Protein Alignment eIF4G2 and eIF4G1

DIOPT Version :9

• Sequence 1: NP_001287489.1
• Gene: eIF4G2 / 42819
• FlyBaseID: FBgn0260634
• Length: 2072
• Species: Drosophila melanogaster
• Sequence 2: NP_001096852.1
• Gene: eIF4G1 / 43839
• FlyBaseID: FBgn0023213
• Length: 1919
• Species: Drosophila melanogaster
• Alignment Length: 2325
• Identity: 519/2325 - (22%)
• Similarity: 845/2325 - (36%)
• Gaps: 769/2325 - (33%)

  Fly    12 TRPQSTHQQNHNHQAQHHQATHSHHHHLQQQQEQQQSHAVFVPNHSGLHHHQQQHLLQQQQQ--Q 74
            ::|||.||.        .|..|||.....|.|..:..:.|.:...|.....|..||..||..  .
  Fly    44 SKPQSLHQP--------LQPQHSHPTAQPQFQINKAYNVVSILKASAQIAQQSPHLTNQQHPPIH 100

  Fly    75 HQQQAAVAAAHLQQHIQQQQQQQVQAQAQAHHQPVIFYNTQPSYAAHSAAV----NNSANGGGAT 135
            |.||.       |||  ||....|..::.:..:||   ..|.|...:.:::    :...|.|
  Fly   101 HPQQT-------QQH--QQSYTNVVNRSLSASEPV---RAQSSVICNGSSILTVNSRQLNSG--- 150

  Fly   136 LQLSAAASSNTLGH-PLTGGHHGGA----------NGVAPGSNMPRALSNPTLPPHFQQSAGLIA 189
             .:::.|..|...: .|||...|..          ||...||    .:||.::.
  Fly   151 -DMNSTAIYNISSYRKLTGSLDGNVCFLNVQDIKQNGNISGS----VVSNKSIV----------- 199

  Fly   190 PAGGNAGGPYISATYIPIN--------QTGPLMGMQPAVTFPTNGAAGASFYAAAPPPPQQKQLP 246
                ..|....|.|.:.||        |.|..||:....|      ||.|:.       .:|.:
  Fly   200 ----GVGSEKSSCTGVSINNQIVLPNAQIGTSMGIAGTTT------AGTSYM-------HEKNI- 246

  Fly   247 PTAQQQGPGGAPGAAQTPTLAYYQ----LGPNAQNSAGNNVVSGANTHRGNMRG---------GQ 298
                   .|.:.....|.....:.    |..|:..::....||..|.:.||.|.         |.
  Fly   247 -------VGVSVNCVNTSKKYDFNNSSLLSNNSYPASTAEYVSTGNNNSGNTRSNPQSGGIFRGP 304

  Fly   299 RSTPTA-----------------------------QHTNYFTAYTMAPGNAQRPAPTNVAPMMNS 334
            .|||.|                             |:|.|.......|.:..:.||   |||
  Fly   305 PSTPNAPRGASGGATRHVHVQPMYSQPLHQNMVLQQYTQYNPRQQTFPASHLQYAP---APM--- 363

  Fly   335 RSGALNGAAAFHHLPHNFGIPSLALGPP-----AGMTTPI-----LAP--AGMQAPPPQPPGGLH 387
                     .::...:   :|:|...||     ..:.|.:     |.|  :|...|.|.|...
  Fly   364 ---------PYYQYQY---VPTLQQQPPHTRSAVTVNTNVNVGNNLQPVQSGPNGPLPVPGAS-- 414

  Fly   388 TFAPHLQSNSATTLPSVPSVTGV-------------PAVASGFSTTSLPTPSVTTAPQLGANSDK 439
              :..:|..::|..|...:|.||             |.|..|..|||:....|...|....
  Fly   415 --SSQIQLLTSTVQPGASTVMGVGGPGSTMGQVGVPPMVGVGVMTTSVQPQPVQVQPASRR---- 473

  Fly   440 VCKRKYAIPIIHPDTMENVMDGWKRSVFIKKDSNSTLTQHTDLDTALDDNSTLCLYQAPTLMDSG 504
              :.::.:.||.|.|.:|::|.     |.|..||:             ||.
  Fly   474 --RHQHRLQIIDPTTKKNILDD-----FDKTKSNT-------------DNE-------------- 504

  Fly   505 SGSSLLSGAMVDQQMQTVKPASSLKQSVSLEKVPEAVYCKDAVGQDVHPSPPPKSTDKDQISVIV 569
                     ..||...|..||:.|.:...  ::|:                        |.||.:
  Fly   505 ---------FSDQVTSTNTPATVLSEGPI--RIPQ------------------------QESVGL 534

  Fly   570 KDILAHSGNAEDHLSFWQYSDVDNVTETHNSLPLVQSDLPDTTDTCQQPVLFQEQAKKQRPKLAN 634
            .::.:.|....:..:...|..::       :.|:.::|:..|      |::
  Fly   535 NNLTSTSSQGSESRTNAPYIPIE-------TTPISRTDVGPT------PIV-------------- 572

  Fly   635 KQSTATPASIANDVAEAAASGCPGVSILSRGQSMVTPAGPSTPPPPSRVAQQKSTKSIVTTAVAA 699
                            :|.:..|.|.||               |.|.|...:|.
  Fly   573 ----------------SAMTDAPSVEIL---------------PTPQRGRSKKI----------- 595

  Fly   700 SVKPTTGSPNRKSSIQA-ATSTTTSSGASSSTASTPTHASSKLKQQPVNNLQHGKQIPGKVSTPA 763
               |.....|...||.| .|..|..:|      |||.                     .:.:..:
  Fly   596 ---PIVSPKNVSESIVAPITDETDDAG------STPI---------------------SRATEES 630

  Fly   764 LPPTASRISAAVTLLAGTANITTTTNSSKKQRQAQKRARELEKKKQKSSITSTTSTQGQNNNGKG 828
            :||..:..:   .|::.::......::|:..:.|....:|:...:.:||:.|.....|
  Fly   631 MPPNQTHPN---LLISDSSKHKQAVSNSEISKDAPTGLKEMHVAELESSVASENHPAG------- 685

  Fly   829 NGNGNAALEINTNSNNAATVTTTSMSTLTTTTTATAPTTKQETAAVDDKETAQPTTDTLSA---T 890
                  .|::|.|.::.:.                             ..:|.|..|::.|   |
  Fly   686 ------ILDVNVNKSSQSL-----------------------------DFSADPEIDSIGAISPT 715

  Fly   891 SNNTKVSSILRDKKTMLNPKEQLTSHNNNNNNNNEDGIEAKVESDPESDIKDDSMSNITGEKSEK 955
            |.|. ||.||.:   :|:..|......|:.....:|  ...||.....::   |:.|.|.|
  Fly   716 SPNA-VSPILHE---VLDNTELSKKLENSTTERFKD--SQSVEKPTHQEL---SLRNATDE---- 767

  Fly   956 HLANEEIVAKFLQKDSPDTSVVHAETQQLQFLNSSSSVCEEDEPVPVISEGVTKTEENAEAEIKF 1020
                .||.|..||      .|...:..|::....|.         |.::..|::...:.|:.||
  Fly   768 ----TEISAMALQ------DVNSLDNNQIEKTYPSK---------PKLNVDVSEDISSRESAIK- 812

  Fly  1021 GDFHEDPRNDTGFICSSTWSSSTISKAAEDDSSQSSR---SADNVDCAPKVVEQISEEKSASSTK 1082
                           |::..::.:....:.||...:.   ..|:.|...||..:|
  Fly   813 ---------------STSTKNTGVDVGLQSDSKPETTLNDKQDSTDLKVKVSAKI---------- 852

  Fly  1083 SSPVHKATGS-GPGSPKTKELKSKSPSPIPVPQVPKNYRYSIETLRELAKRRDSRKPPMVPCQKG 1146
            ||.::...|. .|.:|..|:                  :|..|.|.:|.:.:.||..|.|.
  Fly   853 SSIINYNEGQWSPNNPSGKK------------------QYDREQLLQLREVKASRIQPEVK---- 895

  Fly  1147 DCISQLFVSRQQQP--------QQHHGQHIQQYQHMSFNESLDYVPGKRGRGHGPNKKHHDQHQQ 1203
                  .||...||        ..::.:.:|         |:..:.|        |:.:......
  Fly   896 ------NVSILPQPNLMPSFIRNNNNNKRVQ---------SMVGIIG--------NRSNESAGNY 937

  Fly  1204 MGGSSGMGSGSGGGGGISNSSQRHMDIIRVQLSLKEEIKLSECENAWQPGTLRRVSMAGGQDEDD 1268
            :|....|.....|||   .||.:.|  |.|.|||.:::||||.||||:|..|.:      .|.|.
  Fly   938 IGKQMSMSGVQSGGG---RSSMKGM--IHVNLSLNQDVKLSENENAWRPRVLNK------SDGDS 991

  Fly  1269 DVEGVLKK------VRGILNKLTPDNFEVLLKEMSSIKMDNEAKMTNVMLLIFEKTISEPNFAPT 1327
            |.:..|:|      ||||||||||:.|:.|::|:..:|:|...|:..|::|:|||.|.||||:.:
  Fly   992 DAKSALEKDELVRRVRGILNKLTPERFDTLVEEIIKLKIDTPDKVDEVIVLVFEKAIDEPNFSVS 1056

  Fly  1328 YARFCKVLFHEIKA----------ENKSLFTSSLITRIQHEFESNVNDANAKSKKLQPTMERINQ 1382
            |||.|:.|..|:|.          .|.:.|.::|:.:.:.||..||:.:.||.|||||.:::|.:
  Fly  1057 YARLCQRLAAEVKVIDERMESETKSNSAHFRNALLDKTEQEFTQNVSQSTAKEKKLQPIVDKIKK 1121

  Fly  1383 CSDPAKKAELRAEMEDLEYQFRRRAWGTVRFIGELFKLQSLTNDRVLNCVESLLEHGCEEKLEYM 1447
            |:|..:||||.|.:|:.|.:.|||:.|||||||||||:..||...:.:|:::||....|:.||.:
  Fly  1122 CTDANEKAELEAFLEEEERKIRRRSGGTVRFIGELFKISMLTGKIIYSCIDTLLNPHSEDMLECL 1186

  Fly  1448 CKLLTTVGHLLESSLPEHYQLRDR---IEKIFRRIQDIINRSRGTSHRQQVHIKISSRVRFMMQD 1509
            ||||||||...|.: |.:.:...|   :||...|:|.|.:::.....|      :|||||||:||
  Fly  1187 CKLLTTVGAKFEKT-PVNSKDPSRCYSLEKSITRMQAIASKTDKDGAR------VSSRVRFMLQD 1244

  Fly  1510 VLDLRLRNW-----DQP------------------------ATHQSGQQGGRGQRHKQHDDSKDQ 1545
            |:|||...|     :.|                        :|...|.|||.|:|..:.:....:
  Fly  1245 VIDLRKNKWQTSRNEAPKTMGQIEKEAKNEQLSAQYFGTLSSTTPGGSQGGSGKRDDRGNSRYGE 1309

  Fly  1546 SHSTGGGRGGGMNQHQQSSTHHQHQKHNQ--------HGHDGGNYFMQKMPNKQHHE----NQTL 1598
            |.|:..  .||.:..:..:.:.:||:.|.        .||..||    ...|..|.:    :::|
  Fly  1310 SRSSSA--YGGSHSQRGDNGNLRHQQQNNVGGNVSGGAGHSNGN----NDENTWHVQTSKGSRSL 1368

  Fly  1599 SIDPSKLRFSNSSATDDSI--AKLGNSSHYQWRNVGNRPVSSTQVNASNAPPPT---------SL 1652
            ::|.:||. ..|..:|.::  .|:|..:.:.|       :||.....|:||.||         ||
  Fly  1369 AVDSNKLE-GLSKLSDQNLETKKMGGLTQFIW-------ISSDTTRLSSAPTPTPSNPFAVLSSL 1425

  Fly  1653 L-------------------------------------------------KRPGQNYKFL----- 1663
            :                                                 .|.||..:.|
  Fly  1426 IDKNSNERDRDRSGPRNKGSYNKGSMERDRYDRGMHSRTGSSQGSRENSSSRGGQQGRTLLSSSV 1490

  Fly  1664 -------PY-QQPSAVAGTANAPAGGNKSNVEVNDAFDGKQCQ---------------------- 1698
                   .| ||......|..|.:....|||.....:.|.:.|
  Fly  1491 QKSTSHSKYTQQAPPTRHTVKAQSSVGSSNVNTGPLYRGSEQQTSATFSQTTRSVAPVAVFIEAS 1555

  Fly  1699 --------GLITKLVEEALNTREWQPEVLSIWRSHSGSQQSKTLFHLLTDYLHKSTVKRQHRQAC 1755
                    .:::::|:.:..::|..|..:|..:......:...::::||||||.:.|.:|:|:..
  Fly  1556 ETDLKLIKSVVSEIVDLSAASKEVTPGAVSCIKRVPEKLRCSFIYYILTDYLHLANVGKQYRRYL 1620

  Fly  1756 GNIFAYLMDKDAVEKEIFEEAYSRFGDDFPDLLVDVPNGWGYVFEFLGPIIHSGHLDLKDVWQRR 1820
            ....:.|:.::.:..:....||:.|.....||:||:|..|.|:.:|.||:|....|.:.|:|...
  Fly  1621 SIAVSQLIQQNYISADHLRLAYNEFTVYANDLIVDIPELWLYILQFAGPLIVKKILTISDLWNNN 1685

  Fly  1821 WLDD--FFFAERFVYAFVSYFVQEFGAAYARKLWHNDYKLDRGQLFWSDV---RKYREFVQSHSF 1880
            ..::  ...|::|:..::.|..||.|..:||.:|      .:..|.|||.   .:..:|::.:..
  Fly  1686 LKENSPSNVAKKFLKTYLIYCTQEVGPNFARNMW------IKFNLKWSDFMPESEVADFIKFNRL 1744

  Fly  1881 YFLDNGPGQNQGHAKVKAPT-----TPRSPVEHV-ERIRHLL--AISCDMAIDYINTNVAINDK- 1936
            .:::|         :.|:|.     ||...|::| :.|.|||  ..:.|..|||.|.|:.:.||
  Fly  1745 EYVEN---------ESKSPVIDHRETPEKHVKNVIDHIEHLLKEGTTADCIIDYSNGNIMVVDKL 1800

  Fly  1937 FVRQLTRFLCCDFALTVMTNTHNNIKSGGNSKPLQLNTESFRSCCTPLLRLCIDAQEALEIAC-- 1999
            |:|.||..| .:|::....|::            :|.:|:|:..|.|:|:..||:.|..::.|
  Fly  1801 FIRGLTETL-SNFSIHYKDNSY------------KLESETFQKFCIPVLQRYIDSNEDHQLECLY 1852

  Fly  2000 -IDEAVDALQ--QHFMTEYEDDMAAGETICSTFSVLYESEVIPKESFDKW 2046
             :...|..|:  :..::|     ..||        ||::.||.|||..||
  Fly  1853 TLQLLVHGLEHPRGLLSE-----LIGE--------LYDAFVIQKESLCKW 1889

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
eIF4G2	NP_001287489.1	EIN3	<270..423	CDD:296674	45/219 (21%)
		MIF4G	1274..1514	CDD:280935	109/258 (42%)
		MA3	1697..1812	CDD:280933	29/144 (20%)
eIF4G1	NP_001096852.1	MIF4G	1004..1252	CDD:280935	109/254 (43%)
		MA3	1562..1677	CDD:280933	28/114 (25%)
		W2_eIF4G1_like	1764..1895	CDD:211397	45/152 (30%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45462503
Domainoid	1	1.000	175	1.000	Domainoid score	I3582
eggNOG	1	0.900	-	-		E1_KOG0401
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D594395at2759
OrthoFinder	1	1.000	-	-		FOG0001079
OrthoInspector	1	1.000	-	-		otm47287
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR23253
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	7	6.940