DRSC/TRiP Functional Genomics Resources

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Protein Alignment eIF4G2 and TIF4631

DIOPT Version :9

Sequence 1:NP_001287489.1 Gene:eIF4G2 / 42819 FlyBaseID:FBgn0260634 Length:2072 Species:Drosophila melanogaster
Sequence 2:NP_011678.3 Gene:TIF4631 / 853071 SGDID:S000003394 Length:952 Species:Saccharomyces cerevisiae


Alignment Length:1192 Identity:254/1192 - (21%)
Similarity:396/1192 - (33%) Gaps:415/1192 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly   633 ANKQSTATPASIANDVAEAAASGCPGVSILSRGQSMVTPAGPSTPPPP---SRVAQQKSTKSIVT 694
            |:||.:|......:|..|         |...||.:........|...|   :|..||:..|.   
Yeast    12 ASKQESAALKQTGDDQQE---------SQQQRGYTNYNNGSNYTQKKPYNSNRPHQQRGGKF--- 64

  Fly   695 TAVAASVKPTTGSPNR---KSSIQAATSTTTS-SGASSSTAS-TPTHASSKLKQQPVNNLQHGKQ 754
                        .|||   :.:.....|.... .||:||... |..:.:..:..||       :|
Yeast    65 ------------GPNRYNNRGNYNGGGSFRGGHMGANSSNVPWTGYYNNYPVYYQP-------QQ 110

  Fly   755 IPGKVSTPALPPTASRISAAVTLLAGTANITTTTNSSKKQRQAQKRARELEKKKQKSSITSTTST 819
            :....|.||.|......|...|      .|..||.|.:     ....:|..|.|.:|...||.|.
Yeast   111 MAAAGSAPANPIPVEEKSPVPT------KIEITTKSGE-----HLDLKEQHKAKLQSQERSTVSP 164

  Fly   820 QGQNNNGKGNGNGNAALEINTNSNNAATVTTTSMSTLTTTTTATAPTTKQETAAVDDKETAQPTT 884
            |.::.                       :..||.||.|:|.|.| |:|.      |.|.:::...
Yeast   165 QPESK-----------------------LKETSDSTSTSTPTPT-PSTN------DSKASSEENI 199

  Fly   885 DTLSATSNN----TKVSSILRDKKTMLNPKEQLTSHNNNNN---NNNEDGIEAKVESDP------ 936
            .....|..|    .|:.....:||.    ||||...:.|||   ....:.:|.|....|      
Yeast   200 SEAEKTRRNFIEQVKLRKAALEKKR----KEQLEGSSGNNNIPMKTTPENVEEKGSDKPEVTEKT 260

  Fly   937 --------ESDIKDDSMSNITGEKSEKHLANEEIVAKFL----------QKDSPDTSVVHAETQQ 983
                    |.::|.::.:. .||:.||....||...|.|          |:...:......|.::
Yeast   261 KPAEEKSAEPEVKQETPAE-EGEQGEKGQIKEESTPKVLTFAERLKLKKQQKEREEKTEGKENKE 324

  Fly   984 LQFLNSSSSVCEEDEPVPVISEGVTKTEENAEAEIKFGDFHEDPRNDTGFICSSTWSSSTISKAA 1048
            :.....:.|.. |..|||. ||.|  .||...||.:..:..|              |::|.:...
Yeast   325 VPVQEETKSAI-ESAPVPP-SEQV--KEETEVAETEQSNIDE--------------SATTPAIPT 371

  Fly  1049 EDDSSQSSRSADNVDCAPKVVEQISEEKSASSTKSSPVHKATGSGPGSPKTKELKSKSPSPIPVP 1113
            :.|.:::...|:..|...|:..:...|.:...|..       |:...|.....||..:    |:.
Yeast   372 KSDEAEAEVEAEAGDAGTKIGLEAEIETTTDETDD-------GTNTVSHILNVLKDAT----PIE 425

  Fly  1114 QV-PKNYRYSIETLRELAKRRDSRKPPMVPCQKGDCISQLFVSRQQQPQQHHGQHIQQYQH---- 1173
            .| ..||...||             .|.:..:|                    :|: :|.:    
Yeast   426 DVFSFNYPEGIE-------------GPDIKYKK--------------------EHV-KYTYGPTF 456

  Fly  1174 -MSFNESLD---------------YVPGKRGRGHGPNKKHHDQHQQMGGSSGMGSGSGGGGGISN 1222
             :.|.:.|:               .:|...|||:    :..|       |...|:.|..|....|
Yeast   457 LLQFKDKLNVKADAEWVQSTASKIVIPPGMGRGN----RSRD-------SGRFGNNSSRGHDFRN 510

  Fly  1223 SSQRHMD----------------------------------------IIRVQLSLKEEI-KLSEC 1246
            :|.|:||                                        ..|.....|||: .|...
Yeast   511 TSVRNMDDRANSRTSSKRRSKRMNDDRRSNRSYTSRRDRERGSYRNEEKREDDKPKEEVAPLVPS 575

  Fly  1247 ENAWQP-----GTLRRVSMAGGQD--EDDDVEGVLKKVRGILNKLTPDNFEVLLKEM-----SSI 1299
            .|.|.|     .|.::::..|..:  :.|:||   :|::.:|||||.:.|:.:..|:     .|:
Yeast   576 ANRWVPKFKSKKTEKKLAPDGKTELLDKDEVE---RKMKSLLNKLTLEMFDAISSEILAIANISV 637

  Fly  1300 KMDNEAKMTNVMLLIFEKTISEPNFAPTYARFCKVLFHEIKA-------ENKS---LFTSSLITR 1354
            ...|...:..|:..||.|...||:::..||:.|..:..|:..       |.|:   |....|:.|
Yeast   638 WETNGETLKAVIEQIFLKACDEPHWSSMYAQLCGKVVKELNPDITDETNEGKTGPKLVLHYLVAR 702

  Fly  1355 IQHEFESNVNDANAKSKKLQPTMERINQCSDPAKKAELRAEMEDLEY----QFRRRAWGTVRFIG 1415
            ...||:....|      || ||    |:...|     |..||...||    ..:||..|.|||||
Yeast   703 CHAEFDKGWTD------KL-PT----NEDGTP-----LEPEMMSEEYYAAASAKRRGLGLVRFIG 751

  Fly  1416 ELFKLQSLTNDRVLNC----VESLLEHGCEEKLEYMCKLLTTVGHLLES-------SLPEHYQLR 1469
            .|::|..||...:..|    ::.|.:...||.||.:.:||.|||...|:       :..|..|| 
Yeast   752 FLYRLNLLTGKMMFECFRRLMKDLTDSPSEETLESVVELLNTVGEQFETDSFRTGQATLEGSQL- 815

  Fly  1470 DRIEKIFRRIQDIINRSRGTSHRQQVHIKISSRVRFMMQDVLDLRL-RNWDQPATHQSGQQGGRG 1533
              ::.:|..:.:||..:           |||||::|.:.|:.:||. :||               
Yeast   816 --LDSLFGILDNIIQTA-----------KISSRIKFKLIDIKELRHDKNW--------------- 852

  Fly  1534 QRHKQHDDSKDQSHSTGGGRGGGMNQHQQSSTHHQHQKHNQHGHDGGNYFMQKMPNKQHHENQTL 1598
                 :.|.||....|       :.|..:.....:..|:|..                       
Yeast   853 -----NSDKKDNGPKT-------IQQIHEEEERQRQLKNNSR----------------------- 882

  Fly  1599 SIDPSKLRFSNSSATDDSIAKLGNSSHYQWRNVGNRPVSS----------TQVNASNAPPPTSLL 1653
                     |||..|::|      |:.:.:|.  :.|.:|          :|.|:..||||.   
Yeast   883 ---------SNSRRTNNS------SNRHSFRR--DAPPASKDSFITTRTYSQRNSQRAPPPK--- 927

  Fly  1654 KRPGQNYKFLPYQQPSAVAGTA 1675
                        ::|:|...||
Yeast   928 ------------EEPAAPTSTA 937

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
eIF4G2NP_001287489.1 EIN3 <270..423 CDD:296674
MIF4G 1274..1514 CDD:280935 76/269 (28%)
MA3 1697..1812 CDD:280933
TIF4631NP_011678.3 PTZ00121 <133..362 CDD:173412 63/272 (23%)
eIF_4G1 411..469 CDD:403394 15/95 (16%)
SF-CC1 489..>562 CDD:273721 12/83 (14%)
MIF4G 607..850 CDD:397130 79/275 (29%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 107 1.000 Domainoid score I1435
eggNOG 1 0.900 - - E1_KOG0401
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0001079
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR23253
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
54.910

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