DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pli and peli-1

DIOPT Version :9

Sequence 1:	NP_001097890.1	Gene:	Pli / 42821	FlyBaseID:	FBgn0025574	Length:	424	Species:	Drosophila melanogaster
Sequence 2:	NP_001370430.1	Gene:	peli-1 / 178959	WormBaseID:	WBGene00017766	Length:	458	Species:	Caenorhabditis elegans

Alignment Length:	450	Identity:	208/450 - (46%)
Similarity:	284/450 - (63%)	Gaps:	46/450 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 DGTESP-------ILAEDGGDGHDKPRLRYGELVILGYNGYLPQGDRGRR-RSKFVLHKRTEASG 62
            :||.||       ||.:|          .||||::||:||........:| .:|.||.:|..|:|
Worm     9 NGTPSPPAYSNEAILDDD----------IYGELILLGFNGQAENRATSKRYLTKKVLRRRDSANG 63

  Fly    63 VKRSKHYIVQSPQTSKAILDANQHSISYTLSRNQAVIVEYKEDTETDMFQVGRSSESPIDFVVMD 127
            :|:...:.|.:..| |...|..:|::|:....|::|::||..|...||||:||:|:..|||.|:|
Worm    64 IKKCTVHNVSTSDT-KLTKDKARHTVSFHSDSNKSVVIEYAADPSKDMFQIGRASDDQIDFTVID 127

  Fly   128 T---LPGDKKDAKV-------------MQSTISRFACRILVNRCEPAKARIFAAGFDSSRNIFLG 176
            |   || :..||.|             ..|||||||||||::|....||.::|||||:.:||.:.
Worm   128 TWMFLP-EHSDAAVPARPQIDVLEKGDRTSTISRFACRILIDRENSNKAYLYAAGFDAHQNISIN 191

  Fly   177 EKATKW-QDNVEIDGLTTNGVLIMHP-KGSFCGGNAKCGL--WRECSVGGDVFSLRESRSAQQKG 237
            :|:.|| :.|.|:|||||||||::|| |...........:  |||.|:.|||:..|.:||:..||
Worm   192 KKSLKWTKSNGEVDGLTTNGVLLLHPNKDDLLDDTVDKPMYKWREVSINGDVYEPRVTRSSSAKG 256

  Fly   238 QPIYDECNILQDGTLIDLCGATLLWRSAEGLQHSPTKHDLEKLIDAINAGRPQCPVGLNTLVIPR 302
            ..:.:..|:|||||||||||||:|||:|:||:.||...:||..:|.:|||||||||.|||||||:
Worm   257 VFVPEWTNMLQDGTLIDLCGATILWRTADGLERSPKMRELEMALDRLNAGRPQCPVNLNTLVIPK 321

  Fly   303 KVNIGDQVN--QPYVYLNCGHVQGHHDWGQDENTGAR--RCPMCL-ELGPVVTLCMGLEPAFYVD 362
            |.| |.|:|  ||||||.||||||.|:||..||:|.|  :||:|| |...:|.|.||:||:|::|
Worm   322 KRN-GRQINRRQPYVYLQCGHVQGRHEWGVQENSGQRSGKCPICLVESERIVQLSMGMEPSFHLD 385

  Fly   363 VGAPTYAFNPCGHMATEKTVKYWANVEIPHGTNGFQAVCPFCATPLDGATGYIKLIFQDN 422
            .|...:.||||||||:::||.||:.:.:|.||..:..|||||...|.....:::||||||
Worm   386 SGVLDHTFNPCGHMASKQTVLYWSRIPLPQGTCRYDPVCPFCYQLLATERPFVRLIFQDN 445

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pli	NP_001097890.1	Pellino	21..424	CDD:398402	200/427 (47%)
peli-1	NP_001370430.1	Pellino	17..445	CDD:398402	202/440 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160158716
Domainoid	1	1.000	374	1.000	Domainoid score	I466
eggNOG	1	0.900	-	-		E1_KOG3842
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H41431
Inparanoid	1	1.050	374	1.000	Inparanoid score	I1214
Isobase	1	0.950	-	0	Normalized mean entropy	S2993
OMA	1	1.010	-	-		QHG48577
OrthoDB	1	1.010	-	-		D251367at33208
OrthoFinder	1	1.000	-	-		FOG0001485
OrthoInspector	1	1.000	-	-		oto17643
orthoMCL	1	0.900	-	-		OOG6_104184
Panther	1	1.100	-	-	LDO	PTHR12098
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4716
SonicParanoid	1	1.000	-	-		X944
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	18	17.750