DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment mbc and DOCK4

DIOPT Version :9

Sequence 1:NP_001247267.1 Gene:mbc / 42817 FlyBaseID:FBgn0015513 Length:2008 Species:Drosophila melanogaster
Sequence 2:XP_016868308.1 Gene:DOCK4 / 9732 HGNCID:19192 Length:2006 Species:Homo sapiens


Alignment Length:2116 Identity:639/2116 - (30%)
Similarity:1031/2116 - (48%) Gaps:339/2116 - (16%)


- Green bases have known domain annotations that are detailed below.


  Fly    27 PHRLNLDVGDAVIILKETTHWYYGYRQKAKEIRGIFPKSYIHL---CEYNIVNGEYCIQRTD-IV 87
            |:.|:|::||.|.||::...||.|:..|...|:||||.||:||   |..|....|..|...| ::
Human    53 PYGLSLEIGDTVQILEKCDGWYRGFALKNPNIKGIFPSSYVHLKNACVKNKGQFEMVIPTEDSVI 117

  Fly    88 EEITKVLLEWGSIAKD-YFLTTNPSFPKIRRKMNELNNNRAALISGNLPLDEVRKVKLLATNQID 151
            .|:|..|.:||::.|. |.......|.::...|||:.:.|..::.|:|..|.::.||...|.::|
Human   118 TEMTSTLRDWGTMWKQLYVRNEGDLFHRLWHIMNEILDLRRQVLVGHLTHDRMKDVKRHITARLD 182

  Fly   152 TGNKLLGLDMVVRDESGDILDTNAICTTELYEQHMHAVQRIDKANRLSSERGTTRTPNKYSHNIL 216
            .||:.||||:|.|.|.. ::|...|..||||....|..::.|...:.|            ||::.
Human   183 WGNEQLGLDLVPRKEYA-MVDPEDISITELYRLMEHRHRKKDTPVQAS------------SHHLF 234

  Fly   217 LHVNAFVC-KFQEDSDLLFTLFDGETHKPISENYVVKWSRTGIARDTDQIDNNRVLFTDLSKSDL 280
            :.:.:.:| ...|:.:::|:|||.:.::||||.:.::.:|.|:.:..|:.:.:..||.||..|:|
Human   235 VQMKSLMCSNLGEELEVIFSLFDSKENRPISERFFLRLNRNGLPKAPDKPERHCSLFVDLGSSEL 299

  Fly   281 AIAKMYLVCYAIRIGSMEFKDSAESKRTSMSIANSMLNASSRKASQLSVSSSGSSSSNGEYIIRR 345
            . ..:|:..:.||||.|    .|..|:.:.|:                           :|  ||
Human   300 R-KDIYITVHIIRIGRM----GAGEKKNACSV---------------------------QY--RR 330

  Fly   346 PFGVACKDLTPFINKSDDFRGNIDLPFIMCEKET-----LDGTLRKLIANKDIGKIDSKMAVTIE 405
            |||.|...:...:  :.:.:.::.|...||..|:     .:..::||.|..::...::.:||:::
Human   331 PFGCAVLSIADLL--TGETKDDLILKVYMCNTESEWYQIHENIIKKLNARYNLTGSNAGLAVSLQ 393

  Fly   406 VLRGDIKQIKEEFPRLMHTNVPVARKMGFPEVILPGDVRNDLYLTICSGEFARIAKTSEKNVEVS 470
            :|.|||:||:.|:..:....|.:.||:||..:|:||::|||||:||..|||.:..|:..:||||:
Human   394 LLHGDIEQIRREYSSVFSHGVSITRKLGFSNIIMPGEMRNDLYITIERGEFEKGGKSVARNVEVT 458

  Fly   471 VCVANEQGYLMPGVLSIGAGHQPIDEYKSVVYYHDDKPKWQETFKIHVPIEDFKQCHLRFVLKHR 535
            :.:.:..|..:...:|.|:|..|..||.|.|.||::.|:|.|..|:.:|::.|:..|:||..:|.
Human   459 MFIVDSSGQTLKDFISFGSGEPPASEYHSFVLYHNNSPRWSELLKLPIPVDKFRGAHIRFEFRHC 523

  Fly   536 SSNEQKDRTEKPFGLAYVRLMQANGTTITQGQHILAVYKIDHKK--YDKTVANCYLELPATVAEL 598
            |:.|:.::  |.||.::|.|||.:|.|:..|.|.|.|:|.:...  .|.|   .||:||.:....
Human   524 STKEKGEK--KLFGFSFVPLMQEDGRTLPDGTHELIVHKCEENTNLQDTT---RYLKLPFSKGIF 583

  Fly   599 QGAKPSIGGLTLLPKDQLSIGVNLCSTKLTQSVSLLGLLNWSAHKETLEQSLNALSTVPGEEVVK 663
            .|........|   |:...|...||||||||:..:|.||.|..|.:.:...|:.|..:.|.|:||
Human   584 LGNNNQAMKAT---KESFCITSFLCSTKLTQNGDMLDLLKWRTHPDKITGCLSKLKEIDGSEIVK 645

  Fly   664 FLQDILDALFNILVENDHPEKYDQLVFMSIIHLIETVSDLKYQHFLSVLDVYINESFSFTLAYTK 728
            ||||.||.||.||.||.  :||...||.|::|:|..:.|.|:.||..|:|.||...|:..|||..
Human   646 FLQDTLDTLFGILDENS--QKYGSKVFDSLVHIINLLQDSKFHHFKPVMDTYIESHFAGALAYRD 708

  Fly   729 LMDVLQ---KNISEAISPKEKSADGNDLEESPEVRRLYKTTRYLHYVMKFVIRSRVLYAEMNCNT 790
            |:.||:   ..|:||             |....::.:.|..   .|:.|::::||.|::......
Human   709 LIKVLKWYVDRITEA-------------ERQEHIQEVLKAQ---EYIFKYIVQSRRLFSLATGGQ 757

  Fly   791 DYMDFATRLQELL---RMFIDMIGCPSNLL-KSEGALLKNLHIIATDLMQVFEHVRLSISIVEIL 851
            :..:|...:||||   |.|:......|..| :|:...|.:...:.::|:::|:...::..:.:.|
Human   758 NEEEFRCCIQELLMSVRFFLSQESKGSGALSQSQAVFLSSFPAVYSELLKLFDVREVANLVQDTL 822

  Fly   852 EKFP-----PRRLTQSKMGCIKDFVETKLFTLPKCRAILLPVFCKHIKDHLESKEEGDSKTDIWQ 911
            ...|     ...|...|:.||...||::|:|.|..|.|||||...|:..||             |
Human   823 GSLPTILHVDDSLQAIKLQCIGKTVESQLYTNPDSRYILLPVVLHHLHIHL-------------Q 874

  Fly   912 QEKNLSKAAKVLGQ-----KKSQLHTCDTTANKKIAECIN-IMNNILKLLFRS--DVGSTHNDIR 968
            ::|:|...|::|..     ||:       ::.|.:.|.|: |:.::|.:|.|:  ::.|......
Human   875 EQKDLIMCARILSNVFCLIKKN-------SSEKSVLEEIDVIVASLLDILLRTILEITSRPQPSS 932

  Fly   969 DIMIILFRTVMKAAHALDRDTGLVGKFFAIMLGILQRMDAQHYEYFVKDLHQSGELKHFVIEILL 1033
            ..|...|:.|             .|:|.|.:|.:|::|..:||:..:...:...||:.|:::|..
Human   933 SAMRFQFQDV-------------TGEFVACLLSLLRQMTDRHYQQLLDSFNTKEELRDFLLQIFT 984

  Fly  1034 VFEELVSPHQKAVFPRDWMDMIMHQNTVILGALKHLTVVITDYFLCP-FEKQIWSNFFQCSIAFL 1097
            ||..|:.|.   :||:||..|.:..|.||:..:.:|:..:...||.. |:.:||.::|..::.|:
Human   985 VFRILIRPE---MFPKDWTVMRLVANNVIITTVLYLSDALRKNFLNENFDYKIWDSYFYLAVIFI 1046

  Fly  1098 VQSPLQLNDFNDNKRQIVFARYRDIRKDTAMEIRKMWFQLGQHKPKFVPQLVEPILEMSMIPEKE 1162
            .|..|||..|..:|::.|..:|.|:|.....||..||..||:||..|:|.|:.|.||:::||:.:
Human  1047 NQLCLQLEMFTPSKKKKVLEKYGDMRVTMGCEIFSMWQNLGEHKLHFIPALIGPFLEVTLIPQPD 1111

  Fly  1163 LRQETIPIFFDMMQCEYYSSRLEHESYGDTKFNNAHHKGNFSDFKTAMIEKLDILIGAGKGDAEY 1227
            ||...||||.|||..|...|                  |||...:..:|:|||.|:..||||..|
Human  1112 LRNVMIPIFHDMMDWEQRRS------------------GNFKQVEAKLIDKLDSLMSEGKGDETY 1158

  Fly  1228 KHLFETIM------------LERCAAHNTLNVDGTAFVQMVTRLMDKLLEYRFIIQ-DESKENRM 1279
            :.||.:|:            :||    .|....|.:.:..|||||::||:||..:: .|....::
Human  1159 RELFNSIIPLFGPYPSLLKKIER----ETWRESGVSLIATVTRLMERLLDYRDCMKMGEVDGKKI 1219

  Fly  1280 ACTFSLLQFY-SEVDLKEMYIRYVNKLCALHMEFENYTEAAFTLKLHTELLRWTDTELSHQLRSY 1343
            .||.|||.|| :|::.:||||||::||..||::.:|:||||:||.|:.|||.|:|    ..||.:
Human  1220 GCTVSLLNFYKTELNKEEMYIRYIHKLYDLHLKAQNFTEAAYTLLLYDELLEWSD----RPLREF 1280

  Fly  1344 RHNNCRTHRQLKEALYFEIMEYFDKGKQWECAIDMCRVLARQYEEEIFDYLKLAELLNRMALFYE 1408
            .....:|..|.||.|:..|::.||:||.||..|.:||.:|.|| |..:||..|:::....|..|:
Human  1281 LTYPMQTEWQRKEHLHLTIIQNFDRGKCWENGIILCRKIAEQY-ESYYDYRNLSKMRMMEASLYD 1344

  Fly  1409 KIIKELRHNSEYFRVCFYGRGFPRFLQNRVYIFRGKEYERHSDFCARMLVQHPQAELMQTLEAPG 1473
            ||:.:.|...|:|||.|||:.||.||:|:.::.||.:|||...|..|||.:.|.|..||....|.
Human  1345 KIMDQQRLEPEFFRVGFYGKKFPFFLRNKEFVCRGHDYERLEAFQQRMLNEFPHAIAMQHANQPD 1409

  Fly  1474 DDITNSDGQYIQVNKVEPIMGQAFNKFNDKIINNE-----IVKYFTANNVQKFQFSRPFRDSTNG 1533
            :.|..::.||:|:..|.||      ..:.:::..|     |..::..|::.||::.|||...|..
Human  1410 ETIFQAEAQYLQIYAVTPI------PESQEVLQREGVPDNIKSFYKVNHIWKFRYDRPFHKGTKD 1468

  Fly  1534 GDRDDVRNLWLERTELRISYPLPGILRWFPVVETNTFKISPLERAVEIMKDTNRDIRQLVILHKS 1598
            .: ::.::||:|||.|.:...||||.|||.|.:....::||||.|:|::::.|:.::.|:...::
Human  1469 KE-NEFKSLWVERTSLYLVQSLPGISRWFEVEKREVVEMSPLENAIEVLENKNQQLKTLISQCQT 1532

  Fly  1599 DETLHINPLSMKLNGIVDPAVMGGFAKYEEAFLTDDYLEQNPDDKELVEELKELIANQIPLLDLA 1663
            .:..:||||:|.|||::|.||.||.::|:|||...:|:..:|:|.|.:..|:||:..|..:|:..
Human  1533 RQMQNINPLTMCLNGVIDAAVNGGVSRYQEAFFVKEYILSHPEDGEKIARLRELMLEQAQILEFG 1597

  Fly  1664 IQLHRLRAPDSLKALQEHLERCFADMQQHV-------------------EQRYGRKSCDLKIERD 1709
            :.:|....|..::.|.:.|...|..|:..:                   ..|..|.|....:..|
Human  1598 LAVHEKFVPQDMRPLHKKLVDQFFVMKSSLGIQEFSACMQASPVHFPNGSPRVCRNSAPASVSPD 1662

  Fly  1710 S--VVMRRPNSFLPSLFDGSNNRHSETSMGSSDS-------GLSKST-----FLPRPQTNSIKNP 1760
            .  |:.||.....|::     ||:|.:|:.|..|       |.|:|:     ..|.|.|:|:.:.
Human  1663 GTRVIPRRSPLSYPAV-----NRYSSSSLSSQASAEVSNITGQSESSDEVFNMQPSPSTSSLSST 1722

  Fly  1761 FSGLSFNTRPSLGHSPSIKSNKSKDKTPSKRRTKDGKVKEREAHSLSSSQWYTP---PLSTITST 1822
            .|.           ||::.|:     .||..|... .:.::..||..:| ..:|   |.|.|..|
Human  1723 HSA-----------SPNVTSS-----APSSARASP-LLSDKHKHSRENS-CLSPRERPCSAIYPT 1769

  Fly  1823 PEKEINTSIASLASTSNSSLSGPKTPDPHVLTEELTPKRPLRSEMEKERRLSRPASIATPTASIK 1887
            |.:                      |...:|...:......||    :..||.|.....||.|  
Human  1770 PVE----------------------PSQRMLFNHIGDGALPRS----DPNLSAPEKAVNPTPS-- 1806

  Fly  1888 NFPDTRSLSESSNRNSVETTDSTSEEDIRPPPLPAK----ARDSTDFTSLS-------------Q 1935
                  |.|..|.:.:...:||..   :..||:|.:    |..:...||:|             |
Human  1807 ------SWSLDSGKEAKNMSDSGK---LISPPVPPRPTQTASPARHTTSVSPSPAGRSPLKGSVQ 1862

  Fly  1936 NMDWTPNGYAMLSTISNT-----------SSMSTTSTLTKTSITNTTYEYLETTNFSL---VGAI 1986
            :...:|..|.....|||:           ||:|..||...:...|...|........:   |.:.
Human  1863 SFTPSPVEYHSPGLISNSPVLSGSYSSGISSLSRCSTSETSGFENQVNEQSAPLPVPVPVPVPSY 1927

  Fly  1987 DGNKP---RPPTPP-----------PKPSRHSKHIP 2008
            .|.:|   ...|||           |.|..||..||
Human  1928 GGEEPVRKESKTPPPYSVYERTLRRPVPLPHSLSIP 1963

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mbcNP_001247267.1 SH3_DOCK_AB 14..70 CDD:212805 21/45 (47%)
DOCK_N 86..435 CDD:292790 94/355 (26%)
C2_Dock-A 443..633 CDD:176076 70/191 (37%)
DHR2_DOCK_A 1296..1697 CDD:212570 148/424 (35%)
DOCK4XP_016868308.1 None


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1997
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG54452
OrthoDB 1 1.010 - - D102580at2759
OrthoFinder 1 1.000 - - FOG0000433
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100636
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2355
SonicParanoid 1 1.000 - - X372
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
87.760

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