DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mbc and dock8

DIOPT Version :9

Sequence 1:	NP_001247267.1	Gene:	mbc / 42817	FlyBaseID:	FBgn0015513	Length:	2008	Species:	Drosophila melanogaster
Sequence 2:	XP_001920107.4	Gene:	dock8 / 403040	ZFINID:	ZDB-GENE-060503-743	Length:	2090	Species:	Danio rerio

Alignment Length:	2195	Identity:	402/2195 - (18%)
Similarity:	705/2195 - (32%)	Gaps:	704/2195 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    52 RQKAKEIR--------GIFPKSYIHLCEYNIVNGEYCIQRTDIVEEITKVLLEWGSIAKDYFLTT 108
            |..:.|||        |..|.   |...|| .:|.:|.......|.:..|.|       |.||
Zfish    18 RHSSAEIRRHFSGVSHGSLPH---HRHSYN-ASGSFCFNVPQSYEAVEPVDL-------DEFL-- 69

  Fly   109 NPSFPKIRRKMNELNNNRAALIS--GNLPLDEV------RKVKLLATNQIDTGNKLLGLDMVVRD 165
                      |::|.:..|.::.  |..|.|::      |:.:.:.....:.|   :.||..|||
Zfish    70 ----------MSQLRSGDAEVMQELGEFPDDDLDVELVERECRTIRPTIAEEG---VELDSHVRD 121

  Fly   166 ----------------------ESGDILDTNAICTTELYE------------------------- 183
                                  ...|..|:|.|...:.:|
Zfish   122 CVQSYTQPWLVVSRRSQGYGWISYSDRTDSNKILQRQTFESDVQPDKQEQLDKSPSLTALCDDSA 186

  Fly   184 -----------------QHMHAVQRIDKANRLSSERGTTRTPNKYSHNILLH------------- 218
                             |.:.:|.|......|......:|..|:|.....|:
Zfish   187 RTTLTSSDFNLRALQPDQRVESVLRFSSPEELDRFNQESRQSNRYGELFGLYPPIDEEDAVAIRP 251

  Fly   219 --------------VNAFVCKFQEDSDLLF---TLFDGETHKPISENY--------VVKWSRTGI 258
                          |.....||:.:.:.||   .|:|.:..|.||||:        :..:.||
Zfish   252 IPDCPKEHFGQRILVRCQTVKFEIEIEPLFATMALYDLKEKKKISENFNFDLNSDQMKGFLRT-- 314

  Fly   259 ARDTDQIDNNRVLFTDLSKSDLAIAKMYLVCYAIRIGSM----EFKDSAESKRTSMSIANSMLNA 319
              .|.|:|.:.:..:.:.........:|||   |:|..:    |..|.||   ..|.:..|....
Zfish   315 --HTPQVDTSTLSRSAIFSISYPSPDIYLV---IKIEKVLQQGEIGDCAE---PYMVLKESDTTK 371

  Fly   320 SSRKASQLSVSSSGSSSSNGEYIIRRPFGVACKDLTPFINK----------SDDFRGNID---LP 371
            :..|..:|...:.|.....|.|  |.|...|..::...||.          |.:.||::|   ||
Zfish   372 NRDKLEKLRNQAEGFCQRLGRY--RMPLAFATVNIMSVINSTLERETSDTDSINGRGSMDKKGLP 434

  Fly   372 ---------------------------FIMCEKETL-DGTLRKLIANKDIGKIDSKMAVTI---- 404
                                       ||..|.|.| |..|.|.:|  ||.:..|:..|.|
Zfish   435 RRNSDRFSLMEDNYILSGFKPAVTMCTFIKQEGERLSDEDLFKFLA--DIKRSSSQRRVKIIPGY 497

  Fly   405 ---EVLRG-------------DIKQIKEEFPRLMHTNVPVARKMGFP--EVILPGDV-RNDLY-- 448
               |||..             .:|.:.|:..|      |:...:.||  ||.:|.:: ||.||
Zfish   498 LKLEVLPAPDTVPGCLSPELIPVKPVSEKNQR------PIKEVLEFPSKEVYVPHNIYRNLLYVY 556

  Fly   449 ---LTICSGEFARIAKTSEKNVEVSV--CVANEQGYLMPGVLSIGAGHQPIDEYKSVVYYHDDKP 508
               |.:.:    |:  ||.:|:.|.:  ....:....||.:....:|.:.:.|..:.|.||:..|
Zfish   557 PLRLNLTN----RL--TSARNITVKIQFMSGEDSSCAMPVIFGKSSGPEFLTEVYTPVTYHNRSP 615

  Fly   509 KWQETFKIHVPIEDFKQCHLRFVLKHRSSNEQKDRT---EKPFGLAYVRLMQANGTTITQGQHIL 570
            .:.:..||.:|.....:.||.|...|.|..:::::|   |...|.:::.::  |...:...|..|
Zfish   616 DFYDEIKILLPARLTDKHHLLFTFFHISCQQKQNQTGSVEALIGYSWLPML--NNDRLQTSQQCL 678

  Fly   571 AVYKIDHKKYDKTVANCYL----ELPATVAELQGAKPSIGGLTLLPKDQLSIGVNLCSTKLTQSV 631
            .:.      .||...|..|    :|||.|..::..:...|...|  :.|....|....:.|.:..
Zfish   679 PIV------LDKLPINYSLHTPEKLPAQVPPVKWLENHKGLFNL--ELQAVSSVQTQDSHLERFF 735

  Fly   632 SLLGLL-----------------NWSAHKETLEQSLNALSTVPGEEVVKFLQDILDALFNILVE- 678
            :|...|                 |...|:  |:.|:.:||:...|.:|.||..:||.||.::::
Zfish   736 TLCHALEGKSTFPIRVRDEKIQENMFEHE--LKLSIISLSSAGLEPLVLFLHQVLDKLFRLIMQP 798

  Fly   679 ---NDHPEKYDQLVFMSIIHLIETVSDLK---------------YQHFL---------------- 709
               ........|:.|.|::.:|.::.:.:               |.:|:
Zfish   799 MVIAGQTANLAQIAFESVVSVINSLHNSQELAKDHQGRNCLLATYLYFVFRLPDTQYEIHTSGTG 863

  Fly   710 ----------SVLDVYINESFSFTLAYTKLMDVLQKNISEAISPKE------------------- 745
                      |.|......:..|.|..:::......:|...:||::
Zfish   864 GLMAHPEGRYSTLTRTTATTVGFMLLQSRIRSSSNPDIPAPLSPEDTEVNNILGKVLNHPGSRMS 928

  Fly   746 KSADGNDLEES------PEVRRLYKTTRYLHYVMKF-VIRS----------RVLYAEMNCNTDYM 793
            .:|:.::..:|      |..::|:.....|..|:.. |.|.          .||...|:.:...:
Zfish   929 TAANASNSPQSSTGSTRPTNKKLFHEELALQMVVSTGVCRENVYKYAWFFFEVLVKSMSQHVSQL 993

  Fly   794 DFAT--RLQELLRMFIDMIGCPSNLLKSEGALLKNLHIIATDLMQVFEHVRLSIS---------- 846
            |..|  |.......|.|.|....|::.:|   :.|:.:.....::..|.|.:|::
Zfish   994 DKKTVSRRNRFSDRFKDDITTIVNVVTAE---IGNILVKQQKELEQAEKVNISLAFFLYDLMSLM 1055

  Fly   847 ----IVEILEKFPPRRLTQSKMGCIKDFVETKLFTLPKCRAILLPVFCKHIKDH-------LESK 900
                :.::::.:..:...:|          ..:.||...|...|.|.|.|  :|       ..|.
Zfish  1056 DRGFVFQLVKNYCNQMAAKS----------VNMATLISMRLEFLRVLCSH--EHYLNLSLFFSSP 1108

  Fly   901 EEGDSKTDIWQQEKNLSKAAKVLGQKKSQLHTCDTTANKKIAECINIMNN-----------ILKL 954
            ....:           |.:..|..|..|   :|....| |||...::..:           :.:|
Zfish  1109 SSAPA-----------SPSPSVSSQTSS---SCSFQDN-KIAAMFDLSQDFKQRHYLTGLLLTEL 1158

  Fly   955 LFRSDVGSTHNDIRDIMIILFRTVMKAAHALDRD------TGLVGKFFAIMLGILQRMDAQHYEY 1013
            ....|:.|....::...|....::: .||.||:.      ...:...:..::||:  :|:.:|..
Zfish  1159 STALDIESEGGRVQQKAINATYSLL-CAHDLDQRCSRSEVKAKIAALYLPLVGII--IDSINYLD 1220

  Fly  1014 FVKDLHQSGELKHFVIE------------------------------------------------ 1030
            |.....:||:.|....|
Zfish  1221 FTVSDSRSGKGKSGGPEEDPDNIATINQSVAMAIAGNPFNTLTRNALVSMASVSVKTTNMLTAET 1285

  Fly  1031 ---ILLVFEELVSPHQKAVFPRDWMDMIMHQNTVILGALKHLTVVITDYFLCPFE---KQIWSNF 1089
               :|:.|..::....:.:..|..:||...|    |..|..|..:.|.   | ||   ||.....
Zfish  1286 SRNLLMCFLWIIKNADQNLIQRWTVDMPSSQ----LSRLLELLAICTS---C-FEYRGKQSSDKV 1342

  Fly  1090 FQCSIAFLVQSPLQLND-----------------FNDNKRQIVFARYRDIRKDTAMEIRKMWFQL 1137
            ...::....|:..:|.:                 ...|.|.:........|||..     .|.|.
Zfish  1343 STQALQKSQQAKARLEEALLGGIGARGEMMKRVGVQGNDRTLGLRENLRWRKDLT-----QWRQT 1402

  Fly  1138 GQHKPKFVPQL-----------------VEPILEM--SMIPEKELRQETI----PIFFDMMQCEY 1179
            ...:.|...:|                 |..:|||  ..:|..:.:...:    .:....:.|..
Zfish  1403 NDRQDKSKAELDQEAIISGNLATETNLIVLDLLEMIVQAVPLADCKDNVVGGVLKVLLHSLTCNQ 1467

  Fly  1180 YSSRLEH---------ESYGDTKFNN------------AHH------------------------ 1199
            .::.|.|         ..:||..|..            .|:
Zfish  1468 STTYLSHCFSTLRALIVKFGDLLFEEEAEQCADLCQKVLHYCSSCVDGNRSQACATLYLIMRYSY 1532

  Fly  1200 --KGNFSDFKTAMIEKLDILIGAGKG-DAEY-KHLFETIMLERCAAHNTLNVDGTAFVQMVTRLM 1260
              ..|||..|..:...|..|:|.... ..|| :..|.||:   ..|.....:..|.....|..|:
Zfish  1533 SSASNFSRVKMQVTMSLASLVGKSSDIHEEYLRRSFRTIL---AYAEEDTEMQSTQLPSQVDELL 1594

  Fly  1261 DKLLEYRFIIQDESK--------ENRMACTFSLLQFY-SEVDLKEMYIRYVNKLCALHMEFENYT 1316
            ..|   ..|:.|..|        |..|...:.:.:.| :..||:   :.::..:...|...:.:|
Zfish  1595 RNL---NSILSDTVKMKEFQKDPEMLMDLMYRIAKGYQTSPDLR---LTWLQNMAEKHNGRKCFT 1653

  Fly  1317 EAAFTL----KLHTELLRW----------------------TDTELSHQLRSYRHNNCRTHRQLK 1355
            |:|..|    .|..|.|..                      .::.:|..:.|...:...:.|...
Zfish  1654 ESAMCLVHAAALVAEYLSMLEDHKYLPVGSVTFQNISPNVLEESAVSDDILSPDEDGVCSGRYFT 1718

  Fly  1356 E----ALYFEIMEYFDKGKQWECAIDMCRVLARQYEEEIFDYLKLAELLNRMALFYEKIIKE--L 1414
            |    .|..:..|.|..|..:|...::.:|:....|.. .|:.|||...:::...::.||::  .
Zfish  1719 ENGLVGLLEQAAELFSNGGLFEAVNEVYKVIVPILEAH-RDFRKLASTHDKLQRAFDNIIQKGHK 1782

  Fly  1415 RHNSEYFRVCFYGRGFPRFLQNRVYIFRGKEYERHSDFCARMLVQHPQA------ELMQTLEAPG 1473
            |....||||.|||..|.. |..:.:|::........:...|:...:.|.      |:::......
Zfish  1783 RMFGTYFRVGFYGSKFGD-LDEQEFIYKEPGITHLPEISHRLENFYSQCFGDGVLEMIKDSTPVD 1846

  Fly  1474 DDITNSDGQYIQVNKVEPIMGQAFNKFNDKIINNEIVKYFTANNVQKFQFSRPFRDSTNGGDRDD 1538
            .:..:.:..|||:..|||.       |:|..:.:.:..:....|:::|.::.||..|  |..|.:
Zfish  1847 RNKLSPNKAYIQITFVEPY-------FDDYEMKDRLTNFEKNFNLRRFMYTTPFTKS--GRPRGE 1902

  Fly  1539 VRNLWLERTELRISYPLPGILRWFPVVETNTFKISPLERAVEIMKDTNRDIRQLVILHKSDETLH 1603
            :...:..:|.|...:..|.|.....|::...|.::|:|.|:|.|:...|::.:.....|.|..:
Zfish  1903 LNEQYKRKTILTTMHAFPYIKTRINVIQKEEFDLTPIEVAIEDMQKKTRELAEATHREKPDAVM- 1966

  Fly  1604 INPLSMKLNGIVDPAVMGGFAKYEEAFLTD--------------------------DYLEQN--- 1639
               |.|.|.|.|...|..|..:..:.||.:                          :.:|:|
Zfish  1967 ---LQMVLQGSVTATVNQGPLEVAQVFLNEIPADPKLFRHHNKLRLCFKEFILRCGEAIEKNKQL 2028

  Fly  1640 --PDDKELVEELKE-----------LIANQIPLLDLAIQLHRLRAPDSLK 1676
              ||.||..:|:|:           ::..:||.|...|...|:...||.|
Zfish  2029 ITPDQKEYQQEMKKNYNKLRENLRPMLERKIPELYKPIIKPRIENRDSFK 2078

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mbc	NP_001247267.1	SH3_DOCK_AB	14..70	CDD:212805	7/25 (28%)
		DOCK_N	86..435	CDD:292790	97/523 (19%)
		C2_Dock-A	443..633	CDD:176076	45/204 (22%)
		DHR2_DOCK_A	1296..1697	CDD:212570	93/461 (20%)
dock8	XP_001920107.4	DUF3398	75..161	CDD:288711	15/88 (17%)
		C2_Dock-C	549..731	CDD:176078	44/197 (22%)
		DHR2_DOCK8	1630..2051	CDD:212574	87/438 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1997
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810