DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pli and PELI2

DIOPT Version :9

Sequence 1:	NP_001097890.1	Gene:	Pli / 42821	FlyBaseID:	FBgn0025574	Length:	424	Species:	Drosophila melanogaster
Sequence 2:	NP_067078.1	Gene:	PELI2 / 57161	HGNCID:	8828	Length:	420	Species:	Homo sapiens

Alignment Length:	418	Identity:	249/418 - (59%)
Similarity:	314/418 - (75%)	Gaps:	12/418 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 GGDGH---DKPRLRYGELVILGYNGYLPQGDRGRRRSKFVLHKRTEASGVKRSKHYIVQSPQTSK 78
            |.:.|   :|..::|||||:|||||.||.||||||:|:|.|:||.:|:|||.|..:::.:||.||
Human     5 GQEEHCAPNKEPVKYGELVVLGYNGALPNGDRGRRKSRFALYKRPKANGVKPSTVHVISTPQASK 69

  Fly    79 AILDANQHSISYTLSRNQAVIVEYKEDTETDMFQVGRSSESPIDFVVMDTLPGDKK--DAKVMQS 141
            ||....||||||||||||.|:|||..|.:|||||||||:||||||||.||:.|.:.  :|::.||
Human    70 AISCKGQHSISYTLSRNQTVVVEYTHDKDTDMFQVGRSTESPIDFVVTDTISGSQNTDEAQITQS 134

  Fly   142 TISRFACRILVNRCEPAKARIFAAGFDSSRNIFLGEKATKWQD-NVEIDGLTTNGVLIMHPKGSF 205
            |||||||||:.:|.||..|||||||||||:||||||||.||:: :..:|||||||||:|||:|.|
Human   135 TISRFACRIVCDRNEPYTARIFAAGFDSSKNIFLGEKAAKWKNPDGHMDGLTTNGVLVMHPRGGF 199

  Fly   206 CGGNAKCGLWRECSVGGDVFSLRESRSAQQKGQPIYDECNILQDGTLIDLCGATLLWRSAEGLQH 270
            . ..::.|:|||.||.|||::|||:|||||:|:.:..|.|:||||:||||||||||||:|:||.|
Human   200 T-EESQPGVWREISVCGDVYTLRETRSAQQRGKLVESETNVLQDGSLIDLCGATLLWRTADGLFH 263

  Fly   271 SPTKHDLEKLIDAINAGRPQCPVGLNTLVIPRKVNIGDQV--NQPYVYLNCGHVQGHHDWGQDEN 333
            :||:..:|.|...|||.|||||||||||..| .:|..:.|  .||:.||:||||.|:|:||...:
Human   264 TPTQKHIEALRQEINAARPQCPVGLNTLAFP-SINRKEVVEEKQPWAYLSCGHVHGYHNWGHRSD 327

  Fly   334 TGA--RRCPMCLELGPVVTLCMGLEPAFYVDVGAPTYAFNPCGHMATEKTVKYWANVEIPHGTNG 396
            |.|  |.||||..:||.|.|.:|.|..||||.|.||:||.||||:.:||:.|||:.:.:||||:.
Human   328 TEANERECPMCRTVGPYVPLWLGCEAGFYVDAGPPTHAFTPCGHVCSEKSAKYWSQIPLPHGTHA 392

  Fly   397 FQAVCPFCATPLDGATGYIKLIFQDNLD 424
            |.|.||||||.|.|....||||||..:|
Human   393 FHAACPFCATQLVGEQNCIKLIFQGPID 420

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pli	NP_001097890.1	Pellino	21..424	CDD:398402	247/412 (60%)
PELI2	NP_067078.1	Pellino	12..420	CDD:398402	246/409 (60%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165145849
Domainoid	1	1.000	502	1.000	Domainoid score	I343
eggNOG	1	0.900	-	-		E1_KOG3842
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H41431
Inparanoid	1	1.050	502	1.000	Inparanoid score	I1362
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48577
OrthoDB	1	1.010	-	-		D251367at33208
OrthoFinder	1	1.000	-	-		FOG0001485
OrthoInspector	1	1.000	-	-		otm42154
orthoMCL	1	0.900	-	-		OOG6_104184
Panther	1	1.100	-	-	LDO	PTHR12098
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4716
SonicParanoid	1	1.000	-	-		X944
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800