DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pli and Peli2

DIOPT Version :9

Sequence 1:	NP_001097890.1	Gene:	Pli / 42821	FlyBaseID:	FBgn0025574	Length:	424	Species:	Drosophila melanogaster
Sequence 2:	XP_017455153.1	Gene:	Peli2 / 305835	RGDID:	1565884	Length:	483	Species:	Rattus norvegicus

Alignment Length:	430	Identity:	246/430 - (57%)
Similarity:	310/430 - (72%)	Gaps:	14/430 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 VKRTDGTESPI-LAEDGGDGHDKPRLRYGELVILGYNGYLPQGDRGRRRSKFVLHKRTEASGVKR 65
            ::.|.|::.|. .:.|.|:...:..:...:     |||.||.||||||:|:|.|:|||:|:|||.
  Rat    61 LRDTRGSDPPSPTSRDSGNSEKRVLITTSK-----YNGALPNGDRGRRKSRFALYKRTKANGVKP 120

  Fly    66 SKHYIVQSPQTSKAILDANQHSISYTLSRNQAVIVEYKEDTETDMFQVGRSSESPIDFVVMDTLP 130
            |..::|.:||.||||....||||||||||||.|:|||..|.:|||||||||:||||||||.||:.
  Rat   121 STIHVVSTPQASKAISCKGQHSISYTLSRNQTVVVEYTHDNDTDMFQVGRSTESPIDFVVTDTVS 185

  Fly   131 GDKK-DAKVMQSTISRFACRILVNRCEPAKARIFAAGFDSSRNIFLGEKATKWQD-NVEIDGLTT 193
            |.:. ||::.|||||||||||:.:|.||..|||||||||||:||||||||.||:: ...:|||||
  Rat   186 GGQNDDAQITQSTISRFACRIVCDRNEPYTARIFAAGFDSSKNIFLGEKAAKWKNPGGHMDGLTT 250

  Fly   194 NGVLIMHPKGSFCGGNAKCGLWRECSVGGDVFSLRESRSAQQKGQPIYDECNILQDGTLIDLCGA 258
            ||||:|||:|.|. ..::.|:|||.||.|||::|||:|||||:|:.:..|.|:||||:|||||||
  Rat   251 NGVLVMHPRGGFT-DESQPGVWREISVCGDVYTLRETRSAQQRGKLVESETNVLQDGSLIDLCGA 314

  Fly   259 TLLWRSAEGLQHSPTKHDLEKLIDAINAGRPQCPVGLNTLVIPRKVNIGDQV--NQPYVYLNCGH 321
            |||||:|:||.|:||:..:|.|...|||.|||||||||||..| .:|..:.|  .||:.||:|||
  Rat   315 TLLWRTADGLFHAPTQKHIEALRQEINAARPQCPVGLNTLAFP-SINRKEVVEEKQPWAYLSCGH 378

  Fly   322 VQGHHDWG--QDENTGARRCPMCLELGPVVTLCMGLEPAFYVDVGAPTYAFNPCGHMATEKTVKY 384
            |.|:|.||  .|.....|.||||..:||.|.|.:|.|..||||.|.||:||.||||:.:||:.||
  Rat   379 VHGYHSWGHRSDGEANERECPMCRTVGPYVPLWLGCEAGFYVDAGPPTHAFTPCGHVCSEKSAKY 443

  Fly   385 WANVEIPHGTNGFQAVCPFCATPLDGATGYIKLIFQDNLD 424
            |:.:.:||||:.|.|.||||||.|.|....||||||..:|
  Rat   444 WSQIPLPHGTHAFHAACPFCATQLVGEQNCIKLIFQGPVD 483

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pli	NP_001097890.1	Pellino	21..424	CDD:398402	240/408 (59%)
Peli2	XP_017455153.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166339557
Domainoid	1	1.000	504	1.000	Domainoid score	I325
eggNOG	1	0.900	-	-		E1_KOG3842
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H41431
Inparanoid	1	1.050	504	1.000	Inparanoid score	I1293
OMA	1	1.010	-	-		QHG48577
OrthoDB	1	1.010	-	-		D251367at33208
OrthoFinder	1	1.000	-	-		FOG0001485
OrthoInspector	1	1.000	-	-		otm46302
orthoMCL	1	0.900	-	-		OOG6_104184
Panther	1	1.100	-	-	LDO	PTHR12098
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X944
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.770