Protein Alignment eIF4G2 and eif4g2

DIOPT Version :10

• Sequence 1: NP_651188.1
• Gene: eIF4G2 / 42819
• FlyBaseID: FBgn0260634
• Length: 2072
• Species: Drosophila melanogaster
• Sequence 2: NP_001422978.1
• Gene: eif4g2 / 448460
• XenbaseID: XB-GENE-996465
• Length: 902
• Species: Xenopus tropicalis
• Alignment Length: 996
• Identity: 198/996 - (19%)
• Similarity: 347/996 - (34%)
• Gaps: 293/996 - (29%)

  Fly  1205 GGSSGMGSGSGGGG---------GISNSS----------QRHMDIIRVQLSLKEEIKLSECENAW 1250
            ||:|...:.|||||         .:.||.          ||.:.    ..|.|.::.
 Frog     8 GGASRFSASSGGGGRGASQHYPKTVGNSEYLGKTPGPGVQRWVP----SRSTKRDVN-------- 60

  Fly  1251 QPGTLRRVSMAGGQDEDDDVEGVLKKVRGILNKLTPDNFEVLLKEMSSIKMDNEAKMTNVMLLIF 1315
              .|....:.|....|.:..:.:.:|||||||||.|:.|:.|..|:.::.:|.:..:..|:|||.
 Frog    61 --STNNSANTAISSSEKERHDAIFRKVRGILNKLAPEKFDKLCLELLNVGVDTKLILKGVILLIV 123

  Fly  1316 EKTISEPNFAPTYARFCKVLFHEIK------------AENKSLFTSSLITRIQHEFESNVNDANA 1368
            :|.:.||.::..||:.|..|..|..            .:..:.|...||:::|.|||:...:...
 Frog   124 DKALEEPKYSSLYAQLCLRLAEEAPNFDGPSTDGQPGQKQSTTFRRLLISKLQDEFENRSRNVEL 188

  Fly  1369 KSKKLQPTMERINQCSDPAKKAELRAEMEDLEYQFRRRAWGTVRFIGELFKLQSLTNDRVLNCVE 1433
            ..|:..|                |..|.|:.....:.:..|.::|||||.||..:....:..|::
 Frog   189 YDKRDSP----------------LLPEEEEQRAIAKIKMLGNIKFIGELGKLDLIHESILHRCIK 237

  Fly  1434 SLLE-------HGCEEKLEYMCKLLTTVGHLLESSLPEHYQLRDRIEKIFRRIQDIINRSRGTSH 1491
            :|||       ....|.||.:|:::.|||..|     :|.:.:..:::.|.|:..:
 Frog   238 ALLEKKKRVQLKDMGEDLECLCQIMRTVGPRL-----DHEKAKSLMDQYFARMCAL--------- 288

  Fly  1492 RQQVHIKISSRVRFMMQDVLDLRLRNW-----------------DQPATHQSG-------QQGGR 1532
              :.:.::.:|:||::||.::||...|                 .|.|....|       .||.|
 Frog   289 --KANKELPARIRFLLQDTMELRENTWVPRKAFIDNGPKTITQIRQDAVKDLGVFIPAPMSQGMR 351

  Fly  1533 GQ----------RHK-QHD------DSKDQSHSTGGGRGGGMNQHQQSST---HHQHQKHNQHG- 1576
            ..          |.| :.|      |...|...:|.|.|.|:.|.:.|.|   |...|..|.||
 Frog   352 NDFFLDGPFMPPRMKLERDPLGGLADMFRQMPGSGIGTGPGVIQDRFSPTMGRHRSSQLFNGHGG 416

  Fly  1577 ----------HDGGNYFMQKMPNKQHHENQTLSIDPSKLRFSNSSATDDSIAKLGNSSHYQWRNV 1631
                      ..|...||:.....|.:::|.|        .|....:.|...:...........:
 Frog   417 HILPPTQSQFEIGSKPFMKSQGQSQLYQSQGL--------LSQQGQSKDMPPRFIKKGQLNADEI 473

  Fly  1632 GNRPVSSTQVNASNAP---------PPTSLLKRPGQNYKFLPYQQPSAV----AGTANAPAGGNK 1683
            ..||..|..:|.|..|         ||.:.....||..:......|..:    |.:...|....:
 Frog   474 SLRPAQSFLMNKSQVPKLQPQTMMIPPRTQTPPMGQTPQLGLKTNPPPIQEKPAKSVKKPPPSKE 538

  Fly  1684 SNVEVNDAF------DGKQCQGLITKLVEEALNTREWQPEVLSIWRSHSGSQQSKTLFHLLTDYL 1742
            ..:::.:||      :|.....:  ..|:|....:.:.||::|               .::...|
 Frog   539 ELIKLTEAFVTEYLNNGNAADAI--NSVKEMRAPKHFIPEMIS---------------KIILQSL 586

  Fly  1743 HKSTVKRQHRQACGNIFAYLMDKDAVEKEIFEEAYSRFGDDFPDLLVDVPNGWGYVFEFLGPIIH 1807
            .:|...::...|   :...|..:.....:.|.:|:....|..|.|.||:|....|:.:|....|.
 Frog   587 DRSDEDKEKASA---LLGILRQEGVATSDNFMQAFLNILDQCPKLEVDIPLVKSYLAQFAARAII 648

  Fly  1808 SGHLDLKDVWQ-----------------------RRWLDDFFFAERFVYAFVSYFVQEFGAAYAR 1849
            :..:.|.::.|                       |.||.|.|              |:......:
 Frog   649 ADLVSLSELAQPLENGTLFPLFLLCLQQLAKLGDREWLTDLF--------------QQSKINMQK 699

  Fly  1850 KLWHNDYKLDR--------GQLFWSDVRKY-REFVQSHSFYFLDNGPGQNQGHAKVKAPTTPRSP 1905
            .|...|...||        |..|...:.|. :|.::                  ::|...:|::.
 Frog   700 MLPEIDQNKDRMLEILEGKGLSFLFPLMKLEKELLK------------------QIKMDPSPQTI 746

  Fly  1906 VEHVERIRHLLAISCDMAIDYINTNVAINDKFVRQL-TRFL------CCDFALTVMTNTHNNIKS 1963
            .:.::              |.|:..:.::..||..| |.||      .|..       ..:::.:
 Frog   747 YKWIK--------------DNISPKLHLDKGFVNILMTSFLQYISNEACPM-------EESDLSA 790

  Fly  1964 GGNSKPLQLNTE---SFRSCCTPLLRLCIDAQEALEIACIDEAVDALQQHFMTEYEDDMAAGETI 2025
            ..:.:.|:...:   :|:......|...:|.|.:        |:.|||.|..::   :...| .:
 Frog   791 APSKEQLEQEKQLLLAFKPVMQKFLHDHVDLQVS--------ALYALQVHCCSK---NFPKG-ML 843

  Fly  2026 CSTFSVLYESEVIPKESFDKW 2046
            ...|...|:.|:|.:|:|..|
 Frog   844 LRFFVHFYDMEIIEEEAFLAW 864

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
eIF4G2	NP_651188.1	Herpes_BLLF1	<114..450	CDD:282904
		MIF4G	1274..1514	CDD:397130	66/258 (26%)
		MA3	1697..1812	CDD:397128	20/114 (18%)
eif4g2	NP_001422978.1	MIF4G	82..311	CDD:397130	68/260 (26%)
		PRK12757	<437..>545	CDD:237191	18/115 (16%)
		MA3	540..653	CDD:214714	23/132 (17%)
		W2_eIF4G1_like	724..871	CDD:211397	31/192 (16%)