILEEL-KSVLNCLWRNRFSYHFRHPVDSVSLGVPDYHAVVK 82
            :.||.||  ||.    .:.||.||.|:.| |.||..|||:.||:.|:.|||:..|.:|||:.::|
Frog    10 SSIVNPP--PPEYINRKKTGRLTNQLQYLEKVVLKALWRHHFSWPFQQPVDAAKLNLPDYYQIIK 72

  Fly    83 HPMDLSTIRKRLHNKYYWQASEALEDFKLIFDNCLLYNLEGSPVYQAGKLLMEAFY-----MRME 142
            :|||||||||||...||.:|.:.::||..:|.||.:||..|..:....:.|.:.|.     |..|
Frog    73 NPMDLSTIRKRLEYNYYSKALDCIQDFNTMFTNCYIYNKPGDDIVVMSQELEKVFMEKIAEMPHE 137

  Fly   143 SIDLSTEVELKPKSEKRKRKATESLDQASTSFSAPRASNNYSRQWLSSSSSWLCPPPMPGGVSSF 207
            .|:||.......|| :.|..|..:.:....|...|........|.: ...::.||      |.:.
Frog   138 EIELSVVGNRGVKS-RIKISAVAAEESRDDSDYIPVCKKKMVSQKM-HRRTFPCP------VIAM 194

  Fly   208 NPSFRNFVGPSLIPSFMPDSLVNPMQSMHPMSSM--MNPIFKNNWETNEAMDPPPSEPISYRPLD 270
            .|.....|         |.|::....|.|..||:  :|...|...:|.             .|..
Frog   195 MPKRTTLV---------PLSVIRSSTSSHSASSVSKVNKGIKRKADTT-------------TPAV 237

  Fly   271 SL-AAPLPSPPMEPMTLPWPTPAPV-------ESPASSPPPAPNPPIIICYKSLDRMIEK-SHSD 326
            || |....|.|    ||..|.|..:       .|..:|....|:....|.:...:::.|: .|.:
Frog   238 SLIATSCESSP----TLSEPKPNKILSGTEKTRSAETSAVDLPDSQHHIHFIKSNQICEQLKHCN 298

  Fly   327 HLLKSMVKRKRKQVTWAFNQADYWRRYSQNP----DYDHDREEKLDWKILQERLDSDNFESFDGF 387
            ::|..|:.:|..:..|.|.:       :..|    |.....:..:|...:::::::..::....|
Frog   299 NILNEMMSKKHAEYAWPFYK-------TVIPTSLLDCSDAIKHPMDLATIRDKMENGLYKDTQDF 356

  Fly   388 VSSVRKMFQNALRCFPEDGLVKVSVKKTNEIFEKRLPKYR----------ELIATAKEKGRQLVA 442
            .|.||.||.|:.:..|.|..|....:|..::||....|..          |...|:.|:.....:
Frog   357 ASDVRLMFMNSYKYNPPDNEVVNMARKMQDVFEGMFAKIPDDPLATQSMVERYKTSTEESSSSSS 421

  Fly   443 SREQDFRDS-----QNLLIKQE 459
            |.:....||     |:|.:.||
Frog   422 SEQSSSSDSEDERAQHLALLQE 443

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tbrd-1	NP_001369030.1	Bromodomain	39..143	CDD:413371	47/109 (43%)
tbrd-1	NP_001369030.1	Bromodomain	328..423	CDD:413371	21/98 (21%)
brdt	XP_012817895.2	Bromo_Brdt_I_like	28..134	CDD:99929	46/105 (44%)
		Bromodomain	293..392	CDD:413371	22/105 (21%)
		BET	526..589	CDD:407211
		BRD4_CDT	973..1013	CDD:407248
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000322
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR22880
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.010