DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pli and Peli2

DIOPT Version :9

Sequence 1:	NP_001097890.1	Gene:	Pli / 42821	FlyBaseID:	FBgn0025574	Length:	424	Species:	Drosophila melanogaster
Sequence 2:	NP_291080.2	Gene:	Peli2 / 93834	MGIID:	1891445	Length:	419	Species:	Mus musculus

Alignment Length:	424	Identity:	252/424 - (59%)
Similarity:	312/424 - (73%)	Gaps:	15/424 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 GTESPILAEDGGDGHDKPRLRYGELVILGYNGYLPQGDRGRRRSKFVLHKRTEASGVKRSKHYIV 71
            |.|.|       ...:|..::|||||:|||||.||.||||||:|:|.|:|||.|||||.|..::|
Mouse     5 GQEEP-------SAPNKEPVKYGELVVLGYNGALPNGDRGRRKSRFALYKRTYASGVKPSTIHMV 62

  Fly    72 QSPQTSKAILDANQHSISYTLSRNQAVIVEYKEDTETDMFQVGRSSESPIDFVVMDTLP-GDKKD 135
            .:||.||||.....|||||||||:|.|:|||..|.:|||||||||:||||||||.||:. |..:|
Mouse    63 STPQASKAISSRGHHSISYTLSRSQTVVVEYTHDKDTDMFQVGRSTESPIDFVVTDTVSGGQNED 127

  Fly   136 AKVMQSTISRFACRILVNRCEPAKARIFAAGFDSSRNIFLGEKATKWQD-NVEIDGLTTNGVLIM 199
            |::.|||||||||||:.:|.||..|||||||||||:||||||||.||:: :..:|||||||||:|
Mouse   128 AQITQSTISRFACRIVCDRNEPYTARIFAAGFDSSKNIFLGEKAAKWKNPDGHMDGLTTNGVLVM 192

  Fly   200 HPKGSFCGGNAKCGLWRECSVGGDVFSLRESRSAQQKGQPIYDECNILQDGTLIDLCGATLLWRS 264
            ||:|.|. ..::.|:|||.||.|||::|||:|||||:|:.:..|.|:||||:||||||||||||:
Mouse   193 HPQGGFT-EESQPGVWREISVCGDVYTLRETRSAQQRGKLVESETNVLQDGSLIDLCGATLLWRT 256

  Fly   265 AEGLQHSPTKHDLEKLIDAINAGRPQCPVGLNTLVIPRKVNIGDQV--NQPYVYLNCGHVQGHHD 327
            |:||.|:||:..:|.|...|||.|||||||||||..| .:|..:.|  .||:.||:||||.|:|.
Mouse   257 ADGLFHAPTQKHIEALRQEINAARPQCPVGLNTLAFP-SINRKEVVEEKQPWAYLSCGHVHGYHS 320

  Fly   328 WGQDENTGA--RRCPMCLELGPVVTLCMGLEPAFYVDVGAPTYAFNPCGHMATEKTVKYWANVEI 390
            ||...:|.|  |.||||..:||.|.|.:|.|..||||.|.||:||.||||:.:||:.|||:.:.:
Mouse   321 WGHRSDTEANERECPMCRTVGPYVPLWLGCEAGFYVDAGPPTHAFTPCGHVCSEKSAKYWSQIPL 385

  Fly   391 PHGTNGFQAVCPFCATPLDGATGYIKLIFQDNLD 424
            ||||:.|.|.||||||.|.|....||||||..:|
Mouse   386 PHGTHAFHAACPFCATQLVGEQNCIKLIFQGPVD 419

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pli	NP_001097890.1	Pellino	21..424	CDD:398402	248/408 (61%)
Peli2	NP_291080.2	Pellino	12..419	CDD:282553	248/408 (61%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	498	1.000	Domainoid score	I353
eggNOG	1	0.900	-	-		E1_KOG3842
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H41431
Inparanoid	1	1.050	498	1.000	Inparanoid score	I1362
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48577
OrthoDB	1	1.010	-	-		D251367at33208
OrthoFinder	1	1.000	-	-		FOG0001485
OrthoInspector	1	1.000	-	-		otm44208
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR12098
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4716
SonicParanoid	1	1.000	-	-		X944
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.970