Protein Alignment mbc and Dock2

DIOPT Version :10

• Sequence 1: NP_001247267.1
• Gene: mbc / 42817
• FlyBaseID: FBgn0015513
• Length: 2008
• Species: Drosophila melanogaster
• Sequence 2: NP_203538.2
• Gene: Dock2 / 94176
• MGIID: 2149010
• Length: 1828
• Species: Mus musculus
• Alignment Length: 2006
• Identity: 762/2006 - (37%)
• Similarity: 1121/2006 - (55%)
• Gaps: 247/2006 - (12%)

  Fly     1 MSVWSDCNAKQAEFGIAKCNFDQESKPHRLNLDVGDAVIILKETTHWYYGYRQKAKEIRGIFPKS 65
            |:.|...:.::  .|:|..|| |.|:...|.|.:||.|.|.:....||.||..|.|..:||||.|
Mouse     1 MAPWRKTDKER--HGVAIYNF-QGSEAQHLTLQIGDVVRIQETCGDWYRGYLIKHKLSQGIFPTS 62

  Fly    66 YIHLCEY---------NIVNGEYCIQRTDIVEEITKVLLEWGSIAKD-YFLTTNPSFPKIRRKMN 120
            :|||.|.         ||:..|     ..:.:|:|..|.|||||.|. |..:....|.:::..|.
Mouse    63 FIHLKEVTVEKRRNIENIIPAE-----IPLAQEVTTTLWEWGSIWKQLYVASKKERFLQVQSMMY 122

  Fly   121 ELNNNRAALISGNLPLDEVRKVKLLATNQIDTGNKLLGLDMVVRDESGDILDTNAICTTELYEQH 185
            :|...|:.|:||.||.||::::|...|::||.|||:|.||::||||.|:|||.:......|:..|
Mouse   123 DLMEWRSQLLSGTLPKDELKELKQKVTSKIDYGNKILELDLIVRDEDGNILDPDKTSVISLFHAH 187

  Fly   186 MHAVQRIDKANRLSSERGT--------TRTPNKYSHNILLHVNAFVCKFQEDSDLLFTLFDGETH 242
            ..|..:|  ..|:..|...        :|..:..:|::.:.|..|||:..||::|..:|:|....
Mouse   188 EEATYKI--TERIKEEMSKDQPDYGVYSRISSSPTHSLYVFVRNFVCRIGEDAELFMSLYDPHKQ 250

  Fly   243 KPISENYVVKWSRTGIARDTDQIDNNRVLFTDLSKSDLAIAKMYLVCYAIRIGSMEFKDSAESKR 307
            ..|||||:|:|...|..::.:.::|.:|:||||...||...|::|:|..:|||.|:.||
Mouse   251 TVISENYLVRWGSKGFPKEIEMLNNLKVVFTDLGNKDLNRDKIFLICQIVRIGKMDLKD------ 309

  Fly   308 TSMSIANSMLNASSRKASQLSVSSSGSSSSNGEYIIRRPFGVACKDLTPFIN---KSDDFRGNID 369
                     :||  :|.:|            |   :|||||||..|:|..|.   :||:.:.:.
Mouse   310 ---------INA--KKCTQ------------G---LRRPFGVAVMDITDIIKGKAESDEEKQHF- 347

  Fly   370 LPF--IMCEKETLDGTLRKLIANK-DIGKIDSKMAVTIEVLRGDIKQIKEEFPRLMHTNVPVARK 431
            :||  :..|.:.|...|.|:||:| |.|  ...:.||:::|.|||.||::::|.|:.....||||
Mouse   348 IPFHPVSAENDFLHSLLGKVIASKGDSG--GQGLWVTMKMLVGDIIQIRKDYPHLVDRTTVVARK 410

  Fly   432 MGFPEVILPGDVRNDLYLTICSGEFARIAKTSEKNVEVSVCVANEQGYLMPGVLSIGAGHQPIDE 496
            :||||:|:|||||||:|:|:..|:|.:..||:::||||.:||..|.|.::|..:.:|||.:.::|
Mouse   411 LGFPEIIMPGDVRNDIYITLLQGDFDKYTKTTQRNVEVIMCVCTEDGKVLPNAICVGAGDKAMNE 475

  Fly   497 YKSVVYYHDDKPKWQETFKIHVPIEDFKQCHLRFVLKHRSSNEQKDRTEKPFGLAYVRLMQANGT 561
            |.|||||...:|:|.||.|:.|||||.::.||||:.:||||.|.||:.||.|.::||:||:.:||
Mouse   476 YHSVVYYQVKQPRWMETVKVAVPIEDMQRIHLRFMFRHRSSLESKDKGEKNFAMSYVKLMKEDGT 540

  Fly   562 TITQGQHILAVYKIDHKKYDKTVANCYLELPA-------TVAELQGAKPSIGGLTLLPKDQLSIG 619
            |:..|.|.|.|.|.|.||.:.  |:.||.||:       ..|.|..:..|:|||::..:|..||.
Mouse   541 TLHDGYHELVVLKGDSKKMED--ASAYLTLPSYRHPVENKGATLSRSSSSVGGLSVSSRDVFSIS 603

  Fly   620 VNLCSTKLTQSVSLLGLLNWSAHKETLEQSLNALSTVPGEEVVKFLQDILDALFNILVENDHPEK 684
            ..:|||||||:|.|||||.|....:.|:::|..|..|.||||||||||.|||||||::|:....:
Mouse   604 TLVCSTKLTQNVGLLGLLKWRMKPQLLQENLEKLKIVDGEEVVKFLQDTLDALFNIMMEHSQSNE 668

  Fly   685 YDQLVFMSIIHLIETVSDLKYQHFLSVLDVYINESFSFTLAYTKLMDVLQKNISEAISPKEKSAD 749
            ||.|||.::|::|..::|.|:|||.:||:.||.:.||.||||.|||.||:..:       :.|:.
Mouse   669 YDILVFDALIYIIGLIADRKFQHFNTVLEAYIQQHFSATLAYKKLMTVLKTYL-------DTSSR 726

  Fly   750 GNDLEESPEVRRLYKTTRYLHYVMKFVIRSRVLYAEMNCNTDYMDFATRLQELLRMFIDMIGCPS 814
            |...|.      :.:|.:.|.||.||::|||.|::::....:.|:|    :|.:|...:.|   :
Mouse   727 GEQCEP------ILRTLKALEYVFKFIVRSRTLFSQLYEGKEQMEF----EESMRRLFESI---N 778

  Fly   815 NLLKS--------EGALLKNLHIIATDLMQVFEHVRLSISIVEILEKFPPRRLTQSKMGCIKDFV 871
            ||:||        :.|.||.:..:..|:..||:...||..:.|.....||.:|.:.|:..:.:.|
Mouse   779 NLMKSQYKTTILLQVAALKYIPSVLHDVETVFDAKLLSQLLYEFYTCIPPVKLQKQKVQSMNEIV 843

  Fly   872 ETKLFTLPKCRAILLPVFCKHIKDHLESKEEGDSKTDIWQQEKNLSKAAKVLGQKKSQLHTCDTT 936
            ::.||...:||.|||||..|.:|:.||.:::|..:
Mouse   844 QSNLFKKQECRDILLPVITKELKELLEQRDDGQHQ------------------------------ 878

  Fly   937 ANKKIAECINIMNNILKLLFRSDVGSTHNDIRDIMIILFRTVMKAAHALDRDTGLVGKFFAIMLG 1001
            |.||  .|:.::|:||::|...|...|::.|::||:.|.|||.:....:.||..|:..|.|.|..
Mouse   879 AEKK--HCVELLNSILEVLSCQDAAFTYDHIQEIMVQLLRTVNRTVITMGRDHALISHFVACMTA 941

  Fly  1002 ILQRMDAQHYEYFVKDLHQSGELKHFVIEILLVFEELVSPHQKAVFPRDWMDMIMHQNTVILGAL 1066
            ||.:|..|||.::::....|.:|..|::|..::|::|:.   |.|:|.|||.|.|.||.|.|.|:
Mouse   942 ILDQMGDQHYSFYIETFQTSSDLVDFLMETFIMFKDLIG---KNVYPGDWMAMSMVQNRVFLRAI 1003

  Fly  1067 KHLTVVITDYFL--CPFEKQIWSNFFQCSIAFLVQSPLQLNDFNDNKRQIVFARYRDIRKDTAME 1129
            ......:...||  ..||.|:|:|:|..::||:.|..|||..|...|...:..:|.|:|:.....
Mouse  1004 NKFAETMNQKFLEHTSFEFQLWNNYFHLAVAFITQDSLQLEQFTHAKYNKILNKYGDMRRLIGFS 1068

  Fly  1130 IRKMWFQLGQHKPKFVPQLVEPILEMSMIPEKELRQETIPIFFDMMQCEYYSSRLEHESYGDTKF 1194
            ||.||::|||:|..|:|.:|.|||||::|||.|||:.|||||||||.|||
Mouse  1069 IRDMWYKLGQNKICFIPGMVGPILEMTLIPEAELRKATIPIFFDMMLCEY--------------- 1118

  Fly  1195 NNAHHKGNFSDFKTAMIEKLDILIGAGKGDAEYKHLFETIMLERCAAHNTLNVDGTAFVQMVTRL 1259
               ...|.|..|:..:|.|||..:..|:||.:|..|.|:|::|..|.|.|:......||.:|..|
Mouse  1119 ---QRTGAFKKFENEIILKLDHEVEGGRGDEQYMQLLESILMECTAEHPTIAKSVENFVSLVKGL 1180

  Fly  1260 MDKLLEYRFIIQDESKENRMACTFSLLQFYSEVDLKEMYIRYVNKLCALHMEFENYTEAAFTLKL 1324
            ::|||:||.::.||||:|||:||.:||.||.:.:.:||||||:.||..||::.|||||||:||.|
Mouse  1181 LEKLLDYRGVMTDESKDNRMSCTVNLLNFYKDNNREEMYIRYLYKLRDLHLDCENYTEAAYTLLL 1245

  Fly  1325 HTELLRWTDTELSHQLRSYRHNNCRTHRQLKEALYFEIMEYFDKGKQWECAIDMCRVLARQYEEE 1389
            ||.||:|:|.:.:.|:......:.:|||||||.||..|:.||||||.||.||.:|:.||.|||.|
Mouse  1246 HTWLLKWSDEQCASQVMQTGQQHPQTHRQLKETLYETIIGYFDKGKMWEEAISLCKELAEQYEME 1310

  Fly  1390 IFDYLKLAELLNRMALFYEKIIKELRHNSEYFRVCFYGRGFPRFLQNRVYIFRGKEYERHSDFCA 1454
            ||||..|::.|.:.|.|||.|:|.||...:||.|.:||:|||.||:|:|:|:|||||||..||..
Mouse  1311 IFDYELLSQNLTQQAKFYENIMKILRTKPDYFAVGYYGQGFPSFLRNKVFIYRGKEYERREDFQM 1375

  Fly  1455 RMLVQHPQAELMQTLEAPGDDITNSDGQYIQVNKVEPIMGQAFNKFNDKIINNEIVKYFTANNVQ 1519
            ::|.|.|.||.|.|..|||||:.|:.|||||...|:|::.: ..:|.:|.:.::|:.::.:|.||
Mouse  1376 QLLSQFPNAEKMNTTSAPGDDVRNAPGQYIQCFTVQPVLDE-HPRFKNKPVPDQIINFYKSNYVQ 1439

  Fly  1520 KFQFSRPFR----DSTNGGDRDDVRNLWLERTELRISYPLPGILRWFPVVETNTFKISPLERAVE 1580
            ||.:|||.|    |..|     :..::|:|||....:|.||||||||.||..:...|||||.|:|
Mouse  1440 KFHYSRPVRRGKVDPEN-----EFASMWIERTSFLTAYKLPGILRWFEVVHMSQTTISPLENAIE 1499

  Fly  1581 IMKDTNRDIRQLVILHKSDETLHINPLSMKLNGIVDPAVMGGFAKYEEAFLTDDYLEQNPDDKEL 1645
            .|...|..|..::..::|||:|.||||||.|||||||||||||||||:||.|::|..::|:|::.
Mouse  1500 TMSTVNEKILMMINQYQSDESLPINPLSMLLNGIVDPAVMGGFAKYEKAFFTEEYSREHPEDQDK 1564

  Fly  1646 VEELKELIANQIPLLDLAIQLHRLRAPDSLKALQEHLERCFADMQQHVEQRYG-RKSCDLKIERD 1709
            :..||:|||.|||.|...|::|..|..|:|:...:.:|.||.:::..||:.|| |:..|.:..|
Mouse  1565 LSHLKDLIAWQIPFLGAGIKIHEKRVSDNLRPFHDRMEECFKNLKMKVEKEYGVREMPDFEDRR- 1628

  Fly  1710 SVVMRRPNSFLPSLFDGSNNRHSETSMGSSDSGLSKSTFLPR---------PQTNSIK----NPF 1761
               :.||.|.|.|.     .:.|..|:.|..|..|..:.:|.         |:|..::    :|.
Mouse  1629 ---VGRPRSMLRSY-----RQMSVISLASMHSDCSTPSKVPAESFDLESAPPKTPKVEEEPISPG 1685

  Fly  1762 SGLSFNTRPSLGHSPSIKSNKSKDKTPSKRRTKDGKV--------KEREAHSLSSSQWYTPPLST 1818
            |.|           |.:|..:      ||:|||...|        .|.:...||..|.:   :|.
Mouse  1686 STL-----------PEVKLRR------SKKRTKRSSVVFADEKAATESDLKRLSRKQEF---MSD 1730

  Fly  1819 ITSTPEKEINTSIASLASTSNSSLSGPKTPDPHVLTEELTPKRPLRSEMEKERRLSRPASIATPT 1883
            ...:....|...::.|:..|.:|.|.|..|   .||..:... |...|.....|||:       |
Mouse  1731 TNLSEHAAIPARVSILSQMSFASQSMPTIP---ALTLSVAGV-PGLDEANTSPRLSQ-------T 1784

  Fly  1884 ASIKNFPDTRSLSESSNRNSVET--TDSTSEEDIRPPPLPAKARDSTDFTSLSQNM 1937
            ....:..|.::|.:.......:|  ...:|||..:.|          ||  ||.||
Mouse  1785 FFQVSDGDKKTLKKKKVNQFFKTMLASKSSEESKQIP----------DF--LSTNM 1828

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mbc	NP_001247267.1	SH3_DOCK_AB	14..70	CDD:212805	25/55 (45%)
		DOCK_N	86..435	CDD:465040	124/363 (34%)
		C2_Dock-A	443..633	CDD:176076	90/196 (46%)
		DHR2_DOCK_A	1296..1697	CDD:212570	201/404 (50%)
		Herpes_BLLF1	<1732..>1935	CDD:282904	49/225 (22%)
Dock2	NP_203538.2	SH3	12..67	CDD:473055	25/55 (45%)
		DOCK_N	78..414	CDD:465040	127/377 (34%)
		C2	422..617	CDD:472691	90/196 (46%)
		DHR2_DOCK2	1199..1619	CDD:212579	211/425 (50%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1652..1703		15/67 (22%)