DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment eIF4G2 and EIF4G

DIOPT Version :9

Sequence 1:	NP_001287489.1	Gene:	eIF4G2 / 42819	FlyBaseID:	FBgn0260634	Length:	2072	Species:	Drosophila melanogaster
Sequence 2:	NP_001078319.1	Gene:	EIF4G / 825194	AraportID:	AT3G60240	Length:	1727	Species:	Arabidopsis thaliana

Alignment Length:	1987	Identity:	394/1987 - (19%)
Similarity:	659/1987 - (33%)	Gaps:	640/1987 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    91 QQQQQQQVQAQAQAHHQPVIFYNTQP---SYAAHSAAVNN-------SANGGGATLQLSAAASSN 145
            ||||||...:.|..:.:......:.|   :|..:|:..:|       :|.|||     ....:..
plant    25 QQQQQQHRSSSAAGYGKGAGAPGSAPAPSTYPDNSSLSSNRSFKKPGNAQGGG-----QPRVNLP 84

  Fly   146 TLGHPLTGGHHGGANGVA-------PGSNMPRALSNPTLPPHFQQSAGLI--APAGGN------- 194
            .:.||  ..|:.|.|..:       ||...|   :|||  ..|.::.|.|  ||...:
plant    85 PVNHP--NNHNNGPNAHSRSQVTGEPGVGGP---TNPT--ESFNRNTGPIPKAPTSQSTVMSSKI 142

  Fly   195 ----------AGGPYISATYIPINQTGPLMGMQPAVTFPTNGAAGASFYAAAPPPPQQKQLPPTA 249
                      |.|....|..:.....||.: |.||.|             .:.||....|.....
plant   143 NETPNTAKVAASGDASQAFPLQFGSLGPDL-MVPART-------------TSAPPNMDDQKRAQM 193

  Fly   250 QQQG-------PGGAPGAAQTPTLAYYQLGPNAQNSAGNNVVSGANTHRGNMRGGQRSTPTAQHT 307
            ||..       |...|             ..::.|...:|.:.....|          .|:::..
plant   194 QQSSLRTASNVPASVP-------------KKDSSNKGADNQLMRKEGH----------NPSSEKA 235

  Fly   308 NYFTAYTMAPGNAQRPAPTNVAPMMNSRSGALNGAAAFHHLPH--NFGIPSLALGPPAGMTTPIL 370
            :....: :||     |:.|..:|:.|.|..::........:||  :||      ||...|.||:.
plant   236 DIQVPH-IAP-----PSQTQKSPITNIRMPSVQTPYQHTQVPHPVHFG------GPNMHMQTPVT 288

  Fly   371 APAGMQAPPPQPPGGLHTFAPHLQSNSATTLPSVPSVTGVP------------AVASGFSTTSLP 423
            | ...|.|.|..          |...:...:|......|.|            |...||:|..
plant   289 A-TSFQMPMPMA----------LSMGNTPQIPPQVFYQGHPPHPMHHQGMMHQAQGHGFATPM-- 340

  Fly   424 TPSVTTAPQLG------------ANSDKV--CKRKYAIPIIHPDTMENVMDGWKRSVFIKKDSNS 474
              .....||||            ....|.  .::...:.|.||||.|.:....:...:.:.|| :
plant   341 --GAQIHPQLGHVGVGLSPQYPQQQGGKYGGARKTTPVKITHPDTHEELRLDRRGDPYSEGDS-T 402

  Fly   475 TLTQHTDLDTALDDNSTLC---------LYQAPTLMDSGSGSSLLSGAMVDQQMQTVK-PASSLK 529
            .|..|::........|:..         .|.:.|::.......|.:|.|...|..... |.....
plant   403 ALKPHSNPPPRSQPVSSFAPRPVNLVQPSYNSNTMIYPPVSVPLNNGPMSSAQAPRYHYPVIDGS 467

  Fly   530 QSVSLEKVPEAVYCKDAVGQDVHPSPPPKSTDKDQISVIVKDILAHSGNAEDHLSFWQYSDVDNV 594
            |.|.|            :.|..|.:|.           :::..      |..|||    ||..:.
plant   468 QRVQL------------INQPAHTAPQ-----------LIRPA------APAHLS----SDSTSS 499

  Fly   595 TETHNSLPLVQSDLPDTTDTCQQPVLFQEQ--AKKQRP------KLANKQSTATPASIANDVAEA 651
            .:..|:..::.|.||.......:|....|:  :.|.|.      .|:.|...|...|.:.....:
plant   500 VKARNAQNVMSSALPVNAKVSVKPAGVSEKLGSPKDRSHGEVNISLSQKNVEACSLSSSQQPKPS 564

  Fly   652 AASGCPGVSILSRGQSMVTPAGPSTPPPPSRVAQQKSTKSIVTTAVAASVKPTTGSPNRKSSIQA 716
            ..||.|               ..|.||..|.|......||.|.|.           |..|||::.
plant   565 FVSGVP---------------NSSAPPAKSPVETVPLAKSSVETV-----------PPVKSSVET 603

  Fly   717 ATSTTTSSGASSSTASTPTHASSKLKQQPVNNL--QHGKQIPG---------------------- 757
            |..|||....:...:.:.:......|.:|.:||  ..|:.:|.
plant   604 APVTTTEIRRAEMVSESISVEDQTCKVEPPHNLTENRGQTMPDSLVSDPETATVAAKENLSLPAT 668

  Fly   758 --------KVSTPALPPTASRISAAV-TLLAGTANITT-TTNSSKKQRQAQKRARELEKKKQKSS 812
                    ||||.:..||:..:..:: ....|:::.:: .:.||.:::..:...|....|..:.|
plant   669 NGFRKQLLKVSTTSDAPTSDSVDTSIDKSTEGSSHASSEISGSSPQEKDLKCDNRTASDKLDERS 733

  Fly   813 ITSTTSTQGQNNNG---KGNGNGNAALEINTNSNNAATVTTTSMSTLTTTT---TATAPTTKQET 871
            :.|  ..:.:..:|   |.....:.|.::...|...| ||..:.|.|..:|   ::|.|....||
plant   734 VIS--DAKHETLSGVLEKAQNEVDGATDVCPVSEKLA-VTDDTSSDLPHSTHVLSSTVPLGHSET 795

  Fly   872 AAVDDKETAQPTTDTLSATSNNTKVSSILRDK----------KTMLNPKEQLTSHNNNNNNNNED 926
                .|...:..|...::|....|:..||:..          .....|:|:..|.|..::.:|::
plant   796 ----HKSAVETNTRRNTSTKGKKKIKEILQKADAAGTTSDLYMAYKGPEEKKESSNVVHDVSNQN 856

  Fly   927 -------GIEAKVESDPESDIKDDSMSNITGEKSEKHLANEEIVAKFLQKDSPDTSVVHAETQQL 984
                   .:||.|:::|..:..:|                        .:|:.|.|....||..
plant   857 LLPAIPQAVEAIVDTEPVKNEPED------------------------WEDAADVSTPKLETAD- 896

  Fly   985 QFLNSSSSVCEEDEPVPVISEGVTKTEENAEAE--IKFGDFHEDPRNDTGFICSSTWSSSTISKA 1047
            ..:|:.....:|      :|:....||:....:  :||.|           :|::.
plant   897 NSVNAKRGSSDE------VSDNCINTEKKYSRDFLLKFAD-----------LCTAL--------- 935

  Fly  1048 AEDDSSQSSRSADNVDCAPKVVEQISEEKSASSTKSSPVHKATGSGPGSPKTKELKSKSPSPIPV 1112
                       .:..|.:|.:...:......:|      |....|.|...|..:
plant   936 -----------PEGFDVSPDIANALIVAYMGAS------HHEHDSYPTPGKVMD----------- 972

  Fly  1113 PQVPKNYRYSIETLRELAKRRDSRKPPMVPCQKGDCISQLFVSRQQQPQQHHGQHIQQYQHMSFN 1177
                          |:.:..|..|:|..|   .||  .:...::...|..:.|
plant   973 --------------RQASGARLDRRPSNV---AGD--DRWTKNQGSLPAGYGG------------ 1006

  Fly  1178 ESLDYVPGKRG--------RGHGPNKKHHDQHQQMGGSSGMGSGS--------GGG---GGISNS 1223
             ::.:.||:.|        |..||....  ..|.:|...|||..:        |..   .|:..|
plant  1007 -NVGFRPGQGGNSGVLRNPRMQGPIISR--PMQPVGPMGGMGRNTPDLERWQRGSNFQQKGLFPS 1068

  Fly  1224 SQRHMDIIRVQLSLKEEIKLSECENAWQPGTLRRVSMAGGQDEDDDVEGVLKKVRGILNKLTPDN 1288
            ....|.:            :.:.|..:|.||:.           |:.:...::::.|||||||.|
plant  1069 PHTPMQV------------MHKAERKYQVGTIA-----------DEEQAKQRQLKSILNKLTPQN 1110

  Fly  1289 FEVLLKEMSSIKMDNEAKMTNVMLLIFEKTISEPNFAPTYARFCKVLFHEIKA-----EN--KSL 1346
            ||.|.:::.|:.:||...::.|:..||:|.:.||.|...||.||   ||...|     ||  |..
plant  1111 FEKLFEQVKSVNIDNAVTLSGVISQIFDKALMEPTFCEMYADFC---FHLSGALPDFNENGEKIT 1172

  Fly  1347 FTSSLITRIQHEFESNVNDANAKSKKLQPTMERINQCSDPAKKAELRAEMEDLEYQFRRRAWGTV 1411
            |...|:.:.|.|||....:.           |..::.::..:..:...|.|:...|.|||..|.:
plant  1173 FKRLLLNKCQEEFERGEKEE-----------EEASRVAEEGQVEQTEEEREEKRLQVRRRMLGNI 1226

  Fly  1412 RFIGELFKLQSLTNDRVLNCVESLLEHG---CEEKLEYMCKLLTTVGHLLESSLPEHYQLRDRIE 1473
            |.||||:|.:.||...:..|::.||.:.   .||.:|.:|||::|:|.::     :|.:.:.:::
plant  1227 RLIGELYKKRMLTEKIMHACIQKLLGYNQDPHEENIEALCKLMSTIGVMI-----DHNKAKFQMD 1286

  Fly  1474 KIFRRIQDIINRSRGTSHRQQVHIKISSRVRFMMQDVLDLRLRNWDQ----------PATHQSGQ 1528
            ..|.:::.:       |.:|:    :|||||||:.:.:|||...|.:          ...|:...
plant  1287 GYFEKMKML-------SCKQE----LSSRVRFMLINAIDLRKNKWQERMKVEGPKKIEEVHRDAA 1340

  Fly  1529 QGGRGQRHKQHDDSKDQSHSTGGGR----------GGGMNQHQQSSTHHQHQKHNQHGHDGGNYF 1583
            |..:.|.::.   |:..|.::.|.|          ||||.....:      |..:.||...|..|
plant  1341 QERQTQANRL---SRGPSMNSSGRRGHMEFSSPRGGGGMLSPPAA------QMGSYHGPPQGRGF 1396

  Fly  1584 ----------------MQKMPNKQHHENQTLSIDPS-------KLR----FSNSSATDDSIAKLG 1621
                            |..||.:...| :.:::.|.       .:|    .||:..:|.:.|..|
plant  1397 SNQDIRFDDRPSYEPRMVPMPQRSVCE-EPITLGPQGGLGQGMSIRRPAVASNTYQSDATQAGGG 1460

  Fly  1622 NSSHYQWRNVG-------NRPVS---------------------STQVNASNAPPPTSLLKRPGQ 1658
            :|.    |..|       :||.|                     ::...||:..|..|..::
plant  1461 DSR----RPAGGLNGFGSHRPASPVTHGRSSPQERGTAYVHREFASLSRASDLSPEVSSARQ--- 1518

  Fly  1659 NYKFLPYQQPSAVAGTANAPAGGNKSNVEVNDAFDGKQCQGLITKLVEEALNTRE---------- 1713
                 ..|.|||   |.|:|.         .:|...:|.:.|....::|..:.|:
plant  1519 -----VLQGPSA---TVNSPR---------ENALSEEQLENLSLSAIKEYYSARDENEIGMCMKD 1566

  Fly  1714 -----WQPEVLSIWRSHSGSQQSKTLFHLLTDYLHKSTVKRQHRQACGNIFAYLMDKDAVEKEI- 1772
                 :.|.::|:|.:.|..::.|.     .|.|.|..|.            .:...|....|:
plant  1567 MNSPAYHPTMISLWVTDSFERKDKE-----RDLLAKLLVN------------LVKSADNALNEVQ 1614

  Fly  1773 ----FEEAYSRFGDDFPDLLVDVPNGWGYVFEFLGPI 1805
                ||....    ...|.:.|.|.    ..||||.|
plant  1615 LVKGFESVLK----TLEDAVNDAPK----AAEFLGRI 1643

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
eIF4G2	NP_001287489.1	EIN3	<270..423	CDD:296674	32/166 (19%)
		MIF4G	1274..1514	CDD:280935	76/249 (31%)
		MA3	1697..1812	CDD:280933	24/129 (19%)
EIF4G	NP_001078319.1	MIF4G	1096..1319	CDD:280935	78/252 (31%)
EIF4G	NP_001078319.1	MA3	1546..1654	CDD:295416	23/123 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0401
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D594395at2759
OrthoFinder	1	1.000	-	-		FOG0001079
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23253
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.920