DRSC/TRiP Functional Genomics Resources

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Protein Alignment eIF4G2 and Eif4g3

DIOPT Version :9

Sequence 1:NP_001287489.1 Gene:eIF4G2 / 42819 FlyBaseID:FBgn0260634 Length:2072 Species:Drosophila melanogaster
Sequence 2:XP_006538839.1 Gene:Eif4g3 / 230861 MGIID:1923935 Length:1773 Species:Mus musculus


Alignment Length:2167 Identity:462/2167 - (21%)
Similarity:729/2167 - (33%) Gaps:670/2167 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly   115 QPSYAAHSAAVNNSANGGGATLQLSAAASSNTLGHPLTGGHHGGANGVAPGSNMP----RALSNP 175
            :|:..:.|||...:..|.||     |||::....||...   ..|..||..:..|    |||..|
Mouse     6 KPALKSGSAAAAGTGPGTGA-----AAAAAVPPPHPAAA---AAAAAVAAAAAPPHPNIRALQTP 62

  Fly   176 TLPPHFQQSAGLIAPAGGNAGGPYISATYIPINQTGPLMGMQPAVTFPTNGAA-----GASFYAA 235
            .  |.......:..|.......|.:||.|..:.|    :..||....|...:|     |....||
Mouse    63 A--PQQIPRGPVQQPLEDRLFPPTVSAVYSTVTQ----VARQPGPPTPAPYSAHEISKGLPSLAA 121

  Fly   236 APPPPQQKQLPPTAQQQGPGGAPGAAQTP----------TLAYYQL------GPNAQNSAGNNV- 283
            .||              |...:||.:|||          ||.|.|.      .|.|::..|..| 
Mouse   122 TPP--------------GHASSPGLSQTPYPSGQNAGPATLVYPQAPQTMNSQPQARSPPGRTVP 172

  Fly   284 VSGANTHRGNMRGGQ----RSTPTAQHTNYFTAYTMAPGNAQRPAPTNVAPMMNSRSGALNGAAA 344
            :...:|.:......|    ||........|:..:........|.|..|.:|.:  |.|.....|.
Mouse   173 IHCTDTRKRRKVLEQSPVYRSLAGRGWIKYYIFFQRPQIQPPRAAIPNSSPSI--RPGVQTPTAV 235

  Fly   345 F---------HHLP--------HNFGIPSLALGPPAGMTTPILAPAGMQAPPPQPPG-------- 384
            :         :|||        |.:.||......|     |.:.|.  |..|.||||        
Mouse   236 YQANQHIMMVNHLPMPYPVTQGHQYCIPQYRHSGP-----PYVGPP--QQYPVQPPGPGPFYPGP 293

  Fly   385 GLHTFAPHLQSNSATT--LPSVPSVTGVPAVASGFSTTSLPTPSVTTAPQLGANSDKVCKRKYAI 447
            |...||     |:..|  .||.|.....|.:.   .|...|.|:.              :.|..|
Mouse   294 GPGDFA-----NAYGTPFYPSQPVYQSAPIIV---PTQQQPPPAK--------------REKKTI 336

  Fly   448 PIIHP-----DTMENVMDGWKRSVFIKKDSNSTLTQHTDLDTALDDNSTLCLYQAPTLMDSGSGS 507
            .|..|     |..|.:|                                           ||.||
Mouse   337 RIRDPNQGGKDITEEIM-------------------------------------------SGGGS 358

  Fly   508 SLLSGAMVDQQMQTVKPASSLKQSVSLEKVPEAVYCKDAVGQDVHPSPPPKSTDKDQISVIVKDI 572
            .       :......:|||:                         |:||.:         :...:
Mouse   359 R-------NPTPPIGRPAST-------------------------PTPPQQ---------LPSQV 382

  Fly   573 LAHSGNAEDHLSFWQYSDVDNVTETHNSLPLVQSDLPDTTDTCQQPV-LFQEQAKKQRPK---LA 633
            ..||                         |:|...:.........|| ...:|.::::||   :.
Mouse   383 PEHS-------------------------PVVYGTVESAHLAASTPVTAASDQKQEEKPKPDPVF 422

  Fly   634 NKQSTATPASIANDVAEAAASGCPGVSILSRGQSMVTPAGPSTPPPPSRVAQQKSTKSIVTTAVA 698
            ...||.....::.:..|.|            ||...|.||..||.||       .|.|       
Mouse   423 QSPSTVLRLVLSGEKKEQA------------GQMPETAAGEPTPEPP-------RTSS------- 461

  Fly   699 ASVKPTTGSPNRKSSIQAATSTTTSSGASSSTASTPTHASSKLKQQPVNNLQHGKQIPGKVSTPA 763
                ||:..|..:||:                   |:..|:.|..||:...:...::|......|
Mouse   462 ----PTSLPPLARSSL-------------------PSPMSAALSSQPLFTAEDKCELPSSKEEDA 503

  Fly   764 LPPTASRISAAVTLLAGTANITTTTNSSKKQRQAQKRARELEKKKQKSSITSTTSTQGQNNNG-- 826
             ||..|..|...   |...::|..::..||.........:|        |:||......|..|  
Mouse   504 -PPVPSPTSCTA---ASGPSLTDNSDICKKPCSVAPHDSQL--------ISSTILINEMNGVGEK 556

  Fly   827 ---KGNGNG---------NAALEINTNSNNAATVTTT------SMSTLTTTTTATAPTTKQ---- 869
               |.|..|         ...|||..:......|..|      ||....:....|.||:..    
Mouse   557 LSAKENTVGMLRQEVLPLTLELEILEHPQEELKVECTPTPIAPSMLPAFSPAPPTPPTSPPCPPV 621

  Fly   870 ETAAVDDKETAQPTTDTLSATSNNTKVSSILRDKKTMLNPKEQLTSHNNNNNNNNEDGIEAKVES 934
            ..:|...:..|..|.....|....:..:.:.:|.|.|.:..|           :..|| :|:..:
Mouse   622 VLSAAIARSPAVATEVQRVADEGESLRTCLSKDAKEMQDKAE-----------SESDG-QAEETA 674

  Fly   935 DPESDIKDDSMSNI----TGEKSEKHLANEEIVAKFLQKDSPDTSVVHAETQQLQFLNSSSSVCE 995
            ||:|.....|.:.:    |..||.|....        |..:|| .|:.||.:         ...|
Mouse   675 DPQSLHSGRSPAPVQTATTAPKSWKKTKE--------QTRTPD-EVLEAEAE---------PKAE 721

  Fly   996 EDEPVPVISEGVTKTEENAEAEIKFGDFHEDPRNDTGFICSSTWSSSTISKAAEDDSSQSSRSAD 1060
            |:..|..:.|                  .|..:...||......|:....||.|.:..::....:
Mouse   722 EELAVDSVLE------------------PEQEKMSQGFPSERDPSALKRGKAEEGNGEEAEPVRN 768

  Fly  1061 NVDCAPKVVEQISEEKSASSTKSSPVHKATGSGPGSPKTKELKSKSPSPIPV---PQVPKNYRYS 1122
            ..:.|       ||.:.......|....|.|      .|...|::|..|...   .|..:.:...
Mouse   769 GAESA-------SEGEGGDGNSGSADSSADG------LTFPFKAESWKPADTEGKKQYDREFLLD 820

  Fly  1123 IETLRELAKRRDSRKPPMVPCQKGDCISQLFVSRQQQPQQHHGQHIQQYQHMSFNESLDYVPGKR 1187
            |:.:....::.:...|          ||.:.:.:..||:            :|. .:||  |...
Mouse   821 IQFMPACIQKPEGLPP----------ISDVVLDKINQPR------------LSM-RTLD--PRIL 860

  Fly  1188 GRGHGPNKKHHDQHQQMGGSSGMGSGSGGGGGI---------SNSSQRHMDIIRVQLSLKEEIKL 1243
            .||........|..:|          :.||.|:         |...||......:.:|:||::.|
Mouse   861 PRGPDFTPAFADFPRQ----------TPGGRGVPLLNVGPRRSQPGQRREPRKIITVSVKEDVHL 915

  Fly  1244 SECENAWQPGTLRRVSMAGGQDEDDDVEGV-----LKKVRGILNKLTPDNFEVLLKEMSSIKMDN 1303
            .:.||||:|...|       ....||.|.:     .:|||.|||||||..|..|:|::|::.:|.
Mouse   916 RKAENAWKPSQKR-------DSHADDPESIKTQELFRKVRSILNKLTPQMFNQLMKQVSALTVDT 973

  Fly  1304 EAKMTNVMLLIFEKTISEPNFAPTYARFCKVLF-----HEIKAENKSLFTSSLITRIQHEFESNV 1363
            |.::..|:.|:|||.|.||:|:..||..|:.|.     ...|..|...|...|:.|.|.|||.:.
Mouse   974 EERLKGVIDLVFEKAIDEPSFSVAYANMCRCLVTLKVPMADKPGNTVNFRKLLLNRCQKEFEKDK 1038

  Fly  1364 NDANAKSKKLQPTMERINQCSDPAKKAELRAEMEDLEYQFRRRAWGTVRFIGELFKLQSLTNDRV 1428
            .|.:...||    .:.:...|.|.::..|..|:|:.:.:.|||:.|.::||||||||:.||...:
Mouse  1039 ADDDVFEKK----QKELEAASAPEERTRLHDELEEAKDKARRRSIGNIKFIGELFKLKMLTEAIM 1099

  Fly  1429 LNCVESLLEHGCEEKLEYMCKLLTTVGHLLESSLPEHYQLRDRIEKIFRRIQDIINRSRGTSHRQ 1493
            .:||..||::..||.||.:|:||||:|..|:..     :.:.|:::.|.:::.|:...       
Mouse  1100 HDCVVKLLKNHDEESLECLCRLLTTIGKDLDFE-----KAKPRMDQYFNQMEKIVKER------- 1152

  Fly  1494 QVHIKISSRVRFMMQDVLDLRLRNWDQPATHQSGQQGGR--GQRHKQH--DDSKDQSHSTGGGRG 1554
                |.|||:|||:|||:||||.||    ..:...||.:  .|.||:.  ::.::|         
Mouse  1153 ----KTSSRIRFMLQDVIDLRLCNW----VSRRADQGPKTIEQIHKEAKIEEQEEQ--------- 1200

  Fly  1555 GGMNQHQQSSTHHQHQKHNQHGHDGGNYFMQKMPNKQHHENQTLSIDPSKLRFSNSSATDDSI-- 1617
               .:.||..|..:.:...|...:||...:|...|.:       .:||||.........|:.|  
Mouse  1201 ---RKVQQLMTKEKRRPGVQRVDEGGWNTVQGAKNSR-------VLDPSKFLKITKPTIDEKIQL 1255

  Fly  1618 ---AKLGNSSHYQW--RNVGNRPVSSTQVNASNAPPPTSLLKRPGQNYKFLPYQQPSAVAGTANA 1677
               |:||:     |  .:.|....|.:....|:|    |.|.|      |.|. ||.|.:|:.:|
Mouse  1256 VPKAQLGS-----WGKGSSGGAKASESDALRSSA----SSLNR------FSPL-QPPAPSGSPSA 1304

  Fly  1678 --------------------------PAGGNKSNV----EVNDAFDGKQCQGLITKLVEEALNTR 1712
                                      |||..:.|.    ...|..|.:..:    :...|.|.|.
Mouse  1305 TPLEFDSRRALTSRGSMGREKSDKPIPAGTARPNTFLRGSSKDLLDNQSQE----EQRREMLETV 1365

  Fly  1713 EWQPEVLSIWRSHSGSQQSKT---------------------------LFHLLTDYLH------- 1743
            :.....|...|:.:.:.:|||                           ...::.::||       
Mouse  1366 KQLTGGLDAERASTEADRSKTRELAKSEMCAVPAPDKPALSEEEVERKSKSIIDEFLHINDFKEA 1430

  Fly  1744 --------------------------KSTVKRQHRQACGNIFAYLMDKDAVEKEIFEEAYSRFGD 1782
                                      :|.:.|.|   .|::...|:..:.:.|:.|.:.:|...:
Mouse  1431 TQCIEELSAQGPLHVFVKVGVEFTLERSQITRDH---MGHLLYQLVQSEKLSKQDFFKGFSETLE 1492

  Fly  1783 DFPDLLVDVPNGWGYVFEFLGPIIHSGHLDLKDVWQRRWLDDFFFAERFVYAFVSYFVQEFGAAY 1847
            ...|:.:|:|:.|.|:.|.:.|::..|.:.::::...      |.............:.|.....
Mouse  1493 LADDMAIDIPHIWLYLAELVTPMLKGGGISMRELIVE------FSKPLLPVGRAGVLLSEILHLL 1551

  Fly  1848 ARKLWHNDYKLD----RGQLFWSDVRKYREFVQSHSFYF---LD----NGPGQNQGHAKVKAPTT 1901
            .|::.|.  |:.    ...|.|.|.....|.|  |.|..   ||    .||..::..:|.:.   
Mouse  1552 CRQMSHK--KVGALWREADLSWKDFLPEGEDV--HHFLLEQKLDFTESEGPCSSEALSKKEL--- 1609

  Fly  1902 PRSPVEHVERIRHLL---AISCDMAIDYINTNV----AINDKFVRQLTRFLCCDFALTVMTNTHN 1959
              |..|..:|:..|:   ....:...|::..|:    ..:..|:|.|...: |..|:....:|  
Mouse  1610 --SAEELSQRLEKLIMEEKADDERIFDWVEANLDESQMSSPTFLRALMTAV-CKAAIIADCST-- 1669

  Fly  1960 NIKSGGNSKPLQLNTESFRSCCTPLLRLCIDAQEALEIACIDEAVDALQQHFMTEYEDDMAAGET 2024
                      .:::|...:. ..|:|...:|:....|:    :|:.|||...:   :.|..| ..
Mouse  1670 ----------FRVDTAVIKQ-RVPILLKYLDSDTEKEL----QALYALQASIV---KLDQPA-NL 1715

  Fly  2025 ICSTFSVLYESEVIPKESFDKW 2046
            :...|..||:.|||.:::|.||
Mouse  1716 LRMFFDCLYDEEVISEDAFYKW 1737

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
eIF4G2NP_001287489.1 EIN3 <270..423 CDD:296674 42/190 (22%)
MIF4G 1274..1514 CDD:280935 89/244 (36%)
MA3 1697..1812 CDD:280933 26/174 (15%)
Eif4g3XP_006538839.1 PHA03247 <57..472 CDD:223021 117/604 (19%)
MIF4G 944..1172 CDD:367217 92/247 (37%)
MA3 1410..1522 CDD:367215 18/114 (16%)
W2_eIF4G1_like 1612..1744 CDD:211397 31/148 (21%)
W2 <1723..1769 CDD:388377 8/15 (53%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 175 1.000 Domainoid score I3633
eggNOG 1 0.900 - - E1_KOG0401
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D594395at2759
OrthoFinder 1 1.000 - - FOG0001079
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR23253
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 1 0.960 - -
76.970

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