DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment eIF4G2 and Eif4g1

DIOPT Version :9

Sequence 1:NP_001287489.1 Gene:eIF4G2 / 42819 FlyBaseID:FBgn0260634 Length:2072 Species:Drosophila melanogaster
Sequence 2:XP_006521998.1 Gene:Eif4g1 / 208643 MGIID:2384784 Length:1601 Species:Mus musculus


Alignment Length:2054 Identity:427/2054 - (20%)
Similarity:674/2054 - (32%) Gaps:678/2054 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly   175 PTLPPHFQQSAGLIAPAGGNAGGPYISATYIPINQTGPLMGMQPAVT---FPTNGAAGA-----S 231
            ||.||. .:|.||..||             .|..||.|::...|..|   .|:....|.     .
Mouse     7 PTGPPP-ARSPGLPQPA-------------FPPGQTAPVVFSTPQATQMNTPSQPRQGGFRSLQH 57

  Fly   232 FY-AAAPPPPQQKQLPPTAQQQGPGGAPGAAQTPTLAYYQLGPNAQNSAGNNVVSGANTHRGNMR 295
            || :.|.||........:|....||.||           .:.|     ||:.|:         |.
Mouse    58 FYPSRAQPPSSAASRVQSAAPARPGPAP-----------HVYP-----AGSQVM---------MI 97

  Fly   296 GGQRSTPTAQHTNYFTAYTMAPGNAQRP--APTNVAPMMNSRSGALNGAAAFHHLPHNFGIPSLA 358
            ..|.|...:|...|.      ||..:..  .||...|:.....|...||:     |..||..:.|
Mouse    98 PSQISYSASQGAYYI------PGQGRSTYVVPTQQYPVQPGAPGFYPGAS-----PTEFGTYAGA 151

  Fly   359 LGPPAGMTTPILAPAGMQAPPP----QPPGGLHTFAPHLQSNSATTLPSVPSVTG---VPAVASG 416
            ..|..|:..   .||.: ||.|    |||    ..||  :....|.....|:..|   ...:.||
Mouse   152 YYPAQGVQQ---FPASV-APAPVLMNQPP----QIAP--KRERKTIRIRDPNQGGKDITEEIMSG 206

  Fly   417 FSTTSLPTPSVT---TAPQLGANSDKVCKRKYAIPIIHPDTMENVMDGWKRSVFIKKDSNSTLTQ 478
            ..|.|.|||..|   ..||....|.:|                        :|.|:.|..|    
Mouse   207 ARTASTPTPPQTGGSLEPQPNGESPQV------------------------AVIIRPDDRS---- 243

  Fly   479 HTDLDTALDDNSTLCLYQAPTLMDSGSGSSLLSGAMVDQQMQTVKPASSLKQSVSLEKVPEAVYC 543
                                            .||.:..:.....|    :.|...|..|.:   
Mouse   244 --------------------------------QGAAIGGRPGLPGP----EHSPGTESQPSS--- 269

  Fly   544 KDAVGQDVHPSPPP--KSTDKDQISVIVKDILAHSGNAEDHLSFWQYSDVDNVTETHNSLPLVQS 606
                 ....|||||  :...:..:.|:                               |:|    
Mouse   270 -----PSPTPSPPPILEPGSESNLGVL-------------------------------SIP---- 294

  Fly   607 DLPDTTDTCQQPVLFQEQAKKQRPKLANKQSTATPASIANDVAEAAASGCPGVSILSRGQSMVTP 671
              .||..|...|:..:|               :||.|     .|.....|     ||...::..|
Mouse   295 --GDTMTTGMIPMSVEE---------------STPIS-----CETGEPYC-----LSPEPTLAEP 332

  Fly   672 AGPSTPPPPSRVAQQKSTKSIVTTAVAASVKPTTGSPNRKSSIQAATSTTTSSGASSSTASTPTH 736
                                |:...|..| ||...|....|.:|.            |||..|  
Mouse   333 --------------------ILEVEVTLS-KPIPESEFSSSPLQV------------STALVP-- 362

  Fly   737 ASSKLKQQPVNNLQHGKQIPGKVST---PALPPTASRISAAVTLLAGTANITTTTNSSKKQRQAQ 798
              .|::....|.:...:.:..:|.:   ||.||.:...|.::..:|.||......|.:...    
Mouse   363 --HKVETHEPNGVIPSEDLEPEVESSTEPAPPPLSPCASESLVPIAPTAQPEELLNGAPSP---- 421

  Fly   799 KRARELEKKKQKSSITSTTSTQGQNNNGKGNGNGNAALEINTNSNNAATVTTTSMSTLTTTTTAT 863
                                               .|::::..|.........|.:.|.:..:..
Mouse   422 -----------------------------------PAVDLSPVSEPEEQAKKVSSAALASILSPA 451

  Fly   864 APTTKQETAAVDDKETAQPTTDTLSATSNNTKVSSILRDKKTMLNPKEQLTSHNNNNNNNNEDGI 928
            .|....:|:...::|..:                                       ::::|:|.
Mouse   452 PPVAPSDTSPAQEEEMEE---------------------------------------DDDDEEGG 477

  Fly   929 EAKVESDPESDIKDDSMSNITGEKSEKHLANEEIVAKFLQKDSPDTSV---VHAETQQLQFLNSS 990
            ||:.|...| |:..|| :.:..:.|:    |.|:.|.        |.|   |....::::.||..
Mouse   478 EAESEKGGE-DVPLDS-TPVPAQLSQ----NLEVAAA--------TQVAVSVPKRRRKIKELNKK 528

  Fly   991 SSV-------CEEDEPVPVISEGVTKTEENAEAEIKFGDFHEDPRNDTGFICSSTWSSSTISKAA 1048
            .:|       .|.|..||.: |....|..|...|                               
Mouse   529 EAVGDLLDAFKEVDPAVPEV-ENQPPTGSNPSPE------------------------------- 561

  Fly  1049 EDDSSQSSRSADNVDCAPKVVEQISEEKSASSTKSSPVHKATGSGPGSPKTKELKSKSPSPIPVP 1113
                |:.|          .|..|..|.:....:|...:|.|....||..| .|.||....|:   
Mouse   562 ----SEGS----------MVPTQPEETEETWDSKEDKIHNAENIQPGEQK-YEYKSDQWKPL--- 608

  Fly  1114 QVPKNYRYSIETLRELAKR---RDSRKPPMVPCQKGDCISQLFVS-------RQQQPQQHHGQHI 1168
            .:.:..||..|.|  |..:   ...:||..:|     .|:.:.:.       ||..|.:..|   
Mouse   609 NLEEKKRYDREFL--LGFQFIFASMQKPEGLP-----HITDVVLDKANKTPLRQLDPSRLPG--- 663

  Fly  1169 QQYQHMSFNESLDYVPGKRGRG------HGPNKKHHDQHQQMGGSSG-MGSGSGGGGGISNSSQR 1226
                   .|...|:.|.....|      .||.:         ||..| :..|...|.|...|.|.
Mouse   664 -------INCGPDFTPSFANLGRPALSNRGPPR---------GGPGGELPRGPQAGLGPRRSQQG 712

  Fly  1227 HMDIIRVQLS---LKEEIKLSECENAWQPGTLRRVSMAGGQDEDDD---VEGVLKKVRGILNKLT 1285
            .....|..:|   :.|:|||::.|.||:|.:.|..:.....:||.|   .:.:.::||.||||||
Mouse   713 PRKETRKIISSVIMTEDIKLNKAEKAWKPSSKRTAADKDRGEEDADGSKTQDLFRRVRSILNKLT 777

  Fly  1286 PDNFEVLLKEMSSIKMDNEAKMTNVMLLIFEKTISEPNFAPTYARFCKVLFH-EIKAENKSL--- 1346
            |..|:.|:|:::.:.:|.|.::..|:.|||||.||||||:..||..|:.|.. ::....|..   
Mouse   778 PQMFQQLMKQVTQLAIDTEERLKGVIDLIFEKAISEPNFSVAYANMCRCLMALKVPTTEKPTVTV 842

  Fly  1347 -FTSSLITRIQHEFESNVNDANAKSKKLQPTMERINQCSDPAKKAELRAEMEDLEYQFRRRAWGT 1410
             |...|:.|.|.|||.:.:|.....||    .:.:::.:...::..|:.|:|:.....|||:.|.
Mouse   843 NFRKLLLNRCQKEFEKDKDDDEVFEKK----QKEMDEAATAEERGRLKEELEEARDIARRRSLGN 903

  Fly  1411 VRFIGELFKLQSLTNDRVLNCVESLLEHGCEEKLEYMCKLLTTVGHLLESSLPEHYQLRDRIEKI 1475
            ::||||||||:.||...:.:||..||::..||.||.:|:||||:|..|:.:     :.:.|:::.
Mouse   904 IKFIGELFKLKMLTEAIMHDCVVKLLKNHDEESLECLCRLLTTIGKDLDFA-----KAKPRMDQY 963

  Fly  1476 FRRIQDIINRSRGTSHRQQVHIKISSRVRFMMQDVLDLRLRNWDQPATHQSGQQGGRGQRHKQHD 1540
            |.:::.||...           |.|||:|||:|||||||..||    ..:.|.||.:        
Mouse   964 FNQMEKIIKEK-----------KTSSRIRFMLQDVLDLRQSNW----VPRRGDQGPK-------- 1005

  Fly  1541 DSKDQSHSTGGGRGGGMNQHQQSSTHHQHQKHNQ---------HGHDGGNYFMQKMP-------N 1589
             :.||.|           :..:...|.:|.|..|         .|...|....:.:|       |
Mouse  1006 -TIDQIH-----------KEAEMEEHREHIKVQQLMAKGSDKRRGGPPGPPINRGLPLVDDGGWN 1058

  Fly  1590 KQHHENQTLSIDPSKL-RFSNSSATDDSIAKLGNSSHYQW-----RNVGNRPVSSTQVNASNAPP 1648
            .......:..||.|:| :.:...:.|.:...........|     ...|.:| |.|   ||.|..
Mouse  1059 TVPISKGSRPIDTSRLTKITKPGSIDSNNQLFAPGGRLSWGKGSSGGSGAKP-SDT---ASEATR 1119

  Fly  1649 PTSLLK-------RPGQNYKFLPYQQPSAVAGTANAPAGGNKSNVEVN-------DAFDGKQCQG 1699
            |.:|.:       .|.:|.......|.|:::......||.....:|.:       |..|..:...
Mouse  1120 PATLNRFSALQQTLPAENTDNRRVVQRSSLSRERGEKAGDRGDRLERSERGGDRGDRLDRARTPA 1184

  Fly  1700 L---ITKLVEEALNTREWQPEVL----SIWRSH---------------------SGSQQSKTLFH 1736
            .   .:|.|||....|..|||.|    |:....                     |..:..|....
Mouse  1185 TKRSFSKEVEERSRERPSQPEGLRKAASLTEDRGRDPVKREATLPPVSPPKAALSVDEVEKKSKA 1249

  Fly  1737 LLTDYLH---------------------------------KSTVKRQHRQACGNIFAYLMDKDAV 1768
            ::.:|||                                 :||:.|:|   .|.:...|:....:
Mouse  1250 IIEEYLHLNDMKEAVQCVQELASPSLLFIFVRLGIESTLERSTIAREH---MGRLLHQLLCAGHL 1311

  Fly  1769 EKEIFEEAYSRFGDDFPDLLVDVPNGWGYVFEFLGPIIHSGHLDLKDVWQR--RWLDDFFFAERF 1831
            ....:.:......:...|:.:|:|:.|.|:.|.:.||:....:.:.::::.  :.|.....|...
Mouse  1312 STAQYYQGLYETLELAEDMEIDIPHVWLYLAELITPILQEDGVPMGELFREITKPLRPMGKATSL 1376

  Fly  1832 VYAFVSYFVQEFGAAYARKLWHNDYKLDRGQLFWSDVRKYREFVQSHSFYFLDNGPGQNQG---- 1892
            :...:....:..|......||.      ...|.|      |||:          ..||:.|    
Mouse  1377 LLEILGLLCKSMGPKKVGMLWR------EAGLSW------REFL----------AEGQDVGSFVA 1419

  Fly  1893 HAKV--------KAPTTPRSPVEHVER-IRHLL--AISCDMAIDYINTNV----AINDKFVRQLT 1942
            ..||        :||.......|.:.| :..||  ..|.....|:|:.|:    ..::..||.|.
Mouse  1420 EKKVEYTLGEESEAPGQRTLAFEELRRQLEKLLKDGGSNQRVFDWIDANLNEQQIASNTLVRALM 1484

  Fly  1943 RFLCCDFALTVMTNTHNNIKSGGNSKPLQLNTESFRSCCTPLLRLCIDAQEALEIACIDEAVDAL 2007
            ..:|..   .::..|           ||:::.:..:.....|.:...|.|:.|      :|:.||
Mouse  1485 TTVCYS---AIIFET-----------PLRVDVQVLKVRARLLQKYLCDEQKEL------QALYAL 1529

  Fly  2008 QQHFMTEYEDDMAAGETICSTFSVLYESEVIPKESFDKW 2046
            |...:|..:    ....:...|..||:.:|:.:::|..|
Mouse  1530 QALVVTLEQ----PANLLRMFFDALYDEDVVKEDAFYSW 1564

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
eIF4G2NP_001287489.1 EIN3 <270..423 CDD:296674 40/161 (25%)
MIF4G 1274..1514 CDD:280935 89/244 (36%)
MA3 1697..1812 CDD:280933 29/175 (17%)
Eif4g1XP_006521998.1 PHA03247 <4..463 CDD:223021 136/725 (19%)
rad2 <373..>612 CDD:273166 59/380 (16%)
MIF4G 766..994 CDD:367217 91/247 (37%)
MA3 1243..1355 CDD:367215 18/114 (16%)
W2_eIF4G1_like 1442..1571 CDD:211397 30/147 (20%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 175 1.000 Domainoid score I3633
eggNOG 1 0.900 - - E1_KOG0401
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D594395at2759
OrthoFinder 1 1.000 - - FOG0001079
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR23253
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
65.970

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