DRSC/TRiP Functional Genomics Resources

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Protein Alignment eIF4G2 and Parp14

DIOPT Version :9

Sequence 1:NP_001287489.1 Gene:eIF4G2 / 42819 FlyBaseID:FBgn0260634 Length:2072 Species:Drosophila melanogaster
Sequence 2:XP_006522455.1 Gene:Parp14 / 547253 MGIID:1919489 Length:1846 Species:Mus musculus


Alignment Length:1293 Identity:219/1293 - (16%)
Similarity:383/1293 - (29%) Gaps:459/1293 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly   514 MVDQQMQTVKPASSLKQSVSLEKVPE-AVYCKDAVGQD---------------------VHPSPP 556
            :|:...:.:|..|.|.|::|....|| ...|...|.:.                     :|...|
Mouse   830 VVNAANENLKHISGLAQALSKAAGPELQTECDQIVKEGGVVLPGNAVISKAGKLPCHHVIHAVGP 894

  Fly   557 PKSTDK--DQISVIVKDILAHSGNAEDHLSFWQYSDVDNVTETHNSLPLVQSDLPD-TTDTCQQP 618
            ....||  :.:|::.|.:......||:|..            ...::|.|.:.:.| ..:.|...
Mouse   895 RWKGDKVLECVSLLKKVVRQSLSLAEEHRC------------RSIAMPAVSAGIFDFPLELCVAN 947

  Fly   619 VL--FQE--QAKKQRPKLANKQSTATPASIANDVAEAAASGCPGVSILSRGQSMVTPAGPSTPPP 679
            ::  .:|  |.|:....|........||.:|...|||..:        :...|:...|.||    
Mouse   948 IVSAIKEHFQHKRDTHTLKKIYLVGLPAKVARAFAEAVKT--------TYKDSLSHTAFPS---- 1000

  Fly   680 PSRVAQQKSTKSIVTTAVAASVKPTTGSPNRKSSIQAATSTTTSSGASSSTASTPTHASSKLKQQ 744
                    |.|::|         |...:|.::.|:..:..............:..|||.      
Mouse  1001 --------SLKALV---------PLGKTPQKQGSLLVSPEGLRIRLVEEGVQNATTHAI------ 1042

  Fly   745 PVNNLQHGKQIPGKVSTPALPPTASRISAAVTLLAGTANITTTTNSSKKQRQAQKRARELEKKKQ 809
             ||::           :|.|......:|.|....||                 .|...||.:..|
Mouse  1043 -VNSI-----------SPDLKLNKGPLSQAFLEKAG-----------------PKLQEELTRSGQ 1078

  Fly   810 KSSITSTT--STQGQNNNGK----------GNGNGNAALEINTNSNNAATVTTTSMS----TLTT 858
            ..|:...|  .|.|.|.|.:          .:.|...:|:|..|.......||.::|    ....
Mouse  1079 GVSVDVGTILQTSGCNLNSRHVFHVVPPPWKSNNSAWSLKIMKNIIRDCLKTTENLSLQSIAFPA 1143

  Fly   859 TTTATAPTTKQETAAVDDKETAQPTTDTLSATSNNTKVSSILRDKKTMLNPKEQLTSHNNNNNNN 923
            ..|......|.|.|.:       ..::.|..:|.|.  ...|::.:.:|:||:    |.|     
Mouse  1144 IGTGNLRFPKPEFAKL-------IISEVLKFSSRNQ--LKTLQEVQFLLHPKD----HEN----- 1190

  Fly   924 NEDGIEAKVESDPESDIKDDSMSNITGEKSEKHLANEEIVAKFLQKDSPDTSVVHAETQQLQFLN 988
                |:|         ..|:......|:.|:|:...|:....:....||...:.......:.|..
Mouse  1191 ----IQA---------FSDEFDKRNNGDPSDKNPKAEDTQGIYGSLSSPTLGMHEMNIGPILFQV 1242

  Fly   989 SSSSVCEEDEPVPV--------ISEGVTK-----TEENAEAEIKFGDFHEDPRNDTGFI------ 1034
            ::.::.:|...|.|        :..||:|     ..:|.|.|...    ...:::.|:|      
Mouse  1243 ATGNIIKEVADVIVNSTTLTFDLKSGVSKAILEGAGQNVEQECSL----LAKQSNHGYIVTGGGL 1303

  Fly  1035 --CSS---TWSSSTISKAAE---DDSSQSSRSA--------DNVDCAPKVV--------EQISEE 1075
              |.:   ....:.:.|:..   ::..|.:.|:        .|....|.||        |:..::
Mouse  1304 LQCKNIIHVVGGNDVKKSVSCVLEECEQRNYSSICLPAIGTGNAQQDPNVVAKAIIDAIEEFVQK 1368

  Fly  1076 KSASSTKSSPV-----H---------KATGSGPGSPKTKELKSKSPSPIP-----------VPQV 1115
            ||..:.|...|     |         |.....|..||....|....|.|.           :..:
Mouse  1369 KSVQAVKRVKVVIFQPHILQFFYDNMKEREGSPAPPKQSPAKQSVMSKIACELLAFMKYIFLTLM 1433

  Fly  1116 PKNYRYSIETLRELA-----KRRDSRKPPMV-----------PCQKG-DCISQL------FVSRQ 1157
            .|..:.::.::..||     |:...:|..:|           .|..| |.:::.      .::::
Mouse  1434 LKGVKETLISIFSLAFLGFPKQASPKKNTLVLEKKIEHTVFQVCGSGVDSVNKTISWLKELITKE 1498

  Fly  1158 QQPQQHHGQHIQQYQHMSFNESLDYVPGKRGRGHGPNKKHHDQHQQMGGSSGMGSGSGGGGGISN 1222
            |....:..:.:..:.                         .::::::                 |
Mouse  1499 QLSYTNDDECVSDFD-------------------------MEEYEKL-----------------N 1521

  Fly  1223 SSQRHMDIIRVQLSLKEEIKLSECENAWQPGTLRRVSMAGGQDEDDDVEGVLKKVRGILNKLTPD 1287
            ..|:.::|.......|..|::|        |..|.|..|     .|::||::|.:|....|.:..
Mouse  1522 EIQKELNITIEMNQKKTSIQVS--------GISRDVIKA-----RDEIEGMIKSIRLAKEKESQA 1573

  Fly  1288 NFEVLLKEMSSIKMDNEA---KMTNVMLLIFEKTISEPNFAPTYARFCKVLFHEIKAENKSLFTS 1349
            ::.....|...|..:...   ||||:.|.:..|...:...              ::..|:. ||.
Mouse  1574 DYISTYVEWQYIDKNITQCFDKMTNMKLEVAWKAKKKDTV--------------VQIHNQD-FTV 1623

  Fly  1350 SLITRIQHEFESNVNDANAKSKKLQPTMERINQCSDPAKKAELRAEMEDLEYQFRRRAWGTVRFI 1414
            .|.|          |.|.|...:.. |::|:.:.     :||:.|...|::..            
Mouse  1624 DLST----------NTATAPQGQTF-TVQRLVKA-----EAEIPANWSDMKQD------------ 1660

  Fly  1415 GELFKLQSLTNDRVLNCVESLLEHGCEEKLEYMCKLLTTVGHLLESSLPEHYQLRDRIEKIFRRI 1479
             :|..:...|:|...|.|.|.....|....                           |||| .||
Mouse  1661 -KLLLVNLQTSDPEYNMVASAFRQTCSNFF---------------------------IEKI-ERI 1696

  Fly  1480 QDIINRSRGTSHRQQVHIKISSRVRFMMQDVLDLRLRNWDQPATHQSGQQGGRGQRHKQHDDSK- 1543
            |:                                       ||..:      |.|.:|:..|.| 
Mouse  1697 QN---------------------------------------PALWR------RYQAYKKSMDEKN 1716

  Fly  1544 ----DQSHSTGGGRGGGMNQHQQSSTHHQHQKHNQHGHDGGNYFMQKMPNKQHHENQTLSIDPSK 1604
                ::.|...|.....:.|...:..:..:...|...:..|.||..|                  
Mouse  1717 GNVRNEKHLFHGTEASSLPQLNSNGFNRSYAGKNATAYGKGTYFAVK------------------ 1763

  Fly  1605 LRFSNSSATDDSIAKLGNSSHYQWR---NVGNRPVSSTQVNASNAPPPTSLLKRPGQN 1659
               ::.||.|.......|...|.:.   ..||    .|..|||...||:    |..||
Mouse  1764 ---ASYSACDTYSRPDTNGRKYMYYVRVLTGN----YTNGNASLIVPPS----RDPQN 1810

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
eIF4G2NP_001287489.1 EIN3 <270..423 CDD:296674
MIF4G 1274..1514 CDD:280935 39/242 (16%)
MA3 1697..1812 CDD:280933
Parp14XP_006522455.1 RRM1_PAR14 6..87 CDD:240746
RRM2_PAR14 226..300 CDD:240987
Macro 812..986 CDD:381759 33/167 (20%)
A1pp 1026..1160 CDD:214701 32/175 (18%)
A1pp 1240..1358 CDD:214701 20/121 (17%)
TCCD_inducible_PARP_like 1724..1844 CDD:238719 24/116 (21%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 1 0.950 - 0 Normalized mean entropy S1766
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.950

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