DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mbc and Dock8

DIOPT Version :9

Sequence 1:	NP_001247267.1	Gene:	mbc / 42817	FlyBaseID:	FBgn0015513	Length:	2008	Species:	Drosophila melanogaster
Sequence 2:	NP_001032882.2	Gene:	Dock8 / 499337	RGDID:	1561588	Length:	2099	Species:	Rattus norvegicus

Alignment Length:	2138	Identity:	406/2138 - (18%)
Similarity:	711/2138 - (33%)	Gaps:	624/2138 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    64 KSYIHLCEYNIVN------GEYCI-----QRTDIVEEITKVLLEWGSI-AKDYFLTTNPSFPKIR 116
            ::||.  |:.|||      .|:|.     .|.|..:.:.|...|..:: ..:....|.|     |
  Rat   123 QTYIR--EWLIVNRKNQGSPEFCSFRKTGSRRDFHKTLQKQTFESETLECSEPATQTGP-----R 180

  Fly   117 RKMNELNNNRAALISGNLPL------------DEVRKVKLLATNQIDTGNKLLGLDMVVRDESGD 169
            .:.|.|.:     :||..|:            || |...||..:..|           ...|..:
  Rat   181 HRFNVLCD-----VSGKGPITSCDFDLRSLQPDE-RLENLLQLSAED-----------FEKEKEE 228

  Fly   170 ILDTNAICTTELYEQHMHAVQRIDKANRLSSERGTTRTPNKYSHNILLHVNAFVCKFQEDSDLLF 234
            ...||.  |.||:..:    ..:|:.:.:.. |.....|.::..|.:| |.....||:.:.:.||
  Rat   229 ARKTNR--TAELFALY----PSVDEEDAVEI-RPVPECPKEHLGNRIL-VKVLTLKFEIEIEPLF 285

  Fly   235 ---TLFDGETHKPISENYVVKWSR---TGIAR-DTDQID-----NNRVLFTDLSKSDLAIAKMYL 287
               .|:|.:..|.||||:....:.   .|..| .|..:|     .:.|.......||:     ||
  Rat   286 ASIALYDVKERKKISENFHCDLNSDQFKGFLRAHTPSVDPSSQARSAVFSVTYPSSDI-----YL 345

  Fly   288 VCYAIRIGSM----EFKDSAESKRTSMSIANSMLNASSRKASQLSVSSSGSSSSNGEYIIRRPFG 348
            |   ::|..:    |..|.||   ..|.|..|....|..|..:|.:.:.......|:|  |.||.
  Rat   346 V---VKIEKVLQQGEIADCAE---PYMIIKESDGGKSKEKVEKLKLQAESFCQRLGKY--RMPFA 402

  Fly   349 VACKDLTPFINKSDDFRGNIDLP------------------------------------------ 371
            .|...|..|.|.|...|.:.||.
  Rat   403 WAPISLASFFNVSTLERESTDLEPGAGRNSVGERRSLSQSRRPSERTLSFEENGVGSNFKTTTLA 467

  Fly   372 ---FIMCEKETL-DGTLRKLIANKDIGKIDSKMAVTIEVLRGDIKQIKEEFPRLMHTNV------ 426
               |...|.:.| |..|.|.:|:.   |..|.:...::.:.|.::......|.:|:..:
  Rat   468 TNIFFKQEGDRLSDEDLFKFLADY---KRSSSLQRRVKSIPGSLRLEIAPAPDVMNCCLTPEMLP 529

  Fly   427 ----------PVARKMGFP--EVILPGDV-RNDLYLTICSGEFA-RIAKTSEKNVEVSVCVANEQ 477
                      |....:.||  ||.:|..| ||.||:......|| ::|......:::......:.
  Rat   530 VKPFPENRTRPHKEILEFPIREVYVPHTVYRNLLYVYPQRLNFANKLASARNITIKIQFMCGEDP 594

  Fly   478 GYLMPGVLSIGAGHQPIDEYKSVVYYHDDKPKWQETFKIHVPIEDFKQCHLRFVLKHRSSNEQKD 542
            ...||.:....:|.:.:.|..:.:.||:..|.:.|..||.:|.:.....||.|...|.|..:::.
  Rat   595 SNAMPVIFGKSSGPEFLQEVYTAITYHNKSPDFYEEVKIKLPAKLTVNHHLLFTFYHISCQQKQG 659

  Fly   543 RT-EKPFGLAYVRLMQANGTTITQGQHILAV--------YKIDHKKY-------------DKTVA 585
            .: |...|.:::.::.  ...:..|.:.|.|        |.|...:.             .|.|.
  Rat   660 ASGESLLGYSWLPILL--NERLQTGSYCLPVALEKLPPNYSIHSAEKVPLQNPPIKWAEGHKGVF 722

  Fly   586 NCYLELPATVAELQGAKPSIGGLTLLPKDQLSIGVNLCSTKLTQSVSLLGLLNWSAHKETLEQSL 650
            |..::..::|............|....:.|::..:.:...|:|:        |...|:  |:.|:
  Rat   723 NIEVQAVSSVHTQDNHLEKFFTLCHSLESQVTFPIRVLDQKITE--------NTLEHE--LKLSI 777

  Fly   651 NALSTVPGEEVVKFLQDILDALFNILVE----NDHPEKYDQLVFMSIIHLIETV---SDL-KYQH 707
            ..|::...|.:|.||..:||.||.:.|:    ......:.|..|.|::.:..::   .|| |.||
  Rat   778 ICLNSSRLEPLVLFLHLVLDKLFQLSVQPMVIAGQTANFSQFAFESVVAIANSLHNSKDLRKDQH 842

  Fly   708 FLS-VLDVYINESF------------------------------SFTLAYTKLMDVLQKNISEAI 741
            ..: :|..|::..|                              |.....:|||   |..:..:.
  Rat   843 GRNCLLASYVHYVFRLPELHRDAPKSGGPTAVVPDPRYHTYGRTSAAAVSSKLM---QARVMSSS 904

  Fly   742 SP-----------------KEKSADGN------------DLEESPEVRR---------------- 761
            :|                 ..|.||.|            |:..|....|
  Rat   905 NPDLAGTHCAADEEVKNIMSSKIADRNCSRMSYYCSGNSDVPGSTAAPRPVSKKHFHEELALQMV 969

  Fly   762 ----LYKTT--RYLHYVMKFVIRSRVLYAEMNCNTDYMDF--ATRLQELLRMFIDMIGCPSNLLK 818
                |.:.|  :|..:..:.:::|...|..   |.|..|.  .||..:   .|.|.|....|::.
  Rat   970 VSTGLVRETVFKYAWFFFELLVKSMAQYVH---NLDKRDSFRRTRFSD---RFKDDITTIVNVVT 1028

  Fly   819 SE-GALLKNLHIIATDLMQVFEHVRLSIS-----IVEILEKFPPRRLTQSKMGCIKDF---VETK 874
            || .|||    :......:..|.:.:|::     ::.|:::       ......||.:   :..|
  Rat  1029 SEIAALL----VKPQKESEQAEKINISLAFFLYDLLSIMDR-------GFVFNLIKHYCTQLSAK 1082

  Fly   875 LFTLP---KCRAILLPVFCKHIKDHLESKEEGDSKTDIWQQEKNL------------SKAAKVLG 924
            |.|||   ..|...|.:.|.|                  :...||            |....:..
  Rat  1083 LNTLPTLISMRLEFLRILCSH------------------EHYLNLNLLFMNPDTAPASPCPSISS 1129

  Fly   925 QKKSQLHTCDTTANKKIAECINI-----MNNILKLLFRSDVGSTHNDIRDIMIILFRTVMKAAHA 984
            |..|   :|.:..::|||...::     ..:.|..|..:::....:...|.:..:.|..:.|.|:
  Rat  1130 QNSS---SCSSFQDQKIASMFDLTPEYRQQHFLTGLLFTELAVALDAEGDGISRVQRKAVSAIHS 1191

  Fly   985 L----DRDTGL--------VGKFFAIMLGILQRMDA--QHYEYFVKDLHQSGELKHFVIEILLVF 1035
            |    |.|...        :...:..::||:  :||  |.|:                      |
  Rat  1192 LLSSHDLDPRCLKPEVKVKIAALYLPLVGII--LDALPQLYD----------------------F 1232

  Fly  1036 EELVSPHQKAVFPRDWMDMI--MHQNTVILGALKHLTVVITDYFL--CPFEKQ------------ 1084
            .:..|...:|....:..|:.  ::||..:..|..|..:..:...|  .|:::.
  Rat  1233 TDARSGRSRASGSYEEQDVANGINQNVALAIAGNHFNLKTSGAMLSSLPYKQYNMLNADTTRHLM 1297

  Fly  1085 ---IW--SNFFQCSI-AFLVQSP-LQLN------------------DFNDNKRQIVFARYRDIRK 1124
               :|  .|..|..| .::...| :|||                  ..:|.....|..:.||::.
  Rat  1298 VCFLWIMKNADQSLIRKWIADLPSMQLNRILDLLFICVSCFEYKGKQSSDKVSNQVLQKSRDVKA 1362

  Fly  1125 ------------------------------DTAMEIRK---MWFQLGQHKPKFVPQL-VEPILEM 1155
                                          :..:..||   .|.|..:...|...:| .|.::..
  Rat  1363 KLEEALLRGEGARGEMMRRRIPGTDRFPGLNENLRWRKEQTQWRQANEKLDKTKAELDQEALISG 1427

  Fly  1156 SMIPEKEL----RQETI------------------PIFFDMMQCEYYSSRLEH---------ESY 1189
            ::..|..|    .||.|                  .:..:.:.|:..::.|.|         ..:
  Rat  1428 NLATEANLIILDMQENIIQASSSLDCKDSLLGGVLRVLVNSLSCDQSTTYLTHCFATLRALIAKF 1492

  Fly  1190 GDTKFNN------------AHH--------------------------KGNFSDFKTAMIEKLDI 1216
            ||..|..            .||                          ..||:..|..:...|..
  Rat  1493 GDLLFEEEMEQCADLCQRVLHHCSSSMDVTRSQACATLYLLMRFSFGATSNFARVKMQVTMALAS 1557

  Fly  1217 LIGAGKGDAEYKHLFETIMLERCAAHNTLNVDGTAFVQMVTRLMDKLLEYRFIIQD--------E 1273
            |:|... |...:||.:::......:.....:..|.|...|..|:..|   ..|:.|        |
  Rat  1558 LVGKAP-DFNEEHLRKSLRTILAYSEEDTAMRATLFPTQVEELLCNL---NSILYDTVKMREFQE 1618

  Fly  1274 SKENRMACTFSLLQFY-SEVDLKEMYIRYVNKLCALHMEFENYTEAAFTL----KLHTELLRWTD 1333
            ..|..|...:.:.:.| :..||:   :.::..:...|.:.:.:||||..|    .|..|.|...:
  Rat  1619 DPEMLMDLMYRIAKSYQASPDLR---LTWLQNMAEKHTKRKCFTEAAMCLVHAAALVAEYLSMLE 1680

  Fly  1334 TELSHQLRSYRHNNCRTHRQLKEAL----------------YF----------EIMEYFDKGKQW 1372
            ......:.|....|..::...:.|:                ||          :..|.|..|..:
  Rat  1681 DHSYLPVGSVSFQNISSNVLEESAVSDDTLSPDEDGVCSGRYFTESGLVGLLEQAAELFSTGGLY 1745

  Fly  1373 ECAIDMCRVLARQYEEEIFDYLKLAELLNRMALFYEKIIKE--LRHNSEYFRVCFYGRGFPRFLQ 1435
            |...::.:::....|.. .|:.||....:::...::.||.:  .|....||||.|||..|.. |.
  Rat  1746 ETVNEVYKLVIPILEAH-RDFRKLTSTHDKLQKAFDNIINKDHKRMFGTYFRVGFYGSKFGD-LD 1808

  Fly  1436 NRVYIFRGKEYERHSDFCARMLVQHPQ---AELMQTL-EAPGDDITNSDGQ--YIQVNKVEPIMG 1494
            .:.::::.....:..:...|:...:.|   ||.::.: ::...|.|..|..  |||:..|||.
  Rat  1809 EQEFVYKEPAITKLPEISHRLEGFYGQCFGAEFVEVIKDSTPVDKTKLDPNKAYIQITFVEPY-- 1871

  Fly  1495 QAFNKFNDKIINNEIVKYFTAN-NVQKFQFSRPFRDSTNGGDRDDVRNLWLERTELRISYPLPGI 1558
              |:::..|    :.|.||..| |:::|.::.||  :..|..|.::.......|.|...:..|.|
  Rat  1872 --FDEYEMK----DRVTYFEKNFNLRRFMYTTPF--TLEGRPRGELHEQHRRNTVLTTMHAFPYI 1928

  Fly  1559 LRWFPVVETNTFKISPLERAVEIMKDTNRDIRQLVILHKSDETLHINPLSMKLNGIVDPAVMGGF 1623
            .....|.:...|.::|:|.|:|.||  .:.::..|..|:  |......|.|.|.|.|...|..|.
  Rat  1929 KTRIRVSQKEEFVLTPIEVAIEDMK--KKTLQLAVATHQ--EPPDAKMLQMVLQGSVGATVNQGP 1989

  Fly  1624 AKYEEAFLTDDYLEQNPDDKELVEELKELIANQIPLLDLAIQLHRLRAPDSLKALQEHLERCFAD 1688
            .:..:.||.     :.|.|.:|.....:        |.|..:...:|..::::..:..:.....:
  Rat  1990 LEVAQVFLA-----EIPADPKLYRHHNK--------LRLCFKEFIMRCGEAVEKNRRLITAEQRE 2041

  Fly  1689 MQQHVEQRYGRKSCDLK--IERDSVVMRRP----NSFLPSLFDGSNNRHSET--SMGS 1738
            .||.:::.|.|....|:  |||....:.:|    :|.....|..|:.|..||  |.||
  Rat  2042 YQQELKKNYNRLKDSLRPMIERKIPELYKPIFRVDSQKRDSFHRSSFRKCETQLSQGS 2099

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mbc	NP_001247267.1	SH3_DOCK_AB	14..70	CDD:212805	2/5 (40%)
		DOCK_N	86..435	CDD:292790	86/439 (20%)
		C2_Dock-A	443..633	CDD:176076	39/213 (18%)
		DHR2_DOCK_A	1296..1697	CDD:212570	91/439 (21%)
Dock8	NP_001032882.2	DUF3398	73..164	CDD:288711	11/42 (26%)
		C2_Dock-C	559..739	CDD:176078	34/181 (19%)
		DHR2_DOCK8	1636..2057	CDD:212574	95/452 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1997
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810