Protein Alignment eIF4G2 and EIF4G3

DIOPT Version :9

• Sequence 1: NP_001287489.1
• Gene: eIF4G2 / 42819
• FlyBaseID: FBgn0260634
• Length: 2072
• Species: Drosophila melanogaster
• Sequence 2: XP_011540672.1
• Gene: EIF4G3 / 8672
• HGNCID: 3298
• Length: 1678
• Species: Homo sapiens
• Alignment Length: 2030
• Identity: 426/2030 - (20%)
• Similarity: 694/2030 - (34%)
• Gaps: 652/2030 - (32%)

  Fly   233 YAAAPPPP------------QQKQLPP---TAQQQGPGGAPGAAQTPTLAYYQLGPNAQNSAGNN 282
            :||.|.||            |:.|:.|   |.....|...|| ||||| |.||
Human    49 FAAGPRPPHHQGGFRPIQFFQRPQIQPPRATIPNSSPSIRPG-AQTPT-AVYQ------------ 99

  Fly   283 VVSGANTHRGNM----------RGGQRSTPTAQHTN--YFTAYTMAPGNAQRPAPTNVAPMMNSR 335
                ||.|...:          :|.|...|..:|:.  |.......|.....|.|....|
Human   100 ----ANQHIMMVNHLPMPYPVPQGPQYCIPQYRHSGPPYVGPPQQYPVQPPGPGPFYPGP----- 155

  Fly   336 SGALNGAAAFHHLPHNFGIPSLALGPPAGMTTPILAPAGMQAPPPQ----------PPGGLHTFA 390
                 |...|   |:.:|.|... ..|...:.||:.|...|.||.:          |..|.....
Human   156 -----GPGDF---PNAYGTPFYP-SQPVYQSAPIIVPTQQQPPPAKREKKTIRIRDPNQGGKDIT 211

  Fly   391 PHLQSNSATTLPSVPSVTGVPAVASGFSTTSLPTPSVTTAPQLGANSDKVCKRKYAIPIIHPDTM 455
            ..:.|...:..|:.|  .|.|        ||.|||......|:..:|          |::: .|:
Human   212 EEIMSGGGSRNPTPP--IGRP--------TSTPTPPQQLPSQVPEHS----------PVVY-GTV 255

  Fly   456 ENVMDGWKRSVFIKKDSNSTLTQHTDLDTALDDNSTLCLYQAPTLMDSGSGSSL-LSGAMVDQQM 519
            |                ::.|...|.:..|.|..........|.|........| |||...:|:.
Human   256 E----------------SAHLAASTPVTAASDQKQEEKPKPDPVLKSPSPVLRLVLSGEKKEQEG 304

  Fly   520 QTVKPASSLKQSVSLEKVPEAVYCKDAVGQDVHPSP-------------PPKSTDKDQ--ISVIV 569
            ||    |.....||:.::|            :.|||             |..|....|  .:..:
Human   305 QT----SETTAIVSIAELP------------LPPSPTTVSSVARSTIAAPTSSALSSQPIFTTAI 353

  Fly   570 KDILAHSGNAEDHLSFWQYSDVDNVTETHNSLPLVQSDLPDTTDTCQQPVLFQEQAKKQRPKLAN 634
            .|....|...||.:..   ..:.:.|||.:.||..::|    .|.|::
Human   354 DDRCELSSPREDTIPI---PSLTSCTETSDPLPTNEND----DDICKK----------------- 394

  Fly   635 KQSTATPASIA-NDVAEAAASGCPGVSILSRGQSMVTPAGPSTPPPPSRVAQQKSTKSIVTTAVA 698
                  |.|:| ||:        |.||    ..:::...        :.|:::.|....:...|.
Human   395 ------PCSVAPNDI--------PLVS----STNLINEI--------NGVSEKLSATESIVEIVK 433

  Fly   699 ASVKPTT------GSPNRKSSIQAATSTTTSSGASSSTASTPTHASSKLKQQPVNNLQHGKQIPG 757
            ..|.|.|      .:|..:..::...:..|.|...|...:.||..:|     |.:.
Human   434 QEVLPLTLELEILENPPEEMKLECIPAPITPSTVPSFPPTPPTPPAS-----PPHT--------- 484

  Fly   758 KVSTPALPPTASRISAAVT---LLAGTANITTTTNSSKKQRQAQKRARELEKKKQKSSITSTTST 819
            .|..||...|.|..|||:|   :|....:|.|..:...|:.|   ...|:|...|...|..:
Human   485 PVIVPAAATTVSSPSAAITVQRVLEEDESIRTCLSEDAKEIQ---NKIEVEADGQTEEILDS--- 543

  Fly   820 QGQNNNGKGNGNGNAALEINTNSNNAATVTTTSMSTLTTTTTATAPTTKQETAAVDDKETAQPTT 884
              ||.|.:                         .|.:......|.|
Human   544 --QNLNSR-------------------------RSPVPAQIAITVP------------------- 562

  Fly   885 DTLSATSNNTKVSSILRDKKTMLNPKEQLTSHNNNNNNNNEDGIEAKVESDPESDIKDDSMSNIT 949
                               ||...||::        ....|:.:||::|...|.::..|.:....
Human   563 -------------------KTWKKPKDR--------TRTTEEMLEAELELKAEEELSIDKVLESE 600

  Fly   950 GEKSEKHLANEEIVAKFLQKDSPDTSVVHAETQQLQFLNSSSSVCEEDEPVPVISEGVTKTE--- 1011
            .:|..:....|        :|..|...|.|..:.          .||.|||...:|.|::.|
Human   601 QDKMSQGFHPE--------RDPSDLKKVKAVEEN----------GEEAEPVRNGAESVSEGEGID 647

  Fly  1012 ENAEAEIKFGD---FHEDPRN------------DTGFICSSTWSSSTISKAAEDDSSQSSRSADN 1061
            .|:.:....||   |...|.:            |..|:....:..:.|.|
Human   648 ANSGSTDSSGDGVTFPFKPESWKPTDTEGKKQYDREFLLDFQFMPACIQK--------------- 697

  Fly  1062 VDCAPK--------VVEQISEEKSASSTKSSPVHKATGSGPG-SPKTKELKSKSPSPIPVPQVPK 1117
                |:        |:::|::.|....|...   :....||. :|...:...::|....||....
Human   698 ----PEGLPPISDVVLDKINQPKLPMRTLDP---RILPRGPDFTPAFADFGRQTPGGRGVPICKV 755

  Fly  1118 NYRYSIETLRELAKRRDSRKPPMV---PCQKGDCISQLFV-SRQQQPQQHHGQHIQQYQHMSFNE 1178
            ..|:.:..|.:   .:....||:|   |..|...:..|.| ||:.||
Human   756 QSRHGLPILEQ---SKAPTCPPLVMSHPPMKSLPLGLLNVGSRRSQP------------------ 799

  Fly  1179 SLDYVPGKRGRGHGPNKKHHDQHQQMGGSSGMGSGSGGGGGISNSSQRHMDIIRVQLSLKEEIKL 1243
                     |:...|.|                                  ||.|  |:||::.|
Human   800 ---------GQRREPRK----------------------------------IITV--SVKEDVHL 819

  Fly  1244 SECENAWQPGTLRRVSMAGGQDEDDDVEGV-----LKKVRGILNKLTPDNFEVLLKEMSSIKMDN 1303
            .:.||||:|...|       ..:.||.|.:     .:|||.|||||||..|..|:|::|.:.:|.
Human   820 KKAENAWKPSQKR-------DSQADDPENIKTQELFRKVRSILNKLTPQMFNQLMKQVSGLTVDT 877

  Fly  1304 EAKMTNVMLLIFEKTISEPNFAPTYARFCKVLF-----HEIKAENKSLFTSSLITRIQHEFESNV 1363
            |.::..|:.|:|||.|.||:|:..||..|:.|.     ...|..|...|...|:.|.|.|||.:.
Human   878 EERLKGVIDLVFEKAIDEPSFSVAYANMCRCLVTLKVPMADKPGNTVNFRKLLLNRCQKEFEKDK 942

  Fly  1364 NDANAKSKKLQPTMERINQCSDPAKKAELRAEMEDLEYQFRRRAWGTVRFIGELFKLQSLTNDRV 1428
            .|.:...||    .:.:...|.|.::..|..|:|:.:.:.|||:.|.::||||||||:.||...:
Human   943 ADDDVFEKK----QKELEAASAPEERTRLHDELEEAKDKARRRSIGNIKFIGELFKLKMLTEAIM 1003

  Fly  1429 LNCVESLLEHGCEEKLEYMCKLLTTVGHLLESSLPEHYQLRDRIEKIFRRIQDIINRSRGTSHRQ 1493
            .:||..||::..||.||.:|:||||:|..|:..     :.:.|:::.|.:::.|:...
Human  1004 HDCVVKLLKNHDEESLECLCRLLTTIGKDLDFE-----KAKPRMDQYFNQMEKIVKER------- 1056

  Fly  1494 QVHIKISSRVRFMMQDVLDLRLRNWDQPATHQSGQQGGR--GQRHKQH--DDSKDQSHSTGGGRG 1554
                |.|||:|||:|||:||||.||    ..:...||.:  .|.||:.  ::.::|
Human  1057 ----KTSSRIRFMLQDVIDLRLCNW----VSRRADQGPKTIEQIHKEAKIEEQEEQ--------- 1104

  Fly  1555 GGMNQHQQSSTHHQHQKHNQHGHDGGNYFMQKMPNKQHHENQTLSIDPSKLRFSNSSATDDSI-- 1617
               .:.||..|..:.:...|...:||...:|...|.:       .:||||.........|:.|
Human  1105 ---RKVQQLMTKEKRRPGVQRVDEGGWNTVQGAKNSR-------VLDPSKFLKITKPTIDEKIQL 1159

  Fly  1618 ---AKLGNSSHYQW--RNVGNRPVSSTQVNASNA----------PPPTS---------------L 1652
               |:||:     |  .:.|....|.|....|:|          ||..|               |
Human  1160 VPKAQLGS-----WGKGSSGGAKASETDALRSSASSLNRFSALQPPAPSGSTPSTPVEFDSRRTL 1219

  Fly  1653 LKRPGQNYKFLPYQQPSAVAGTANAPAGGNKSNVEVNDAFDGKQCQGLIT-------------KL 1704
            ..|.....:......|||.|.......||:..::..|.:.:.::.:.|.|             ..
Human  1220 TSRGSMGREKNDKPLPSATARPNTFMRGGSSKDLLDNQSQEEQRREMLETVKQLTGGVDVERNST 1284

  Fly  1705 VEEALNTREWQPEVLSIWRSHSGS--------QQSKTLFHLLTDYLH------------------ 1743
            ..|...|||.....:|...:|..:        ::||:   ::.::||
Human  1285 EAERNKTRESAKPEISAMSAHDKAALSEEELERKSKS---IIDEFLHINDFKEAMQCVEELNAQG 1346

  Fly  1744 ----------KSTVKRQH--RQACGNIFAYLMDKDAVEKEIFEEAYSRFGDDFPDLLVDVPNGWG 1796
                      :||::|..  |...|.:...|:..:.:.|:.|.:.:|...:...|:.:|:|:.|.
Human  1347 LLHVFVRVGVESTLERSQITRDHMGQLLYQLVQSEKLSKQDFFKGFSETLELADDMAIDIPHIWL 1411

  Fly  1797 YVFEFLGPIIHSGHLDLKDVWQRRWLDDFFFAER---------FVYAFVSYFVQEFGAAYARKLW 1852
            |:.|.:.|::..|.:.::::       ...|::.         .:...:....::........||
Human  1412 YLAELVTPMLKEGGISMREL-------TIEFSKPLLPVGRAGVLLSEILHLLCKQMSHKKVGALW 1469

  Fly  1853 HNDYKLDRGQLFWSDVRKYREFVQSHSF-------YFLDNGPGQNQGHAKVKAPTTPRSPVEHVE 1910
            .      ...|.|.|.....|.|  |:|       :...:.|..::..:|.:.     |..|..:
Human  1470 R------EADLSWKDFLPEGEDV--HNFLLEQKLDFIESDSPCSSEALSKKEL-----SAEELYK 1521

  Fly  1911 RIRHLL---AISCDMAIDYINTNV----AINDKFVRQLTRFLCCDFALTVMTNTHNNIKSG--GN 1966
            |:..|:   ..:.:...|::..|:    ..:..|:|.|...:|               |:.  .:
Human  1522 RLEKLIIEDKANDEQIFDWVEANLDEIQMSSPTFLRALMTAVC---------------KAAIIAD 1571

  Fly  1967 SKPLQLNTESFRSCCTPLLRLCIDAQEALEIACIDEAVDALQQHFMTEYEDDMAAGETICSTFSV 2031
            |...:::|...:. ..|:|...:|:....|:    :|:.|||...:   :.|..| ..:...|..
Human  1572 SSTFRVDTAVIKQ-RVPILLKYLDSDTEKEL----QALYALQASIV---KLDQPA-NLLRMFFDC 1627

  Fly  2032 LYESEVIPKESFDKW 2046
            ||:.|||.:::|.||
Human  1628 LYDEEVISEDAFYKW 1642

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
eIF4G2	NP_001287489.1	EIN3	<270..423	CDD:296674	34/174 (20%)
		MIF4G	1274..1514	CDD:280935	89/244 (36%)
		MA3	1697..1812	CDD:280933	29/165 (18%)
EIF4G3	XP_011540672.1	MIF4G	848..1076	CDD:280935	92/247 (37%)
		MA3	1315..1427	CDD:280933	21/114 (18%)
		W2_eIF4G1_like	1521..1649	CDD:211397	30/146 (21%)
		W2	<1628..1674	CDD:302589	8/15 (53%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	174	1.000	Domainoid score	I3681
eggNOG	1	0.900	-	-		E1_KOG0401
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D594395at2759
OrthoFinder	1	1.000	-	-		FOG0001079
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23253
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	5.010