DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mbc and dock11

DIOPT Version :9

Sequence 1:	NP_001247267.1	Gene:	mbc / 42817	FlyBaseID:	FBgn0015513	Length:	2008	Species:	Drosophila melanogaster
Sequence 2:	XP_009301359.1	Gene:	dock11 / 799686	ZFINID:	ZDB-GENE-060503-196	Length:	2067	Species:	Danio rerio

Alignment Length:	2134	Identity:	389/2134 - (18%)
Similarity:	709/2134 - (33%)	Gaps:	713/2134 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    50 GYRQKAKEIRG-------IFPKSYIHLCEYNIVNGEYCIQRTDIVEEITKVLLEWGSIAKDYFLT 107
            |:.||| .|..       :|.:.|.:|.:  :.:|.|.:   :..::........|||..|..:.
Zfish   167 GWLQKA-NINSSLSVSMKVFKRRYFYLSQ--LPDGSYIL---NSYKDEKNYKESKGSIYLDSCID 225

  Fly   108 TNPSFPKIRR-----KMNELNNNRAALISGNLPLDEVRKVK--LLAT-----NQIDTGNKLLGLD 160
            ..|. ||:||     ||.|..::..|..|.....|.|..:|  ||:|     |..:|....|..|
Zfish   226 VVPC-PKMRRNGFELKMQERYSHYLAADSEAEMEDWVNTIKQALLSTMEDRRNGSETSEGSLDDD 289

  Fly   161 MVVRDESGDILDTNAICTTELYEQHMHAVQRIDKANRLSSERGTTRTPNKYSHNILLHVNAFVCK 225
            ...:.:...|.::..   ..|:.:.|...:..|:.:::|...|..:.
Zfish   290 SSSQGKPESITESFG---RSLHPELMKYARETDQLSKMSRNEGRQKI------------------ 333

  Fly   226 FQEDSDLLFTLFDG--ETHKPISENY-----------------VVKWSRTGIARDTDQIDNNRVL 271
            |..|.::....|.|  ...||..|.:                 .|.....|:..:.:....:..|
Zfish   334 FSLDPEVQRLDFSGIEPDVKPFEERFGRRIMVSCHNLTFNLQGCVSEKNDGVLTNVEPFFISLAL 398

  Fly   272 FTDLSKSDLAIAKMYL------VCYAIRIGSMEFKDSA---ESKRTSMS---------IANSMLN 318
            | ||||.....|..::      |...|:.||......|   |:....|:         :|.|:|:
Zfish   399 F-DLSKGCKISADFHVDLNPPCVREMIQTGSAGTPTEAGEDENDPVKMNGHGLPLLQRVAESLLH 462

  Fly   319 ASSRKASQLSVSSSGSS---SSNGEYIIRRPFGVA-CKDLTPFINKSDDFR-------------- 365
            ..::  ...||::..:.   .:..|.:::.  |:. |.|  |:|..||..:
Zfish   463 FPTQ--GIFSVTNPHADIFLLARVEKVLQN--GITHCAD--PYIKPSDISKTVQKVLKTAKQTCQ 521

  Fly   366 --GNIDLPFIMCEKETL---------DGTLRKL-------IANKDIGK---------------ID 397
              |...:||....|:..         ||....|       |:.:|:.|               |.
Zfish   522 RLGQYRMPFAWAAKQVFKDSQGTLDTDGKFSPLYRQDSSKISTEDLIKLLTDLKKPEKNKLQIIP 586

  Fly   398 SKMAVTIEVLRGDIKQ--------IK-------------EEFPRLMHTNVPVARKMGFPEVILPG 441
            .::.:|:|.:..|:..        :|             |||       ||...:...|..|
Zfish   587 GQINITVECVPPDLSNSVTSSYIPVKPFADQCDSVSVEVEEF-------VPEEARFNHPFTI--- 641

  Fly   442 DVRNDLYLTICSGEFARIAKTSEKNVEVSVCV----ANEQG-------YLMPGVLSIGAGHQPI- 494
             ..|.||:.....::.. .|..:|...::|||    ::|:|       |..||        .|:
Zfish   642 -YNNHLYIYPQQLKYDS-QKAFDKARNIAVCVQFKDSDEEGSSPLKCIYGKPG--------DPLF 696

  Fly   495 -DEYKSVVYYHDDKPKWQETFKIHVPIEDFKQCHLRFVLKH-------RSSNEQKDRTEKPFGLA 551
             ....:.|.:|:..|::.:..||.:|:...::.|:.|...|       ::::::::..|...|.:
Zfish   697 TTSAFAAVLHHNQSPEFYDEIKIELPVHIHEKHHILFTFYHISCDLGTKTTSKKREGVETLVGYS 761

  Fly   552 YVRLM-----QANGTTITQGQHILAVYKIDHKK-------YDKTVANCYLELPATVAELQGAKPS 604
            :..|:     :::...:....::||.|..|..:       |.|.|.|              |||
Zfish   762 WTPLLKDGRIKSSDLQLPVSANLLAGYLCDKSQDIKKVFPYIKWVDN--------------AKP- 811

  Fly   605 IGGLTLLPKDQLSIGVNLCSTKLTQSVSLLGLLNWSAHKETLEQS-----------LNALSTVPG 658
                      ...:...:.||..||.   |.|.|:..|.:.:..:           |..|..|..
Zfish   812 ----------LFKVRAYVASTIYTQD---LHLHNFFQHCQLMRSTSQGNPAELIKYLKCLHAVET 863

  Fly   659 EEVVKFLQDILDALFNILVENDHPEKYDQLVFMS----IIHLIETVSDLKYQHFLSVLDVY---I 716
            :.|:|||..:|..||.:|   ....|..|.|.::    |||::....:...:|:|.....|   |
Zfish   864 QVVIKFLPTVLVQLFEVL---SMASKEGQDVAVNSTRVIIHIVSQCHEEGLEHYLRSFLKYVFRI 925

  Fly   717 NESFSFTLAYTKLMDVLQKNISEAISPKEKSADGNDLEESPEVRRLYKTTRYLHYVMKFVIRSRV 781
            |.:.|.....|.  :||...::..            |:::.::....|..:|..:..:.:.||..
Zfish   926 NNATSENSVTTH--EVLATAVTVI------------LKQTADINTCNKLLKYSWFFFETMARSMA 976

  Fly   782 LYAEMNCNTDYMDFATRLQELLRMFIDMIGCPSNLLKSEGALLKNLHIIATDLMQVFEHVRLSIS 846
            .|. |:.|...|..|.|..|..:..:..:                       |:.:..|:  :|.
Zfish   977 QYL-MDGNRMKMPRAQRFPESFQQALQCL-----------------------LLSIMPHI--TIR 1015

  Fly   847 IVEILEK----------FPPRRLTQSKMG----CIKDFV------ETKLFTLPKCRAILLPVFCK 891
            .|||.|:          |..|.||....|    .|.|::      :.|:.|  :.:...|...|.
Zfish  1016 YVEIPEEARCVNFSLACFIKRCLTFMNRGFAFSLINDYMCGFSLKDPKVLT--EMKFDFLMTVCN 1078

  Fly   892 HIKDHL--ESKEEGDSKTDIWQQEKNLSKAAKVLGQKKSQLHTCDTTANKKIAE--CINIMNNIL 952
            |  :|.  .:......:|.:.:.:..:|.||:..|       ..|.:....:.|  |.|  :.::
Zfish  1079 H--EHYIPLNLPMAFGRTKLQRVQDFISYAAECFG-------VVDQSLEYSLTEDYCKN--HFLV 1132

  Fly   953 KLLFR--SDVGSTHNDIRDIMIILFRTVMKAAHALD-----------RDTGLVGKFFAIM----- 999
            .||.|  :|......:||.:.:.:.:.:| ..||:|           |...|....|.::
Zfish  1133 GLLLREVADGLQACPEIRQLAVAVLKNLM-IKHAMDDRYNAFKNQQARICLLYLPLFELLYQNLS 1196

  Fly  1000 ------------LGILQR----MDAQHYEYFV--------------------------------K 1016
                        ||::.|    :|::.....|                                .
Zfish  1197 QMNSPRQMCRNGLGLMYRDDLSVDSRRSSTIVDKEPSGSVTQNGLSRRGESRGSMYGDPGTPDIN 1261

  Fly  1017 DLHQ----------SGELKHFVIEILLVFEELVSPHQKAVFPRDWMDMIMHQNTVILGALKHLTV 1071
            :||:          :|.|..:.|..||:                              ...|:..
Zfish  1262 ELHRRGSTMSTVPAAGRLGQYEIRGLLL------------------------------CYLHIVR 1296

  Fly  1072 VITDYFLCPFEKQIWSNFFQCSIAFLVQSPLQLNDFNDNKRQIVFARYRDIRKDTAMEIRKMWFQ 1136
            .::|..|..:    ||..          :|..:.:|. :..:|...::|.:.:......::.|
Zfish  1297 TLSDDTLTAY----WSKV----------NPQDIMNFL-SLLEICIIQFRYVGRRNISRSQEPW-- 1344

  Fly  1137 LGQHKPKFVPQLVEPILEMSMIPEKELRQETIPIF---FDMMQCEYYSSRLEHESYGDTKFN--- 1195
                    |.:|..|          |.:.:|:|:.   ..:||     ::|:..|..||...
Zfish  1345 --------VSKLFSP----------ERKSQTMPVLRGRASLMQ-----AKLQQFSTMDTSLTLNM 1386

  Fly  1196 -------NAHH----KGNFS----------------DFKTAMIEK----------LD---ILIGA 1220
                   ..:|    :||.|                .||..:::.          .|   .|:..
Zfish  1387 AGGPTEAEINHQSLLEGNTSTEVCLTVLDVLSLFTQSFKNQLLDSDGHNALMTKIFDTYLTLLKV 1451

  Fly  1221 GKGDAEYKHLFETI-------------------------MLERCAAH-NTLNVDGTAFVQMVTR- 1258
            |:.:...||:|.::                         :|:.|.:. :.|..:.:|.:.::.|
Zfish  1452 GQSETAIKHIFASLRAFIVKFQVPLFKGRVVLCGSLCYEVLKCCMSKLSVLRGEASALLYLLMRH 1516

  Fly  1259 ------------------------LMDKLL--EYRF-----IIQDESKENRMACTFSLLQFYSEV 1292
                                    :.|..|  ..||     ||.:.:..:::..|.:   |.|||
Zfish  1517 NFDYTKRKSFLRVHLQIIIAVSQLIADVALTGSSRFQESLSIINNFANSDKIMKTTT---FPSEV 1578

  Fly  1293 DLKEMYIRYVNKLCALHMEFENYTEAAFTLKLH--------TELLR-WTDTELSHQLRSYRHNN- 1347
            ....|.||.|....|...|.|...|....|:..        .||.| |.|:    ..|::..|.
Zfish  1579 KGLTMRIRTVLMATAQMREHEKDPEMLLDLQYSLARSYASTPELRRTWLDS----MARAHSKNGD 1639

  Fly  1348 ------CRTH--------------------------------RQLKEALYFEIMEYFD------- 1367
                  |..|                                ..:||.:..:.:.|.:
Zfish  1640 FSEAAMCNVHVAALMAEYLHRKKLFPSGLAAFKRTTQNIDEEGAMKEDIGMQDVYYTEDVLVEQL 1704

  Fly  1368 --------KGKQWECAIDMCRVLARQYEEEIFDYLKLAELLNRMALFYEKIIKELRHN----SEY 1420
                    |.:::|....:.|::...||:. .::.||..|.:.:...|.||::.::..    ..|
Zfish  1705 EVCVESLWKAERFELITHIARLIIPVYEKR-HEFEKLRRLYDTLQRAYAKILEVMQSGRRLLGTY 1768

  Fly  1421 FRVCFYGRGFPRFLQNRVYIFRGKEYERHSDFCARMLVQHPQ------AELMQTLEAPGDDITNS 1479
            |||.|:|:||......:.||::..:.....:...|:|..:.:      .:::|..........:|
Zfish  1769 FRVAFFGQGFFEEEDGKEYIYKEPKLTTLPEISHRLLKLYGEKFGSENVKIIQDSNKVNQKDLDS 1833

  Fly  1480 DGQYIQVNKVEPIMGQAFNKFNDKIINNEIVKYFTANNVQKFQFSRPFRDSTNGGDRDDVRNLWL 1544
            ...||||..|:|.       |::|.:......:...:|:|:|.|..||  :..|..:..|.....
Zfish  1834 KFAYIQVTYVKPF-------FDEKEMAERKTDFEKCHNIQRFVFETPF--TLTGKKQGGVEEQCK 1889

  Fly  1545 ERTELRISYPLPGILRWFPVVETNTFKISPLERAVEIMKDTNRDIRQLVILHKSDETLHINPLSM 1609
            .||.|..:...|.:.:...||.....::.|::.|::.||:.:.::.:|.    |::.:::..|.:
Zfish  1890 RRTVLTTANTFPYVKKRIEVVGEKHTELKPIDVAIDEMKEKSSELAKLC----SNQEVNMITLQL 1950

  Fly  1610 KLNGIVDPAVMGGFAKYEEAFLTDDYLEQNPDDKELVEELKELIANQIPLLDLAIQLH-RLRAPD 1673
            ||.|.|...|..|...|..|||.:   .::....:.|::|||:....:....:|:.:: ||...|
Zfish  1951 KLQGCVSVQVNAGPMAYARAFLDE---SKSGQSNKKVKDLKEIFRQFVNACSMALDINERLIKED 2012

  Fly  1674 ------SLKA-----------------LQEHLERCFADMQQHVEQRYGRKSCDL 1704
                  .|||                 .||.:.|.......||.:.....|.||
Zfish  2013 QYEYHEGLKANFKSMVKELSEIIHEQIFQEDMMRSLLQNSLHVFRAISGTSTDL 2066

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mbc	NP_001247267.1	SH3_DOCK_AB	14..70	CDD:212805	7/26 (27%)
		DOCK_N	86..435	CDD:292790	86/469 (18%)
		C2_Dock-A	443..633	CDD:176076	41/221 (19%)
		DHR2_DOCK_A	1296..1697	CDD:212570	101/497 (20%)
dock11	XP_009301359.1	DUF3398	55..145	CDD:288711
		PH_DOCK-D	158..275	CDD:270087	30/114 (26%)
		PH	163..268	CDD:278594	27/107 (25%)
		C2_Dock-D	642..830	CDD:176079	42/224 (19%)
		DHR2_DOCK11	1620..2031	CDD:212573	87/431 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1997
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810