Protein Alignment eIF4G2 and Eif4g1

DIOPT Version :10

• Sequence 1: NP_651188.1
• Gene: eIF4G2 / 42819
• FlyBaseID: FBgn0260634
• Length: 2072
• Species: Drosophila melanogaster
• Sequence 2: XP_006521998.1
• Gene: Eif4g1 / 208643
• MGIID: 2384784
• Length: 1601
• Species: Mus musculus
• Alignment Length: 2054
• Identity: 427/2054 - (20%)
• Similarity: 674/2054 - (32%)
• Gaps: 678/2054 - (33%)

  Fly   175 PTLPPHFQQSAGLIAPAGGNAGGPYISATYIPINQTGPLMGMQPAVT---FPTNGAAGA-----S 231
            ||.||. .:|.||..||             .|..||.|::...|..|   .|:....|.     .
Mouse     7 PTGPPP-ARSPGLPQPA-------------FPPGQTAPVVFSTPQATQMNTPSQPRQGGFRSLQH 57

  Fly   232 FY-AAAPPPPQQKQLPPTAQQQGPGGAPGAAQTPTLAYYQLGPNAQNSAGNNVVSGANTHRGNMR 295
            || :.|.||........:|....||.||           .:.|     ||:.|:         |.
Mouse    58 FYPSRAQPPSSAASRVQSAAPARPGPAP-----------HVYP-----AGSQVM---------MI 97

  Fly   296 GGQRSTPTAQHTNYFTAYTMAPGNAQRP--APTNVAPMMNSRSGALNGAAAFHHLPHNFGIPSLA 358
            ..|.|...:|...|.      ||..:..  .||...|:.....|...||:     |..||..:.|
Mouse    98 PSQISYSASQGAYYI------PGQGRSTYVVPTQQYPVQPGAPGFYPGAS-----PTEFGTYAGA 151

  Fly   359 LGPPAGMTTPILAPAGMQAPPP----QPPGGLHTFAPHLQSNSATTLPSVPSVTG---VPAVASG 416
            ..|..|:..   .||.: ||.|    |||    ..||  :....|.....|:..|   ...:.||
Mouse   152 YYPAQGVQQ---FPASV-APAPVLMNQPP----QIAP--KRERKTIRIRDPNQGGKDITEEIMSG 206

  Fly   417 FSTTSLPTPSVT---TAPQLGANSDKVCKRKYAIPIIHPDTMENVMDGWKRSVFIKKDSNSTLTQ 478
            ..|.|.|||..|   ..||....|.:|                        :|.|:.|..|
Mouse   207 ARTASTPTPPQTGGSLEPQPNGESPQV------------------------AVIIRPDDRS---- 243

  Fly   479 HTDLDTALDDNSTLCLYQAPTLMDSGSGSSLLSGAMVDQQMQTVKPASSLKQSVSLEKVPEAVYC 543
                                            .||.:..:.....|    :.|...|..|.:
Mouse   244 --------------------------------QGAAIGGRPGLPGP----EHSPGTESQPSS--- 269

  Fly   544 KDAVGQDVHPSPPP--KSTDKDQISVIVKDILAHSGNAEDHLSFWQYSDVDNVTETHNSLPLVQS 606
                 ....|||||  :...:..:.|:                               |:|
Mouse   270 -----PSPTPSPPPILEPGSESNLGVL-------------------------------SIP---- 294

  Fly   607 DLPDTTDTCQQPVLFQEQAKKQRPKLANKQSTATPASIANDVAEAAASGCPGVSILSRGQSMVTP 671
              .||..|...|:..:|               :||.|     .|.....|     ||...::..|
Mouse   295 --GDTMTTGMIPMSVEE---------------STPIS-----CETGEPYC-----LSPEPTLAEP 332

  Fly   672 AGPSTPPPPSRVAQQKSTKSIVTTAVAASVKPTTGSPNRKSSIQAATSTTTSSGASSSTASTPTH 736
                                |:...|..| ||...|....|.:|.            |||..|
Mouse   333 --------------------ILEVEVTLS-KPIPESEFSSSPLQV------------STALVP-- 362

  Fly   737 ASSKLKQQPVNNLQHGKQIPGKVST---PALPPTASRISAAVTLLAGTANITTTTNSSKKQRQAQ 798
              .|::....|.:...:.:..:|.:   ||.||.:...|.::..:|.||......|.:...
Mouse   363 --HKVETHEPNGVIPSEDLEPEVESSTEPAPPPLSPCASESLVPIAPTAQPEELLNGAPSP---- 421

  Fly   799 KRARELEKKKQKSSITSTTSTQGQNNNGKGNGNGNAALEINTNSNNAATVTTTSMSTLTTTTTAT 863
                                               .|::::..|.........|.:.|.:..:..
Mouse   422 -----------------------------------PAVDLSPVSEPEEQAKKVSSAALASILSPA 451

  Fly   864 APTTKQETAAVDDKETAQPTTDTLSATSNNTKVSSILRDKKTMLNPKEQLTSHNNNNNNNNEDGI 928
            .|....:|:...::|..:                                       ::::|:|.
Mouse   452 PPVAPSDTSPAQEEEMEE---------------------------------------DDDDEEGG 477

  Fly   929 EAKVESDPESDIKDDSMSNITGEKSEKHLANEEIVAKFLQKDSPDTSV---VHAETQQLQFLNSS 990
            ||:.|...| |:..|| :.:..:.|:    |.|:.|.        |.|   |....::::.||..
Mouse   478 EAESEKGGE-DVPLDS-TPVPAQLSQ----NLEVAAA--------TQVAVSVPKRRRKIKELNKK 528

  Fly   991 SSV-------CEEDEPVPVISEGVTKTEENAEAEIKFGDFHEDPRNDTGFICSSTWSSSTISKAA 1048
            .:|       .|.|..||.: |....|..|...|
Mouse   529 EAVGDLLDAFKEVDPAVPEV-ENQPPTGSNPSPE------------------------------- 561

  Fly  1049 EDDSSQSSRSADNVDCAPKVVEQISEEKSASSTKSSPVHKATGSGPGSPKTKELKSKSPSPIPVP 1113
                |:.|          .|..|..|.:....:|...:|.|....||..| .|.||....|:
Mouse   562 ----SEGS----------MVPTQPEETEETWDSKEDKIHNAENIQPGEQK-YEYKSDQWKPL--- 608

  Fly  1114 QVPKNYRYSIETLRELAKR---RDSRKPPMVPCQKGDCISQLFVS-------RQQQPQQHHGQHI 1168
            .:.:..||..|.|  |..:   ...:||..:|     .|:.:.:.       ||..|.:..|
Mouse   609 NLEEKKRYDREFL--LGFQFIFASMQKPEGLP-----HITDVVLDKANKTPLRQLDPSRLPG--- 663

  Fly  1169 QQYQHMSFNESLDYVPGKRGRG------HGPNKKHHDQHQQMGGSSG-MGSGSGGGGGISNSSQR 1226
                   .|...|:.|.....|      .||.:         ||..| :..|...|.|...|.|.
Mouse   664 -------INCGPDFTPSFANLGRPALSNRGPPR---------GGPGGELPRGPQAGLGPRRSQQG 712

  Fly  1227 HMDIIRVQLS---LKEEIKLSECENAWQPGTLRRVSMAGGQDEDDD---VEGVLKKVRGILNKLT 1285
            .....|..:|   :.|:|||::.|.||:|.:.|..:.....:||.|   .:.:.::||.||||||
Mouse   713 PRKETRKIISSVIMTEDIKLNKAEKAWKPSSKRTAADKDRGEEDADGSKTQDLFRRVRSILNKLT 777

  Fly  1286 PDNFEVLLKEMSSIKMDNEAKMTNVMLLIFEKTISEPNFAPTYARFCKVLFH-EIKAENKSL--- 1346
            |..|:.|:|:::.:.:|.|.::..|:.|||||.||||||:..||..|:.|.. ::....|..
Mouse   778 PQMFQQLMKQVTQLAIDTEERLKGVIDLIFEKAISEPNFSVAYANMCRCLMALKVPTTEKPTVTV 842

  Fly  1347 -FTSSLITRIQHEFESNVNDANAKSKKLQPTMERINQCSDPAKKAELRAEMEDLEYQFRRRAWGT 1410
             |...|:.|.|.|||.:.:|.....||    .:.:::.:...::..|:.|:|:.....|||:.|.
Mouse   843 NFRKLLLNRCQKEFEKDKDDDEVFEKK----QKEMDEAATAEERGRLKEELEEARDIARRRSLGN 903

  Fly  1411 VRFIGELFKLQSLTNDRVLNCVESLLEHGCEEKLEYMCKLLTTVGHLLESSLPEHYQLRDRIEKI 1475
            ::||||||||:.||...:.:||..||::..||.||.:|:||||:|..|:.:     :.:.|:::.
Mouse   904 IKFIGELFKLKMLTEAIMHDCVVKLLKNHDEESLECLCRLLTTIGKDLDFA-----KAKPRMDQY 963

  Fly  1476 FRRIQDIINRSRGTSHRQQVHIKISSRVRFMMQDVLDLRLRNWDQPATHQSGQQGGRGQRHKQHD 1540
            |.:::.||...           |.|||:|||:|||||||..||    ..:.|.||.:
Mouse   964 FNQMEKIIKEK-----------KTSSRIRFMLQDVLDLRQSNW----VPRRGDQGPK-------- 1005

  Fly  1541 DSKDQSHSTGGGRGGGMNQHQQSSTHHQHQKHNQ---------HGHDGGNYFMQKMP-------N 1589
             :.||.|           :..:...|.:|.|..|         .|...|....:.:|       |
Mouse  1006 -TIDQIH-----------KEAEMEEHREHIKVQQLMAKGSDKRRGGPPGPPINRGLPLVDDGGWN 1058

  Fly  1590 KQHHENQTLSIDPSKL-RFSNSSATDDSIAKLGNSSHYQW-----RNVGNRPVSSTQVNASNAPP 1648
            .......:..||.|:| :.:...:.|.:...........|     ...|.:| |.|   ||.|..
Mouse  1059 TVPISKGSRPIDTSRLTKITKPGSIDSNNQLFAPGGRLSWGKGSSGGSGAKP-SDT---ASEATR 1119

  Fly  1649 PTSLLK-------RPGQNYKFLPYQQPSAVAGTANAPAGGNKSNVEVN-------DAFDGKQCQG 1699
            |.:|.:       .|.:|.......|.|:::......||.....:|.:       |..|..:...
Mouse  1120 PATLNRFSALQQTLPAENTDNRRVVQRSSLSRERGEKAGDRGDRLERSERGGDRGDRLDRARTPA 1184

  Fly  1700 L---ITKLVEEALNTREWQPEVL----SIWRSH---------------------SGSQQSKTLFH 1736
            .   .:|.|||....|..|||.|    |:....                     |..:..|....
Mouse  1185 TKRSFSKEVEERSRERPSQPEGLRKAASLTEDRGRDPVKREATLPPVSPPKAALSVDEVEKKSKA 1249

  Fly  1737 LLTDYLH---------------------------------KSTVKRQHRQACGNIFAYLMDKDAV 1768
            ::.:|||                                 :||:.|:|   .|.:...|:....:
Mouse  1250 IIEEYLHLNDMKEAVQCVQELASPSLLFIFVRLGIESTLERSTIAREH---MGRLLHQLLCAGHL 1311

  Fly  1769 EKEIFEEAYSRFGDDFPDLLVDVPNGWGYVFEFLGPIIHSGHLDLKDVWQR--RWLDDFFFAERF 1831
            ....:.:......:...|:.:|:|:.|.|:.|.:.||:....:.:.::::.  :.|.....|...
Mouse  1312 STAQYYQGLYETLELAEDMEIDIPHVWLYLAELITPILQEDGVPMGELFREITKPLRPMGKATSL 1376

  Fly  1832 VYAFVSYFVQEFGAAYARKLWHNDYKLDRGQLFWSDVRKYREFVQSHSFYFLDNGPGQNQG---- 1892
            :...:....:..|......||.      ...|.|      |||:          ..||:.|
Mouse  1377 LLEILGLLCKSMGPKKVGMLWR------EAGLSW------REFL----------AEGQDVGSFVA 1419

  Fly  1893 HAKV--------KAPTTPRSPVEHVER-IRHLL--AISCDMAIDYINTNV----AINDKFVRQLT 1942
            ..||        :||.......|.:.| :..||  ..|.....|:|:.|:    ..::..||.|.
Mouse  1420 EKKVEYTLGEESEAPGQRTLAFEELRRQLEKLLKDGGSNQRVFDWIDANLNEQQIASNTLVRALM 1484

  Fly  1943 RFLCCDFALTVMTNTHNNIKSGGNSKPLQLNTESFRSCCTPLLRLCIDAQEALEIACIDEAVDAL 2007
            ..:|..   .::..|           ||:::.:..:.....|.:...|.|:.|      :|:.||
Mouse  1485 TTVCYS---AIIFET-----------PLRVDVQVLKVRARLLQKYLCDEQKEL------QALYAL 1529

  Fly  2008 QQHFMTEYEDDMAAGETICSTFSVLYESEVIPKESFDKW 2046
            |...:|..:    ....:...|..||:.:|:.:::|..|
Mouse  1530 QALVVTLEQ----PANLLRMFFDALYDEDVVKEDAFYSW 1564

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
eIF4G2	NP_651188.1	Herpes_BLLF1	<114..450	CDD:282904	75/295 (25%)
		MIF4G	1274..1514	CDD:397130	89/244 (36%)
		MA3	1697..1812	CDD:397128	29/175 (17%)
Eif4g1	XP_006521998.1	PHA03247	<4..463	CDD:223021	136/725 (19%)
		rad2	<373..>612	CDD:273166	59/380 (16%)
		MIF4G	766..994	CDD:397130	91/247 (37%)
		MA3	1243..1355	CDD:397128	18/114 (16%)
		W2_eIF4G1_like	1442..1571	CDD:211397	30/147 (20%)