DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mbc and DOCK7

DIOPT Version :9

Sequence 1:	NP_001247267.1	Gene:	mbc / 42817	FlyBaseID:	FBgn0015513	Length:	2008	Species:	Drosophila melanogaster
Sequence 2:	NP_001354490.1	Gene:	DOCK7 / 85440	HGNCID:	19190	Length:	2140	Species:	Homo sapiens

Alignment Length:	2055	Identity:	365/2055 - (17%)
Similarity:	637/2055 - (30%)	Gaps:	720/2055 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   190 QRIDKANRLSSERGTTRTPNKYSHNILLH---------------------------VNAFVCKFQ 227
            :.||:.|      ...|..|::.....||                           |.....||:
Human   217 EEIDRQN------DDQRKSNRHKELFALHPSPDEEEPIERLSVPDIPKEHFGQRLLVKCLSLKFE 275

  Fly   228 EDSDLLF---TLFDGETHKPISENY----------------VVKWSRTGIARDTDQIDNNRVLF- 272
            .:.:.:|   .|:|.:..|.||||:                |...:.|.:||.        .:|
Human   276 IEIEPIFASLALYDVKEKKKISENFYFDLNSEQMKGLLRPHVPPAAITTLARS--------AIFS 332

  Fly   273 -TDLSKSDLAIAKMYLVCYAIRIGS-----MEFKDSAESKR------------------------ 307
             |..|:....:.|:..|.....||.     |.||::..:|.
Human   333 ITYPSQDVFLVIKLEKVLQQGDIGECAEPYMIFKEADATKNKEKLEKLKSQADQFCQRLGKYRMP 397

  Fly   308 ---TSMSIANSMLNASS--RKASQLSVSS-----SGSSSSNGEYIIRR---------------PF 347
               |::.:.|.:.:|.|  |.::::.:|:     |.|...|...:.||               .|
Human   398 FAWTAIHLMNIVSSAGSLERDSTEVEISTGERKGSWSERRNSSIVGRRSLERTTSGDDACNLTSF 462

  Fly   348 GVACKDLTPFINKSDDFRGNIDLPFIMCEKETLDGTLRKLIANKDIGKIDSKMAVTIEVLRGDIK 412
            ..|...:|.|..:..|...:.||...:.:.......||:|            ..:|.: |:.||.
Human   463 RPATLTVTNFFKQEGDRLSDEDLYKFLADMRRPSSVLRRL------------RPITAQ-LKIDIS 514

  Fly   413 QIKEE-----FPRLMHTNV-------PVARKMGFP--EVILPGDV-RNDLYLTICSGEFARIAKT 462
            ...|.     .|.|:...:       |....:.||  :|.:|... ||.||:...|..||. .:.
Human   515 PAPENPHYCLTPELLQVKLYPDSRVRPTREILEFPARDVYVPNTTYRNLLYIYPQSLNFAN-RQG 578

  Fly   463 SEKNVEVSV--CVANEQGYLMPGVLSIGAGHQPIDEYKSVVYYHDDKPKWQETFKIHVPIEDFKQ 525
            |.:|:.|.|  ....:....||.:....:..:...|..:.|.||:..|.:.|..|:.:|......
Human   579 SARNITVKVQFMYGEDPSNAMPVIFGKSSCSEFSKEAYTAVVYHNRSPDFHEEIKVKLPATLTDH 643

  Fly   526 CHLRFVLKHRSSNEQKDRT--EKPFGLAYVRLMQANGTTITQGQHILAVYKIDHKKYDKTVANCY 588
            .||.|...|.|. :||..|  |.|.|..::.::| ||...| ||..|.|               .
Human   644 HHLLFTFYHVSC-QQKQNTPLETPVGYTWIPMLQ-NGRLKT-GQFCLPV---------------S 690

  Fly   589 LELPATVAELQGAKPSIGGLTLLP--KDQLSIGVNLCSTKLTQSVSL---LGLLN-WSAH----- 642
            ||.|.....:...:..:.|:..:.  |...::.|...|:..||...|   ..|:| ...|
Human   691 LEKPPQAYSVLSPEVPLPGMKWVDNHKGVFNVEVVAVSSIHTQDPYLDKFFALVNALDEHLFPVR 755

  Fly   643 -----------KETLEQSLNALSTVPGEEVVKFLQDILDALFNILVENDHPEKYDQLV------- 689
                       :..|:.|::||::...|.||:||..:||.|..:::.  .|....|:|
Human   756 IGDMRIMENNLENELKSSISALNSSQLEPVVRFLHLLLDKLILLVIR--PPVIAGQIVNLGQASF 818

  Fly   690 --FMSIIHLIETVSDLKYQHFL----SVLDVYINESFSF----------------------TLAY 726
              ..|||:.:.  .:|:..|..    |:|..||:..|..                      |:|.
Human   819 EAMASIINRLH--KNLEGNHDQHGRNSLLASYIHYVFRLPNTYPNSSSPGPGGLGGSVHYATMAR 881

  Fly   727 TKLMDV-LQKNISEAISPKEKSADGNDLEESPEVRRLY--------------------------- 763
            :.:... |..|.|.::|.......|.......|||.:.
Human   882 SAVRPASLNLNRSRSLSNSNPDISGTPTSPDDEVRSIIGSKGLDRSNSWVNTGGPKAAPWGSNPS 946

  Fly   764 --------------------KTTRYLHYVMKFVIRSRVLYAEMN-----CNTDYMDFATRLQELL 803
                                :|:.:|..:...:...::.:.|:.     |:....:.|  ||:..
Human   947 PSAESTQAMDRSCNRMSSHTETSSFLQTLTGRLPTKKLFHEELALQWVVCSGSVRESA--LQQAW 1009

  Fly   804 RMFIDMIGC-------------------PSNLLKSEGALLKNLHIIATDLMQVF-------EHVR 842
            ..|..|:..                   |...:....||:..   ||:|::..|       |.:.
Human  1010 FFFELMVKSMVHHLYFNDKLEAPRKSRFPERFMDDIAALVST---IASDIVSRFQKDTEMVERLN 1071

  Fly   843 LSIS-----IVEILEKFPPRRLTQSKMGCIKDFVETKLFTLP------KCRAILLPVFCKHIKDH 896
            .|::     ::.::::.....|.:|   |.|. |.:||::||      ..|...|.:.|.|  :|
Human  1072 TSLAFFLNDLLSVMDRGFVFSLIKS---CYKQ-VSSKLYSLPNPSVLVSLRLDFLRIICSH--EH 1130

  Fly   897 LESKEEGDSKTDIWQQEKNLSKAAKVLGQKKSQLHTCDTTANKKIAECINIMNNILKLLFRSDVG 961
            ..:                |:....:|....|...:..:..::......|:.:..:..:|...|.
Human  1131 YVT----------------LNLPCSLLTPPASPSPSVSSATSQSSGFSTNVQDQKIANMFELSVP 1179

  Fly   962 STHND------IRDIMII----------LFRTVMKAAHAL----DRD--------TGLVGKFFAI 998
            .....      :.::.:|          |.:.|:...|.|    |.|        ...|...:..
Human  1180 FRQQHYLAGLVLTELAVILDPDAEGLFGLHKKVINMVHNLLSSHDSDPRYSDPQIKARVAMLYLP 1244

  Fly   999 MLGILQRMDAQHYEYFVKDLH----------------QSGELKHFVIEILLV---FEELVSP--- 1041
            ::||:.....|.|::  .:.|                :||.:....:.:.:.   ..:|..|
Human  1245 LIGIIMETVPQLYDF--TETHNQRGRPICIATDDYESESGSMISQTVAMAIAGTSVPQLTRPGSF 1307

  Fly  1042 -------HQKAVFPRDWMDMIMHQNTVILGALKHLTVVITDYFLCPFEKQIWSNFFQCSIAFLVQ 1099
                   .|...|..:....::   ..:|..||:....:.         |.|         |...
Human  1308 LLTSTSGRQHTTFSAESSRSLL---ICLLWVLKNADETVL---------QKW---------FTDL 1351

  Fly  1100 SPLQLNDFND------------------NKRQIVFARYRDIRKDTAME-------------IRKM 1133
            |.||||...|                  ....:.|.:.:|:|  ..:|             :|:.
Human  1352 SVLQLNRLLDLLYLCVSCFEYKGKKVFERMNSLTFKKSKDMR--AKLEEAILGSIGARQEMVRRS 1414

  Fly  1134 WFQLGQHKPKFVPQLV-------------------------------------EPILEMSMIPEK 1161
            ..|||.:.....|:..                                     |.:::.::..|.
Human  1415 RGQLGTYTIASPPERSPSGSAFGSQENLRWRKDMTHWRQNTEKLDKSRAEIEHEALIDGNLATEA 1479

  Fly  1162 EL-----------------RQETI-----PIFFDMMQCEYYSSRLEH------------------ 1186
            .|                 .:|:|     .:....|.|...:..|:|
Human  1480 NLIILDTLEIVVQTVSVTESKESILGGVLKVLLHSMACNQSAVYLQHCFATQRALVSKFPELLFE 1544

  Fly  1187 ------------------ESYGDTKFN-----------NAHHKGNFSDFKTAMIEKLDILIGAGK 1222
                              .|.|..:.:           |.....||:..|..:...|..|:|..:
Human  1545 EETEQCADLCLRLLRHCSSSIGTIRSHASASLYLLMRQNFEIGNNFARVKMQVTMSLSSLVGTSQ 1609

  Fly  1223 GDAE--YKHLFETIMLERCAAHNTLNVDGTAFVQMVTRLMDKLLEYRFIIQD--------ESKEN 1277
            ...|  .:...:||:   ..|...|.:..|.|...|   .|.:.....|:.|        |..|.
Human  1610 NFNEEFLRRSLKTIL---TYAEEDLELRETTFPDQV---QDLVFNLHMILSDTVKMKEHQEDPEM 1668

  Fly  1278 RMACTFSLLQFY-SEVDLKEMYIRYVNKLCALHMEFENYTEAAFTLKLHTELLRWTDTELSHQL- 1340
            .:...:.:.:.| :..||:   :.::..:...|.|..|:.|||..| :|:..|   ..|....|
Human  1669 LIDLMYRIAKGYQTSPDLR---LTWLQNMAGKHSERSNHAEAAQCL-VHSAAL---VAEYLSMLE 1726

  Fly  1341 -RSYRHNNCRTHRQLKEAL----------------------YFE------IMEY----FDKGKQW 1372
             |.|....|.|.:.:...:                      ||.      ::|.    |.....:
Human  1727 DRKYLPVGCVTFQNISSNVLEESAVSDDVVSPDEEGICSGKYFTESGLVGLLEQAAASFSMAGMY 1791

  Fly  1373 ECAIDMCRVLARQYEEEIFDYLKLAELLNRMALFYEKIIKEL----RHNSEYFRVCFYGRGFPRF 1433
            |...::.:||...:|.. .|..||:.:..::...:.||:.:.    |....||||.|||..|..
Human  1792 EAVNEVYKVLIPIHEAN-RDAKKLSTIHGKLQEAFSKIVHQSTGWERMFGTYFRVGFYGTKFGD- 1854

  Fly  1434 LQNRVYIFRGKEYERHSDFCARMLVQHPQAELMQTLEA-----PGDDIT--------------NS 1479
            |..:.::::.....:             .||:...||.     .|:|:.              :.
Human  1855 LDEQEFVYKEPAITK-------------LAEISHRLEGFYGERFGEDVVEVIKDSNPVDKCKLDP 1906

  Fly  1480 DGQYIQVNKVEPIMGQAFNKFNDKIINNEIVKYFTAN-NVQKFQFSRPFRDSTNGGDRDDVRNLW 1543
            :..|||:..|||.    |:.:..|    :.:.||..| |:::|.:..||  :.:|....::...:
Human  1907 NKAYIQITYVEPY----FDTYEMK----DRITYFDKNYNLRRFMYCTPF--TLDGRAHGELHEQF 1961

  Fly  1544 LERTELRISYPLPGILRWFPVVETNTFKISPLERAVEIMKDTNRDIRQLVILHKSDETLHINPLS 1608
            ..:|.|..|:..|.|.....|.......::|:|.|:|.|:...:::........:|..:    |.
Human  1962 KRKTILTTSHAFPYIKTRVNVTHKEEIILTPIEVAIEDMQKKTQELAFATHQDPADPKM----LQ 2022

  Fly  1609 MKLNGIVDPAVMGGFAKYEEAFLT--------------------------DDYLEQN-----PDD 1642
            |.|.|.|...|..|..:..:.||:                          :|.|.:|     ||.
Human  2023 MVLQGSVGTTVNQGPLEVAQVFLSEIPSDPKLFRHHNKLRLCFKDFTKRCEDALRKNKSLIGPDQ 2087

  Fly  1643 KE-----------LVEELKELIANQIPLL---DLAIQLHR 1668
            ||           |.|.|:.||..:||.|   .|.:..||
Human  2088 KEYQRELERNYHRLKEALQPLINRKIPQLYKAVLPVTCHR 2127

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mbc	NP_001247267.1	SH3_DOCK_AB	14..70	CDD:212805
		DOCK_N	86..435	CDD:292790	62/358 (17%)
		C2_Dock-A	443..633	CDD:176076	49/196 (25%)
		DHR2_DOCK_A	1296..1697	CDD:212570	99/476 (21%)
DOCK7	NP_001354490.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	138..183
DOCK7	NP_001354490.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	888..971		9/82 (11%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1997
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810