DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment mbc and dock1

DIOPT Version :10

Sequence 1:NP_001247267.1 Gene:mbc / 42817 FlyBaseID:FBgn0015513 Length:2008 Species:Drosophila melanogaster
Sequence 2:XP_073773972.1 Gene:dock1 / 572187 ZFINID:ZDB-GENE-080108-5 Length:1886 Species:Danio rerio


Alignment Length:2081 Identity:777/2081 - (37%)
Similarity:1127/2081 - (54%) Gaps:296/2081 - (14%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MSVWSDCNAKQAEFGIAKCNFDQESKPHRLNLDVGDAVIILKETTHWYYGYRQKAKEIRGIFPKS 65
            ||.|  ...|:.::|:|..|:|..|. ..|:|.:||.|.||:....||.|||.:.|..:|:||..
Zfish     1 MSRW--VPTKKEKYGVAVYNYDARSN-EELSLQIGDTVHILETYEGWYRGYRLRRKSKKGVFPAC 62

  Fly    66 YIHLCEYNIVNG---EYCI-QRTDIVEEITKVLLEWGSIAKDYFL-TTNPSFPKIRRKMNELNNN 125
            ||||.|..:...   |..| ....:|.|:|..|.||.:|.:|.:: .....|..:|..:.:|...
Zfish    63 YIHLKEATVEGSGQKETVIPTELPLVHEVTTTLREWAAIWRDLYVGDKREMFNTVRDMIYDLIEW 127

  Fly   126 RAALISGNLPLDEVRKVKLLATNQIDTGNKLLGLDMVVRDESGDILDTNAICTTELYEQHMHAVQ 190
            |:.::||.||.||:.::|...|:::|.|||.|.||:||||:.|:|||.:...|..|:..|..|.:
Zfish   128 RSQILSGTLPQDELTELKQRVTSKMDYGNKYLDLDLVVRDKDGNILDPDLTSTVNLFRAHETASK 192

  Fly   191 RIDKANRLSSERGTTR------------TPNKYSHNILLHVNAFVCKFQEDSDLLFTLFDGETHK 243
            :|:.  |:..|:...:            ||   |..:.:.:...|||..||:::|.:|:|....|
Zfish   193 QIEA--RIQEEKSQKQNLDLNRLAKFASTP---SFALFVTLKNVVCKIGEDAEVLMSLYDPIESK 252

  Fly   244 PISENYVVKWSRTGIARDTDQIDNNRVLFTDLSKSDLAIAKMYLVCYAIRIGSMEFKDSAESKRT 308
            .|||||:|:||.:|:.:|.||:.|.|.:||||...||...|:..||..:|:|.||.:|:...|.|
Zfish   253 FISENYLVRWSSSGLVKDIDQLHNLRAVFTDLGSEDLKREKISFVCQIVRVGRMELRDNNTKKLT 317

  Fly   309 SMSIANSMLNASSRKASQLSVSSSGSSSSNGEYIIRRPFGVACKDLTPFI-NKSDDFRGNIDLPF 372
            |.                                :|||||||..|:|..| .|.||......:||
Zfish   318 SG--------------------------------LRRPFGVAVMDVTDIITGKMDDEDKQHFIPF 350

  Fly   373 ----------------------IMCEKETLDGTLRKLIANKDIGKIDSKMAVTIEVLRGDIKQIK 415
                                  :..|.:.|...:.|:||.|::......:.||:::|.|||.||:
Zfish   351 QPLALDDAIRHRQLNISRFSPRVAGESDFLQSVINKVIAAKEVNHKGQGLWVTLKLLPGDIHQIR 415

  Fly   416 EEFPRLMHTNVPVARKMGFPEVILPGDVRNDLYLTICSGEFARIAKTSEKNVEVSVCVANEQGYL 480
            ::||.|:..:..|||||||||:|:|||||||:|:|:..|:|.:.:||:.|||||::.|.:|.|..
Zfish   416 KDFPHLVDRSTAVARKMGFPEIIMPGDVRNDIYVTLVQGDFDKGSKTTPKNVEVTMSVHDEDGKK 480

  Fly   481 MPGVLSIGAGHQPIDEYKSVVYYHDDKPKWQETFKIHVPIEDFKQCHLRFVLKHRSSNEQKDRTE 545
            :..|:..|||.:.|.|||||:||...:|:|.||.|:.:||||..:.||||..|||||.:.||::|
Zfish   481 LESVIFPGAGDEGILEYKSVIYYQVKQPRWYETIKVAIPIEDVNRSHLRFTFKHRSSQDCKDKSE 545

  Fly   546 KPFGLAYVRLMQANGTTITQGQHILAVYKIDHKKYDKTVANCYLELPATVAELQGAKPSIG---- 606
            |.|.|::|:||:.:|||:..|:|.|.|||.:.||.:.  ::.||.|.:|..|::...||.|    
Zfish   546 KNFALSFVKLMRYDGTTLRDGEHDLIVYKAEAKKLED--SSMYLSLASTKPEMEERNPSSGKNAQ 608

  Fly   607 --GLTLLPKDQLSIGVNLCSTKLTQSVSLLGLLNWSAHKETLEQSLNALSTVPGEEVVKFLQDIL 669
              |...:.||...|...:|||||||:|.|||||.|.::...|:|:|..|..|.|.||||||||.|
Zfish   609 NLGSFTISKDSFQISTLVCSTKLTQNVDLLGLLKWRSNTSLLQQNLRHLMKVEGGEVVKFLQDTL 673

  Fly   670 DALFNILVENDHPEKYDQLVFMSIIHLIETVSDLKYQHFLSVLDVYINESFSFTLAYTKLMDVLQ 734
            ||||||::||...|.:|.|||.:::.:|..::|.|:.||..||:.||.:.||.|||||||..||:
Zfish   674 DALFNIMMENSDSETFDTLVFDALVFIIGLIADRKFHHFNPVLETYIRKHFSATLAYTKLNKVLK 738

  Fly   735 KNISEAISPKEKSADGNDLEESPEVRRLYKTTRYLHYVMKFVIRSRVLYAEMNCNTDYMDFATRL 799
            ..:..|    ||.::           :|.|..:.:.|:.||::|||||:.::..|....||...|
Zfish   739 NYVDNA----EKLSE-----------QLLKALKAIEYIFKFIVRSRVLFNQLYENKGESDFMESL 788

  Fly   800 QELLRMFIDMIGCPSNLLKS-EGALLKNLHIIATDLMQVFEHVRLSISIVEILEKFPPRRLTQSK 863
            :.|...|..|:...:..... :||.||.:..|..||..||:...||....|.:.|.|..||.:.|
Zfish   789 RNLFASFNAMMNSGAEGTGGVKGAALKYVPTIVNDLKLVFDPKELSKLFSEFILKVPLGRLVKQK 853

  Fly   864 MGCIKDFVETKLFTLPKCRAILLPVFCKHIKDHLESKEEGDSKTDIWQQEKNLSKAAKVLGQKKS 928
            :.|:.|.|.:.|||...||.||||:....:|.|||:.||.:|                       
Zfish   854 LHCMIDIVHSDLFTQHDCREILLPLMTDQLKLHLENHEELES----------------------- 895

  Fly   929 QLHTCDTTANKKIAECINIMNNILKLLFRSDVGSTHNDIRDIMIILFRTVMKAAHALDRDTGLVG 993
                           |..::::||::|:|.|||.|...::.||..|.||:.:...::.||:.|:|
Zfish   896 ---------------CCQLLSDILEVLYRKDVGPTQWHVQIIMEKLLRTINRTVISMGRDSSLIG 945

  Fly   994 KFFAIMLGILQRMDAQHYEYFVKDLHQSGELK----HFVIEILLVFEELVSPHQKAVFPRDWMDM 1054
            .|.|.|.|.|::||..||.:.:...   |:::    .|::|..::|::|:.   |.|:|.||:.|
Zfish   946 SFVACMTGTLRQMDDYHYTHLISTF---GKMRTDVVDFLMETFIMFKDLIG---KNVYPGDWVIM 1004

  Fly  1055 IMHQNTVILGALKHLTVVITDYFL--CPFEKQIWSNFFQCSIAFLVQSPLQLNDFNDNKRQIVFA 1117
            .|.||.|.|.|:.....|::..||  ..||.|:|:|:|..::|||.|..|||.:|:.:||..:|.
Zfish  1005 NMMQNKVFLRAINQYAAVLSKKFLDQTNFELQLWNNYFHLAVAFLTQESLQLENFSSDKRAKIFH 1069

  Fly  1118 RYRDIRKDTAMEIRKMWFQLGQHKPKFVPQLVEPILEMSMIPEKELRQETIPIFFDMMQCEYYSS 1182
            :|:|:|:....|||.||:.||.||.||:|::|.|||||:::||.|||:.||||||||||||:   
Zfish  1070 KYQDMRRQIGFEIRDMWYNLGPHKIKFIPEMVGPILEMTLVPEIELRKATIPIFFDMMQCEF--- 1131

  Fly  1183 RLEHESYGDTKFNNAHHKGNFSDFKTAMIEKLDILIGAGKGDAEYKHLFETIMLERCAAHNTLNV 1247
                           |.:..|..|:..:|.|||..:..|:||.:||.||:.|:||.|..|..|..
Zfish  1132 ---------------HFRRCFQTFENEIITKLDHEVEGGRGDEQYKILFQKILLEHCRKHKYLAK 1181

  Fly  1248 DGTAFVQMVTRLMDKLLEYRFIIQDESKENRMACTFSLLQFYSEVDLKEMYIRYVNKLCALHMEF 1312
            .|..||.:|.||:::||:||.|:.||:|||||:||.::|.||.|::.:||||||:.|||.||.|.
Zfish  1182 TGETFVTLVVRLLERLLDYRTIMHDENKENRMSCTVNVLNFYKEIEREEMYIRYLYKLCDLHKEC 1246

  Fly  1313 ENYTEAAFTLKLHTELLRWTDTELSHQLRSYRHNNCRTHRQLKEALYFEIMEYFDKGKQWECAID 1377
            :|||||.:||.||.:||:|::...:..|.........|..|||:.||.||:.||||||.||.||.
Zfish  1247 DNYTEAGYTLLLHAKLLKWSEEACAAHLTQRDGYQASTQGQLKDQLYQEIINYFDKGKMWEEAIV 1311

  Fly  1378 MCRVLARQYEEEIFDYLKLAELLNRMALFYEKIIKELRHNSEYFRVCFYGRGFPRFLQNRVYIFR 1442
            :.:.||.|||.|:||:.:|:.||.:.|.|||.|:|.:|...:||.|.:.|.|||.||:|:::|:|
Zfish  1312 LGKELAEQYENEMFDFEQLSTLLRKQAQFYESIVKVIRPKPDYFAVGYNGLGFPSFLRNKMFIYR 1376

  Fly  1443 GKEYERHSDFCARMLVQHPQAELMQTLEAPGDDITNSDGQYIQVNKVEPIMGQAFNKFNDKIINN 1507
            ||||||..||.||:|.|.|.||.|:|...|.:||.||.|||||...|:|:: :...||.:|.::.
Zfish  1377 GKEYERWEDFEARLLTQFPNAEKMKTTTPPSEDIRNSSGQYIQCFTVKPLL-ELPPKFQNKPVSE 1440

  Fly  1508 EIVKYFTANNVQKFQFSRPFRDSTNGGDRD---DVRNLWLERTELRISYPLPGILRWFPVVETNT 1569
            :||.::|.|.|||||:|||.|.    |::|   :..|:|:|||....:|.||||||||.|:..:.
Zfish  1441 QIVSFYTVNEVQKFQYSRPVRK----GEKDPDNEFSNMWIERTTYVTAYKLPGILRWFEVLSVSA 1501

  Fly  1570 FKISPLERAVEIMKDTNRDIRQLVILHKSDETLHINPLSMKLNGIVDPAVMGGFAKYEEAFLTDD 1634
            .:|||||.|:|.|:.||..|..:|..|.:|..|.||||||.|||||||||||||..||:||.|:.
Zfish  1502 EEISPLENAMETMQLTNEKISNMVQRHLNDPNLPINPLSMLLNGIVDPAVMGGFTNYEKAFFTEK 1566

  Fly  1635 YLEQNPDDKELVEELKELIANQIPLLDLAIQLHRLRAPDSLKALQEHLERCFADMQQHVEQRYGR 1699
            |..::|:|:|.:|.||:|||.|||.|...:::|..:..::|:...|.||.||..:::.||::||.
Zfish  1567 YFLEHPNDQEKIERLKDLIAWQIPNLAEGVRIHGEKVTEALRPFHERLEACFRQLKEKVEKQYGI 1631

  Fly  1700 KSCDLKIERDSVVMRRPNSFLPSLFD---GSNNRHSETS--MGSSDSGLSKSTFLPRPQTNSIKN 1759
            ::                  ||.:.|   ||..|....|  |.||...||.::.......||...
Zfish  1632 RT------------------LPPMTDERRGSRPRSMVRSFTMPSSQRPLSVASVTSLSSDNSPSR 1678

  Fly  1760 PFSGLSFNTRPSLGHSPSIKSNKSKDKTPSKRRTKDGKVKEREAHSLSSSQWYTPPLSTITSTPE 1824
            |.|. .|...|.|   |..:..||:||.......||.|.|::|..:....:.:           :
Zfish  1679 PGSD-GFALEPLL---PKKQHFKSQDKLDRDEPEKDRKEKKKEKRNSKHQELF-----------D 1728

  Fly  1825 KEINTSIASLASTSNSSLSGPKTPDPHVLTEELTPKRPLRSEME-----KERRLS----RPASIA 1880
            ||:.|  |.:...:|.::         :|:|.::|.||.|.:.:     .|:|||    .||:..
Zfish  1729 KELKT--ADIPLQANEAV---------ILSETISPLRPQRPKSQVINLLGEKRLSVSPGAPANQF 1782

  Fly  1881 TPTASIKNFPDTR---SLSESSNRNSVETTDSTSEEDIRPPPLPAKARDSTDFTSLSQNMDWTPN 1942
            .|:......|..:   ||...||.....|  |.:::...|||||.|: ...|:.:|..|.|..  
Zfish  1783 VPSVPPPITPRAKLQFSLLSGSNLELNGT--SYADKGETPPPLPVKS-SMGDYGNLMDNSDLA-- 1842

  Fly  1943 GYAMLSTISNTSSMSTTSTLTKTSITNTTYEYLETTNFSLVGAIDGNKPRPPTPPPKPSRHSKHI 2007
                                                              .||.||.|..|.:|:
Zfish  1843 --------------------------------------------------SPTTPPPPPPHQRHL 1857

  Fly  2008 P 2008
            |
Zfish  1858 P 1858

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mbcNP_001247267.1 SH3_DOCK_AB 14..70 CDD:212805 24/55 (44%)
DOCK_N 86..435 CDD:465040 123/384 (32%)
C2_Dock-A 443..633 CDD:176076 88/195 (45%)
DHR2_DOCK_A 1296..1697 CDD:212570 197/403 (49%)
Herpes_BLLF1 <1732..>1935 CDD:282904 56/216 (26%)
dock1XP_073773972.1 None

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