Protein Alignment eIF4G2 and Eif4g3

DIOPT Version :10

• Sequence 1: NP_651188.1
• Gene: eIF4G2 / 42819
• FlyBaseID: FBgn0260634
• Length: 2072
• Species: Drosophila melanogaster
• Sequence 2: XP_038965571.1
• Gene: Eif4g3 / 298573
• RGDID: 1311370
• Length: 1807
• Species: Rattus norvegicus
• Alignment Length: 1915
• Identity: 404/1915 - (21%)
• Similarity: 655/1915 - (34%)
• Gaps: 636/1915 - (33%)

  Fly   159 ANGVAPGSNMPRALSNPTLPPHFQQSAGLIAPAGGNAGGPYISATYIPINQTGPLMGMQPAVTFP 223
            |.|..||:....|.:...:||....:|...|.|
  Rat    16 AAGTGPGTGAAAAAAAAAVPPPHPAAAAAAAAA-------------------------------- 48

  Fly   224 TNGAAGASFYAAAPPPPQQKQLPPTAQQQGPGGAPGAAQTPTLAYYQLGPNAQNSAGNNVVSGAN 288
               ||.|:..|||||.|..:.|...|.||.|   .|..|.|.
  Rat    49 ---AAAAAAVAAAPPHPNIRALQTPAPQQIP---RGPVQQPL----------------------- 84

  Fly   289 THRGNMRGGQRSTPTAQHTNYFTAYTMAPGNAQRPAPTNVAPMMNSRSGALNGAAAFHHLPHNFG 353
                    ..|..|......|.|...:    |::|.|...:|.            :.|.:  |.|
  Rat    85 --------EDRIFPPTVSAVYSTVTQV----ARQPGPPTPSPY------------SAHEI--NKG 123

  Fly   354 IPSLALGPPAGMTTPILA----PAGMQAPP-----PQPPGGLHTFAPHLQSNSATTLPSVPSVTG 409
            .|:||..||...::|.|:    |:|..|.|     ||.|               .|:.|.|....
  Rat   124 HPNLAATPPGHASSPGLSQTPYPSGQNAGPATLVYPQAP---------------QTMNSQPQARS 173

  Fly   410 VPAVASGFSTTSLPTPSVTTAPQLGANSDKVCKRKYAIPIIHPDTMENVMDGWKRSVFIKKDSNS 474
            .|:                                .|:|:..|       |.|||         .
  Rat   174 PPS--------------------------------RAVPVHCP-------DNWKR---------R 190

  Fly   475 TLTQHTDLDTALDDNSTL--CLY------------------------QAPTLMDSGSGSSLLSGA 513
            .:.:.|.:..:|.....:  |::                        |.|......|..||..||
  Rat   191 KVLEQTPVYRSLAGRGWIKYCIFAAGPRPAHHQGGFRPIQFFQRPQIQPPRAAIPNSSPSLRPGA 255

  Fly   514 M----VDQQMQTVKPASSLKQSVSLEKVPEAVYCKDAVGQDVHPSPPPKSTDKDQISVIVKDILA 574
            .    |.|..|.:...:.|.....:.:.|:  ||   :.|..|..||
  Rat   256 QTPTAVYQANQHIMMVNHLPMPYPVPQGPQ--YC---IPQYRHSGPP------------------ 297

  Fly   575 HSGNAEDHLSFWQY----------------SDVDNV--TETHNSLPLVQSDLPDTTDTCQQPVLF 621
            :.|..:      ||                .|..|.  |..:.|.|:.|| .|....|.|||
  Rat   298 YVGPPQ------QYPVQPPGPGPFYPGPGPGDFANAYGTPFYPSQPVYQS-APIIVPTQQQP--- 352

  Fly   622 QEQAKKQRPKLANKQSTATPASIANDVAEAAASGCPGVSILSRGQSMVTPAG--PSTPPPPSRVA 684
             ..||:::..:..:.    |.....|:.|...||       ...::...|.|  .|||.||.::.
  Rat   353 -PPAKREKKTIRIRD----PNQGGKDITEEIMSG-------GGSRNPTPPIGRPTSTPTPPQQLP 405

  Fly   685 QQKSTKS-----IVTTAVAASVKPTTGSPNRKSS-------IQAATSTT---TSSGASSSTA-ST 733
            .|....|     .|.:|..|:..|.|.:.::|..       :..:.||.   ..||.....| ..
  Rat   406 SQAPEHSPVVYGTVESAHLAASTPVTAASDQKQEEKPKPDPVFQSPSTVLRLVLSGEKKEQAGQI 470

  Fly   734 PTHASSKLKQQPVNNLQHGKQIPGKVSTPALPPTA-----SRISAAVTLLAGTANITTTTNSSKK 793
            |..|:.:...:|          |...|...|||.|     |.:|||:              ||::
  Rat   471 PETAAGEPSPEP----------PRTSSPTTLPPLARSSLPSPMSAAL--------------SSQQ 511

  Fly   794 QRQAQKRARELEKKKQKS----SITSTTSTQGQN----------------------------NNG 826
            ...|:.:. ||...|..:    |.||.|:..|.:                            |..
  Rat   512 LLTAEDKC-ELSSSKDDAPPVRSPTSCTAAPGPSLTDDIGLCKKPCGVAPPDGQLVSSPVLINEM 575

  Fly   827 KGNGNGNAALEINTNSNNAATVTTTSMSTLT----------------TTTTATAPTTKQETAAVD 875
            .|.|....|.|      |...:....:..||                .|.|...|:|....:...
  Rat   576 NGVGEKLPAKE------NTVDMVRQEVLPLTLELEILEHPQEERKVECTPTPITPSTMPSFSPAP 634

  Fly   876 DKETAQP--TTDTLSAT-SNNTKVSSILRDKKTMLNPKEQLTSHNNNNNNNNEDGIEAKVESDPE 937
            ....|.|  |...|||| :.:..|::::   :.:::..|.|.:..:.:....:|  :|:.|||.:
  Rat   635 PTPPASPPCTPVVLSATIARSPAVATVI---QRVVDEGESLRTCLSKDAKETQD--KAEAESDGQ 694

  Fly   938 SDIKDDSMSNITGEKSEKHLANEEIVAKFLQKD-----SPDTSVVHAETQ-QLQFLNSSSSVCEE 996
            ::...|..:...| :|...:.......|..:|.     :|| .|:.||.: :.:...|..||.|.
  Rat   695 TEETADPQNAHAG-RSPAPVQTATTAPKTWKKTKERTRTPD-EVLEAEAEPKAEEELSVDSVLEP 757

  Fly   997 DEPVPVISEGVTKTEENAEAEIKFGDFHEDPRNDTGFICSSTWSSSTISKA-AEDDSSQSSRSAD 1060
            ::  ..:|:|.              .|..||              ||:.:| ||:::.:.:....
  Rat   758 EQ--EKMSQGF--------------QFERDP--------------STLKRAKAEEENGEEAEPVR 792

  Fly  1061 NVDCAPKVVEQISEEKSASSTKSSPVHKATGSGPGSPKTKELKSKSPSPIPV---PQVPKNYRYS 1122
            |            ..:|||..:....:..:....|...|...|::|..|...   .|..:.:...
  Rat   793 N------------GAESASEGEGGDANSGSTDSSGDGVTFPFKAESWKPADTEGKKQYDREFLLD 845

  Fly  1123 IETLRELAKRRDSRKPPMVPCQKGDCISQLFVSRQQQPQQHHGQHIQQYQHMSFNESLDYVPGKR 1187
            |:.:....::.:...|          ||.:.:.:..||:..             ..:||.....|
  Rat   846 IQFMPACIQKPEGLPP----------ISDVVLDKINQPRLP-------------MRTLDPRILPR 887

  Fly  1188 GRGHGPNKKHHDQHQQMGGSSGMGSGSGGGGGI---------SNSSQRHMDIIRVQLSLKEEIKL 1243
            |....|            ..:..|..:.||.|:         |...||......:.:|:||::.|
  Rat   888 GPDFTP------------AFADFGRQTPGGRGVPLLSVGPRRSQPGQRREPRKIITVSVKEDVHL 940

  Fly  1244 SECENAWQPGTLRRVSMAGGQDEDDDVEGV-----LKKVRGILNKLTPDNFEVLLKEMSSIKMDN 1303
            .:.||||:|...|       ....||.|.:     .:|||.|||||||..|..|:|::|::.:|.
  Rat   941 RKAENAWKPSQKR-------DSHADDPESIKTQELFRKVRSILNKLTPQMFNQLMKQVSALTVDT 998

  Fly  1304 EAKMTNVMLLIFEKTISEPNFAPTYARFCKVLF-----HEIKAENKSLFTSSLITRIQHEFESNV 1363
            |.::..|:.|:|||.|.||:|:..||..|:.|.     ...|..|...|...|:.|.|.|||.:.
  Rat   999 EERLKGVIDLVFEKAIDEPSFSVAYANMCRCLVTLKVPMADKPGNTVNFRKLLLNRCQKEFEKDK 1063

  Fly  1364 NDANAKSKKLQPTMERINQCSDPAKKAELRAEMEDLEYQFRRRAWGTVRFIGELFKLQSLTNDRV 1428
            .|.:...||    .:.:...|.|.::..|..|:|:.:.:.|||:.|.::||||||||:.||...:
  Rat  1064 ADDDVFEKK----QKELEAASAPEERTRLHDELEEAKDKARRRSIGNIKFIGELFKLKMLTEAIM 1124

  Fly  1429 LNCVESLLEHGCEEKLEYMCKLLTTVGHLLESSLPEHYQLRDRIEKIFRRIQDIINRSRGTSHRQ 1493
            .:||..||::..||.||.:|:||||:|..|:..     :.:.|:::.|.:::.|:...
  Rat  1125 HDCVVKLLKNHDEESLECLCRLLTTIGKDLDFE-----KAKPRMDQYFNQMEKIVKER------- 1177

  Fly  1494 QVHIKISSRVRFMMQDVLDLRLRNWDQPATHQSGQQGGR--GQRHKQH--DDSKDQSHSTGGGRG 1554
                |.|||:|||:|||:||||.||    ..:...||.:  .|.||:.  ::.::|
  Rat  1178 ----KTSSRIRFMLQDVIDLRLCNW----VSRRADQGPKTIEQIHKEAKIEEQEEQ--------- 1225

  Fly  1555 GGMNQHQQSSTHHQHQKHNQHGHDGGNYFMQKMPNKQHHENQTLSIDPSKLRFSNSSATDDSI-- 1617
               .:.||..|..:.:...|...:||...:|...|.:       .:||||.........|:.|
  Rat  1226 ---RKVQQLMTKEKRRPGVQRVDEGGWNTVQGAKNSR-------VLDPSKFLKITKPTIDEKIQL 1280

  Fly  1618 ---AKLGNSSHYQW--RNVGNRPVSSTQVNASNAPPPTSLLKRPGQNYKFLPYQQPSAVAGTANA 1677
               |:||:     |  .:.|....|.|....|:|    |.|.|      |.|. ||.|.:|:.:|
  Rat  1281 VPKAQLGS-----WGKGSSGGAKASETDALRSSA----SSLNR------FSPL-QPPAPSGSPSA 1329

  Fly  1678 --------------------------PAGGNKSNV----EVNDAFDGKQCQGLITKLVE------ 1706
                                      |||..:.|.    ...|..|.:..:....:::|
  Rat  1330 TPLDFDSRRALTSRGSMGREKSDKPLPAGTARPNTFLRGSSKDLLDNQSQEEQRREMLETVKQLT 1394

  Fly  1707 -----EALNTREWQPEVLSIWRSH------------SGSQQSKTLFHLLTDYLH----------- 1743
                 |..:|...:.:...:.:|.            |..:..:....::.::||
  Rat  1395 GGVDAERASTEADRSKARELVKSEVCTVPAPDKPALSEEEVERKSKSIIDEFLHINDFKEATQCI 1459

  Fly  1744 ----------------------KSTVKRQHRQACGNIFAYLMDKDAVEKEIFEEAYSRFGDDFPD 1786
                                  :|.:.|.|   .|::...|:..:.:.|:.|.:.:|...:...|
  Rat  1460 EELSAQGPLHVFVKVGVEFTLERSQITRDH---MGHLLYQLVQSEKLSKQDFFKGFSETLELADD 1521

  Fly  1787 LLVDVPNGWGYVFEFLGPIIHSGHLDLKDV 1816
            :.:|:|:.|.|:.|.:.|::..|.:.::::
  Rat  1522 MAIDIPHIWLYLAELVTPMLKEGGISMREL 1551

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
eIF4G2	NP_651188.1	Herpes_BLLF1	<114..450	CDD:282904	58/299 (19%)
		MIF4G	1274..1514	CDD:397130	89/244 (36%)
		MA3	1697..1812	CDD:397128	23/170 (14%)
Eif4g3	XP_038965571.1	PHA03247	<65..498	CDD:223021	116/602 (19%)
		MIF4G	969..1197	CDD:397130	92/247 (37%)
		MA3	1435..1547	CDD:397128	18/114 (16%)