DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment mbc and dock4b

DIOPT Version :9

Sequence 1:NP_001247267.1 Gene:mbc / 42817 FlyBaseID:FBgn0015513 Length:2008 Species:Drosophila melanogaster
Sequence 2:NP_001159700.1 Gene:dock4b / 654774 ZFINID:ZDB-GENE-060130-74 Length:1977 Species:Danio rerio


Alignment Length:2100 Identity:626/2100 - (29%)
Similarity:1036/2100 - (49%) Gaps:318/2100 - (15%)


- Green bases have known domain annotations that are detailed below.


  Fly    21 FDQESKP------------HRLNLDVGDAVIILKETTHWYYGYRQKAKEIRGIFPKSYIHLCEYN 73
            |.:|.||            |.|.|::||.|.||::...||.|:..|....:||||..||||...:
Zfish    30 FCKELKPPDLLAGFRGTVQHGLPLEIGDTVQILEKCEGWYRGFVLKNPNAKGIFPCCYIHLKNAH 94

  Fly    74 IVN-GEY--CIQRTD-IVEEITKVLLEWGSIAKDYFLTTNPS-FPKIRRKMNELNNNRAALISGN 133
            |.| |::  .:...| ::.|:|..|.:||::.|..|:..... |.::...|||:.:.|..::.|:
Zfish    95 IKNKGQFETVVPSEDSVITEMTSTLRDWGAMWKQLFVKNEGDLFNRLWHVMNEILDLRRQVLVGH 159

  Fly   134 LPLDEVRKVKLLATNQIDTGNKLLGLDMVVRDESGDILDTNAICTTELYE--QHMHAVQRIDKAN 196
            |..|.:|.||...|.::|.||:.||||:|.|.|. .::|.:.|..||||.  :|.|..:      
Zfish   160 LTHDRMRDVKQHITARLDWGNEQLGLDLVPRREF-SMVDPDDISVTELYRLMEHRHRKK------ 217

  Fly   197 RLSSERGTTRTPNKYS-HNILLHVNAFV-CKFQEDSDLLFTLFDGETHKPISENYVVKWSRTGIA 259
                     .||...| |::.:|:.:.: ....|:.::.|.::|...::|:||.:.||.::.|:.
Zfish   218 ---------ETPAPVSTHHLFVHLKSLMSSNLGEELEVFFFIYDSRENRPLSERFFVKLNKNGLP 273

  Fly   260 RDTDQIDNNRVLFTDLSKSDLAIAKMYLVCYAIRIGSMEFKDSAESKRTSMSIANSMLNASSRKA 324
            :..::.:....||.||..|||. ..:|:|.:.||||.|                    .|..:| 
Zfish   274 KFPEKTERQCTLFVDLGSSDLR-KDVYIVVHIIRIGRM--------------------GAGEKK- 316

  Fly   325 SQLSVSSSGSSSSNGEYIIRRPFG---VACKDLTPFINKSDDFRGNIDLPFIMCEKET-----LD 381
                      :..|.:|  |||||   |:..||....:|.|..     |....|..|:     .|
Zfish   317 ----------NLCNVQY--RRPFGCAVVSIADLLTADSKDDHL-----LKVYACNTESDWSQIHD 364

  Fly   382 GTLRKLIANKDIGKIDSKMAVTIEVLRGDIKQIKEEFPRLMHTNVPVARKMGFPEVILPGDVRND 446
            ..::|:.:..::...::.:||.:::|.|||:|::.|:..|....|.:.:|:||.:||:||::|||
Zfish   365 NIIKKVNSRYNLSGSNTGLAVALQLLHGDIEQLRREYMVLFTRGVSITKKLGFSDVIMPGEMRND 429

  Fly   447 LYLTICSGEFARIAKTSEKNVEVSVCVANEQGYLMPGVLSIGAGHQPIDEYKSVVYYHDDKPKWQ 511
            ||:|:..|||.:..|:..:|||:::...:..|.::.|.:::|:|....|||.:.|.||::.|:|.
Zfish   430 LYMTLEKGEFEKGGKSVARNVEITIYALDADGQILKGFVAVGSGEPGGDEYHTFVLYHNNSPRWA 494

  Fly   512 ETFKIHVPIEDFKQCHLRFVLKHRSSNEQKDRTEKP-FGLAYVRLMQANGTTITQGQHILAVYKI 575
            |..|:.:|::.|:..|:||..:|.|:   ||:.||. ||.::|.|||.:|.|:..|.|.|.|:|.
Zfish   495 EQIKLPIPVDMFRGSHVRFEFRHCST---KDKGEKKLFGFSFVPLMQEDGRTLPDGTHELIVHKC 556

  Fly   576 DHKKYDKTVANC--YLELPATVAELQGAKPSIGGLTLLPKDQLSIGVNLCSTKLTQSVSLLGLLN 638
            :.   :..:.:|  ||:||.:.:.|.|...::.|    .|:.|.|...||||||||:..:|.||.
Zfish   557 EE---NANLQDCSRYLKLPFSKSNLPGNNQTVKG----TKESLWITSFLCSTKLTQNGDMLDLLK 614

  Fly   639 WSAHKETLEQSLNALSTVPGEEVVKFLQDILDALFNILVENDHPEKYDQLVFMSIIHLIETVSDL 703
            |.||.|.:..||:.|..:.|.|:||||||.||.||.||.|:.  ::|...||..::|:|..:.|.
Zfish   615 WRAHPERISDSLSKLKEIDGSEIVKFLQDTLDTLFGILDESS--QRYALKVFDCLVHIINLLQDS 677

  Fly   704 KYQHFLSVLDVYINESFSFTLAYTKLMDVLQKNISEAISPKEKSADGNDLEESPEVRRLYKTTRY 768
            |:|||..|:|.||...|:..|:|..|:.||:..:...|          |.:....::::.|.|  
Zfish   678 KFQHFKPVMDTYIESHFAGALSYRDLIKVLKWYVDRII----------DADRQEHIQQVLKAT-- 730

  Fly   769 LHYVMKFVIRSRVLYAEMNCNTDYMDFATRLQEL---LRMFIDMIGCPSN-----LLKSEGALLK 825
             .|:.|::::||.|:|......:..:|...:.||   :|.|:..    .|     :..::...|:
Zfish   731 -EYIFKYIVQSRRLFALATGGQNEEEFRCCMHELFMSIRFFLSQ----ENKSMRPITHTQAVFLQ 790

  Fly   826 NLHIIATDLMQVFEHVRLSISIVEILEKFPPRR-----LTQSKMGCIKDFVETKLFTLPKCRAIL 885
            :...:..:|:::|....::..:.|.|...|...     |...|:.||...|:::|:|.|..|.:|
Zfish   791 SFPAVYNELLKLFTVREVATFVRETLGSLPTASQPDCPLEAVKLHCIAKTVDSQLYTNPDSRCVL 855

  Fly   886 LPVFCKHIKDHLESKEEGDSKTDIWQQEKNLSKAAKVLGQKKSQLHTCDTTANKKIAECINIMNN 950
            |||..:.::.|:             |::::|...|.:|        ||                 
Zfish   856 LPVVLRLLQAHM-------------QEQRDLVMCAHIL--------TC----------------- 882

  Fly   951 ILKLLFRSDVGSTHND-----IRDIMIILFRTVMKAAHALDRDTG---------LVGKFFAIMLG 1001
            :|.||.:.|..|:.::     :..::.:|.||:::.|:. .:..|         :.|:|.:.:|.
Zfish   883 MLSLLKKDDTDSSSSEEVDLIVESVLAVLLRTILEVANR-PQPAGPTLRPQVQDVTGEFVSCLLA 946

  Fly  1002 ILQRMDAQHYEYFVKDLHQSGELKHFVIEILLVFEELVSPHQKAVFPRDWMDMIMHQNTVILGAL 1066
            :|:.|..:||:..::......:|:.|::.|..||..|:.|.   :||:||..|.:..|.:|:..:
Zfish   947 LLRHMKDKHYQQLLQRFTSKEDLRDFLLHIFTVFRILIRPE---MFPKDWTVMRLVTNNIIITTV 1008

  Fly  1067 KHLTVVITDYFLC-PFEKQIWSNFFQCSIAFLVQSPLQLNDFNDNKRQIVFARYRDIRKDTAMEI 1130
            .:|:..:...||. .|:.::|.::|..|:.|:.|:.|||..|:.:|::.:..:|.|:|.....||
Zfish  1009 LYLSDALRKNFLSEKFDYKVWDSYFCLSVIFINQTCLQLETFSASKKKKILEKYGDMRVMMGCEI 1073

  Fly  1131 RKMWFQLGQHKPKFVPQLVEPILEMSMIPEKELRQETIPIFFDMMQCEYYSSRLEHESYGDTKFN 1195
            ..||..||:||..|:|.::.|.||::::|:.:||...||||.|||..|...|             
Zfish  1074 FSMWQNLGEHKLNFIPAMIGPFLEVTLVPQPDLRNVMIPIFHDMMDWEQRRS------------- 1125

  Fly  1196 NAHHKGNFSDFKTAMIEKLDILIGAGKGDAEYKHLFETIMLERCAAHNTLNVDGTAFVQMVTRLM 1260
                 |||...:..:|:|||.|:..||||..|:.||.:|:|:: ....|....|.:.:..|||||
Zfish  1126 -----GNFKQVEAKLIDKLDSLMSEGKGDETYRELFNSILLKK-IERETWRESGISLIATVTRLM 1184

  Fly  1261 DKLLEYRFIIQ-DESKENRMACTFSLLQFY-SEVDLKEMYIRYVNKLCALHMEFENYTEAAFTLK 1323
            ::||:||..:: .|....::.||.|||.|| :|::.:||||||::||..||::.:|||||::||.
Zfish  1185 ERLLDYRDCMKLGEVDGKKIGCTVSLLNFYKTELNKEEMYIRYIHKLYDLHLKAQNYTEASYTLL 1249

  Fly  1324 LHTELLRWTDTELSHQLRSYRHNNCRTHRQLKEALYFEIMEYFDKGKQWECAIDMCRVLARQYEE 1388
            |:.|||.|::    ..||.:.....::..|.||.|:..|::.||:||.||..|.:||.||.|| |
Zfish  1250 LYDELLEWSE----RPLREFLSYPMQSEWQRKEYLHLTIIQNFDRGKCWENGILLCRELADQY-E 1309

  Fly  1389 EIFDYLKLAELLNRMALFYEKIIKELRHNSEYFRVCFYGRGFPRFLQNRVYIFRGKEYERHSDFC 1453
            ..:||..|:::....|.||:||:.:.|...|:|||.|||:.||.||:|:.::.||.:|||...|.
Zfish  1310 SYYDYRNLSKMRMMEASFYDKIMDQQRLEPEFFRVGFYGKKFPFFLRNKEFVCRGHDYERLEAFQ 1374

  Fly  1454 ARMLVQHPQAELMQTLEAPGDDITNSDGQYIQVNKVEPIMGQAFNKFNDKIINNEIVKYFTANNV 1518
            .|||.:.|.|..||....|...|..::.||:|:..|.||.........|.:.:| |..::..|::
Zfish  1375 QRMLNEFPHAIAMQHANQPDQTIYQAEAQYLQIYAVTPIPDSQDVLQRDGVPDN-IKSFYKVNHI 1438

  Fly  1519 QKFQFSRPFRDSTNGGDRDDVRNLWLERTELRISYPLPGILRWFPVVETNTFKISPLERAVEIMK 1583
            .:|::.|||...|...: ::.::||:|||.|.:...||||.|||.|......::||||.|:|:::
Zfish  1439 WRFRYDRPFHKGTKDKE-NEFKSLWVERTTLTLVQSLPGISRWFEVERRELVEVSPLENAIEVIE 1502

  Fly  1584 DTNRDIRQLVILHKSDETLHINPLSMKLNGIVDPAVMGGFAKYEEAFLTDDYLEQNPDDKELVEE 1648
            :.|..:|.|:...::.:..:||||:|.|||::|.||.||.|:|:|||...||:..:|:|.:.:..
Zfish  1503 NKNLQLRTLITQCQTRQMQNINPLTMCLNGVIDAAVNGGLARYQEAFFVKDYIMNHPEDGDKIGR 1567

  Fly  1649 LKELIANQIPLLDLAIQLHRLRAPDSLKAL------QEHLERCFADMQQ-------------HVE 1694
            |:||:..|..:|:..:.:|....|..::.|      |.||.:....:|:             :..
Zfish  1568 LRELMFEQAHILEFGLTVHEKFVPQDMRPLHKKLVDQFHLMKSSLGIQEFPAYVRASPIHFTNGS 1632

  Fly  1695 QRYGRKSCDLKIERDS---VVMRRPNSFLPSLFDGSNNRHSETSMGSSDS-------GLSKST-- 1747
            .|.||.|....:..|.   ||.||.....|::     ||:|.:|:.|..|       |.|:|:  
Zfish  1633 PRVGRNSAPNIMSPDGGARVVSRRSPLSYPAV-----NRYSSSSLSSQASNEVSNITGHSESSDE 1692

  Fly  1748 ---FLPRPQTNSIKNPFSGLSFNTRPSLGHSPSIKSNKSKDKTPSKRRTKDGKVKEREAHSLSSS 1809
               ..|.|.|:|:.:..|.           ||::.|:     .||..|   |..:..:.|.....
Zfish  1693 VFNMQPSPSTSSLSSNHSA-----------SPNVSSS-----APSSAR---GSPQLSDKHKHPRE 1738

  Fly  1810 QWYTP---PLSTITSTPEKEINTSIASLASTSNSSLSGPKTPDPHVLTEELTPKRPLRSEMEKER 1871
            ...:|   |.|.:...|.:.....:...|..|:...|.|....|..:.      :|..|....:.
Zfish  1739 NCLSPRDRPCSAVYPNPMEPTQRPVPHPAGDSSLPRSDPNISSPDKVV------KPAPSSWSLDM 1797

  Fly  1872 RLS-----------RPASIATPTASIKNFPDTRSLSESSNRNSVETTDSTSEEDIRPP--PLPAK 1923
            .||           ||....:|..:      |||.|..|...|.:.|..       ||  |.|.:
Zfish  1798 PLSEFNGKCPPVPPRPPYSGSPART------TRSQSPVSTSRSPQKTSV-------PPFTPSPTE 1849

  Fly  1924 ARDSTDFTSLSQNMDWTPNGYAMLSTISNTSSMSTTSTLTKTSITNTTYEYLETTNFSLVGAIDG 1988
            .:.    |.|..|.......|:     |..||:|..|....:...||..::: ..|.:..|:.:.
Zfish  1850 CQS----TGLVSNSPVLSGSYS-----SGISSLSRCSVSEASGTENTPTDHV-LPNSASSGSDEL 1904

  Fly  1989 NKPRPPTPPPKPSRHSKHIP 2008
            .:....||||. |.|.::.|
Zfish  1905 IRRENKTPPPY-SIHERNNP 1923

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mbcNP_001247267.1 SH3_DOCK_AB 14..70 CDD:212805 23/60 (38%)
DOCK_N 86..435 CDD:292790 96/361 (27%)
C2_Dock-A 443..633 CDD:176076 70/192 (36%)
DHR2_DOCK_A 1296..1697 CDD:212570 151/419 (36%)
dock4bNP_001159700.1 SH3_DOCK4_B 38..91 CDD:212982 19/52 (37%)
DOCK_N 95..418 CDD:292790 100/377 (27%)
C2_Dock-B 426..609 CDD:176077 70/192 (36%)
DHR2_DOCK4 1222..1612 CDD:212578 150/396 (38%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1997
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG54452
OrthoDB 1 1.010 - - D102580at2759
OrthoFinder 1 1.000 - - FOG0000433
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100636
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2355
SonicParanoid 1 1.000 - - X372
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
98.760

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