DRSC/TRiP Functional Genomics Resources

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Protein Alignment eIF4G2 and EIF4G1

DIOPT Version :9

Sequence 1:NP_001287489.1 Gene:eIF4G2 / 42819 FlyBaseID:FBgn0260634 Length:2072 Species:Drosophila melanogaster
Sequence 2:NP_001181875.2 Gene:EIF4G1 / 1981 HGNCID:3296 Length:1606 Species:Homo sapiens


Alignment Length:2062 Identity:414/2062 - (20%)
Similarity:684/2062 - (33%) Gaps:680/2062 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly   169 PRALSNPTLPPHFQQSAGLIAPAGGNAGGPYISATYIPINQTGPLMGMQPAVT---FPTNGAAGA 230
            |::...|..|     |.||..||             .|..||.|::...|..|   .|:....|.
Human     5 PQSTGPPPAP-----SPGLPQPA-------------FPPGQTAPVVFSTPQATQMNTPSQPRQGG 51

  Fly   231 -----SFYAAAPPPPQQKQLPPTAQQQGPGGAPGAAQTPTLAYYQLGPNAQ-NSAGNNVVSGANT 289
                 .||      |.:.|.|.:|..:....||.          :.||.|. ..||:.|:     
Human    52 FRSLQHFY------PSRAQPPSSAASRVQSAAPA----------RPGPAAHVYPAGSQVM----- 95

  Fly   290 HRGNMRGGQRSTPTAQHTNYFTAYTMAPGNAQRP--APTNVAPMMNSRSGALNGAAAFHHLPHNF 352
                |...|.|.|.:|...|.      ||..:..  .||...|:.....|...||:     |..|
Human    96 ----MIPSQISYPASQGAYYI------PGQGRSTYVVPTQQYPVQPGAPGFYPGAS-----PTEF 145

  Fly   353 GIPSLALGPPAGMTTPILAPAGMQAPPP----QPPGGLHTFAPHLQSNSATTLPSVPSVTG---V 410
            |..:.|..|..|:..   .|.|: ||.|    |||    ..||  :....|.....|:..|   .
Human   146 GTYAGAYYPAQGVQQ---FPTGV-APTPVLMNQPP----QIAP--KRERKTIRIRDPNQGGKDIT 200

  Fly   411 PAVASGFSTTSLPTPSVT---TAPQLGANSDKVCKRKYAIPIIHPDTMENVMDGWKRSVFIKKDS 472
            ..:.||..|.|.|||..|   ..||....:.:|.      .|:.||..       .:...|....
Human   201 EEIMSGARTASTPTPPQTGGGLEPQANGETPQVA------VIVRPDDR-------SQGAIIADRP 252

  Fly   473 NSTLTQHTDLDTALDDNSTLCLYQAPT-----LMDSGSGSSLLSGAMVDQQMQTVKPASSLKQSV 532
            .....:|:..::.....|       ||     :::.||..:|...::....|.|::  .|:::|.
Human   253 GLPGPEHSPSESQPSSPS-------PTPSPSPVLEPGSEPNLAVLSIPGDTMTTIQ--MSVEEST 308

  Fly   533 SLEKVPEAVYCKDAVGQDVHPSPPPKSTDKDQISVIVKDILAHSGNAEDHLSFWQYSDVDNVTET 597
            .:.:         ..|:....||.|        :.:.:.||    ..|..||       ..|.|:
Human   309 PISR---------ETGEPYRLSPEP--------TPLAEPIL----EVEVTLS-------KPVPES 345

  Fly   598 HNSLPLVQSDLPDTTDTCQQPVLFQEQAKKQRPKLANKQSTATPASIANDVAEAAASGCPGVSIL 662
            ..|...:|:..|..:.|.:                .::.:...|:.......|::....|     
Human   346 EFSSSPLQAPTPLASHTVE----------------IHEPNGMVPSEDLEPEVESSPELAP----- 389

  Fly   663 SRGQSMVTPAGPS-TPPPPSRVAQQKSTKSIVTTAVAASVKPTTGSPNRKSSIQAATSTTTSSGA 726
                   .||.|| :|.|.:..||.:...:...:..|..:.|.:....:...:.|:.:..|...|
Human   390 -------PPACPSESPVPIAPTAQPEELLNGAPSPPAVDLSPVSEPEEQAKEVTASMAPPTIPSA 447

  Fly   727 SSSTASTPTHASSKLKQQPVNNLQHGKQIPG------KVSTPALPPTASRISAAVTLLAGTANIT 785
            :.:||.:.|..:.:.:.:.....:.|:....      |.....|||.::.|.|.::.....|..|
Human   448 TPATAPSATSPAQEEEMEEEEEEEEGEAGEAGEAESEKGGEELLPPESTPIPANLSQNLEAAAAT 512

  Fly   786 TTTNSSKKQRQAQKRARELEKK----------KQKSSITSTTSTQ---GQNNNGKGNGNGNAALE 837
            ....|..|:|   ::.:||.||          |:.:........|   |.|...:..|:|     
Human   513 QVAVSVPKRR---RKIKELNKKEAVGDLLDAFKEANPAVPEVENQPPAGSNPGPESEGSG----- 569

  Fly   838 INTNSNNAATVTTTSMSTLTTTTTATAPTTKQETAAVDDKETAQPTTDTLSATSNNTKVSSILRD 902
                                     ..|..::.....|.||                       |
Human   570 -------------------------VPPRPEEADETWDSKE-----------------------D 586

  Fly   903 KKTMLNPKEQLTSHNNNNNNNNEDGIEAKVESDPESDIKDDSMSNITGEKSEKHLANEEIVAKFL 967
            |           .||..|....|...|          .|.|....:..|:.:::  :.|.:..| 
Human   587 K-----------IHNAENIQPGEQKYE----------YKSDQWKPLNLEEKKRY--DREFLLGF- 627

  Fly   968 QKDSPDTSVVHAETQQLQFLNSSSSVCEEDEPVPVISEGVTKTEENAEAEIKFGDFHEDPRNDTG 1032
                             ||:.:|   .::.|.:|.||:.|.                 |..|.|.
Human   628 -----------------QFIFAS---MQKPEGLPHISDVVL-----------------DKANKTP 655

  Fly  1033 FICSSTWSSSTISKAAEDDSSQSSRSAD-----NVDCAPKVVEQISE-EKSASSTKSSPVHKATG 1091
            .                       |..|     .::|.|......:. .::..||:..|     .
Human   656 L-----------------------RPLDPTRLQGINCGPDFTPSFANLGRTTLSTRGPP-----R 692

  Fly  1092 SGPGSPKTKELKSKSPSPIPVPQVPKNYRYSIETLRELAKRRDSRKPPMVPCQKGDCISQLFVSR 1156
            .|||.              .:|:.|..          |..||.                      
Human   693 GGPGG--------------ELPRGPAG----------LGPRRS---------------------- 711

  Fly  1157 QQQPQQHHGQHIQQYQHMSFNESLDYVPGKRGRGHGPNKKHHDQHQQMGGSSGMGSGSGGGGGIS 1221
            ||.|::.                             |.|                          
Human   712 QQGPRKE-----------------------------PRK-------------------------- 721

  Fly  1222 NSSQRHMDIIRVQLSLKEEIKLSECENAWQPGTLRRVSMAGGQDEDDD---VEGVLKKVRGILNK 1283
                    ||...| :.|:|||::.|.||:|.:.|..:.....:||.|   .:.:.::||.||||
Human   722 --------IIATVL-MTEDIKLNKAEKAWKPSSKRTAADKDRGEEDADGSKTQDLFRRVRSILNK 777

  Fly  1284 LTPDNFEVLLKEMSSIKMDNEAKMTNVMLLIFEKTISEPNFAPTYARFCKVLFH-EIKAENKSL- 1346
            |||..|:.|:|:::.:.:|.|.::..|:.|||||.||||||:..||..|:.|.. ::....|.. 
Human   778 LTPQMFQQLMKQVTQLAIDTEERLKGVIDLIFEKAISEPNFSVAYANMCRCLMALKVPTTEKPTV 842

  Fly  1347 ---FTSSLITRIQHEFESNVNDANAKSKKLQPTMERINQCSDPAKKAELRAEMEDLEYQFRRRAW 1408
               |...|:.|.|.|||.:.:|.....||    .:.:::.:...::..|:.|:|:.....|||:.
Human   843 TVNFRKLLLNRCQKEFEKDKDDDEVFEKK----QKEMDEAATAEERGRLKEELEEARDIARRRSL 903

  Fly  1409 GTVRFIGELFKLQSLTNDRVLNCVESLLEHGCEEKLEYMCKLLTTVGHLLESSLPEHYQLRDRIE 1473
            |.::||||||||:.||...:.:||..||::..||.||.:|:||||:|..|:..     :.:.|::
Human   904 GNIKFIGELFKLKMLTEAIMHDCVVKLLKNHDEESLECLCRLLTTIGKDLDFE-----KAKPRMD 963

  Fly  1474 KIFRRIQDIINRSRGTSHRQQVHIKISSRVRFMMQDVLDLRLRNWDQPATHQSGQQGGRGQRHKQ 1538
            :.|.:::.||...           |.|||:|||:|||||||..||    ..:.|.||.:      
Human   964 QYFNQMEKIIKEK-----------KTSSRIRFMLQDVLDLRGSNW----VPRRGDQGPK------ 1007

  Fly  1539 HDDSKDQSHSTGGGRGGGMNQHQQSSTHHQHQKHNQ---------HGHDGGNYFMQKMP------ 1588
               :.||.|           :..:...|.:|.|..|         .|...|....:.:|      
Human  1008 ---TIDQIH-----------KEAEMEEHREHIKVQQLMAKGSDKRRGGPPGPPISRGLPLVDDGG 1058

  Fly  1589 -NKQHHENQTLSIDPSKL-RFSNSSATDDSIAKLGNSSHYQW--RNVGNRPVSSTQVNASNAPPP 1649
             |.......:..||.|:| :.:...:.|.:...........|  .:.|......:...:..|.|.
Human  1059 WNTVPISKGSRPIDTSRLTKITKPGSIDSNNQLFAPGGRLSWGKGSSGGSGAKPSDAASEAARPA 1123

  Fly  1650 TSLLKRPGQNYKFLPYQ--------QPSAVAGTANAPAGGNKSNVEVN-------DAFDGKQCQG 1699
            ||.|.|.....:.:|.:        |.|:::......||.....:|.:       |..|..:...
Human  1124 TSTLNRFSALQQAVPTESTDNRRVVQRSSLSRERGEKAGDRGDRLERSERGGDRGDRLDRARTPA 1188

  Fly  1700 L---ITKLVEEALNTREWQPE---------------------------VLSIWRSHSGSQQSKTL 1734
            .   .:|.|||....|..|||                           |..:..:.|..:..|..
Human  1189 TKRSFSKEVEERSRERPSQPEGLRKAASLTEDRDRGRDAVKREAALPPVSPLKAALSEEELEKKS 1253

  Fly  1735 FHLLTDYLHKSTVKR-----QHRQACGNIFAYL-------MDKDAVEK----------------- 1770
            ..::.:|||.:.:|.     |...:...:|.::       :::.|:.:                 
Human  1254 KAIIEEYLHLNDMKEAVQCVQELASPSLLFIFVRHGVESTLERSAIAREHMGQLLHQLLCAGHLS 1318

  Fly  1771 ---------EIFEEAYSRFGDDFPDLLVDVPNGWGYVFEFLGPIIHSGHLDLKDVWQR--RWLDD 1824
                     ||.|.|        .|:.:|:|:.|.|:.|.:.||:..|.:.:.::::.  :.|..
Human  1319 TAQYYQGLYEILELA--------EDMEIDIPHVWLYLAELVTPILQEGGVPMGELFREITKPLRP 1375

  Fly  1825 FFFAERFVYAFVSYFVQEFGAAYARKLWHNDYKLDRGQLFWSDVRKYREFVQSHSFYFLDNGPGQ 1889
            ...|...:...:....:..|......||.      ...|.|      :||:..          ||
Human  1376 LGKAASLLLEILGLLCKSMGPKKVGTLWR------EAGLSW------KEFLPE----------GQ 1418

  Fly  1890 NQG----HAKV--------KAPTTPRSPVEHVER-IRHLL--AISCDMAIDYINTNVA----IND 1935
            :.|    ..||        :||.....|.|.:.| :..||  ..|.....|:|..|::    :::
Human  1419 DIGAFVAEQKVEYTLGEESEAPGQRALPSEELNRQLEKLLKEGSSNQRVFDWIEANLSEQQIVSN 1483

  Fly  1936 KFVRQLTRFLCCDFALTVMTNTHNNIKSGGNSKPLQLNTESFRSCCTPLLRLCIDAQEALEIACI 2000
            ..||.|...:|..   .::..|           ||:::....::....|.:...|.|:.|     
Human  1484 TLVRALMTAVCYS---AIIFET-----------PLRVDVAVLKARAKLLQKYLCDEQKEL----- 1529

  Fly  2001 DEAVDALQQHFMT-EYEDDMAAGETICSTFSVLYESEVIPKESFDKW 2046
             :|:.|||...:| |...::     :...|..||:.:|:.:::|..|
Human  1530 -QALYALQALVVTLEQPPNL-----LRMFFDALYDEDVVKEDAFYSW 1570

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
eIF4G2NP_001287489.1 EIN3 <270..423 CDD:296674 43/162 (27%)
MIF4G 1274..1514 CDD:280935 89/244 (36%)
MA3 1697..1812 CDD:280933 31/182 (17%)
EIF4G1NP_001181875.2 PHA03247 <21..583 CDD:223021 140/731 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 173..229 18/61 (30%)
PABPC1-binding 179..207 6/29 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 241..326 16/117 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 339..607 60/379 (16%)
EIF4E-binding 614..625 2/12 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 674..720 14/125 (11%)
eIF3/EIF4A-binding 689..1092 141/561 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 738..764 8/25 (32%)
MIF4G 768..993 CDD:397130 89/244 (36%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1031..1234 33/202 (16%)
MA3 1249..1361 CDD:397128 21/119 (18%)
W2_eIF4G1_like 1445..1577 CDD:211397 32/151 (21%)
EIF4A-binding 1457..1606 29/139 (21%)
Necessary but not sufficient for MKNK1-binding 1592..1606
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 174 1.000 Domainoid score I3681
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D594395at2759
OrthoFinder 1 1.000 - - FOG0001079
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR23253
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
55.070

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