Protein Alignment mbc and dock1

DIOPT Version :9

• Sequence 1: NP_001247267.1
• Gene: mbc / 42817
• FlyBaseID: FBgn0015513
• Length: 2008
• Species: Drosophila melanogaster
• Sequence 2: NP_001103481.1
• Gene: dock1 / 572187
• ZFINID: ZDB-GENE-080108-5
• Length: 1866
• Species: Danio rerio
• Alignment Length: 2061
• Identity: 777/2061 - (37%)
• Similarity: 1127/2061 - (54%)
• Gaps: 276/2061 - (13%)

  Fly     1 MSVWSDCNAKQAEFGIAKCNFDQESKPHRLNLDVGDAVIILKETTHWYYGYRQKAKEIRGIFPKS 65
            ||.|  ...|:.::|:|..|:|..|. ..|:|.:||.|.||:....||.|||.:.|..:|:||..
Zfish     1 MSRW--VPTKKEKYGVAVYNYDARSN-EELSLQIGDTVHILETYEGWYRGYRLRRKSKKGVFPAC 62

  Fly    66 YIHLCEYNIVNG---EYCI-QRTDIVEEITKVLLEWGSIAKDYFL-TTNPSFPKIRRKMNELNNN 125
            ||||.|..:...   |..| ....:|.|:|..|.||.:|.:|.:: .....|..:|..:.:|...
Zfish    63 YIHLKEATVEGSGQKETVIPTELPLVHEVTTTLREWAAIWRDLYVGDKREMFNTVRDMIYDLIEW 127

  Fly   126 RAALISGNLPLDEVRKVKLLATNQIDTGNKLLGLDMVVRDESGDILDTNAICTTELYEQHMHAVQ 190
            |:.::||.||.||:.::|...|:::|.|||.|.||:||||:.|:|||.:...|..|:..|..|.:
Zfish   128 RSQILSGTLPQDELTELKQRVTSKMDYGNKYLDLDLVVRDKDGNILDPDLTSTVNLFRAHETASK 192

  Fly   191 RIDKANRLSSERGTTR------------TPNKYSHNILLHVNAFVCKFQEDSDLLFTLFDGETHK 243
            :|:.  |:..|:...:            ||   |..:.:.:...|||..||:::|.:|:|....|
Zfish   193 QIEA--RIQEEKSQKQNLDLNRLAKFASTP---SFALFVTLKNVVCKIGEDAEVLMSLYDPIESK 252

  Fly   244 PISENYVVKWSRTGIARDTDQIDNNRVLFTDLSKSDLAIAKMYLVCYAIRIGSMEFKDSAESKRT 308
            .|||||:|:||.:|:.:|.||:.|.|.:||||...||...|:..||..:|:|.||.:|:...|.|
Zfish   253 FISENYLVRWSSSGLVKDIDQLHNLRAVFTDLGSEDLKREKISFVCQIVRVGRMELRDNNTKKLT 317

  Fly   309 SMSIANSMLNASSRKASQLSVSSSGSSSSNGEYIIRRPFGVACKDLTPFI-NKSDDFRGNIDLPF 372
            |.                                :|||||||..|:|..| .|.||......:||
Zfish   318 SG--------------------------------LRRPFGVAVMDVTDIITGKMDDEDKQHFIPF 350

  Fly   373 --IMCEKETLDGTLRKLIANKDIGKIDSKMAVTIEVLRGDIKQIKEEFPRLMHTNVPVARKMGFP 435
              :..|.:.|...:.|:||.|::......:.||:::|.|||.||:::||.|:..:..||||||||
Zfish   351 QPVAGESDFLQSVINKVIAAKEVNHKGQGLWVTLKLLPGDIHQIRKDFPHLVDRSTAVARKMGFP 415

  Fly   436 EVILPGDVRNDLYLTICSGEFARIAKTSEKNVEVSVCVANEQGYLMPGVLSIGAGHQPIDEYKSV 500
            |:|:|||||||:|:|:..|:|.:.:||:.|||||::.|.:|.|..:..|:..|||.:.|.|||||
Zfish   416 EIIMPGDVRNDIYVTLVQGDFDKGSKTTPKNVEVTMSVHDEDGKKLESVIFPGAGDEGILEYKSV 480

  Fly   501 VYYHDDKPKWQETFKIHVPIEDFKQCHLRFVLKHRSSNEQKDRTEKPFGLAYVRLMQANGTTITQ 565
            :||...:|:|.||.|:.:||||..:.||||..|||||.:.||::||.|.|::|:||:.:|||:..
Zfish   481 IYYQVKQPRWYETIKVAIPIEDVNRSHLRFTFKHRSSQDCKDKSEKNFALSFVKLMRYDGTTLRD 545

  Fly   566 GQHILAVYKIDHKKYDKTVANCYLELPATVAELQGAKPSIG------GLTLLPKDQLSIGVNLCS 624
            |:|.|.|||.:.||.:.  ::.||.|.:|..|::...||.|      |...:.||...|...:||
Zfish   546 GEHDLIVYKAEAKKLED--SSMYLSLASTKPEMEERNPSSGKNAQNLGSFTISKDSFQISTLVCS 608

  Fly   625 TKLTQSVSLLGLLNWSAHKETLEQSLNALSTVPGEEVVKFLQDILDALFNILVENDHPEKYDQLV 689
            |||||:|.|||||.|.::...|:|:|..|..|.|.||||||||.|||||||::||...|.:|.||
Zfish   609 TKLTQNVDLLGLLKWRSNTSLLQQNLRHLMKVEGGEVVKFLQDTLDALFNIMMENSDSETFDTLV 673

  Fly   690 FMSIIHLIETVSDLKYQHFLSVLDVYINESFSFTLAYTKLMDVLQKNISEAISPKEKSADGNDLE 754
            |.:::.:|..::|.|:.||..||:.||.:.||.|||||||..||:..:..|    ||.::
Zfish   674 FDALVFIIGLIADRKFHHFNPVLETYIRKHFSATLAYTKLTKVLKNYVDNA----EKLSE----- 729

  Fly   755 ESPEVRRLYKTTRYLHYVMKFVIRSRVLYAEMNCNTDYMDFATRLQELLRMFIDMIGCPSNLLKS 819
                  :|.|..:.:.|:.||::|||||:.::..|....||...|:.|...|..|:...:.....
Zfish   730 ------QLLKALKAIEYIFKFIVRSRVLFNQLYENKGESDFMESLRNLFASFNAMMNSGAEGTGG 788

  Fly   820 -EGALLKNLHIIATDLMQVFEHVRLSISIVEILEKFPPRRLTQSKMGCIKDFVETKLFTLPKCRA 883
             :||.||.:..|..||..||:...||....|.:.|.|..||.:.|:.|:.|.|.:.|||...||.
Zfish   789 VKGAALKYVPTIVNDLKLVFDPKELSKLFSEFILKVPLGRLVKQKLHCMIDIVHSDLFTQHDCRE 853

  Fly   884 ILLPVFCKHIKDHLESKEEGDSKTDIWQQEKNLSKAAKVLGQKKSQLHTCDTTANKKIAECINIM 948
            ||||:....:|.|||:.||.:|                                      |..::
Zfish   854 ILLPLMTDQLKLHLENHEELES--------------------------------------CCQLL 880

  Fly   949 NNILKLLFRSDVGSTHNDIRDIMIILFRTVMKAAHALDRDTGLVGKFFAIMLGILQRMDAQHYEY 1013
            ::||::|:|.|||.|...::.||..|.||:.:...::.||:.|:|.|.|.|.|.|::||..||.:
Zfish   881 SDILEVLYRKDVGPTQWHVQIIMEKLLRTINRTVISMGRDSSLIGSFVACMTGTLRQMDDYHYTH 945

  Fly  1014 FVKDLHQSGELK----HFVIEILLVFEELVSPHQKAVFPRDWMDMIMHQNTVILGALKHLTVVIT 1074
            .:...   |:::    .|::|..::|::|:.   |.|:|.||:.|.|.||.|.|.|:.....|::
Zfish   946 LISTF---GKMRTDVVDFLMETFIMFKDLIG---KNVYPGDWVIMNMMQNKVFLRAINQYAAVLS 1004

  Fly  1075 DYFL--CPFEKQIWSNFFQCSIAFLVQSPLQLNDFNDNKRQIVFARYRDIRKDTAMEIRKMWFQL 1137
            ..||  ..||.|:|:|:|..::|||.|..|||.:|:.:||..:|.:|:|:|:....|||.||:.|
Zfish  1005 KKFLDQTNFELQLWNNYFHLAVAFLTQESLQLENFSSDKRAKIFHKYQDMRRQIGFEIRDMWYNL 1069

  Fly  1138 GQHKPKFVPQLVEPILEMSMIPEKELRQETIPIFFDMMQCEYYSSRLEHESYGDTKFNNAHHKGN 1202
            |.||.||:|::|.|||||:::||.|||:.||||||||||||:                  |.:..
Zfish  1070 GPHKIKFIPEMVGPILEMTLVPEIELRKATIPIFFDMMQCEF------------------HFRRC 1116

  Fly  1203 FSDFKTAMIEKLDILIGAGKGDAEYKHLFETIMLERCAAHNTLNVDGTAFVQMVTRLMDKLLEYR 1267
            |..|:..:|.|||..:..|:||.:||.||:.|:||.|..|..|...|..||.:|.||:::||:||
Zfish  1117 FQTFENEIITKLDHEVEGGRGDEQYKILFQKILLEHCRKHKYLAKTGETFVTLVVRLLERLLDYR 1181

  Fly  1268 FIIQDESKENRMACTFSLLQFYSEVDLKEMYIRYVNKLCALHMEFENYTEAAFTLKLHTELLRWT 1332
            .|:.||:|||||:||.::|.||.|::.:||||||:.|||.||.|.:|||||.:||.||.:||:|:
Zfish  1182 TIMHDENKENRMSCTVNVLNFYKEIEREEMYIRYLYKLCDLHKECDNYTEAGYTLLLHAKLLKWS 1246

  Fly  1333 DTELSHQLRSYRHNNCRTHRQLKEALYFEIMEYFDKGKQWECAIDMCRVLARQYEEEIFDYLKLA 1397
            :...:..|.........|..|||:.||.||:.||||||.||.||.:.:.||.|||.|:||:.:|:
Zfish  1247 EEACAAHLTQRDGYQASTQGQLKDQLYQEIINYFDKGKMWEEAIVLGKELAEQYENEMFDFEQLS 1311

  Fly  1398 ELLNRMALFYEKIIKELRHNSEYFRVCFYGRGFPRFLQNRVYIFRGKEYERHSDFCARMLVQHPQ 1462
            .||.:.|.|||.|:|.:|...:||.|.:.|.|||.||:|:::|:|||||||..||.||:|.|.|.
Zfish  1312 TLLRKQAQFYESIVKVIRPKPDYFAVGYNGLGFPSFLRNKMFIYRGKEYERWEDFEARLLTQFPN 1376

  Fly  1463 AELMQTLEAPGDDITNSDGQYIQVNKVEPIMGQAFNKFNDKIINNEIVKYFTANNVQKFQFSRPF 1527
            ||.|:|...|.:||.||.|||||...|:|:: :...||.:|.::.:||.::|.|.|||||:|||.
Zfish  1377 AEKMKTTTPPSEDIRNSSGQYIQCFTVKPLL-ELPPKFQNKPVSEQIVSFYTVNEVQKFQYSRPV 1440

  Fly  1528 RDSTNGGDRD---DVRNLWLERTELRISYPLPGILRWFPVVETNTFKISPLERAVEIMKDTNRDI 1589
            |.    |::|   :..|:|:|||....:|.||||||||.|:..:..:|||||.|:|.|:.||..|
Zfish  1441 RK----GEKDPDNEFSNMWIERTTYVTAYKLPGILRWFEVLSVSAEEISPLENAMETMQLTNEKI 1501

  Fly  1590 RQLVILHKSDETLHINPLSMKLNGIVDPAVMGGFAKYEEAFLTDDYLEQNPDDKELVEELKELIA 1654
            ..:|..|.:|..|.||||||.|||||||||||||..||:||.|:.|..::|:|:|.:|.||:|||
Zfish  1502 SNMVQRHLNDPNLPINPLSMLLNGIVDPAVMGGFTNYEKAFFTEKYFLEHPNDQEKIERLKDLIA 1566

  Fly  1655 NQIPLLDLAIQLHRLRAPDSLKALQEHLERCFADMQQHVEQRYGRKSCDLKIERDSVVMRRPNSF 1719
            .|||.|...:::|..:..::|:...|.||.||..:::.||::||.::
Zfish  1567 WQIPNLAEGVRIHGEKVTEALRPFHERLEACFRQLKEKVEKQYGIRT------------------ 1613

  Fly  1720 LPSLFD---GSNNRHSETS--MGSSDSGLSKSTFLPRPQTNSIKNPFSGLSFNTRPSLGHSPSIK 1779
            ||.:.|   ||..|....|  |.||...||.::.......||...|.|. .|...|.|   |..:
Zfish  1614 LPPMTDERRGSRPRSMVRSFTMPSSQRPLSVASVTSLSSDNSPSRPGSD-GFALEPLL---PKKQ 1674

  Fly  1780 SNKSKDKTPSKRRTKDGKVKEREAHSLSSSQWYTPPLSTITSTPEKEINTSIASLASTSNSSLSG 1844
            ..||:||.......||.|.|::|..:....:.:           :||:.|  |.:...:|.::
Zfish  1675 HFKSQDKLDRDEPEKDRKEKKKEKRNSKHQELF-----------DKELKT--ADIPLQANEAV-- 1724

  Fly  1845 PKTPDPHVLTEELTPKRPLRSEME-----KERRLS----RPASIATPTASIKNFPDTR---SLSE 1897
                   :|:|.::|.||.|.:.:     .|:|||    .||:...|:......|..:   ||..
Zfish  1725 -------ILSETISPLRPQRPKSQVINLLGEKRLSVSPGAPANQFVPSVPPPITPRAKLQFSLLS 1782

  Fly  1898 SSNRNSVETTDSTSEEDIRPPPLPAKARDSTDFTSLSQNMDWTPNGYAMLSTISNTSSMSTTSTL 1962
            .||.....|  |.:::...|||||.|: ...|:.:|..|.|..
Zfish  1783 GSNLELNGT--SYADKGETPPPLPVKS-SMGDYGNLMDNSDLA---------------------- 1822

  Fly  1963 TKTSITNTTYEYLETTNFSLVGAIDGNKPRPPTPPPKPSRHSKHIP 2008
                                          .||.||.|..|.:|:|
Zfish  1823 ------------------------------SPTTPPPPPPHQRHLP 1838

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mbc	NP_001247267.1	SH3_DOCK_AB	14..70	CDD:212805	24/55 (44%)
		DOCK_N	86..435	CDD:292790	123/364 (34%)
		C2_Dock-A	443..633	CDD:176076	88/195 (45%)
		DHR2_DOCK_A	1296..1697	CDD:212570	197/403 (49%)
dock1	NP_001103481.1	SH3_DOCK1_5_A	12..67	CDD:212984	24/55 (44%)
		DOCK_N	71..415	CDD:292790	125/380 (33%)
		C2_Dock-A	423..617	CDD:176076	88/195 (45%)
		DHR2_DOCK	1210..1609	CDD:297424	197/403 (49%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	439	1.000	Domainoid score	I532
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H55575
Inparanoid	1	1.050	1161	1.000	Inparanoid score	I197
OMA	1	1.010	-	-		QHG54452
OrthoDB	1	1.010	-	-		D102580at2759
OrthoFinder	1	1.000	-	-		FOG0000433
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100636
Panther	1	1.100	-	-	O	PTHR45653
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X372
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	12	11.980