DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mbc and DOCK5

DIOPT Version :9

Sequence 1:	NP_001247267.1	Gene:	mbc / 42817	FlyBaseID:	FBgn0015513	Length:	2008	Species:	Drosophila melanogaster
Sequence 2:	NP_079216.4	Gene:	DOCK5 / 80005	HGNCID:	23476	Length:	1870	Species:	Homo sapiens

Alignment Length:	2024	Identity:	742/2024 - (36%)
Similarity:	1101/2024 - (54%)	Gaps:	261/2024 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSVWSDCNAKQAEFGIAKCNFDQESKPHRLNLDVGDAVIILKETTHWYYGYRQKAKEIRGIFPKS 65
            |:.|  ...|:.::|:|..|:: .|:...|:|.:||.|.||:....||.||..:.|..:||||::
Human     1 MARW--IPTKRQKYGVAIYNYN-ASQDVELSLQIGDTVHILEMYEGWYRGYTLQNKSKKGIFPET 62

  Fly    66 YIHLCE---------YNIVNGEYCIQRTDIVEEITKVLLEWGSIAKDYFLTTNPS-FPKIRRKMN 120
            ||||.|         ..::.||     ..:|:|:|..|.||..|.:..::....: |.::::...
Human    63 YIHLKEATVEDLGQHETVIPGE-----LPLVQELTSTLREWAVIWRKLYVNNKLTLFRQLQQMTY 122

  Fly   121 ELNNNRAALISGNLPLDEVRKVKLLATNQIDTGNKLLGLDMVVRDESGDILDTNAICTTELYEQH 185
            .|...|:.::||.||.||:.::|...|.:||.||::||||:||||::|:|||.:...|..|::.|
Human   123 SLIEWRSQILSGTLPKDELAELKKKVTAKIDHGNRMLGLDLVVRDDNGNILDPDETSTIALFKAH 187

  Fly   186 MHAVQRIDKANRLSSE---------RGTTRTPNKYSHNILLHVNAFVCKFQEDSDLLFTLFDGET 241
            ..|.:||::  ::..|         ||.:.....:::.:.::...|||...||::|...|:|.:.
Human   188 EVASKRIEE--KIQEEKSILQNLDLRGQSIFSTIHTYGLYVNFKNFVCNIGEDAELFMALYDPDQ 250

  Fly   242 HKPISENYVVKWSRTGIARDTDQIDNNRVLFTDLSKSDLAIAKMYLVCYAIRIGSMEFKDSAESK 306
            ...|||||:::|...|:.::.::::|.:.:|||||..||...::.|||..:|:|.||.|:
Human   251 STFISENYLIRWGSNGMPKEIEKLNNLQAVFTDLSSMDLIRPRVSLVCQIVRVGHMELKE----- 310

  Fly   307 RTSMSIANSMLNASSRKASQLSVSSSGSSSSNGEYIIRRPFGVACKDLTPFIN-KSDDFRGNIDL 370
                                      |...:.|   :|||||||..|:|..|: |.||......:
Human   311 --------------------------GKKHTCG---LRRPFGVAVMDITDIIHGKVDDEEKQHFI 346

  Fly   371 PF-----------------------IMCEKETLDGTLRKLIANKDIGKIDSKMAVTIEVLRGDIK 412
            ||                       ::.|.|.|...|.|:||.|::......:.|::::|.||:.
Human   347 PFQQIAMETYIRQRQLIMSPLITSHVIGENEPLTSVLNKVIAAKEVNHKGQGLWVSLKLLPGDLT 411

  Fly   413 QIKEEFPRLMHTNVPVARKMGFPEVILPGDVRNDLYLTICSGEFARIAKTSEKNVEVSVCVANEQ 477
            |:::.|..|:..:..:||||||||:|||||||||:|:|:..|||.:..|.:.|||||::.|.:|:
Human   412 QVQKNFSHLVDRSTAIARKMGFPEIILPGDVRNDIYVTLIHGEFDKGKKKTPKNVEVTMSVHDEE 476

  Fly   478 GYLMPGVLSIGAGHQPIDEYKSVVYYHDDKPKWQETFKIHVPIEDFKQCHLRFVLKHRSSNEQKD 542
            |.|:...:..|||::.|.||||||||...:|.|.||.|:.:.||:..:||:||..:||||.|.:|
Human   477 GKLLEKAIHPGAGYEGISEYKSVVYYQVKQPCWYETVKVSIAIEEVTRCHIRFTFRHRSSQETRD 541

  Fly   543 RTEKPFGLAYVRLMQANGTTITQGQHILAVYKIDHKKYDKTVANCYLELPAT-----VAELQGAK 602
            ::|:.||:|:|:||..:|||:..|:|.|.|||.|:||.:.  |..||.||.|     ..|||.:|
Human   542 KSERAFGVAFVKLMNPDGTTLQDGRHDLVVYKGDNKKMED--AKFYLTLPGTKMEMEEKELQASK 604

  Fly   603 PSIGGLTLLP-----KDQLSIGVNLCSTKLTQSVSLLGLLNWSAHKETLEQSLNALSTVPGEEVV 662
            ..:   |..|     ||...|...:|||||||:|.|||||||.::.:.::.:|..|..|.|.|:|
Human   605 NLV---TFTPSKDSTKDSFQIATLICSTKLTQNVDLLGLLNWRSNSQNIKHNLKKLMEVDGGEIV 666

  Fly   663 KFLQDILDALFNILVENDHPEKYDQLVFMSIIHLIETVSDLKYQHFLSVLDVYINESFSFTLAYT 727
            |||||.|||||||::|....|.||.|||.:::.:|..:.|:|:|||..||:.||.:.||.||||.
Human   667 KFLQDTLDALFNIMMEMSDSETYDFLVFDALVFIISLIGDIKFQHFNPVLETYIYKHFSATLAYV 731

  Fly   728 KLMDVLQKNISEAISPKEKSADGNDLEESPEVRRLYKTTRYLHYVMKFVIRSRVLYAEM-NCNTD 791
            ||..||...::.|             ::|.:...|:...:.|.|:.:|:|:|||||... ..:.|
Human   732 KLSKVLNFYVANA-------------DDSSKTELLFAALKALKYLFRFIIQSRVLYLRFYGQSKD 783

  Fly   792 YMDFATRLQELLRMFIDMIGCP-SNLLKSEGALLKNLHIIATDLMQVFEHVRLSISIVEILEKFP 855
            ..:|...:::|...|..::..| ...:|.:||.||.|..|..|:..||:.|.||:...:.::..|
Human   784 GDEFNNSIRQLFLAFNMLMDRPLEEAVKIKGAALKYLPSIINDVKLVFDPVELSVLFCKFIQSIP 848

  Fly   856 PRRLTQSKMGCIKDFVETKLFTLPKCRAILLPVFCKHIKDHLESKEEGDSKTDIWQQEKNLSKAA 920
            ..:|.:.|:.|:...||:.||...:||.:|||:....:...|   ::..:|.|
Human   849 DNQLVRQKLNCMTKIVESTLFRQSECREVLLPLLTDQLSGQL---DDNSNKPD------------ 898

  Fly   921 KVLGQKKSQLHTCDTTANKKIAECINIMNNILKLLFRSDVGSTHNDIRDIMIILFRTVMKAAHAL 985
               .:..|||                 ::|||::|.|.|||:|...|:.||..|.|.:.:....:
Human   899 ---HEASSQL-----------------LSNILEVLDRKDVGATAVHIQLIMERLLRRINRTVIGM 943

  Fly   986 DRDTGLVGKFFAIMLGILQRMDAQHYEYFVKDLHQSGELKHFVIEILLVFEELVSPHQKAVFPRD 1050
            :|.:..:|.|.|.|:.:||:||..||.:::.......::..|::|..::|::|:.   |.|:.:|
Human   944 NRQSPHIGSFVACMIALLQQMDDSHYSHYISTFKTRQDIIDFLMETFIMFKDLIG---KNVYAKD 1005

  Fly  1051 WMDMIMHQNTVILGALKHLTVVITDYFL--CPFEKQIWSNFFQCSIAFLVQSPLQLNDFNDNKRQ 1113
            ||.|.|.||.|.|.|:.....|:|.:|:  ..||.|:|:|:|..::|||....|||..|:..||.
Human  1006 WMVMNMTQNRVFLRAINQFAEVLTRFFMDQASFELQLWNNYFHLAVAFLTHESLQLETFSQAKRN 1070

  Fly  1114 IVFARYRDIRKDTAMEIRKMWFQLGQHKPKFVPQLVEPILEMSMIPEKELRQETIPIFFDMMQCE 1178
            .:..:|.|:||:....||.||:.||.||.||:|.:|.||||:::.||.|||:.||||||||||||
Human  1071 KIVKKYGDMRKEIGFRIRDMWYNLGPHKIKFIPSMVGPILEVTLTPEVELRKATIPIFFDMMQCE 1135

  Fly  1179 YYSSRLEHESYGDTKFNNAHHKGNFSDFKTAMIEKLDILIGAGKGDAEYKHLFETIMLERCAAHN 1243
            :                |....|||..|:..:|.|||..:..|:||.:||.|.|.::||.|..|.
Human  1136 F----------------NFSGNGNFHMFENELITKLDQEVEGGRGDEQYKVLLEKLLLEHCRKHK 1184

  Fly  1244 TLNVDGTAFVQMVTRLMDKLLEYRFII-QDESKENRMACTFSLLQFYSEVDLKEMYIRYVNKLCA 1307
            .|:..|..|..:|:.|::.||:||.|| |||||||||:||.::|.||.|...:::||||:.||..
Human  1185 YLSSSGEVFALLVSSLLENLLDYRTIIMQDESKENRMSCTVNVLNFYKEKKREDIYIRYLYKLRD 1249

  Fly  1308 LHMEFENYTEAAFTLKLHTELLRWTDTE-LSHQLR--SYRHNNCRTHRQLKEALYFEIMEYFDKG 1369
            ||.:.|||||||:||.||.|||:|:|.. :.|.|:  ||   ...|.::|||.||.||:.|||||
Human  1250 LHRDCENYTEAAYTLLLHAELLQWSDKPCVPHLLQKDSY---YVYTQQELKEKLYQEIISYFDKG 1311

  Fly  1370 KQWECAIDMCRVLARQYEEEIFDYLKLAELLNRMALFYEKIIKELRHNSEYFRVCFYGRGFPRFL 1434
            |.||.||.:.:.||..||.::|||..|..||.:.|.|||.|||.:|...|||.|.:||:|||.||
Human  1312 KMWEKAIKLSKELAETYESKVFDYEGLGNLLKKRASFYENIIKAMRPQPEYFAVGYYGQGFPSFL 1376

  Fly  1435 QNRVYIFRGKEYERHSDFCARMLVQHPQAELMQTLEAPGDDITNSDGQYIQVNKVEPIMGQAFNK 1499
            :|:::|:|||||||..||..|:|.|.|.||.|.:...||:||.:|..||:|...|:|:|... ..
Human  1377 RNKIFIYRGKEYERREDFSLRLLTQFPNAEKMTSTTPPGEDIKSSPKQYMQCFTVKPVMSLP-PS 1440

  Fly  1500 FNDKIINNEIVKYFTANNVQKFQFSRPFRDSTNGGDRD---DVRNLWLERTELRISYPLPGILRW 1561
            :.||.:..:|:.|:.||.||:|::|||||.    |::|   :...:|:|||....:|..||||:|
Human  1441 YKDKPVPEQILNYYRANEVQQFRYSRPFRK----GEKDPDNEFATMWIERTTYTTAYTFPGILKW 1501

  Fly  1562 FPVVETNTFKISPLERAVEIMKDTNRDIRQLVILHKSDETLHINPLSMKLNGIVDPAVMGGFAKY 1626
            |.|.:.:|.:|||||.|:|.|:.||..|...|..|..|.:|.::||||.|:|||||||||||:.|
Human  1502 FEVKQISTEEISPLENAIETMELTNERISNCVQQHAWDRSLSVHPLSMLLSGIVDPAVMGGFSNY 1566

  Fly  1627 EEAFLTDDYLEQNPDDKELVEELKELIANQIPLLDLAIQLHRLRAPDSLKALQEHLERCFADMQQ 1691
            |:||.|:.||:::|:|:|.||.||.|||.|:|||...|::|..:..:.||.|.|.|..||.::::
Human  1567 EKAFFTEKYLQEHPEDQEKVELLKRLIALQMPLLTEGIRIHGEKLTEQLKPLHERLSSCFRELKE 1631

  Fly  1692 HVEQRYGRKSCDLKIERDSVVMRRPNSFLPSLFDGSNNRHSETSMGSSDSGLSKSTFLPRPQTNS 1756
            .||:.||            |:...||.        :..:.|.|.          |..||...:::
Human  1632 KVEKHYG------------VITLPPNL--------TERKQSRTG----------SIVLPYIMSST 1666

  Fly  1757 IKNPFSGLSFNTRPSLGHSPSIKSNKSKDKTPSKRRTKDGKVKEREAHSLSSSQWYTPPLSTITS 1821
            ::.    ||..   |:..|....|:.|.|..|| |...||.:.|......:||......||....
Human  1667 LRR----LSIT---SVTSSVVSTSSNSSDNAPS-RPGSDGSILEPLLERRASSGARVEDLSLREE 1723

  Fly  1822 TPEKEINTSIASLASTSNSSLSGPKTPDPHVLTEELTPKRPLRSEMEKERRLSRPASIATPTASI 1886
            ..|..|:.......|.|.|.:...|.|:|.:::.....:|| :|....:.||| |...::|..|.
Human  1724 NSENRISKFKRKDWSLSKSQVIAEKAPEPDLMSPTRKAQRP-KSLQLMDNRLS-PFHGSSPPQST 1786

  Fly  1887 KNFPD------TRSLS-------------------------ESSNRNSVETTD--STSEEDIRPP 1918
            ...|.      ||:||                         |.|.|||.|...  ....|...||
Human  1787 PLSPPPLTPKATRTLSSPSLQTDGIAATPVPPPPPPKSKPYEGSQRNSTELAPPLPVRREAKAPP 1851

  Fly  1919 PLPAKARDS 1927
            |.|.|||.|
Human  1852 PPPPKARKS 1860

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mbc	NP_001247267.1	SH3_DOCK_AB	14..70	CDD:212805	23/55 (42%)
		DOCK_N	86..435	CDD:292790	111/382 (29%)
		C2_Dock-A	443..633	CDD:176076	90/199 (45%)
		DHR2_DOCK_A	1296..1697	CDD:212570	196/406 (48%)
DOCK5	NP_079216.4	SH3_DOCK1_5_A	12..67	CDD:212984	23/55 (42%)
		DOCK_N	75..434	CDD:292790	113/399 (28%)
		C2	442..637	CDD:301316	90/199 (45%)
		DHR2_DOCK5	1238..1637	CDD:212581	196/406 (48%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1679..1702		8/23 (35%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1772..1870		26/90 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	482	1.000	Domainoid score	I411
eggNOG	1	0.900	-	-		E1_KOG1997
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1275	1.000	Inparanoid score	I169
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54452
OrthoDB	1	1.010	-	-		D102580at2759
OrthoFinder	1	1.000	-	-		FOG0000433
OrthoInspector	1	1.000	-	-		otm41198
orthoMCL	1	0.900	-	-		OOG6_100636
Panther	1	1.100	-	-	O	PTHR45653
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X372
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.840