Protein Alignment mbc and Dock7

DIOPT Version :9

• Sequence 1: NP_001247267.1
• Gene: mbc / 42817
• FlyBaseID: FBgn0015513
• Length: 2008
• Species: Drosophila melanogaster
• Sequence 2: XP_006503371.1
• Gene: Dock7 / 67299
• MGIID: 1914549
• Length: 2142
• Species: Mus musculus
• Alignment Length: 2192
• Identity: 401/2192 - (18%)
• Similarity: 665/2192 - (30%)
• Gaps: 785/2192 - (35%)

  Fly    85 DIVEEITKVLLEWGSIAKDYFLTTNPSFPKIRRKMNELNNNRAALISGNLP-----LDEVRKVKL 144
            |.:...|:   :|..:.:.|........|....|..|...        .||     .||......
Mouse   115 DCIRSYTE---DWAVVVRKYHKLGTGFNPNTLDKQKERQK--------GLPRQVFESDEAPDGSS 168

  Fly   145 LATNQIDTGNKLLGLD-----------MVVRDESGDILDTNAICTTELYE-QHMHAVQRIDKANR 197
            ....|.|...:.:.:|           ..:::...|.|..|.:..|...| .|.:..||  |:||
Mouse   169 YQDEQDDLKRRSMSIDDTPRGSWACSIFDLKNSLPDALLPNLLDRTPNEEIDHQNDDQR--KSNR 231

  Fly   198 LSS--------------ER-GTTRTPNKYSHNILLHVNAFVCKFQEDSDLLF---TLFDGETHKP 244
            ...              || .....|.::....|| |.....||:.:.:.:|   .|:|.:..|.
Mouse   232 HKELFALHPSPDEEEPIERLSVPDVPKEHFGQRLL-VKCLSLKFEIEIEPIFASLALYDVKEKKK 295

  Fly   245 ISENY----------------VVKWSRTGIARDTDQIDNNRVLF--TDLSKSDLAIAKMYLVCYA 291
            ||||:                |...:.|.:||.        .:|  |..|:....:.|:..|...
Mouse   296 ISENFYFDLNSEQMKGLLRPHVPPAAITTLARS--------AIFSITYPSQDVFLVIKLEKVLQQ 352

  Fly   292 IRIGS-----MEFKDSAESKR---------------------------TSMSIANSMLNASS--R 322
            ..||.     |.||::..:|.                           |::.:.|.:.:|.|  |
Mouse   353 GDIGECAEPYMIFKEADATKNKEKLEKLKSQADQFCQRLGKYRMPFAWTAIHLMNIVSSAGSLER 417

  Fly   323 KASQLSVSS-----SGSSSSNGEYIIRR---------------PFGVACKDLTPFINKSDDFRGN 367
            .::::.:|:     |.|...|...:.||               .|..|...:..|..:..|...:
Mouse   418 DSTEVEISTGERKGSWSERRNSSLVGRRSLERTTSGDDACNLTSFRPATLTVANFFKQEGDRLSD 482

  Fly   368 IDLPFIMCEKETLDGTLRKLIANKDIGKIDSKMAVTIEVLRGDIKQIKEE-----FPRLMHTNV- 426
            .||...:.:.......||:|            ..:|.: |:.||....|.     .|.|:...:
Mouse   483 EDLYKFLADMRRPSSVLRRL------------RPITAQ-LKIDISPAPENPHYCLTPELLQVKLY 534

  Fly   427 ------PVARKMGFP--EVILPGDV-RNDLYLTICSGEFARIAKTSEKNVEVSV--CVANEQGYL 480
                  |....:.||  :|.:|... ||.||:...|..||. .:.|.:|:.|.|  ....:....
Mouse   535 PDSRVRPTREILEFPARDVYVPNTTYRNLLYIYPQSLNFAN-RQGSARNITVKVQFMYGEDPSNA 598

  Fly   481 MPGVLSIGAGHQPIDEYKSVVYYHDDKPKWQETFKIHVPIEDFKQCHLRFVLKHRSSNEQKDRT- 544
            ||.:....:..:...|..:.|.||:..|.:.|..|:.:|.......||.|...|.|. :||..|
Mouse   599 MPVIFGKSSCSEFSKEAYTAVVYHNRSPDFHEEIKVKLPATLTDHHHLLFTFYHVSC-QQKQNTP 662

  Fly   545 -EKPFGLAYVRLMQANGTTITQGQHILAVYKIDHKKYDKTVANCYLELPATVAELQGAKPSIGGL 608
             |.|.|..::.::| ||...| ||..|.|               .||.|.....:...:..:.|:
Mouse   663 LETPVGYTWIPMLQ-NGRLKT-GQFCLPV---------------SLEKPPQAYSVLSPEVPLPGM 710

  Fly   609 TLLP--KDQLSIGVNLCSTKLTQSVSL---LGLLN-WSAH----------------KETLEQSLN 651
            ..:.  |...::.|...|:..||...|   ..|:| ...|                :..|:.|::
Mouse   711 KWVDNHKGVFNVEVVAVSSIHTQDPYLDKFFALVNALDEHMFPVRIGDMRIMENNLESELKSSIS 775

  Fly   652 ALSTVPGEEVVKFLQDILDALFNILVENDHPEKYDQLV------FMSIIHLIETV-SDLKYQHFL 709
            ||::...|.||:||..:||.|..::|.  .|....|:|      |.::..:|..: .:|:..|..
Mouse   776 ALNSSQLEPVVRFLHLLLDKLILLVVR--PPVIAGQIVNLGQASFEAMASIINRLHKNLEGNHDQ 838

  Fly   710 ----SVLDVYINESFSF----------------------TLAYTKLMDV-LQKNISEAISPKEKS 747
                ::|..||...|..                      |:|.:.:... |..|.|.::|.....
Mouse   839 HGRNNLLASYIYYVFRLPNTYPNSPSPGPGGLGGSVHYATMARSAVRPASLNLNRSRSLSNSNPD 903

  Fly   748 ADGNDLEESPEVRRLY----------------------------------------------KTT 766
            ..|.......|||.:.                                              :|:
Mouse   904 ISGTPTSPDDEVRSIIGSKGLDRSNSWVNTGPKAAPWGSNPSPSAESTQAMDRSCNRMSSHTETS 968

  Fly   767 RYLH------------------------------------------------YVMKFVIRSRVLY 783
            .:|.                                                :..:.:::|.|.:
Mouse   969 SFLQTLTGRLPTKKGKEDELEKLSLLLFHEELALQWVVCSGSVRESALQQAWFFFELMVKSMVHH 1033

  Fly   784 AEMNCNTDYMDFATRLQELLRMFIDMIGCPSNLLKSEGALLKNLHIIATDLMQVFEH-----VRL 843
            ...|   |.:| |.|.......|:|.|          .||:..   ||.|::..|:.     .||
Mouse  1034 LYFN---DKLD-APRKSRFPERFMDDI----------AALVST---IAGDVVSRFQKDTEMVERL 1081

  Fly   844 SISIVEILEKFPPRRLTQSKMG--------CIKDFVETKLFTLP------KCRAILLPVFCKHIK 894
            :.|:...|...    |:....|        |.|. |..||::||      ..|...|.:.|.|
Mouse  1082 NTSLAFFLNDL----LSVMDRGFVFSLIKSCYKQ-VSAKLYSLPNPSVLVSLRLDFLRIICSH-- 1139

  Fly   895 DH-----------------------LESKEEGDSKTDIWQQEKN------------------LSK 918
            :|                       ..|:..|.|.:...|:..|                  |::
Mouse  1140 EHYVTLNLPCSLLTPPASPSPSVSSATSQSSGFSTSVQDQKIANMFELSLPFRQQHYLAGLVLTE 1204

  Fly   919 AAKVLGQKKSQLHTCDTTANKKIAECINIMNNILKLLFRSDVGSTH-NDIR--DIMIILFRTVMK 980
            .|.:|......|.    ..:||:   ||:::|:|         ||| :|.|  |..|       |
Mouse  1205 LALILDPDAEGLF----GLHKKV---INMVHNLL---------STHDSDPRYSDPQI-------K 1246

  Fly   981 AAHALDRDTGLVGKFFAIMLGILQRMDAQHYEYFVKDLH----------------QSGELKHFVI 1029
            |.         |...:..::||:.....|.|::  .:.|                :||.:....:
Mouse  1247 AR---------VAMLYLPLIGIIMETVPQLYDF--TESHNQRGRPICIAPDDYDSESGSMISQTV 1300

  Fly  1030 EILLV---FEELVSP----------HQKAVFPRDWMDMIMHQNTVILGALKHLTVVITDYFLCPF 1081
            .:.:.   ..:|..|          .|...|..:....::   ..:|..||:....:.
Mouse  1301 AMAIAGTSVPQLTRPGSFLLTSTSGRQHTTFSAESSRSLL---ICLLWVLKNADETVL------- 1355

  Fly  1082 EKQIWSNFFQCSIAFLVQSPLQLNDFND------------------NKRQIVFARYRDIRKDTAM 1128
              |.|         |...|.||||...|                  ....:.|.:.:|:|.....
Mouse  1356 --QKW---------FTDLSVLQLNRLLDLLYLCVSCFEYKGKKVFERMNSLTFKKSKDMRAKLEE 1409

  Fly  1129 EI-----------------------------------RK---MWFQLGQHKPKFVPQLV-EPILE 1154
            .|                                   ||   .|.|..:...|...::. |.:::
Mouse  1410 AILGSIGARQEMVRRSRGQLERSPSGSAFGSQENLRWRKDMTHWRQNSEKLDKSRAEIEHEALID 1474

  Fly  1155 MSMIPEKEL-----------------RQETI-----PIFFDMMQCEYYSSRLEH----------- 1186
            .::..|..|                 .:|:|     .:....|.|...:..|:|
Mouse  1475 GNLATEANLIILDTLEIIVQTVSVTESKESILGGVLKVLLQSMACNQSAVYLQHCFATQRALVSK 1539

  Fly  1187 ----------ESYGDTKFNNAHH--------------------------KGNFSDFKTAMIEKLD 1215
                      |...|.......|                          ..||:..|..:...|.
Mouse  1540 FPELLFEEETEQCADLCLRLLRHCSSSISTIRSHASASLYLLMRQNFEIGNNFARVKMQVTMSLS 1604

  Fly  1216 ILIGAGKGDAE--YKHLFETIMLERCAAHNTLNVDGTAFVQMVTRLMDKLLEYRFIIQD------ 1272
            .|:|..:...|  .:...:||:   ..|...|.:..|.|...|   .|.:.....|:.|
Mouse  1605 SLVGTSQNFNEEFLRRSLKTIL---TYAEEDLELRETTFPDQV---QDLVFNLHMILSDTVKMKE 1663

  Fly  1273 --ESKENRMACTFSLLQFY-SEVDLKEMYIRYVNKLCALHMEFENYTEAAFTLKLHTELLRWTDT 1334
              |..|..:...:.:.:.| :..||:   :.::..:...|.|..|:.|||..| :|:..|   ..
Mouse  1664 HQEDPEMLIDLMYRIAKGYQTSPDLR---LTWLQNMAGKHSERSNHAEAAQCL-VHSAAL---VA 1721

  Fly  1335 ELSHQL--RSYRHNNCRTHRQLKEAL----------------------YFE------IMEY---- 1365
            |....|  |.|....|.|.:.:...:                      ||.      ::|.
Mouse  1722 EYLSMLEDRKYLPVGCVTFQNISSNVLEESAVSDDVVSPDEEGICSGKYFTESGLVGLLEQAAAS 1786

  Fly  1366 FDKGKQWECAIDMCRVLARQYEEEIFDYLKLAELLNRMALFYEKIIKEL----RHNSEYFRVCFY 1426
            |.....:|...::.:||...:|.. .|..||:.:..::...:.||:.:.    |....||||.||
Mouse  1787 FSMAGMYEAVNEVYKVLIPIHEAN-RDAKKLSTIHGKLQEAFSKIVHQSTGWERMFGTYFRVGFY 1850

  Fly  1427 GRGFPRFLQNRVYIFRGKEYERHSDFCARMLVQHPQAELMQTLEA-----PGDDI---------- 1476
            |..|.. |..:.::::.....:             .||:...||.     .|:|:
Mouse  1851 GTKFGD-LDEQEFVYKEPAITK-------------LAEISHRLEGFYGERFGEDVLEVIKDSNPV 1901

  Fly  1477 ----TNSDGQYIQVNKVEPIMGQAFNKFNDKIINNEIVKYFTAN-NVQKFQFSRPFRDSTNGGDR 1536
                .:.:..|||:..|||        |.|.....:.:.||..| |:::|.:..||  :.:|...
Mouse  1902 DKCKLDPNKAYIQITYVEP--------FFDTYEMKDRITYFDKNYNLRRFMYCTPF--TLDGRAH 1956

  Fly  1537 DDVRNLWLERTELRISYPLPGILRWFPVVETNTFKISPLERAVEIMKDTNRDIRQLVILHKSDET 1601
            .::...:..:|.|..|:..|.|.....|.......::|:|.|:|.|:...:::........:|..
Mouse  1957 GELHEQFKRKTILTTSHAFPYIKTRVNVTHKEEIILTPIEVAIEDMQKKTQELAFATHQDPADPK 2021

  Fly  1602 LHINPLSMKLNGIVDPAVMGGFAKYEEAFLT--------------------------DDYLEQN- 1639
            :    |.|.|.|.|...|..|..:..:.||:                          :|.|.:|
Mouse  2022 M----LQMVLQGSVGTTVNQGPLEVAQVFLSEIPGDPKLFRHHNKLRLCFKDFTKRCEDALRKNK 2082

  Fly  1640 ----PDDKE-----------LVEELKELIANQIPLL---DLAIQLHR 1668
                ||.||           |.|.|:.||..:||.|   .|.:..||
Mouse  2083 SLIGPDQKEYQRELERNYHRLKEALQPLINRKIPQLYKAVLPVTCHR 2129

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mbc	NP_001247267.1	SH3_DOCK_AB	14..70	CDD:212805
		DOCK_N	86..435	CDD:292790	83/467 (18%)
		C2_Dock-A	443..633	CDD:176076	49/196 (25%)
		DHR2_DOCK_A	1296..1697	CDD:212570	99/476 (21%)
Dock7	XP_006503371.1	DUF3398	52..161	CDD:371776	9/56 (16%)
		C2_Dock-C	560..737	CDD:176078	49/195 (25%)
		DHR2_DOCK7	1646..2120	CDD:212576	104/509 (20%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1997
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810