Protein Alignment mbc and Dock5

DIOPT Version :10

• Sequence 1: NP_001247267.1
• Gene: mbc / 42817
• FlyBaseID: FBgn0015513
• Length: 2008
• Species: Drosophila melanogaster
• Sequence 2: NP_808448.2
• Gene: Dock5 / 68813
• MGIID: 2652871
• Length: 1868
• Species: Mus musculus
• Alignment Length: 2019
• Identity: 744/2019 - (36%)
• Similarity: 1109/2019 - (54%)
• Gaps: 253/2019 - (12%)

  Fly     1 MSVWSDCNAKQAEFGIAKCNFDQESKPHRLNLDVGDAVIILKETTHWYYGYRQKAKEIRGIFPKS 65
            |:.|  ...|:.::|:|..|:: .|:...|:|.:||.|.||:....||.||..:.:..:||||::
Mouse     1 MARW--IPTKRQKYGVAIYNYN-ASQDVELSLQIGDTVHILEMYEGWYRGYALQNRSKKGIFPET 62

  Fly    66 YIHLCEYNIVNG---EYCIQ-RTDIVEEITKVLLEWGSIAKDYFLTTNPS-FPKIRRKMNELNNN 125
            ||||.|..:.:|   |..|. ...:|:|:|..|.||..|.:..::....: |.::::....|...
Mouse    63 YIHLKEATVEDGGQHETVIPGELPLVQELTNTLREWAVIWRKLYVNNKVTLFRQLQQMTYSLIEW 127

  Fly   126 RAALISGNLPLDEVRKVKLLATNQIDTGNKLLGLDMVVRDESGDILDTNAICTTELYEQHMHAVQ 190
            |:.::||.||.||:.::|...|.:||.||::||||:||||::|:|||.:...|..|:..|..|.:
Mouse   128 RSQILSGTLPKDELAELKKKVTAKIDHGNRMLGLDLVVRDDNGNILDPDETSTVALFRAHEVASK 192

  Fly   191 RIDKANRLSSE---------RGTTRTPNKYSHNILLHVNAFVCKFQEDSDLLFTLFDGETHKPIS 246
            ||::  ::..|         ||.......:::.:.::...|||...||::|...|:|.:....||
Mouse   193 RIEE--KIQEEKSILQNLDLRGQAIFSTVHTYGLYVNFKNFVCNIGEDAELFIALYDPDQSTFIS 255

  Fly   247 ENYVVKWSRTGIARDTDQIDNNRVLFTDLSKSDLAIAKMYLVCYAIRIGSMEFKDSAESKRTSMS 311
            |||:::|...|:.::.::::|.:.:|||||.:||...::.|||..:|:|.||.|:
Mouse   256 ENYLIRWGSNGMPKEIEKLNNLQAVFTDLSSTDLIRPRISLVCQIVRVGRMELKE---------- 310

  Fly   312 IANSMLNASSRKASQLSVSSSGSSSSNGEYIIRRPFGVACKDLTPFIN-KSDDFRGNIDLPF--- 372
                                 |...:.|   :|||||||..|::..:: |.||......:||
Mouse   311 ---------------------GKKHTCG---LRRPFGVAVMDISDIVHGKVDDEEKQHFIPFQQI 351

  Fly   373 --------------------IMCEKETLDGTLRKLIANKDIGKIDSKMAVTIEVLRGDIKQIKEE 417
                                ::.|.|.|...|.|:||.|::......:.|::::|.||:.|:::.
Mouse   352 AMETYIRQRQLIMSPLITSHVIGENEPLTSVLNKVIAAKEVNHKGQGLWVSLKLLPGDLTQVQKN 416

  Fly   418 FPRLMHTNVPVARKMGFPEVILPGDVRNDLYLTICSGEFARIAKTSEKNVEVSVCVANEQGYLMP 482
            |..|:..:..:||||||||:|||||||||:|:|:..|||.:..|.:.|||||::.|.:|:|.|:.
Mouse   417 FSHLVDRSTAIARKMGFPEIILPGDVRNDIYVTLIHGEFDKGKKKTPKNVEVTMSVFDEEGNLLE 481

  Fly   483 GVLSIGAGHQPIDEYKSVVYYHDDKPKWQETFKIHVPIEDFKQCHLRFVLKHRSSNEQKDRTEKP 547
            ..:..|||::.:.||||||||...:|.|.||.|:.:.||:..:||:||..:||||.|.:|::|:.
Mouse   482 KAIHPGAGYEGVSEYKSVVYYQVKQPCWYETVKVFIAIEEVTRCHIRFTFRHRSSQESRDKSERA 546

  Fly   548 FGLAYVRLMQANGTTITQGQHILAVYKIDHKKYDKTVANCYLELPATVA-----ELQGAK-PSIG 606
            ||:|:|:||.|:|||:..|:|.|.|||.|:||.:.  |..||.||.|.|     |||.:| ||:
Mouse   547 FGVAFVKLMNADGTTLQDGRHDLVVYKGDNKKMED--AKYYLTLPGTKAELEEKELQASKNPSV- 608

  Fly   607 GLTLLP-----KDQLSIGVNLCSTKLTQSVSLLGLLNWSAHKETLEQSLNALSTVPGEEVVKFLQ 666
               ..|     ||...|...:|||||||:|.|||||||.::.:.::.:|..|..|.|.|:|||||
Mouse   609 ---FTPSKDSTKDSFQIATLICSTKLTQNVDLLGLLNWRSNSQNIKHNLKKLMEVDGGEIVKFLQ 670

  Fly   667 DILDALFNILVENDHPEKYDQLVFMSIIHLIETVSDLKYQHFLSVLDVYINESFSFTLAYTKLMD 731
            |.|||||||::|....|.||.|||.:::.:|..:.|:|:|||..||:.||.:.||.|||:.||..
Mouse   671 DTLDALFNIMMEMSDNETYDFLVFDALVFIISLIGDIKFQHFNPVLETYIYKHFSATLAHVKLSK 735

  Fly   732 VLQKNISEAISPKEKSADGNDLEESPEVRRLYKTTRYLHYVMKFVIRSRVLYAEM-NCNTDYMDF 795
            ||...::.|             |:..:...|:...:.|.|:.:|:|:|||||... ..:.|..:|
Mouse   736 VLNFYVANA-------------EDPSKTELLFAALKALKYLFRFIIQSRVLYLRFYGQSEDGDEF 787

  Fly   796 ATRLQELLRMFIDMIGCP-SNLLKSEGALLKNLHIIATDLMQVFEHVRLSISIVEILEKFPPRRL 859
            ...:::|...|..::..| ...:|.:||.||.|..|..|:..||:.:.||:...:.::..|..:|
Mouse   788 NDSIRQLFLAFNTLMDRPLEEAVKIKGAALKYLPSIINDVKLVFDPMELSVLFCKFIQSIPDNQL 852

  Fly   860 TQSKMGCIKDFVETKLFTLPKCRAILLPVFCKHIKDHLESKEEGDSKTDIWQQEKNLSKAAKVLG 924
            .:.|:.|:...||:.||...:||.:|||:....:...|   ::..:|.|               .
Mouse   853 VRQKLNCMTKIVESSLFQQAECREVLLPLLTDQLSGQL---DDHSTKPD---------------H 899

  Fly   925 QKKSQLHTCDTTANKKIAECINIMNNILKLLFRSDVGSTHNDIRDIMIILFRTVMKAAHALDRDT 989
            :..|||                 ::|||::|.|:|||.|...::.||..|.|.:.:....:.|.:
Mouse   900 EASSQL-----------------LSNILEVLDRTDVGPTSAHVQLIMERLLRRINRTVIGMSRQS 947

  Fly   990 GLVGKFFAIMLGILQRMDAQHYEYFVKDLHQSGELKHFVIEILLVFEELVSPHQKAVFPRDWMDM 1054
            ..:|.|.|.|:.:|::|:..||.:::.......::..|::|..::|::|:.   |.|:.:|||.|
Mouse   948 PHIGSFVACMIAVLRQMEDSHYSHYISTFKTRQDIIDFLMETFIMFKDLIG---KNVYAKDWMVM 1009

  Fly  1055 IMHQNTVILGALKHLTVVITDYFL--CPFEKQIWSNFFQCSIAFLVQSPLQLNDFNDNKRQIVFA 1117
            .|.||.|.|.|:.....|:|..|:  ..||.|:|:|:|..::|||....|||..|::.||..:..
Mouse  1010 NMTQNRVFLRAINQFAEVLTKSFMDQASFELQLWNNYFHLAVAFLTHESLQLETFSEAKRNKIVK 1074

  Fly  1118 RYRDIRKDTAMEIRKMWFQLGQHKPKFVPQLVEPILEMSMIPEKELRQETIPIFFDMMQCEYYSS 1182
            :|.|:||:....||.||:.||.||.||:|.:|.||||:::.||.|||:.||||||||||||:
Mouse  1075 KYGDMRKEIGFRIRDMWYNLGPHKIKFIPSMVGPILEVTLTPEVELRKATIPIFFDMMQCEF--- 1136

  Fly  1183 RLEHESYGDTKFNNAHHKGNFSDFKTAMIEKLDILIGAGKGDAEYKHLFETIMLERCAAHNTLNV 1247
                         |....|||..|:..:|.|||..:..|:||.:||.|.|.::||.|..|..|..
Mouse  1137 -------------NLSGNGNFHMFENELITKLDQEVEGGRGDEQYKVLLEKLLLEHCRKHKYLAN 1188

  Fly  1248 DGTAFVQMVTRLMDKLLEYR-FIIQDESKENRMACTFSLLQFYSEVDLKEMYIRYVNKLCALHME 1311
            .|.||..:|:.|::.||:|| .||.||||||||:||.::|.||.:...:::||||:.||..||.:
Mouse  1189 SGEAFAFLVSSLLENLLDYRTIIIHDESKENRMSCTVNVLNFYKDKKREDIYIRYLYKLRDLHRD 1253

  Fly  1312 FENYTEAAFTLKLHTELLRWTDTE-LSHQLR--SYRHNNCRTHRQLKEALYFEIMEYFDKGKQWE 1373
            .|||||||:||.||.|||:|:|.. :.|.|:  ||   ...|.::|||.||.||:.||||||.||
Mouse  1254 CENYTEAAYTLLLHAELLQWSDKPCVPHLLQRDSY---YVYTQQELKEKLYQEIISYFDKGKMWE 1315

  Fly  1374 CAIDMCRVLARQYEEEIFDYLKLAELLNRMALFYEKIIKELRHNSEYFRVCFYGRGFPRFLQNRV 1438
            .||.:.:.||..||.::|||..|..||.:.|||||.|||.:|...|||.|.:||:|||.||:|::
Mouse  1316 KAIKLSKELAETYESKVFDYEGLGSLLKKRALFYENIIKAMRPQPEYFAVGYYGQGFPSFLRNKI 1380

  Fly  1439 YIFRGKEYERHSDFCARMLVQHPQAELMQTLEAPGDDITNSDGQYIQVNKVEPIMGQAFNKFNDK 1503
            :|:|||||||..||..|:|.|.|.||.|.:...||:||.:|..||:|...|:|:|... ..:.||
Mouse  1381 FIYRGKEYERREDFSLRLLTQFPNAEKMTSTTPPGEDIKSSPKQYLQCFTVKPVMSLP-PSYKDK 1444

  Fly  1504 IINNEIVKYFTANNVQKFQFSRPFRDSTNGGDRD---DVRNLWLERTELRISYPLPGILRWFPVV 1565
            .:..:|:.|:.||.||:|.:|||||.    |::|   :...:|:|||..|.:|..||||:||...
Mouse  1445 PVPEQILNYYRANEVQQFSYSRPFRK----GEKDPENEFATMWIERTTYRTAYTFPGILKWFEAK 1505

  Fly  1566 ETNTFKISPLERAVEIMKDTNRDIRQLVILHKSDETLHINPLSMKLNGIVDPAVMGGFAKYEEAF 1630
            |.:..:|||||.|:|.|:.||..:...|..|..|.:|.::||||.|:|||||||||||:.||:||
Mouse  1506 EISVEEISPLENAIETMELTNERVSNCVQQHAWDHSLSVHPLSMLLSGIVDPAVMGGFSNYEKAF 1570

  Fly  1631 LTDDYLEQNPDDKELVEELKELIANQIPLLDLAIQLHRLRAPDSLKALQEHLERCFADMQQHVEQ 1695
            .|:.||:::|:|:|.||.||.|||.|||||...|::|..:..:.||.|...|..||.::::.||:
Mouse  1571 FTEKYLQEHPEDQEKVELLKRLIALQIPLLTEGIRIHGEKLTEQLKPLHARLSSCFRELKEKVEK 1635

  Fly  1696 RYGRKSCDLKIERDSVVMRRP----NSFLPSLFDGSNNRHSETSMGSSDSGLSKSTFLPRPQTNS 1756
            .||..:..     .|:..|:|    :..||.:...:..|.|.||:.||....|         :||
Mouse  1636 LYGVITLP-----PSMTERKPSRAGSMVLPYILSSTLRRLSVTSVASSVISTS---------SNS 1686

  Fly  1757 IKNPFSGLSFNTRPSLGHSPSIKSNKSKDKTPSKRRTKDGKVKEREAHSLSSSQWYTPPLSTITS 1821
            ..|.      ::||  |...||.....:.:..|..|.:|...||...:.:|..:
Mouse  1687 SDNA------SSRP--GSDGSILEPLFERRASSGARVEDLPPKEDSENRISKFK----------- 1732

  Fly  1822 TPEKEINTS----IASLASTSNSSLSGPKTPDP---HVLTEELTP---KRPLRSEM--------E 1868
              .|:.|.|    ||..|...:....|.||..|   .::...|||   ..||:|..        :
Mouse  1733 --RKDWNLSKSQVIAEKAPEPDVMSPGKKTQRPKSLQLVDSRLTPFHSPSPLQSTALSPPPLTPK 1795

  Fly  1869 KERRLSRPASIATP--TASIKNFPDTRSLS-ESSNRNSVETT-------DSTSEEDIRPPPLPAK 1923
            ..|.||.| |:.|.  |||:...|..:|.. |||.|||.|..       ||.:     |||.|.|
Mouse  1796 ATRTLSSP-SLQTDGLTASVPPPPPPKSKPYESSQRNSAEIAPPLPVRRDSKA-----PPPPPPK 1854

  Fly  1924 ARDS 1927
            ||.|
Mouse  1855 ARKS 1858

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mbc	NP_001247267.1	SH3_DOCK_AB	14..70	CDD:212805	22/55 (40%)
		DOCK_N	86..435	CDD:465040	109/382 (29%)
		C2_Dock-A	443..633	CDD:176076	92/200 (46%)
		DHR2_DOCK_A	1296..1697	CDD:212570	196/406 (48%)
		Herpes_BLLF1	<1732..>1935	CDD:282904	64/224 (29%)
Dock5	NP_808448.2	SH3_DOCK1_5_A	12..67	CDD:212984	22/55 (40%)
		DOCK_N	75..434	CDD:465040	111/394 (28%)
		C2	442..637	CDD:472691	92/200 (46%)
		DHR2_DOCK5	1238..1637	CDD:212581	196/406 (48%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1681..1730		14/65 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1742..1868		41/123 (33%)