DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment mbc and DOCK8

DIOPT Version :9

Sequence 1:NP_001247267.1 Gene:mbc / 42817 FlyBaseID:FBgn0015513 Length:2008 Species:Drosophila melanogaster
Sequence 2:NP_982272.2 Gene:DOCK8 / 81704 HGNCID:19191 Length:2099 Species:Homo sapiens


Alignment Length:1991 Identity:362/1991 - (18%)
Similarity:650/1991 - (32%) Gaps:599/1991 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly   202 RGTTRTPNKYSHNILLHVNAFVCKFQEDSDLLF---TLFDGETHKPISENYVVKWSRTGIARDTD 263
            |.....|.::..|.:| |.....||:.:.:.||   .|:|.:..|.||||:       ....::|
Human   254 RPVPECPKEHLGNRIL-VKLLTLKFEIEIEPLFASIALYDVKERKKISENF-------HCDLNSD 310

  Fly   264 QIDN-NRVLFTDLSKSDLAIAKMYLVCY-------AIRIGSM----EFKDSAESKRTSMSIANSM 316
            |... .|.....::.|..|.:.::.|.|       .::|..:    |..|.||....   |..|.
Human   311 QFKGFLRAHTPSVAASSQARSAVFSVTYPSSDIYLVVKIEKVLQQGEIGDCAEPYTV---IKESD 372

  Fly   317 LNASSRKASQLSVSSSGSSSSNGEYIIRRPFGVACKDLTPFINKSDDFRGNIDLPFI-----MCE 376
            ...|..|..:|.:.:.......|:|  |.||..|...|:.|.|.|...|...|:..:     :.|
Human   373 GGKSKEKIEKLKLQAESFCQRLGKY--RMPFAWAPISLSSFFNVSTLEREVTDVDSVVGRSSVGE 435

  Fly   377 KETLDGTLRKL---------------------------------IANKDIGKI--DSKMAVTIE- 405
            :.|| ...|:|                                 ::::|:.|.  |.|.:.::: 
Human   436 RRTL-AQSRRLSERALSLEENGVGSNFKTSTLSVSSFFKQEGDRLSDEDLFKFLADYKRSSSLQR 499

  Fly   406 -------VLRGDIKQIKE--------------EFPRLMHTNVPVARKMGFP--EVILPGDV-RND 446
                   :||.:|....|              .||.  :...|....:.||  ||.:|..| ||.
Human   500 RVKSIPGLLRLEISTAPEIINCCLTPEMLPVKPFPE--NRTRPHKEILEFPTREVYVPHTVYRNL 562

  Fly   447 LYLTICSGEFA-RIAKTSEKNVEVSVCVANEQGYLMPGVLSIGAGHQPIDEYKSVVYYHDDKPKW 510
            ||:......|. ::|......:::......:....||.:....:|.:.:.|..:.|.||:..|.:
Human   563 LYVYPQRLNFVNKLASARNITIKIQFMCGEDASNAMPVIFGKSSGPEFLQEVYTAVTYHNKSPDF 627

  Fly   511 QETFKIHVPIEDFKQCHLRFVLKHRSSNEQKDRT-EKPFGLAYVRLMQANGTTITQGQHILAV-- 572
            .|..||.:|.:.....||.|...|.|..:::..: |...|.:::.::.  ...:..|.:.|.|  
Human   628 YEEVKIKLPAKLTVNHHLLFTFYHISCQQKQGASVETLLGYSWLPILL--NERLQTGSYCLPVAL 690

  Fly   573 ------YK-------------IDHKKYDKTVANCYLELPATVAELQGAKPSIGGLTLLPKDQLSI 618
                  |.             |...:..|.|.|..::..::|............|....:.|::.
Human   691 EKLPPNYSMHSAEKVPLQNPPIKWAEGHKGVFNIEVQAVSSVHTQDNHLEKFFTLCHSLESQVTF 755

  Fly   619 GVNLCSTKLTQSVSLLGLLNWSAHKETLEQSLNALSTVPGEEVVKFLQDILDALFNILVE----N 679
            .:.:    |.|.:|.:.|      :..|:.|:..|::...|.:|.||..:||.||.:.|:    .
Human   756 PIRV----LDQKISEMAL------EHELKLSIICLNSSRLEPLVLFLHLVLDKLFQLSVQPMVIA 810

  Fly   680 DHPEKYDQLVFMSIIHLIETVSDLK---------------YQHFL-----------------SVL 712
            .....:.|..|.|::.:..::.:.|               |.|::                 ::|
Human   811 GQTANFSQFAFESVVAIANSLHNSKDLSKDQHGRNCLLASYVHYVFRLPEVQRDVPKSGAPTALL 875

  Fly   713 DVYINESFSFTLAYTKLMDVLQKNISEAISP-----------------KEKSADGN--------- 751
            |.....::..|.|......:||..:..:.:|                 ..|.||.|         
Human   876 DPRSYHTYGRTSAAAVSSKLLQARVMSSSNPDLAGTHSAADEEVKNIMSSKIADRNCSRMSYYCS 940

  Fly   752 ---DLEESPEVRR--------------------LYKTT--RYLHYVMKFVIRSRVLYAEMNCNTD 791
               |...||...|                    :.:.|  :|..:..:.:::|...:..   |.|
Human   941 GSSDAPSSPAAPRPASKKHFHEELALQMVVSTGMVRETVFKYAWFFFELLVKSMAQHVH---NMD 1002

  Fly   792 YMDF--ATRLQELLRMFIDMIGCPSNLLKSEGALLKNLHIIATDLMQVFEHVRLSISIVEILEKF 854
            ..|.  .||..:   .|:|.|....|::.||.|.|     :.....:..:..:::||:...|...
Human  1003 KRDSFRRTRFSD---RFMDDITTIVNVVTSEIAAL-----LVKPQKENEQAEKMNISLAFFLYDL 1059

  Fly   855 PPRRLTQSKMGCIKDFV-------ETKLFTLP---KCRAILLPVFCKHIKDHLESKEEGDSKTDI 909
                |:....|.:.:.:       ..||..||   ..|...|.:.|.|                 
Human  1060 ----LSLMDRGFVFNLIRHYCSQLSAKLSNLPTLISMRLEFLRILCSH----------------- 1103

  Fly   910 WQQEKNLSKAAKVLGQKKSQLHTCDTTANKKIAECINIMNNILKLLFRSDVGSTHNDIRDIMIIL 974
               |..|:.....:....:....|.:.:::..:.|.:..:..:..:|  |:.|.:.....:..:|
Human  1104 ---EHYLNLNLFFMNADTAPTSPCPSISSQNSSSCSSFQDQKIASMF--DLTSEYRQQHFLTGLL 1163

  Fly   975 FRTVMKAAHALDRDTGLVGKFFAIMLGILQRMDAQHYEYFVKDLHQSGELKHFVIEILLVFEEL- 1038
            |   .:.|.|||.:...:.|        :||.       .|..:|.           ||...:| 
Human  1164 F---TELAAALDAEGEGISK--------VQRK-------AVSAIHS-----------LLSSHDLD 1199

  Fly  1039 ---VSPHQKAVFPRDWMDMIMHQNTVILGALKHLTVVITDYFLCPF--------------EKQ-- 1084
               |.|..|......::.::    .:||.||..         ||.|              |:|  
Human  1200 PRCVKPEVKVKIAALYLPLV----GIILDALPQ---------LCDFTVADTRRYRTSGSDEEQEG 1251

  Fly  1085 -----------IWSNFFQCSIAFLVQSPLQLNDFN----DNKRQIVFARYRDIRKDTAMEIRKMW 1134
                       |..|.|....:.:|.|.|....:|    |..|.::.. :..|.|:....:.:.|
Human  1252 AGAINQNVALAIAGNNFNLKTSGIVLSSLPYKQYNMLNADTTRNLMIC-FLWIMKNADQSLIRKW 1315

  Fly  1135 F------QLG------------------QHKPKFVPQL------VEPILEMSMI----------- 1158
            .      ||.                  |...|...|:      |:..||.:::           
Human  1316 IADLPSTQLNRILDLLFICVLCFEYKGKQSSDKVSTQVLQKSRDVKARLEEALLRGEGARGEMMR 1380

  Fly  1159 ----------------------------------PEKELRQETI----------PIFFDM----- 1174
                                              .:.||.||.:          .|..||     
Human  1381 RRAPGNDRFPGLNENLRWKKEQTHWRQANEKLDKTKAELDQEALISGNLATEAHLIILDMQENII 1445

  Fly  1175 -----------------------MQCEYYSSRLEH---------ESYGDTKFNN----------- 1196
                                   :.|:..::.|.|         ..:||..|..           
Human  1446 QASSALDCKDSLLGGVLRVLVNSLNCDQSTTYLTHCFATLRALIAKFGDLLFEEEVEQCFDLCHQ 1510

  Fly  1197 -AHH--------------------------KGNFSDFKTAMIEKLDILIGAGKGDAEYKHLFETI 1234
             .||                          ..||:..|..:...|..|:|... |...:||..::
Human  1511 VLHHCSSSMDVTRSQACATLYLLMRFSFGATSNFARVKMQVTMSLASLVGRAP-DFNEEHLRRSL 1574

  Fly  1235 MLERCAAHNTLNVDGTAFVQMVTRLMDKLLEYRFIIQD--------ESKENRMACTFSLLQFY-S 1290
            ......:.....:..|.|...|..|:..|   ..|:.|        |..|..|...:.:.:.| :
Human  1575 RTILAYSEEDTAMQMTPFPTQVEELLCNL---NSILYDTVKMREFQEDPEMLMDLMYRIAKSYQA 1636

  Fly  1291 EVDLKEMYIRYVNKLCALHMEFENYTEAAFTL----KLHTELLRWTDTELSHQLRSYRHNNCRTH 1351
            ..||:   :.::..:...|.:.:.|||||..|    .|..|.|...:......:.|....|..::
Human  1637 SPDLR---LTWLQNMAEKHTKKKCYTEAAMCLVHAAALVAEYLSMLEDHSYLPVGSVSFQNISSN 1698

  Fly  1352 RQLKEAL-----------------YF----------EIMEYFDKGKQWECAIDMCRVLARQYEEE 1389
             .|:|::                 ||          :..|.|..|..:|...::.:::....|..
Human  1699 -VLEESVVSEDTLSPDEDGVCAGQYFTESGLVGLLEQAAELFSTGGLYETVNEVYKLVIPILEAH 1762

  Fly  1390 IFDYLKLAELLNRMALFYEKIIKE--LRHNSEYFRVCFYGRGFPRFLQNRVYIFRGKEYERHSDF 1452
             .::.||....:::...::.|:.:  .|....||||.|:|..|.. |..:.::::.....:..:.
Human  1763 -REFRKLTLTHSKLQRAFDSIVNKDHKRMFGTYFRVGFFGSKFGD-LDEQEFVYKEPAITKLPEI 1825

  Fly  1453 CARMLVQHPQ---AELMQTL-EAPGDDITNSDGQ--YIQVNKVEPIMGQAFNKFNDKIINNEIVK 1511
            ..|:...:.|   ||.::.: ::...|.|..|..  |||:..|||.    |:::..|    :.|.
Human  1826 SHRLEAFYGQCFGAEFVEVIKDSTPVDKTKLDPNKAYIQITFVEPY----FDEYEMK----DRVT 1882

  Fly  1512 YFTAN-NVQKFQFSRPFRDSTNGGDRDDVRNLWLERTELRISYPLPGILRWFPVVETNTFKISPL 1575
            ||..| |:::|.::.||  :..|..|.::...:...|.|...:..|.|.....|::...|.::|:
Human  1883 YFEKNFNLRRFMYTTPF--TLEGRPRGELHEQYRRNTVLTTMHAFPYIKTRISVIQKEEFVLTPI 1945

  Fly  1576 ERAVEIMKDTNRDIRQLVILHKSDETLHINPLSMKLNGIVDPAVMGGFAKYEEAFLTDDYLEQNP 1640
            |.|:|.||.....:...:.....|..:    |.|.|.|.|...|..|..:..:.||.     :.|
Human  1946 EVAIEDMKKKTLQLAVAINQEPPDAKM----LQMVLQGSVGATVNQGPLEVAQVFLA-----EIP 2001

  Fly  1641 DDKELVEELKELIANQIPLLDLAIQLHRLRAPDSLKALQEHLERCFADMQQHVEQRYGRKSCDLK 1705
            .|.:|.....:        |.|..:...:|..::::..:..:.....:.||.:::.|.:...:|:
Human  2002 ADPKLYRHHNK--------LRLCFKEFIMRCGEAVEKNKRLITADQREYQQELKKNYNKLKENLR 2058

  Fly  1706 --IERDSVVMRRP----NSFLPSLFDGSNNRHSET--SMGS 1738
              |||....:.:|    .|.....|..|:.|..||  |.||
Human  2059 PMIERKIPELYKPIFRVESQKRDSFHRSSFRKCETQLSQGS 2099

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mbcNP_001247267.1 SH3_DOCK_AB 14..70 CDD:212805
DOCK_N 86..435 CDD:292790 61/309 (20%)
C2_Dock-A 443..633 CDD:176076 39/213 (18%)
DHR2_DOCK_A 1296..1697 CDD:212570 88/440 (20%)
DOCK8NP_982272.2 DUF3398 73..164 CDD:288711
C2_Dock-C 559..739 CDD:176078 34/181 (19%)
DHR2_DOCK8 1636..2057 CDD:212574 91/453 (20%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1997
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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