DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment mbc and Dock4

DIOPT Version :9

Sequence 1:NP_001247267.1 Gene:mbc / 42817 FlyBaseID:FBgn0015513 Length:2008 Species:Drosophila melanogaster
Sequence 2:XP_038934052.1 Gene:Dock4 / 366608 RGDID:1561724 Length:1978 Species:Rattus norvegicus


Alignment Length:2123 Identity:641/2123 - (30%)
Similarity:1048/2123 - (49%) Gaps:323/2123 - (15%)


- Green bases have known domain annotations that are detailed below.


  Fly    13 EFGIAKCNFDQESKPHRLNLDVGDAVIILKETTHWYYGYRQKAKEIRGIFPKSYIHL---CEYNI 74
            ::|:...:| :.:.|:.|:|::||.|.||::...||.|:..|...|:||||.||:||   |..|.
  Rat     9 KYGVVIASF-RGTVPYGLSLEIGDTVQILEKCDGWYRGFALKNPNIKGIFPSSYVHLKNACVKNK 72

  Fly    75 VNGEYCIQRTD-IVEEITKVLLEWGSIAKD-YFLTTNPSFPKIRRKMNELNNNRAALISGNLPLD 137
            ...|..|...| ::.|:|..|.:|||:.|. |.......|.::...|||:.:.|..::.|:|..|
  Rat    73 GQFEMVIPTEDSVITEMTSTLRDWGSMWKQLYVRNEGDLFHRLWHIMNEILDLRRQVLVGHLTHD 137

  Fly   138 EVRKVKLLATNQIDTGNKLLGLDMVVRDESGDILDTNAICTTELYEQHMHAVQRIDKANRLSSER 202
            .::.||...|.::|.||:.||||:|.|.|.. ::|...|..||||....|..::.|...:.|   
  Rat   138 RMKDVKRHITARLDWGNEQLGLDLVPRKEYA-MVDPEDISITELYRLMEHRHRKKDTPVQAS--- 198

  Fly   203 GTTRTPNKYSHNILLHVNAFVC-KFQEDSDLLFTLFDGETHKPISENYVVKWSRTGIARDTDQID 266
                     ||::.:.:.:.:| ...|:.:::|:|||.:.::||||.:.::.:|.|:.:..|:.:
  Rat   199 ---------SHHLFVQMKSLMCSNLGEELEVIFSLFDSKENRPISERFFLRLNRNGLPKAPDKPE 254

  Fly   267 NNRVLFTDLSKSDLAIAKMYLVCYAIRIGSMEFKDSAESKRTSMSIANSMLNASSRKASQLSVSS 331
            .:..||.||..|:|. ..:|:..:.||||.|    .|..|:.:.|:                   
  Rat   255 RHCSLFVDLGSSELR-KDIYITVHIIRIGRM----GAGEKKNACSV------------------- 295

  Fly   332 SGSSSSNGEYIIRRPFGVACKDLTPFINKSDDFRGNIDLPFIMCEKET-----LDGTLRKLIANK 391
                    :|  |||||.|...:...:  :.:.:.::.|...||..|:     .:..::||.|..
  Rat   296 --------QY--RRPFGCAVLSIADLL--TGETKDDLVLKVYMCNTESEWYQIHENIIKKLNARY 348

  Fly   392 DIGKIDSKMAVTIEVLRGDIKQIKEEFPRLMHTNVPVARKMGFPEVILPGDVRNDLYLTICSGEF 456
            ::...::.:||::::|.|||:||:.|:..:....|.:.||:||.::|:||::|||||:|:..|||
  Rat   349 NLTGSNAGLAVSLQLLHGDIEQIRREYSSVFSHGVSITRKLGFSDIIMPGEMRNDLYITVERGEF 413

  Fly   457 ARIAKTSEKNVEVSVCVANEQGYLMPGVLSIGAGHQPIDEYKSVVYYHDDKPKWQETFKIHVPIE 521
            .:..|:..:||||::.:.:..|..:...:|.|:|.....||.|.|.||::.|:|.|..|:.:|::
  Rat   414 EKGGKSVARNVEVTMFIVDSNGQPLKDFISFGSGEPLASEYHSFVLYHNNSPRWSELLKLPIPVD 478

  Fly   522 DFKQCHLRFVLKHRSSNEQKDRTEKPFGLAYVRLMQANGTTITQGQHILAVYKIDHKK--YDKTV 584
            .|:..|:||..:|.|:.|:.::  |.||.::|.|||.:|.|:..|.|.|.|:|.:...  .|.| 
  Rat   479 KFRGSHIRFEFRHCSTKEKGEK--KLFGFSFVPLMQEDGRTLPDGTHELIVHKCEENTNLQDTT- 540

  Fly   585 ANCYLELPATVAELQGAKPSIGGLTLLPKDQLSIGVNLCSTKLTQSVSLLGLLNWSAHKETLEQS 649
              .||:.|.:.....|........|   |:...|...||||||||:..:|.||.|..|.:.:...
  Rat   541 --RYLKFPFSKVIFLGNNNQTMKAT---KESFWITSFLCSTKLTQNGDMLDLLKWRTHPDKITGC 600

  Fly   650 LNALSTVPGEEVVKFLQDILDALFNILVENDHPEKYDQLVFMSIIHLIETVSDLKYQHFLSVLDV 714
            |:.|..:.|.|:||||||.||.||.||.||.  :||...||.|::|:|..:.|.|:.||..|:|.
  Rat   601 LSKLKEIDGSEIVKFLQDTLDTLFGILDENS--QKYGSKVFDSLVHIINLLQDSKFHHFKPVMDT 663

  Fly   715 YINESFSFTLAYTKLMDVLQ---KNISEAISPKEKSADGNDLEESPEVRRLYKTTRYLHYVMKFV 776
            ||...|:..|||..|:.||:   ..|:||             |....::.:.|..   .|:.|::
  Rat   664 YIESHFAGALAYRDLIKVLKWYVDRITEA-------------ERQEHIQEVLKAQ---EYIFKYI 712

  Fly   777 IRSRVLYAEMNCNTDYMDFATRLQELL---RMFIDMIGCPSNLL-KSEGALLKNLHIIATDLMQV 837
            ::||.|::......:..:|...:||||   |.|:......:..| :|:...|.:...:.::|:::
  Rat   713 VQSRRLFSLATGGQNEEEFRCCIQELLMSVRFFLSQESKGTGALSQSQAVFLSSFPAVYSELLKL 777

  Fly   838 FEHVRLSISIVEILEKFP-----PRRLTQSKMGCIKDFVETKLFTLPKCRAILLPVFCKHIKDHL 897
            |:...::..:.:.|...|     ...|...|:.||...||::|:|.|..|.|||||...|:..||
  Rat   778 FDVREVANLVQDTLGSLPTIMHVDDSLQAIKLQCIGKTVESQLYTNPDSRYILLPVVLHHLHIHL 842

  Fly   898 ESKEEGDSKTDIWQQEKNLSKAAKVLGQ-----KKSQLHTCDTTANKKIAECIN-IMNNILKLLF 956
                         |::|:|...|::|..     ||:       ::.|.:.|.|: |:.::|.:|.
  Rat   843 -------------QEQKDLIMCARILSNVFCLIKKN-------SSEKSVLEEIDVIVASLLDILL 887

  Fly   957 RS--DVGSTHNDIRDIMIILFRTVMKAAHALDRDTGLVGKFFAIMLGILQRMDAQHYEYFVKDLH 1019
            |:  ::.|........|.:.|:.|             .|:|.|.:|.:|::|..:||:..:...:
  Rat   888 RTILEITSRPQASSSAMRLQFQDV-------------TGEFVACLLSLLRQMTDRHYQQLLNSFN 939

  Fly  1020 QSGELKHFVIEILLVFEELVSPHQKAVFPRDWMDMIMHQNTVILGALKHLTVVITDYFLCP-FEK 1083
            ...||:.|:::|..||..|:.|.   :||:||..|.:..|.||:..:.:|:..:...||.. |:.
  Rat   940 TKEELRDFLLQIFTVFRILIRPE---MFPKDWTVMRLVANNVIITTVLYLSDALRKNFLNENFDY 1001

  Fly  1084 QIWSNFFQCSIAFLVQSPLQLNDFNDNKRQIVFARYRDIRKDTAMEIRKMWFQLGQHKPKFVPQL 1148
            :||.::|..::.|:.|..|||..|..:|::.|..:|.|:|.....||..||..||:||..|:|.|
  Rat  1002 KIWDSYFYLAVIFINQLCLQLEMFTPSKKKKVLEKYGDMRVTMGCEIFSMWQNLGEHKLHFIPAL 1066

  Fly  1149 VEPILEMSMIPEKELRQETIPIFFDMMQCEYYSSRLEHESYGDTKFNNAHHKGNFSDFKTAMIEK 1213
            :.|.||:::||:.:||...||||.|||..|...|                  |||...:..:|:|
  Rat  1067 IGPFLEVTLIPQPDLRNVMIPIFHDMMDWEQRRS------------------GNFKQVEAKLIDK 1113

  Fly  1214 LDILIGAGKGDAEYKHLFETIM------------LERCAAHNTLNVDGTAFVQMVTRLMDKLLEY 1266
            ||.|:..||||..|:.||.:|:            :||    .|....|.:.:..|||||::||:|
  Rat  1114 LDSLMSEGKGDETYRELFNSIIPLFGPYPSLLKKIER----ETWRESGVSLIATVTRLMERLLDY 1174

  Fly  1267 RFIIQ-DESKENRMACTFSLLQFY-SEVDLKEMYIRYVNKLCALHMEFENYTEAAFTLKLHTELL 1329
            |..:: .|....::.||.|||.|| :|::.:||||||::||..||::.:|:||||:||.|:.|||
  Rat  1175 RDCMKIGEVDGKKIGCTVSLLNFYKTELNKEEMYIRYIHKLYDLHLKAQNFTEAAYTLLLYDELL 1239

  Fly  1330 RWTDTELSHQLRSYRHNNCRTHRQLKEALYFEIMEYFDKGKQWECAIDMCRVLARQYEEEIFDYL 1394
            .|:|    ..||.:.....:|..|.||.|:..|::.||:||.||..|.:||.:|.|| |..:||.
  Rat  1240 EWSD----RPLREFLTYPMQTEWQRKEHLHLTIIQNFDRGKCWENGIILCRKIAEQY-ESYYDYR 1299

  Fly  1395 KLAELLNRMALFYEKIIKELRHNSEYFRVCFYGRGFPRFLQNRVYIFRGKEYERHSDFCARMLVQ 1459
            .|:::....|..|:||:.:.|...|:|||.|||:.||.||:|:.::.||.:|||...|..|||.:
  Rat  1300 NLSKMRMMEASLYDKIMDQQRLEPEFFRVGFYGKKFPFFLRNKEFVCRGHDYERLEAFQQRMLNE 1364

  Fly  1460 HPQAELMQTLEAPGDDITNSDGQYIQVNKVEPIMGQAFNKFNDKIINNE-----IVKYFTANNVQ 1519
            .|.|..||....|.:.|..::.||:|:..|.||      ..:.:::..|     |..::..|::.
  Rat  1365 FPHAIAMQHANQPDETIFQAEAQYLQIYAVTPI------PESQEVLQREGVPDNIKSFYKVNHIW 1423

  Fly  1520 KFQFSRPFRDSTNGGDRDDVRNLWLERTELRISYPLPGILRWFPVVETNTFKISPLERAVEIMKD 1584
            ||::.|||...|...: ::.::||:|||.|.:...||||.|||.|.:....::||||.|:|::::
  Rat  1424 KFRYDRPFHKGTKDKE-NEFKSLWVERTSLYLVQSLPGISRWFEVEKREVVEMSPLENAIEVLEN 1487

  Fly  1585 TNRDIRQLVILHKSDETLHINPLSMKLNGIVDPAVMGGFAKYEEAFLTDDYLEQNPDDKELVEEL 1649
            .|:.::.|:...:|.:..:||||:|.|||::|.||.||.::|:|||...||:..:|:|.|.:..|
  Rat  1488 KNQQLKTLISQCQSRQMQNINPLTMCLNGVIDAAVNGGVSRYQEAFFVKDYILSHPEDGEKIARL 1552

  Fly  1650 KELIANQIPLLDLAIQLHRLRAPDSLKALQEHLERCFADMQQ-------------------HVEQ 1695
            :||:..|..:|:..:.:|....|..::.|.:.|...|..|:.                   :...
  Rat  1553 RELMLEQAQILEFGLAVHEKFVPQDMRPLHKKLVDQFFVMKSSFGIQEFPACIQASPVHFPNGSP 1617

  Fly  1696 RYGRKSCDLKIERDS--VVMRRPNSFLPSLFDGSNNRHSETSMGSSDS-------GLSKST---- 1747
            |..|.|....:..|.  |:.||.....|::     ||:|.:|:.|..|       |.|:|:    
  Rat  1618 RVCRNSAPASMSPDGTRVIPRRSPLSYPAV-----NRYSSSSLSSQASAEVSNITGQSESSDEVF 1677

  Fly  1748 -FLPRPQTNSIKNPFSGLSFNTRPSLGHSPSIKSNKSKDKTPSKRRTKDGKVKEREAHSLSSSQW 1811
             ..|.|.|:|:.:..|.           ||::.|:     .||..|... .:.::..||..:| .
  Rat  1678 NMQPSPSTSSLSSTHSA-----------SPNVTSS-----APSSARASP-LLSDKHKHSRENS-C 1724

  Fly  1812 YTP---PLSTITSTP----EKEINTSIASLA-STSNSSLSGP-KTPDPHVLTEELTPKRPLRSEM 1867
            .:|   |.|.|..||    ::.:...|...| ..|:.:||.| |..:|...:..|...:..::..
  Rat  1725 LSPRDRPCSAIYPTPVEPSQRMLFNHIGDGALPRSDPNLSAPEKAVNPTPSSWSLDSGKEAKNMS 1789

  Fly  1868 EKERRLS-----RPASIATP---TASIKNFPDTRSLSESSNRNSVETTDSTSEEDIRPPPLPAKA 1924
            :..:.:|     ||...|:|   |.|:...|..||..:|            |.:...|.|:    
  Rat  1790 DSGKLISPPVPPRPTQTASPARHTTSVSPSPAGRSPLKS------------SVQSFTPSPV---- 1838

  Fly  1925 RDSTDFTS--LSQNMDWTPNGYAMLSTISNTSSMSTTSTLTKTSITNTTYEY-----------LE 1976
                ::.|  ||.|.......|:     |..||:|..||...:...|...|.           :.
  Rat  1839 ----EYNSPGLSSNSPVLSGSYS-----SGISSLSRCSTSETSGFENQANEQSVPVPVPVPVPMP 1894

  Fly  1977 TTNFSLVGAIDGNKPRPPTPP-----------PKPSRHSKHIP 2008
            ..:||  |:.:..:....|||           |.|..||..||
  Rat  1895 VPSFS--GSEEPVRKESKTPPPYSVYERTLRRPVPLPHSLSIP 1935

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mbcNP_001247267.1 SH3_DOCK_AB 14..70 CDD:212805 23/58 (40%)
DOCK_N 86..435 CDD:292790 95/355 (27%)
C2_Dock-A 443..633 CDD:176076 67/191 (35%)
DHR2_DOCK_A 1296..1697 CDD:212570 150/424 (35%)
Dock4XP_038934052.1 SH3_DOCK4_B 10..65 CDD:212982 22/55 (40%)
DOCK_N 69..392 CDD:406558 99/371 (27%)
C2_Dock-B 400..584 CDD:176077 67/191 (35%)
DHR2_DOCK4 1206..1596 CDD:212578 150/401 (37%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG54452
OrthoDB 1 1.010 - - D102580at2759
OrthoFinder 1 1.000 - - FOG0000433
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100636
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 1 1.000 - - X372
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
76.830

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