DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment mbc and Dock11

DIOPT Version :9

Sequence 1:NP_001247267.1 Gene:mbc / 42817 FlyBaseID:FBgn0015513 Length:2008 Species:Drosophila melanogaster
Sequence 2:XP_006541469.1 Gene:Dock11 / 75974 MGIID:1923224 Length:2086 Species:Mus musculus


Alignment Length:1667 Identity:314/1667 - (18%)
Similarity:595/1667 - (35%) Gaps:467/1667 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly   339 GEYIIRRPFGVACKDLTPFINKSDDFRGNIDLPFIMCEKETLDGTLRKL-------IANKDIGK- 395
            |:|  |.||..|.:.:      ..|.:|::|          |||....|       ::|:||.| 
Mouse   521 GQY--RMPFAWAARPI------FKDVQGSLD----------LDGRFSPLYKQDSSKLSNEDILKL 567

  Fly   396 --------------IDSKMAVTIEVLRGDIKQ--------IK-------------EEFPRLMHTN 425
                          |..::::|:|.:..|:..        :|             |||       
Mouse   568 LSEYKKPEKTKLQIIPGQLSITVECVPVDLPNCITSSYVPLKPFEKNCQNITVEVEEF------- 625

  Fly   426 VPVARKMGFPEVILPGDVRNDLYLTICSGEFARIAKTSEKNVEVSVCVA-----NEQGYLMPGVL 485
            ||...|..:|..|    .:|.||:.....::.. .|:..|...::|||.     ......:..:.
Mouse   626 VPEMTKYCYPFTI----YKNHLYVYPLQLKYDS-QKSFAKARNIAVCVEFRDSDESDASALKCIY 685

  Fly   486 SIGAGHQPIDEYKSVVYYHDDKPKWQETFKIHVPIEDFKQCHLRFVLKH-------RSSNEQKDR 543
            ...||........:||.:|:..|::.:..||.:||...::.||.|...|       :.:.:::|.
Mouse   686 GKPAGSVFTTNAYAVVSHHNQNPEFYDEIKIELPIHLHQKHHLLFTFYHVSCEINTKGTTKKQDT 750

  Fly   544 TEKPFGLAYVRLMQANGTTITQGQHILAVYKIDHKKYDKTVANCYLELPATVAELQGAKPSIGGL 608
            .|.|.|.|:|.|:: :|..||..|.:.....:.....:...|....:..|.:..:.||||     
Mouse   751 VETPVGFAWVPLLK-DGRVITLEQQLPVSANLPPGYLNVNDAESRRQSNADIKWVDGAKP----- 809

  Fly   609 TLLPKDQLSIGVNLCSTKLTQSVSLLGL-----LNWSAHKET---LEQSLNALSTVPGEEVVKFL 665
                  .|.|..:|.||..||.:.:...     |..|..||.   |.:.|..|..:..:.:::||
Mouse   810 ------LLKIKTHLESTIYTQDLHVHKFFHHCQLIQSGSKEVPGELIKYLKCLHAMEIQVMIQFL 868

  Fly   666 QDILDALFNILVENDHPEKYDQLVFMSIIHLIETVSDLKYQHFLSVLDVY--------------I 716
            ..||..||.:|....|.:.......|.::|::....:...:.:|.....|              |
Mouse   869 PVILMQLFRVLTNMTHEDDVPINCTMVLLHIVSKCHEEGLESYLRSFIKYSFRPEKPSTLQAQLI 933

  Fly   717 NESFSFT-----------LAYTKLM-------DVLQKNISEAISPKEKSADGNDLEES----PEV 759
            :|:.:.|           ||..||:       :::.|:::..:           |||:    |..
Mouse   934 HETLATTMIAILKQSADFLAINKLLKYSWFFFEIIAKSMATYL-----------LEENKIKLPRG 987

  Fly   760 RRLYKTTRY-LHYVMKFVI-RSRVLYAEM-----NCNTDYMDFATRLQELL-RMFIDMIGCPSNL 816
            :|..:...: ||.::..:| ...:.|||:     |.|.....|..|...|: |.|:      .||
Mouse   988 QRFPEAYHHVLHSLLLAIIPHVTIRYAEIPDESRNGNYSLASFLKRCLTLMDRGFV------FNL 1046

  Fly   817 LKS--EGALLKNLHIIAT---DLMQVF---EH-VRLSISIVEILEKFPPRRLTQSKMGCIKDFVE 872
            :..  .|...|:..::|.   :.:|..   || :.|::          |....:.|:..::||..
Mouse  1047 INDYISGFSPKDPKVLAEYKFEFLQTICNHEHYIPLNL----------PMAFAKPKLQRVQDFFS 1101

  Fly   873 TKLFTLPKCRAI-------LLPVFCKH--------------IKDHLESKEEGDS---------KT 907
               |.:.:..::       |...:|||              ::|:.|.:....|         ..
Mouse  1102 ---FAVDRLTSVDSNLEYSLSDEYCKHHFLVGLLLRETSIALQDNYEIRYTAISVIKNLLIKHAF 1163

  Fly   908 DIWQQEKN----------------LSKAAKVLGQKKSQLHTC---DTTANKKIAEC--INIMN-- 949
            |...|.||                |....::.|  :..|::|   .::|::....|  ::..|  
Mouse  1164 DTRYQHKNQQAKIAQLYLPFVGLLLENIQRLAG--RDTLYSCAAMPSSASRDEFPCGFVSPTNRG 1226

  Fly   950 --------------------------------------------NILKLLFRSDVGSTHN----- 965
                                                        |..:...||.| |.:|     
Mouse  1227 SLASDKDTAYGSFQNGHGIKREDSRGSLIPEGATGFPDPGSTSENTRQSSSRSSV-SQYNRLDQY 1290

  Fly   966 DIRDIMIILFRTVMKAAHALDRDTGL-----VGKFFAIMLGILQRMDAQHYEYF----VKDLHQS 1021
            :||::::.....|    ..:..||.|     |.....|.:.:|..:...|:.|.    :..:|.:
Mouse  1291 EIRNLLMCYLYIV----KMISEDTLLTYWNKVSPQELINILVLLEVCLFHFRYMGKRNIARVHDA 1351

  Fly  1022 GELKHFVIE----------------------ILLVFEELVSPHQKAVFPRDWMDMIMHQNTVILG 1064
            ...|||.|:                      :..:.......|..|....|    |.||..:...
Mouse  1352 WLSKHFGIDRKSQTMPALRNRSGVMQARLQHLSSLESSFTLNHSSATTEAD----IFHQALLEGN 1412

  Fly  1065 ALKHLTVVITD---YFLCPFEKQIWSN---------FFQCSIAFLV--QSPLQLNDFNDNKRQIV 1115
            ....:::.:.|   :|...|:.|:.:|         .|...:|||.  ||.:.|..        |
Mouse  1413 TATEVSLTVLDTISFFTQCFKNQLLNNDGHNPLMKKVFDIHLAFLKNGQSEVSLKH--------V 1469

  Fly  1116 FARYRDIRKDTAMEIRKMWFQLGQHKPKFVPQLVEPILEMSMIPEKELRQETIPIFFDMMQCEY- 1179
            ||..|..       |.|......:.:..........:|:.........|.|...:.:.:|:..: 
Mouse  1470 FASLRSF-------ISKFPSAFFKGRVNMCAAFCYEVLKCCTSKISSTRNEASALLYLLMRNNFE 1527

  Fly  1180 YSSRLEHESYGDTKFNNAHHKGNFSDFKTAMIEKLDILIGAGK--------GDAEYKHLFETIML 1236
            |:.|                       ||.:...|.|:|...:        |.:.::   |::.:
Mouse  1528 YTKR-----------------------KTFLRTHLQIIIAVSQLIADVALSGGSRFQ---ESLFI 1566

  Fly  1237 ERCAAHNTLNVDGTAF---VQMVTRLMDKLLEYRFIIQDESKENRMA--CTFSLLQFYSEVDLKE 1296
            ....|::...:..|||   |:.:|:.:..:|.....:::..|:..|.  ..:||.:.|:..  .|
Mouse  1567 INNFANSDRPMKATAFPTEVKDLTKRIRTVLMATAQMKEHEKDPEMLIDLQYSLAKSYAST--PE 1629

  Fly  1297 MYIRYVNKLCALHMEFENYTEAAFTLKLHTELLRWTDTELSHQLRSYRHNNCRTHRQL------- 1354
            :...:::.:..:|::..:::|||... :|...|   ..|..|:.:.: .:.|...:::       
Mouse  1630 LRKTWLDSMAKIHIKNGDFSEAAMCY-VHVAAL---VAEFLHRKKLF-PSGCSAFKKITPNIDEE 1689

  Fly  1355 --------------KEALYFEIMEY----FDKGKQWECAIDMCRVLARQYEEEIFDYLKLAELLN 1401
                          .|.:..|::|.    ..|.:::|...::.:::...||:. .::.||.::..
Mouse  1690 GAMKEDAGMMDVHYSEEVLLELLEQCVDGLWKAERYEVISEISKLIIPIYEKR-REFEKLTQVYR 1753

  Fly  1402 RMALFYEKIIKELRHNSE-----YFRVCFYGRGFPRFLQNRVYIFRGKEYERHSDFCARMLVQHP 1461
            .:...|.||: |:.|..:     :|||.|||:.|......:.||::..:....|:...|::..:.
Mouse  1754 TLHGAYTKIL-EVMHTKKRLLGTFFRVAFYGQSFFEEEDGKEYIYKEPKLTGLSEISLRLVKLYG 1817

  Fly  1462 Q------AELMQTLEAPGDDITNSDGQYIQVNKVEPIMGQAFNKFNDKIINNEIVKYFTANNVQK 1520
            :      .:::|..:.......:....:|||..|:|.       |:||.:.....::...:|:.:
Mouse  1818 EKFGTENVKIIQDSDKVNAKELDPKFAHIQVTYVKPY-------FDDKELTERKTEFERNHNINR 1875

  Fly  1521 FQFSRPFRDSTNGGDRDDVRNLWLERTELRISYPLPGILRWFPVVETNTFKISPLERAVEIMKDT 1585
            |.|..|:  :.:|..:..:......||.|..|...|.:.:..|:.......:.|::.|.:.:||.
Mouse  1876 FVFEAPY--TLSGKKQGCIEEQCKRRTILTTSNSFPYVKKRIPINCEQQVNLKPIDVATDEIKDK 1938

  Fly  1586 NRDIRQLVILHKSDETLHIN--PLSMKLNGIVDPAVMGGFAKYEEAFLTDDYLEQNPDDKELVEE 1648
            ..:      |||...::.::  .|.:||.|.|...|..|...|..|||.:....:.|..|  |.|
Mouse  1939 TAE------LHKLCSSVDVDMIQLQLKLQGCVSVQVNAGPLAYARAFLNESQANKYPPKK--VNE 1995

  Fly  1649 LKELIANQIPLLDLAIQLH-RLRAPDSLKALQEHLERCFADM 1689
            ||::....|....:|::|: ||...|.:: ..|.|:..|.||
Mouse  1996 LKDMFRKFIQACSIALELNERLIKEDQIE-YHEGLKSNFRDM 2036

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mbcNP_001247267.1 SH3_DOCK_AB 14..70 CDD:212805
DOCK_N 86..435 CDD:292790 28/138 (20%)
C2_Dock-A 443..633 CDD:176076 46/201 (23%)
DHR2_DOCK_A 1296..1697 CDD:212570 90/433 (21%)
Dock11XP_006541469.1 DUF3398 37..147 CDD:371776
PH_DOCK-D 161..283 CDD:270087
C2_Dock-D 639..828 CDD:176079 46/201 (23%)
DHR2_DOCK11 1628..2040 CDD:212573 90/434 (21%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1997
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

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