DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment eIF4G2 and eIFiso4G2

DIOPT Version :9

Sequence 1:	NP_001287489.1	Gene:	eIF4G2 / 42819	FlyBaseID:	FBgn0260634	Length:	2072	Species:	Drosophila melanogaster
Sequence 2:	NP_179983.1	Gene:	eIFiso4G2 / 816939	AraportID:	AT2G24050	Length:	747	Species:	Arabidopsis thaliana

Alignment Length:	713	Identity:	154/713 - (21%)
Similarity:	269/713 - (37%)	Gaps:	192/713 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly  1220 ISNSSQ-RHMDIIRVQLSLKEEIKLS----------ECENAWQ-------------PGTLRRVSM 1260
            |:|.:| ||.:........:.:|..|          |.::.||             |.:.:|.::
plant   104 ITNHTQHRHTETDNRDWHSRSQIPTSGKEWLRDDPREAKSTWQGSGPTPVLIKAEVPWSAKRGAL 168

  Fly  1261 AGGQDEDDDVEGVLKKVRGILNKLTPDNFEVLLKEMSSIKMDNEAKMTNVMLLIFEKTISEPNFA 1325
            :       |.:.|:|.|:||||||||:.:|:|..::....:.:...:..|:.||||..|.:|.|.
plant   169 S-------DKDRVVKSVKGILNKLTPEKYELLKGQLIDAGITSADILKEVIQLIFENAILQPTFC 226

  Fly  1326 PTYARFCKVLFHEIKAENKSL-----------FTSSLITRIQHEFESNVNDANAKSKKLQPTMER 1379
            ..||..|    .:|..:..|.           |...|:...|..||.        :.||:   |.
plant   227 EMYALLC----FDINGQLPSFPSEEPGGKEITFKRVLLNNCQEAFEG--------AGKLK---EE 276

  Fly  1380 INQCSDPAKKAELRAEME--DLEYQFRRRAWGTVRFIGELFKLQSLTNDRVLNCVESLL---EHG 1439
            |.|.::|.:      |||  |.|...:.|..|.:|.||||.|.:.:....|.:.|:.||   ...
plant   277 IRQMTNPDQ------EMERMDKEKMAKLRTLGNIRLIGELLKQKMVPEKIVHHIVQELLGDDTKA 335

  Fly  1440 C--EEKLEYMCKLLTTVGHLLESSLPEHYQLRDRIEKIFRRIQDIINRSRGTSHRQQVHIKISSR 1502
            |  |..:|.:|:...|:|..|:.| |....:.|   ..|.|::::..           |.::..|
plant   336 CPAEGDVEALCQFFITIGKQLDDS-PRSRGIND---TYFGRLKELAR-----------HPQLELR 385

  Fly  1503 VRFMMQDVLDLRLRNW---------------DQPATHQSGQQGGRGQRHKQHDDSKDQSHSTGGG 1552
            :|||:|:|:|||...|               ...|....|.:.|.....:.:::::........|
plant   386 LRFMVQNVVDLRANKWVPRREEVKAKKINEIHSEAERNLGMRPGAMASMRNNNNNRAAVSGAADG 450

  Fly  1553 RGGGMNQHQQSSTHHQHQKHNQHGHDGGNYFMQKMP-----------------------NKQHHE 1594
            .|.|                |..|..|....|..||                       |:|..:
plant   451 MGLG----------------NILGRPGTGGMMPGMPGTRVMPMDEDGWEMARTRSMPRGNRQTVQ 499

  Fly  1595 NQTLSIDPSKLRFSNSSATDDSIAKLGNSSHYQWRNVGNRPVSSTQVNASNAPP----PTSLLKR 1655
            .......|:   .:.|.:.:..:...|:..   ..|.|.||....|.|.|::.|    |...:::
plant   500 QPRFQPPPA---INKSLSVNSRLLPQGSGG---LLNGGGRPSPLLQGNGSSSAPQASKPIPTVEK 558

  Fly  1656 PGQNYKFLPYQQPSAVAGTANAPAGGNKSNVEVNDAFDGKQCQGLITKLVEEALNTRE------W 1714
            |....:..|..|.:.:|.:.||.....|:...:.:.|.        .:||:|||...|      :
plant   559 PQPRSQPQPQPQAAPLANSLNAGELERKTKSLLEEYFS--------IRLVDEALQCVEELKSPSY 615

  Fly  1715 QPEVLSIWRSHSGSQQSKTLFHLLTDYLHKSTVKRQHRQACGNIFAYLMDKDAVEKEIFEEAYSR 1779
            .||::....| .|.:::..|.                 :....:..:|:.|:.:..:........
plant   616 HPELVKETIS-LGLEKNPPLV-----------------EPIAKLLKHLISKNVLTSKDLGAGCLL 662

  Fly  1780 FGDDFPDLLVDV---PNGWGYVFEFLGPIIHSGHLD---LKDVWQRRWLDDFFFAERFVYAFV 1836
            :|....|:.:|:   ||.:|   ||||.::.:..||   ::||.::  ::|.:|.:..:.|.:
plant   663 YGSMLDDIGIDLPKAPNSFG---EFLGELVSAKVLDFELVRDVLKK--MEDEWFRKTVLNAVI 720

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
eIF4G2	NP_001287489.1	EIN3	<270..423	CDD:296674
		MIF4G	1274..1514	CDD:280935	73/257 (28%)
		MA3	1697..1812	CDD:280933	23/123 (19%)
eIFiso4G2	NP_179983.1	MIF4G	176..400	CDD:397130	75/259 (29%)
eIFiso4G2	NP_179983.1	MA3	583..695	CDD:397128	25/140 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0401
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D594395at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23253
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.920