DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment eIF4G2 and eif4g1a

DIOPT Version :9

Sequence 1:NP_001287489.1 Gene:eIF4G2 / 42819 FlyBaseID:FBgn0260634 Length:2072 Species:Drosophila melanogaster
Sequence 2:XP_009296603.1 Gene:eif4g1a / 572435 ZFINID:ZDB-GENE-070112-702 Length:1640 Species:Danio rerio


Alignment Length:2138 Identity:414/2138 - (19%)
Similarity:687/2138 - (32%) Gaps:798/2138 - (37%)


- Green bases have known domain annotations that are detailed below.


  Fly   169 PRALSNPTLPPHFQQSAGLIAPAGGNAGGPYISATYIPINQTGPLMGMQPAVTFPTNGAAGASFY 233
            |:.::.|...||..||.||            ..|.|.|        |...:|.||          
Zfish     5 PQPITGPPAVPHPAQSPGL------------TQAAYPP--------GQPSSVVFP---------- 39

  Fly   234 AAAPPPPQQKQLPPTAQQQGPGGAPGAAQTPTLAYYQLGPNAQNSAGNNVVSGANTHRGNMRGGQ 298
               .|.||....|...|     .|||..     |.:|.|       |...:....|:|.||:|..
Zfish    40 ---GPSPQMNTAPQPRQ-----FAPGPR-----ALHQQG-------GFRSLQPYYTNRPNMQGSA 84

  Fly   299 RSTPTAQHTNYFTAYTMAPGNAQRPA----------------------------------PTNVA 329
            ...||:.     |...:||.:..:|.                                  ||...
Zfish    85 PRVPTSN-----TTRPVAPTHVYQPTSQVMMIPQQQLQFAANSQGHPIYLHGQFRSPYMPPTQQF 144

  Fly   330 PMMNSRSGALNGAAAFHHLPHNFGI--PSLA----------------------LGPPAGMTTPIL 370
            |:.:..:|...|::     |..:|.  ||||                      ..|......|..
Zfish   145 PVSSGTAGFYGGSS-----PAEYGTYDPSLAGRERRGGGGRGTSRENGRLSLHGAPLTSQRYPAA 204

  Fly   371 A--PAGMQAPPPQPPGGLHTFAPHLQSNSATTLPSVPSVTG----------------------VP 411
            |  ||..|...|.||..: ...|..|..:.....:.|..||                      ..
Zfish   205 AYYPATQQYQTPVPPTPV-MMNPAQQQQAPLPQQAAPQPTGPVKPRERKQIRIRDPNQGGRDITE 268

  Fly   412 AVASGFSTTSLPTPSVTTAPQLGANSDKVCKRKYAIPIIHPDTMENVMDGWKRSVFIKKDSNSTL 476
            .:.||..|||.|||..|...::|:.                               ::.:..|..
Zfish   269 EIMSGGRTTSTPTPPQTAGTEVGSP-------------------------------VQTNGESVP 302

  Fly   477 TQHTDLDTALDDNSTLCLY---------------QAPTLMDSGSGSSLLSGAMVDQQMQTVKPAS 526
            |...::.|  ||.....:.               .||:.:||                   ||.|
Zfish   303 TFPAEIST--DDEVKAMVSPASASTPPPCKTPEPPAPSSIDS-------------------KPES 346

  Fly   527 SLKQSVSLEKVPEAVYCKDAVGQDVHPSPPPKSTDKDQISVIVKDILAHSGNAEDHLSFWQYSDV 591
            .::.:....|:|.... :|.|...  |||||.:..                              
Zfish   347 EVRPASPESKIPSPPE-EDLVVPS--PSPPPANNP------------------------------ 378

  Fly   592 DNVTETHNSLPLVQSDLPDTTDTCQQPVLFQEQAKKQRPKLANKQSTATPASIANDVAEAAASGC 656
                         |:..|...|:...|||.:..|:|:                            
Zfish   379 -------------QTSEPQIADSVDAPVLPEASAQKE---------------------------- 402

  Fly   657 PGVSILSRGQSMVTPAGPSTPPPPSRVAQQKSTKSIVTTAVAASVKPTTGSPNRKSSIQAATSTT 721
                          |..|..|..|.. |::|..:.:..|.|.|:..|...:   .|:::::.:..
Zfish   403 --------------PKEPCAPVEPEE-AEEKEYEPVAETEVTAASSPAVVA---SSAVESSPNVA 449

  Fly   722 TS-SGASSST-ASTPTHASSKLKQQPVNNLQHGKQIPGKVSTPALPPTASRISAAVTLLAGTANI 784
            .. .||...| ...|..|:.:.|:||:.|              .||..::.:.            
Zfish   450 EDRDGAPVITEMPVPELAADEPKEQPLLN--------------GLPQDSAEVP------------ 488

  Fly   785 TTTTNSSKKQRQAQKRARELEKKKQKSSITSTTSTQGQNNNGKGNGNGNAALEINTNSNNAATVT 849
                 ..|.:..|...|.::..:.|:|.:|:.                .|::| .|....|....
Zfish   489 -----DVKPESSANPVAEQVVPQDQQSCLTAV----------------KASVE-ETEKEKAEEAP 531

  Fly   850 TTSMSTLTTTTTATAPTTKQETAAVDDKETAQPTTDTLSATSNNTKVSSILRDKKTM--LNPKEQ 912
            |.:...|...||..|               |.|.               :|:.||.:  ||.|:.
Zfish   532 TPAPVCLVEETTMQA---------------ASPI---------------VLKKKKKIKDLNKKDV 566

  Fly   913 LTSHNNNNNNNNEDGIEAKVESDPESDIKDDSMSNITGEKSEKHLANEEIVAKFLQKDSPDTSVV 977
                        .|.::|..|.:.|                               |.:|:..||
Zfish   567 ------------GDVLDAFKEPEEE-------------------------------KPAPEPEVV 588

  Fly   978 HAETQQLQFLNSSSSVCEEDEPVPVISEGVTKTEENAEAEIKFGDFHEDPRNDTGFICSSTWSSS 1042
                             :::.|.|.:.|    |:|                         ||   
Zfish   589 -----------------QKEPPAPPVEE----TDE-------------------------TW--- 604

  Fly  1043 TISKAAEDDSSQSSRSADNVDCAPKVVEQISEEKSASSTKSSPVHKATGSGPGSPKTKE------ 1101
                    :..:.....:|::  |:..:.:.::......:..|:         :|:.|:      
Zfish   605 --------EEKEDKLDTENIE--PEASKPVEQKYQYKEEQWKPI---------NPEEKKRYDREF 650

  Fly  1102 ------LKSKSPSPIPVPQVPKNYRYSIETLRELAKRRDSRKPPMVPCQKGDCISQLFVSRQQQP 1160
                  :.:....|..:|.:.       :.:.:.|.:...|  |:.|....:|            
Zfish   651 LLGFQFISASMHKPEGLPHIS-------DVVLDKANKTPLR--PLDPRSLMNC------------ 694

  Fly  1161 QQHHGQHIQQYQHMSFNESLDYVPGKRGRGHGPNKKHHDQHQQMGGSSGMGSGSGGGGGISNSSQ 1225
                              ..|:.|                     ..:.:|..|.||||...|::
Zfish   695 ------------------GPDFTP---------------------SYANLGRQSSGGGGRGPSAR 720

  Fly  1226 ------------RHMDIIRVQLSLKEEIKLSECENAWQPGTLRRVSMAGGQDEDDDVEG-----V 1273
                        |:..|| ..:|||:.|:|::.||||.|...::| .:.|::|:||.|.     :
Zfish   721 RPQPGRGKDQISRNPKII-TSVSLKDNIELNQAENAWTPSVKKQV-RSRGEEEEDDAEAAKTQEL 783

  Fly  1274 LKKVRGILNKLTPDNFEVLLKEMSSIKMDNEAKMTNVMLLIFEKTISEPNFAPTYARFCKVLFH- 1337
            .::||.:||||||..|:.|:|:::.:.:|.|.::..|:.|||||.||||||:..||..|:.|.. 
Zfish   784 FRRVRSVLNKLTPQMFQQLMKQVTELAIDTEERLKGVIDLIFEKAISEPNFSVAYANMCRCLMGL 848

  Fly  1338 EIKAENKS----LFTSSLITRIQHEFESNVNDANAKSKKLQPTMERINQCSDPAKKAELRAEMED 1398
            ::...:|.    .|...|:.|.|.|||.:.:|.....:|    .:.::..::..::..|..|::|
Zfish   849 KVPTSDKPGVTVNFRKLLLNRCQKEFEKDKDDDEIFEQK----QKELDAATEEEERQRLNDELQD 909

  Fly  1399 LEYQFRRRAWGTVRFIGELFKLQSLTNDRVLNCVESLLEHGCEEKLEYMCKLLTTVGHLLESSLP 1463
            .:.:.|:|:.|.::||||||||:.||...:.:|:..||::..|:.||.:|:||:|:|..|:..  
Zfish   910 AKDKARKRSLGNIKFIGELFKLKMLTEPIMHDCIVKLLKNHDEDSLECLCRLLSTIGKDLDFE-- 972

  Fly  1464 EHYQLRDRIEKIFRRIQDIINRSRGTSHRQQVHIKISSRVRFMMQDVLDLRLRNWDQPATHQSGQ 1528
               :.:.|:::.|.:::.||...           |.|||:|||:|||||||..||    ..:.|.
Zfish   973 ---KAKPRMDQYFHQMEKIIKEK-----------KTSSRIRFMLQDVLDLRKNNW----VPRRGD 1019

  Fly  1529 QGGR--GQRHK-----QHDD---------SKDQSHSTGGGRGGGMNQHQQSSTHHQHQK------ 1571
            ||.:  .|.||     :|.:         ||..|....|||||   .|.......|.|.      
Zfish  1020 QGPKTIDQIHKEAELEEHREQIKVQQQLLSKKDSSQGRGGRGG---PHSSGGRGSQTQDEGWNIV 1081

  Fly  1572 -----------------------HNQ--------------HGHDGGNYFMQKMPNKQHHENQTLS 1599
                                   :||              .|..||.  ..|...:|.....|.|
Zfish  1082 PITTKSRPIDTSRLSKITKPGDFNNQLLAPGGKGSWGSWGKGSSGGT--GAKSTGEQDQGRPTTS 1144

  Fly  1600 I-----------DPSKLRFS----------NSSATDDSIAKLGNSSHYQW------RNVG-NRPV 1636
            .           .||....|          |||:.|.|....|:...:..      |:.| :||:
Zfish  1145 TLNRFSALQQSGPPSSSSSSMDSDRRVPQRNSSSRDRSDRDRGDRDRFDRFDRRDDRDRGLDRPL 1209

  Fly  1637 -----------SSTQVNASNAPPPTSLL--------KRPGQNYKFLPYQQPSAVAGTANAPAGGN 1682
                       |..:....|..||.|:.        :..|...:....:....:|..|..|....
Zfish  1210 QAITKRSFSRESEERRGGDNRGPPDSVRRVSSMTDNRDRGSRDRDRSKETVKPMAAPALPPPAPV 1274

  Fly  1683 KSNVEVNDAFDGKQCQGLITKLVEEALNTREWQPEVLSIWRSHSGSQQSKTLFHLLTD----YLH 1743
            |..:...| .|.|.     ..::||.|:..:.:..|..:...:|.|    .||..:.:    .|.
Zfish  1275 KPAMSEED-LDKKS-----KSIIEEYLHINDLKEAVQCVQELNSVS----LLFVFVRNGVEATLE 1329

  Fly  1744 KSTVKRQHRQACGNIFAYLMDKDAVEKEIFEEAYSRFGDDFPDLLVDVPNGWGYVFEFLGPIIHS 1808
            :||:.|:|   .|.:|..|:....:..|.:.:......:...|:.:|:|:.|.|:.|.:.|::..
Zfish  1330 RSTIAREH---IGLLFQKLVSAKILHPEQYYKGLQEILEIADDMAIDIPHIWLYLAEIITPMLQD 1391

  Fly  1809 GHLDLKDVWQR--RWLDDFFFAERFVYAFVSYFVQEFGAAYARKLWHNDYKLDRGQLFWSDV--- 1868
            |.:.:..:::.  :.|.....|...:...::.|.:......|..:|     |:.| |.|.|.   
Zfish  1392 GGIPMGQLFREVSKPLLPMGKAAILLVDVLNIFCKGLSHKKAGAMW-----LEAG-LSWKDFLPE 1450

  Fly  1869 -RKYREFVQSHSFYFLDNGPGQNQGHAKVKAPTTPRSPVEHVERIRHLLAISCDMAIDYINTNV- 1931
             ....:||......|...    .:.....|...|.....:|::|:....| :.....|::..|: 
Zfish  1451 DEDVNKFVTEQKMEFTLG----EESEKPSKKELTAEELSKHLDRLLQEKA-NNQRIYDWVEANLD 1510

  Fly  1932 ---AINDKFVRQLTRFLC-----CDFALTVMTNTHNNIKSGGNSKPLQLNTESFRSCCTPLLRLC 1988
               ..:.:|||.|...:|     |:                   .|.:::.|........|.:..
Zfish  1511 EQKMSSSQFVRALMMSVCQSAIICE-------------------NPYRVDVEQINQRAKLLQKYL 1556

  Fly  1989 IDAQEALEIACIDEAVDALQQHFMTEYEDDMAAGETICSTFSVLYESEVIPKESFDKW 2046
            .|.|:.|      :|:.|||. .|.:.|.   ....:...|..||:.:||.:|:|.||
Zfish  1557 SDEQKEL------QALYALQA-LMVQMEQ---PANLLRMFFDALYDEDVIKEEAFYKW 1604

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
eIF4G2NP_001287489.1 EIN3 <270..423 CDD:296674 44/234 (19%)
MIF4G 1274..1514 CDD:280935 83/244 (34%)
MA3 1697..1812 CDD:280933 25/118 (21%)
eif4g1aXP_009296603.1 MIF4G 784..1012 CDD:280935 85/247 (34%)
MA3 1285..1395 CDD:280933 26/121 (21%)
W2_eIF4G1_like 1482..1611 CDD:211397 32/153 (21%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 175 1.000 Domainoid score I3582
eggNOG 1 0.900 - - E1_KOG0401
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D594395at2759
OrthoFinder 1 1.000 - - FOG0001079
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR23253
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 1 0.960 - -
ZFIN 00.000 Not matched by this tool.
76.970

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