DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment eIF4G2 and ifg-1

DIOPT Version :9

Sequence 1:	NP_001287489.1	Gene:	eIF4G2 / 42819	FlyBaseID:	FBgn0260634	Length:	2072	Species:	Drosophila melanogaster
Sequence 2:	NP_001368728.1	Gene:	ifg-1 / 174322	WormBaseID:	WBGene00002066	Length:	1160	Species:	Caenorhabditis elegans

Alignment Length:	1265	Identity:	255/1265 - (20%)
Similarity:	429/1265 - (33%)	Gaps:	429/1265 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   674 PSTPPPPSRVAQQKSTKSIVTTA---------VAASVKPTTGSPNRKSSIQAATSTTTSSGASSS 729
            |..|..|::.|||:.|.    ||         ....|.|||     |.:|:.......::.|.::
Worm   117 PEMPYQPAQPAQQQMTH----TAPQEPKRQRKALEIVDPTT-----KKAIEVTPHLAPAAPAPAA 172

  Fly   730 TASTPTHASSKLKQ--------QPVNNLQHGKQ-----------IPGKVSTPALP---------- 765
            .|:.......|.||        |..|.|.|..:           :|..|....||
Worm   173 PAAPIAPEEEKKKQNITLEFLNQVKNELHHEDRRHDNPPAVPAAVPAAVQAAVLPNFSVPPPALG 237

  Fly   766 --PTASRISAAVTLLAGTANITTTTNSSKKQRQAQKRARELEKKKQKSSITSTTSTQGQNNNGKG 828
              |.|:.|:..|            ..|..|..:|..:| :.|.|:.::.:|..:|....
Worm   238 QTPPAASIAPQV------------VPSVPKTPEAPAKA-DYEVKQAETLVTPVSSPHAS------ 283

  Fly   829 NGNGNAALEINTNSNNAATVTTTSMSTLT---TTTTATAPTTKQETAAVDDKETAQPTTDTLSAT 890
                      :|.:...|:.|..|.||:.   .|.|.|...:|:||.  |||
Worm   284 ----------DTTTTTPASGTAESASTVADVRVTPTLTKEESKEETD--DDK------------- 323

  Fly   891 SNNTKVSSILRDKKTMLNPKEQLTSHNNNNNNNNEDGIEAKVESDPESDIKDDSMSNITGEKSEK 955
                                    ...|:...:..|..::..|..||         .:..||::|
Worm   324 ------------------------FEENDERESTPDVADSSTEKTPE---------ELEIEKAQK 355

  Fly   956 HLANEEIVAKFLQKDSPDTSVVHAETQQLQFLNSSSSVCEEDEPVPVISEGVTKTEENAEAEIKF 1020
            ..  |||..|.|::::.:..:     ::|....|:           |||:|.            |
Worm   356 EA--EEIEKKKLREEALEKRI-----EELILAGSA-----------VISDGT------------F 390

  Fly  1021 G-DFHEDPRNDTGFICSSTWSSSTISKAAEDDSSQSSRSADNVDCAPKVVEQISEEKSASSTKSS 1084
            | ||....|.                                       :|::.
Worm   391 GRDFMVTIRE---------------------------------------IEKVF----------- 405

  Fly  1085 PVHKATGSGPGSPKTKELKSKSPSPIPVPQVPKNYRYSIETLRELAKRRDSRKPPMVP--CQKGD 1147
                               |::|.|:...|: .::...|:|:|.    .|::||...|  ..||.
Worm   406 -------------------SRTPCPLSPAQL-ADFGLDIKTMRV----SDNKKPNFTPNWANKGG 446

  Fly  1148 CISQLFVSRQQQPQQHHGQHIQQYQHMSFNESLDYVPGKRGRGHGPNKKHHDQHQQMGGSSGMGS 1212
                   :|||.|.                         |||                 ::..|:
Worm   447 -------NRQQVPY-------------------------RGR-----------------TTTDGT 462

  Fly  1213 GSGGGGGISNSSQRHMDIIRVQLSLKEEIKLSECENAWQPGTLRRVSMAGGQDEDDDVEGVLKKV 1277
            |.||.........:...::|..:...:.:.|...::||:|.  |:.:......|:..|..|.|||
Worm   463 GRGGQQQRDRMHNKRPPVVRPSIERVQRVTLPSSKDAWKPD--RQKTAEAVASEEAAVIEVCKKV 525

  Fly  1278 RGILNKLTPDNFEVLLKEMSSIKM-DNEAKMTNVMLLIFEKTISEPNFAPTYARFCKV-LFHEI- 1339
            |.::||:||.:...|.:|..|..: .|:|::..|:.::|:|.:.||.|...||..||. ..||:
Worm   526 RSLMNKVTPTSQRPLTEEFISYNVSSNDAQLAQVVEIVFDKAVEEPKFCALYAEMCKAQANHELS 590

  Fly  1340 KAENKSLFTSSLITRIQHEFESNVNDANAKSKKLQPTMERINQCSDPAKKAELRAEMEDLEYQFR 1404
            :...||.|.:.::||.|..|:.. .|.:|....:      |.:..||.||..:.||.:.   :||
Worm   591 QTGGKSAFRNKVLTRTQMTFQDK-KDIDADKLAI------IEKEEDPVKKELMLAEEKQ---KFR 645

  Fly  1405 RRAWGTVRFIGELFKLQSLTNDRVLNCVESLL----------EHGCEEKLEYMCKLLTTVGHLLE 1459
            ||.:|.:.|:|.|::.|.|:...|..|...|.          |...||.:....:|:.|||.:|:
Worm   646 RRKFGVMTFMGYLYRNQLLSTKIVQTCTFELFNSIKDQDIKKEDVDEESIHCGLQLIETVGVMLD 710

  Fly  1460 SSLPEHYQLRDR----IEKIFRRIQDIINRSRGTSHRQQVHIKISSRVRFMMQDVLDLRLRNWDQ 1520
            .|       :|.    :::.|:::             :......|:::|||:.::::||...|..
Worm   711 KS-------KDSTTVFLDQWFQKL-------------EAAKPYCSNKIRFMIMNLMELRKDKWIP 755

  Fly  1521 PATHQSGQQGGRGQRHK-------QHDDSKDQSHSTGGGRGGGMNQHQQSSTHHQHQKHNQHGHD 1578
            ..:.:||.: ...:.||       :::.::||.......|.||:..:..|.........|....:
Worm   756 RKSTESGPK-KIDEIHKDIRQEKIENEKARDQYDRDRDRRHGGVRPNSNSLRKSVPVSRNSLDRN 819

  Fly  1579 GGNYFMQKMPNKQHHENQ-----------TLSIDPSKLRFSNSSATDDSIAKLGNSSHYQWRNVG 1632
            .|         .||.|.:           :.|:.|..:  |.||..::::.|.....|......|
Worm   820 RG---------MQHPEQKRAAAAANTKLASSSVQPKNI--SLSSMDNNTLGKSKKEWHSGASGGG 873

  Fly  1633 NRPVSSTQVNASNAPPPTSLLKRPGQN---YKFLPYQQPSAVAGTANAPA--------GGNKSNV 1686
            |       .::.:|.|..|...|...|   .|....::.:|:|......|        ....||.
Worm   874 N-------TSSESAVPVKSAWGRRDSNDQRKKSTVDEKQAALAAAKEISAMSISSRRSTSQNSNT 931

  Fly  1687 EVNDAFDGKQCQGLITKLVEEALNTREWQPEVLSIWRS-----HSGSQQSKTLFHLLTDYLHK-- 1744
            :..|           .:|.||....|   .::::..:|     .||....|.|...:|||:.|
Worm   932 DKTD-----------DELTEEEKAVR---AKIMNTVKSDLLEMSSGELSQKELVDSITDYVGKEK 982

  Fly  1745 ------STVKRQHRQACGNIFAYLMDKD--------------AVEKEIFEEA---YSRFGDDFPD 1786
                  :.|.....:|.  |...|.|.|              ..||:.|.|.   :.:|.:|. :
Worm   983 YGSPSLTVVYEMIIRAV--IEKGLKDDDRKKLAIALRMSLVSKTEKQAFIEGATRFCKFANDV-E 1044

  Fly  1787 LLVDVPNGWGYVFEFLGPIIHSGHLDLKDV 1816
            |..|.|..|....|.|....|:.|.::.:|
Worm  1045 LQQDYPKLWTVTGEVLVNTSHAPHDEIGEV 1074

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
eIF4G2	NP_001287489.1	EIN3	<270..423	CDD:296674
		MIF4G	1274..1514	CDD:280935	69/256 (27%)
		MA3	1697..1812	CDD:280933	33/144 (23%)
ifg-1	NP_001368728.1	gliding_GltJ	<231..343	CDD:411345	29/179 (16%)
ifg-1	NP_001368728.1	MIF4G	522..752	CDD:397130	71/259 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160164157
Domainoid	1	1.000	103	1.000	Domainoid score	I4256
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	177	1.000	Inparanoid score	I2691
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001079
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23253
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	5.080