DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment eIF4G2 and TIF4632

DIOPT Version :9

Sequence 1:	NP_001287489.1	Gene:	eIF4G2 / 42819	FlyBaseID:	FBgn0260634	Length:	2072	Species:	Drosophila melanogaster
Sequence 2:	NP_011466.1	Gene:	TIF4632 / 852833	SGDID:	S000003017	Length:	914	Species:	Saccharomyces cerevisiae

Alignment Length:	964	Identity:	219/964 - (22%)
Similarity:	350/964 - (36%)	Gaps:	240/964 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   765 PPTASRISAAVTLLAGTANITTTTNSSKKQRQAQKR---ARELEKKKQKSSITSTTSTQGQNNNG 826
            ||..::.|.|              |:|:......:.   |||....||..|......|...||..
Yeast    22 PPHDNQYSGA--------------NNSQPNNHYNENLYSAREPHNNKQYQSKNGKYGTNKYNNRN 72

  Fly   827 KGNGNG-------NAALEINTNSNNAATVTTTSMSTLTTTTTATAP----TTKQETAAVDDKETA 880
            ...||.       |....:|.|..|.|     .:..:.......||    ..:|.........|.
Yeast    73 NSQGNAQYYNNRFNNGYRLNNNDYNPA-----MLPGMQWPANYYAPQMYYIPQQMVPVASPPYTH 132

  Fly   881 QP--TTDTLSATSNNTKVSSILRDKKTMLNPKEQLTSHNNNNNNNNEDGIEAKVESD-------- 935
            ||  |.....:|...||: .|.......||.|:.......:......||:|.|.:|.
Yeast   133 QPLNTNPEPPSTPKTTKI-EITTKTGERLNLKKFHEEKKASKGEEKNDGVEQKSKSGTPFEKEAT 196

  Fly   936 ---PESDIKDDSMSNITGEKS------EKHLANEEIVAKFLQKDSPDTSVVHAETQQLQFLNS-- 989
               |.::...|:::..:.|||      .|.|..|::..:....:.....:: :||::.|..::
Yeast   197 PVLPANEAVKDTLTETSNEKSTSEAENTKRLFLEQVRLRKAAMERKKNGLI-SETEKKQETSNHD 260

  Fly   990 ------SSSVCEEDEPVPVISEGVTKTEENAEAEI--KFGDFHEDPRNDTGFICSSTWSSSTISK 1046
                  .:||. |.||   |.|....|.|..|..|  |.|...:.|::.||    |...|.|.::
Yeast   261 NTDTTKPNSVI-ESEP---IKEAPKPTGEANEVVIDGKSGASVKTPQHVTG----SVTKSVTFNE 317

  Fly  1047 AAEDDSSQSSRSADNVDCAPKVVEQISEEKSASSTKSSPVHKATGSGPGSPKTKE---LKSKSP- 1107
            ...:.|||      :||   ::|:.....:.:.:|....|:|:......|..|.|   :|...|
Yeast   318 PENESSSQ------DVD---ELVKDDDTTEISDTTGGKTVNKSDDETINSVITTEENTVKETEPS 373

  Fly  1108 -SPIPVPQVPKNYRYSIETL--------------RELAKRRDSR-KPPMVPCQKGDCISQLFVSR 1156
             |.|.:|.|.:    .:|||              .|..:|.|.: |.|.|....|......|..:
Yeast   374 TSDIEMPTVSQ----LLETLGKAQPISDIYEFAYPENVERPDIKYKKPSVKYTYGPTFLLQFKDK 434

  Fly  1157 QQ-QPQQHHGQHIQQY----QHMSFNESLD--------YVPGKRGRGHGPNKKHHDQHQQMGGSS 1208
            .: :|.....:.:...    .|::.|:..|        ..|..||..|..:.:...:.:    |.
Yeast   435 LKFRPDPAWVEAVSSKIVIPPHIARNKPKDSGRFGGDFRSPSMRGMDHTSSSRVSSKRR----SK 495

  Fly  1209 GMGSGSGGGGGISNSSQRHMDIIRV-QLSLKEEI-KLSECENAWQPGTLRRVSMA------GGQD 1265
            .||.......|.::...|.....:. :.:.|||| .|....|.|.|.:  ||...      .|:.
Yeast   496 RMGDDRRSNRGYTSRKDREKAAEKAEEQAPKEEIAPLVPSANRWIPKS--RVKKTEKKLAPDGKT 558

  Fly  1266 EDDDVEGVLKKVRGILNKLTPDNFEVLLKEMSSI----KMDNEAKMTNVML-LIFEKTISEPNFA 1325
            |..|.|.|.:|::.:|||||.:.|:.:..|:..|    |.:::.:...::: .||.|...||:::
Yeast   559 ELFDKEEVERKMKSLLNKLTLEMFDSISSEILDIANQSKWEDDGETLKIVIEQIFHKACDEPHWS 623

  Fly  1326 PTYARFC----KVLFHEIK-AENK-----SLFTSSLITRIQHEFESNVND---ANAKSKKLQPTM 1377
            ..||:.|    |.|...|| .||:     .|....|:.|...|||....|   |......|:|.|
Yeast   624 SMYAQLCGKVVKDLDPNIKDKENEGKNGPKLVLHYLVARCHEEFEKGWADKLPAGEDGNPLEPEM 688

  Fly  1378 ERINQCSDPAKKAELRAEMEDLEYQF----RRRAWGTVRFIGELFKLQSLTNDRVLNCVESLLE- 1437
                              |.| ||..    :||..|.|||||.|:.|..||...:..|...|::
Yeast   689 ------------------MSD-EYYIAAAAKRRGLGLVRFIGYLYCLNLLTGKMMFECFRRLMKD 734

  Fly  1438 ---HGCEEKLEYMCKLLTTVGH------------LLESSLPEHYQLRDRIEKIFRRIQDIINRSR 1487
               ...||.||.:.:||.|||.            .||.|:        .::.:|..:|.||:  .
Yeast   735 LNNDPSEETLESVIELLNTVGEQFEHDKFVTPQATLEGSV--------LLDNLFMLLQHIID--G 789

  Fly  1488 GTSHRQQVHIKISSRVRFMMQDVLDLR-LRNWDQ------PATHQSGQQGGRGQRHKQHDDSKDQ 1545
            ||         ||:|::|.:.||.:|| :::|:.      |.|.|        |.|::.:..:
Yeast   790 GT---------ISNRIKFKLIDVKELREIKHWNSAKKDAGPKTIQ--------QIHQEEEQLR-- 835

  Fly  1546 SHSTGGGRGGGMNQHQQSSTHHQHQKHNQHGHDGGNYFMQKMPNKQHHENQTLS 1599
                           |:.::...:.:.|.|.....|.:.....|.|:.:..:.:
Yeast   836 ---------------QKKNSQRSNSRFNNHNQSNSNRYSSNRRNMQNTQRDSFA 874

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
eIF4G2	NP_001287489.1	EIN3	<270..423	CDD:296674
		MIF4G	1274..1514	CDD:280935	77/277 (28%)
		MA3	1697..1812	CDD:280933
TIF4632	NP_011466.1	eIF_4G1	381..440	CDD:403394	12/62 (19%)
TIF4632	NP_011466.1	MIF4G	567..808	CDD:397130	78/278 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	107	1.000	Domainoid score	I1435
eggNOG	1	0.900	-	-		E1_KOG0401
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23253
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.000