DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pli and Peli3

DIOPT Version :9

Sequence 1:	NP_001097890.1	Gene:	Pli / 42821	FlyBaseID:	FBgn0025574	Length:	424	Species:	Drosophila melanogaster
Sequence 2:	NP_766423.3	Gene:	Peli3 / 240518	MGIID:	1924963	Length:	445	Species:	Mus musculus

Alignment Length:	436	Identity:	223/436 - (51%)
Similarity:	294/436 - (67%)	Gaps:	18/436 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 RTDGTESP------ILAEDGGD--GHDKPRLRYGELVILGYNGYLPQGDRGRRRSKFVLHKRTEA 60
            ||...:.|      ||:..|.:  ..::| ::||||::|||||.|..||:|||||:..|.:|..|
Mouse    13 RTSDLQHPGSQGSCILSCPGEEALAGEEP-IKYGELIVLGYNGCLASGDKGRRRSRLALSRRPHA 76

  Fly    61 SGVKRSKHYIVQSPQTSKAILDANQHSISYTLSRNQAVIVEYKEDTETDMFQVGRSSESPIDFVV 125
            :|||....:.:.:|..|||:.:..|||||:||||:.:|||||..|::.||||:|||:|:.|||||
Mouse    77 NGVKPDVMHHISTPLVSKALSNRGQHSISFTLSRSHSVIVEYTHDSDKDMFQIGRSTENMIDFVV 141

  Fly   126 MDTLP-GDKKDAKVMQSTISRFACRILVNRCEPAKARIFAAGFDSSRNIFLGEKATKWQ--DNVE 187
            .||.| |...:....||||||:|||||.:|..|..|||:|||||:|.||||||:|.||:  |.:
Mouse   142 TDTSPGGGATEGPSAQSTISRYACRILCDRRPPYTARIYAAGFDASSNIFLGERAAKWRTPDGL- 205

  Fly   188 IDGLTTNGVLIMHPKGSFCGGNAKCGLWRECSVGGDVFSLRESRSAQQKGQPIYDECNILQDGTL 252
            :|||||||||:|||.|.|...:|. |:|||.||.|:|::||:||||||:|:.:.:|.|:||||:|
Mouse   206 MDGLTTNGVLVMHPAGGFSEDSAP-GVWREISVCGNVYTLRDSRSAQQRGKLVENESNVLQDGSL 269

  Fly   253 IDLCGATLLWRSAEGLQHSPTKHDLEKLIDAINAGRPQCPVGLNTLVI--PRKVNIGDQVNQPYV 315
            |||||||||||:..||..:||...||......||.||||||||:||..  |.:........||:|
Mouse   270 IDLCGATLLWRTPAGLLRAPTLKQLEAQRQEANAARPQCPVGLSTLAFPSPARGRTAPDKQQPWV 334

  Fly   316 YLNCGHVQGHHDWG--QDENTGARRCPMCLELGPVVTLCMGLEPAFYVDVGAPTYAFNPCGHMAT 378
            |:.||||.|:|.||  :::....|.||:|..:||.|.|.:|.|....:|.|.|::||.||||:.:
Mouse   335 YVRCGHVHGYHGWGCRREQGPQERECPLCRLVGPYVPLWLGQEAGLCLDPGPPSHAFAPCGHVCS 399

  Fly   379 EKTVKYWANVEIPHGTNGFQAVCPFCATPLDGATGYIKLIFQDNLD 424
            |||.:|||...:||||:.|.|.||||...|.|..|.::||||..||
Mouse   400 EKTARYWAQTPLPHGTHAFHAACPFCGAWLTGELGCVRLIFQGPLD 445

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pli	NP_001097890.1	Pellino	21..424	CDD:398402	215/409 (53%)
Peli3	NP_766423.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..24		3/10 (30%)
Peli3	NP_766423.3	Pellino	38..445	CDD:368071	215/409 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167835919
Domainoid	1	1.000	498	1.000	Domainoid score	I353
eggNOG	1	0.900	-	-		E1_KOG3842
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	498	1.000	Inparanoid score	I1362
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48577
OrthoDB	1	1.010	-	-		D251367at33208
OrthoFinder	1	1.000	-	-		FOG0001485
OrthoInspector	1	1.000	-	-		otm44208
orthoMCL	1	0.900	-	-		OOG6_104184
Panther	1	1.100	-	-	O	PTHR12098
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4716
SonicParanoid	1	1.000	-	-		X944
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.800