DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment eIF4G2 and Paip1

DIOPT Version :9

Sequence 1:	NP_001287489.1	Gene:	eIF4G2 / 42819	FlyBaseID:	FBgn0260634	Length:	2072	Species:	Drosophila melanogaster
Sequence 2:	NP_663432.1	Gene:	Paip1 / 218693	MGIID:	2384993	Length:	400	Species:	Mus musculus

Alignment Length:	341	Identity:	71/341 - (20%)
Similarity:	129/341 - (37%)	Gaps:	106/341 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly  1264 QDEDDDVEGVLKKVRGILNKLT--PDNFEVLLKEMSSIK---MDNEAKMTNVMLLIFEKTISEPN 1323
            :|..:|...:.:.|:..||.||  |.:||..:::.:...   :..:..:..::.||:::..|.||
Mouse    70 EDGCEDYPTLSEYVQDFLNHLTEQPGSFETEIEQFAETLNGWVTTDDALQELVELIYQQATSIPN 134

  Fly  1324 FAPTYARFCKVLFHEIKAENKS-LFTSSLITRIQHEFESNVNDANAKSKKLQPTMERINQCSDPA 1387
            |:...||.|..|.|.:....:| .|...|:.|.:.|:|:  .|..||..::.
Mouse   135 FSYMGARLCNYLSHHLTISPQSGNFRQLLLQRCRTEYEA--KDQAAKGDEVT------------- 184

  Fly  1388 KKAELRAEMEDLEYQFRRRAWGTVRFIGELFKLQSL--TNDRVLNC----------VESLLEHGC 1440
                            |:|....|.|:|||:....:  ||.:|...          :.:|..:..
Mouse   185 ----------------RKRFHAFVLFLGELYLNLEIKGTNGQVTRADILQVGLRELLNALFSNPM 233

  Fly  1441 EEKLEYMCKLLTTVGHLLESSLPEHYQLRDRIEKIFRRIQDIINRSRGTSHRQQVHIKISSRVRF 1505
            ::.|....|||...|.:||.:..|  :.:..:|:|.:||::::           :....|..|:.
Mouse   234 DDNLICAVKLLKLTGSVLEDTWKE--KGKTDMEEIIQRIENVV-----------LDANCSRDVKQ 285

  Fly  1506 MMQDVLDLRLRNWDQPATHQSGQQGGRGQRHKQHDDSKDQSHSTGGGRGGGMNQHQQSSTHHQHQ 1570
            |:..:::||..||            ||             .|:|              ||:.:..
Mouse   286 MLLKLVELRSSNW------------GR-------------VHAT--------------STYREAT 311

  Fly  1571 KHNQHGHDGGNYFMQK 1586
            ..|.     .||||.:
Mouse   312 PEND-----PNYFMNE 322

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
eIF4G2	NP_001287489.1	EIN3	<270..423	CDD:296674
		MIF4G	1274..1514	CDD:280935	54/257 (21%)
		MA3	1697..1812	CDD:280933
Paip1	NP_663432.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..36
		PABPC1-interacting motif-2 (PAM2). /evidence=ECO:0000250	37..64
		MIF4G	81..297	CDD:280935	56/259 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	356..376
		PABPC1-interacting motif-1 (PAM1). /evidence=ECO:0000250	361..400
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0401
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810