DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment eIF4G2 and Eif4g2

DIOPT Version :9

Sequence 1:	NP_001287489.1	Gene:	eIF4G2 / 42819	FlyBaseID:	FBgn0260634	Length:	2072	Species:	Drosophila melanogaster
Sequence 2:	NP_001017374.2	Gene:	Eif4g2 / 361628	RGDID:	1305294	Length:	906	Species:	Rattus norvegicus

Alignment Length:	982	Identity:	206/982 - (20%)
Similarity:	362/982 - (36%)	Gaps:	261/982 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly  1205 GGSSGMGSGSGGGGGISNSSQRHMDIIRVQLSLKEEIKLSECENA--WQP--GTLRRVSMAGGQ- 1264
            ||:|...:.|||||  |..:.:|..   ......|.:..:..:||  |.|  .|.|..:.|...
  Rat     8 GGASRFSASSGGGG--SRGAPQHYP---KTAGNSEFLGKTPGQNAQKWIPARSTRRDDNSAANNS 67

  Fly  1265 -DEDDDVEGVLKKVRGILNKLTPDNFEVLLKEMSSIKMDNEAKMTNVMLLIFEKTISEPNFAPTY 1328
             :|.:..:.:.:|||||||||||:.|:.|..|:.::.::::..:..|:|||.:|.:.||.::..|
  Rat    68 ANEKERHDAIFRKVRGILNKLTPEKFDKLCLELLNVGVESKLILKGVILLIVDKALEEPKYSSLY 132

  Fly  1329 ARFCKVL------FHEIKAENK------SLFTSSLITRIQHEFESNVNDANAKSKKLQPTMERIN 1381
            |:.|..|      |....||.:      :.|...||:::|.|||:...:.:...|:..|
  Rat   133 AQLCLRLAEDAPNFDGPAAEGQPGQKQSTTFRRLLISKLQDEFENRTRNVDVYDKRENP------ 191

  Fly  1382 QCSDPAKKAELRAEMEDLEYQFRRRAWGTVRFIGELFKLQSLTNDRVLNCVESLLE-------HG 1439
                      |..|.|:.....:.:..|.::|||||.||..:....:..|:::|||       ..
  Rat   192 ----------LLPEEEEQRAIAKIKMLGNIKFIGELGKLDLIHESILHKCIKTLLEKKKRVQLKD 246

  Fly  1440 CEEKLEYMCKLLTTVGHLLESSLPEHYQLRDRIEKIFRRIQDIINRSRGTSHRQQVHIKISSRVR 1504
            ..|.||.:|:::.|||..|     :|.:.:..:::.|.|:..::           :..::.:|:|
  Rat   247 MGEDLECLCQIMRTVGPRL-----DHERAKSLMDQYFARMCSLM-----------LSKELPARIR 295

  Fly  1505 FMMQDVLDLRLRNW--------DQPATHQSGQQG---------------GRGQ----------RH 1536
            |::||.::||..:|        :.|.|....:|.               ||..          |.
  Rat   296 FLLQDTVELREHHWVPRKAFLDNGPKTINQIRQDAVKDLGVFIPAPMAQGRNDFFLEGPFMPPRM 360

  Fly  1537 KQHDDSK-------DQSHSTGGGRGGGMNQHQQSST---HHQHQKHNQH-GH----------DGG 1580
            |...|..       .|...:|.|.|.|:.|.:.|.|   |..:|..|.| ||          :.|
  Rat   361 KMDRDPLGGLADMFGQMPGSGIGTGPGVIQDRFSPTMGRHRSNQLFNGHGGHIMPPTQSQFGEMG 425

  Fly  1581 NYFMQKMPNKQHHENQTLSIDPSKLRFSNSSATDDSIAKLGNSSHYQWRNVGNRPVSSTQVNASN 1645
            ..||:.....|.:.||:..: .|:|:    ..:.|...:...........:..||..|..:|.:.
  Rat   426 GKFMKSQGLSQLYHNQSQGL-LSQLQ----GQSKDMPPRFSKKGQLNADEISLRPAQSFLMNKNQ 485

  Fly  1646 AP---------PPTS---------LLKRPGQNYKFLPYQQPSAVAGTANAPAGGNKSNVEVNDAF 1692
            .|         ||::         |.:.|....|..|.......|.|:..|....:..:::.:|
  Rat   486 VPKLQPQITMIPPSAQPPRTQTPPLGQTPQLGLKTNPPLIQEKPAKTSKKPPPSKEELLKLTEA- 549

  Fly  1693 DGKQCQGLITKLVEEALNTREWQPEVLSIWRSHSGSQQSKTLFHLLTDYLHKSTV-----KRQHR 1752
                       :|.|.||:......|       ||.::.:...|.|.:.|.|..:     ..:.:
  Rat   550 -----------VVTEYLNSGNANDAV-------SGVREMRAPKHFLPEMLSKVIILSLDRSDEDK 596

  Fly  1753 QACGNIFAYLMDKDAVEKEIFEEAYSRFGDDFPDLLVDVPNGWGYVFEFLGPIIHSGHLDLKDVW 1817
            :...::.:.|..:.....:.|.:|:....:..|.|.||:|....|:.:|....|.|..:.:.::.
  Rat   597 EKASSLISLLKQEGIATSDNFMQAFLNVLEQCPKLEVDIPLVKSYLAQFAARAIISELVSISELA 661

  Fly  1818 Q-----------------------RRWLDDFFFAERFVYAFVSYFVQEFGAAYARKLWHNDYKLD 1859
            |                       |.||.:.|              |:......:.|...|...|
  Rat   662 QPLESGTHFPLFLLCLQQLAKLQDREWLTELF--------------QQSKVNMQKMLPEIDQNKD 712

  Fly  1860 R--------GQLFWSDVRKY-REFVQSHSFYFLDNGPGQNQGHAKVKAPTTPRSPVEHVERIRHL 1915
            |        |..|...:.|. :|.::                  ::|...:|::..:.::
  Rat   713 RMLEILEGKGLSFLFPLLKLEKELLK------------------QIKLDPSPQTIYKWIK----- 754

  Fly  1916 LAISCDMAIDYINTNVAINDKFVRQL-TRFLCCDFALTVMTNTHNNIKSGGNSKPLQLNTE---- 1975
                     |.|:..:.::..||..| |.||  .:..:.::...:...|.......||..|
  Rat   755 ---------DNISPKLHVDKGFVNILMTSFL--QYISSEVSPPSDETDSSSAPSKEQLEQEKQLL 808

  Fly  1976 -SFRSCCTPLLRLCIDAQEALEIACIDEAVDALQQHFMTEYEDDMAAGETICSTFSVLYESEVIP 2039
             ||:......|...:|.|.:        |:.|||.|.   |......| .:...|...|:.|:|.
  Rat   809 LSFKPVMQKFLHDHVDLQVS--------ALYALQVHC---YNSSFPKG-MLLRFFVHFYDMEIIE 861

  Fly  2040 KESFDKW 2046
            :|:|..|
  Rat   862 EEAFLAW 868

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
eIF4G2	NP_001287489.1	EIN3	<270..423	CDD:296674
		MIF4G	1274..1514	CDD:280935	68/258 (26%)
		MA3	1697..1812	CDD:280933	23/119 (19%)
Eif4g2	NP_001017374.2	MIF4G	78..308	CDD:280935	70/261 (27%)
		MA3	543..656	CDD:214714	24/131 (18%)
		W2_eIF4G1_like	739..875	CDD:211397	33/158 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0401
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D594395at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23253
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.920