DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tbrd-1 and brd2

DIOPT Version :9

Sequence 1:	NP_001369030.1	Gene:	tbrd-1 / 42823	FlyBaseID:	FBgn0039124	Length:	513	Species:	Drosophila melanogaster
Sequence 2:	XP_012809277.2	Gene:	brd2 / 100038037	XenbaseID:	XB-GENE-481598	Length:	778	Species:	Xenopus tropicalis

Alignment Length:	483	Identity:	124/483 - (25%)
Similarity:	192/483 - (39%)	Gaps:	84/483 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 NELQSNSNQPPPRNEPYLQPVNGIVQPPVIPPPNRPGRRTNILEEL-KSVLNCLWRNRFSYHFRH 65
            |...|..:|.|..|.|          ||......:|||.||.|:.| |.|:..||:::||:.||.
Frog    47 NMTSSVFHQLPQTNPP----------PPEFSNSKKPGRSTNQLQYLHKVVMKSLWKHQFSWPFRQ 101

  Fly    66 PVDSVSLGVPDYHAVVKHPMDLSTIRKRLHNKYYWQASEALEDFKLIFDNCLLYNLEGSPVYQAG 130
            |||:|.||:||||.::|.|||:.||:|||.|.|||.|.|.::||..:|.||.:||.....:....
Frog   102 PVDAVKLGLPDYHKIIKQPMDMGTIKKRLENNYYWSALECMQDFNTMFTNCYIYNKPTDDIVLMA 166

  Fly   131 KLLMEAFYMRMESIDLSTEVELKPKSEKRKR----KATESLDQASTSFSAPRASNNYSRQWLSSS 191
            :.|.:.|..::..:. ..|.|:...:.|.|.    |.:......:|:...|..|        |.|
Frog   167 QSLEKMFLQKVAQMP-QEEQEIPNTASKIKNVKISKTSGPTGGVTTAHQVPAVS--------SQS 222

  Fly   192 SSWLCPPPMPGGVSSF-------NPSFRNFVGPSLIPSFMPDSLVNPMQSMHPMSSMMNPIFKNN 249
            |.:...|.:|..:.|.       ||..::......:.|.:|.:              ..|:.|..
Frog   223 SLYPSSPEVPTTMLSLAHSSIISNPVLKSMPSSQAVLSVLPGA--------------TQPVAKKK 273

  Fly   250 WETNEAMDPPPSEPISYRPLDSLAAPLPSPPMEPMTLPWPTPAPVESPASSPPPAPNPPIIICYK 314
            ....:|....|:..........|     ||.....|.|...||..||.....||..:.|     .
Frog   274 GVKRKADTTTPTTTAIIATSGDL-----SPLQASETKPAKIPARRESGRPIKPPKKDLP-----D 328

  Fly   315 SLDRMIEK--------SHSDHLLKSMVKRKRKQVTWAFNQA---------DYWRRYSQNPDYDHD 362
            |......|        .:.:.:||.::.:|.....|.|.:.         ||         ||..
Frog   329 SQQHQTSKKGKLSEQLKYCNGILKELLSKKHAAYAWPFYKPVDVSALGLHDY---------YDII 384

  Fly   363 REEKLDWKILQERLDSDNFESFDGFVSSVRKMFQNALRCFPEDGLVKVSVKKTNEIFEKRLPKYR 427
            : ..:|...:::::|:..|:....|.::||.||.|..:..|.|..|....:|..::||.|..|..
Frog   385 K-HPMDLSTIKKKMDNREFKDAQEFAAAVRLMFSNCYKYNPPDHDVVAMARKLQDVFEFRYAKMP 448

  Fly   428 E--LIATAKEKGRQLVASREQDFRDSQN 453
            :  |:........||..|..:...:|.:
Frog   449 DEPLVVNPPSTSSQLPPSDSKSSSESSS 476

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tbrd-1	NP_001369030.1	Bromodomain	39..143	CDD:413371	47/104 (45%)
tbrd-1	NP_001369030.1	Bromodomain	328..423	CDD:413371	24/103 (23%)
brd2	XP_012809277.2	Bromo_Brdt_I_like	74..180	CDD:99929	47/105 (45%)
		Bromo_Brdt_II_like	343..444	CDD:99930	24/110 (22%)
		BET	610..674	CDD:407211
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000322
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR22880
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.010