Protein Alignment mbc and Dock2

DIOPT Version :9

• Sequence 1: NP_001247267.1
• Gene: mbc / 42817
• FlyBaseID: FBgn0015513
• Length: 2008
• Species: Drosophila melanogaster
• Sequence 2: XP_038943067.1
• Gene: Dock2 / 360509
• RGDID: 1564189
• Length: 1829
• Species: Rattus norvegicus
• Alignment Length: 2010
• Identity: 749/2010 - (37%)
• Similarity: 1111/2010 - (55%)
• Gaps: 267/2010 - (13%)

  Fly     1 MSVWSDCNAKQAEFGIAKCNFDQESKPHRLNLDVGDAVIILKETTHWYYGYRQKAKEIRGIFPKS 65
            |:.|...:.::  .|:|..|| |.|....|.|.:||.|.|.:....||.||..|.|..:||||.|
  Rat     1 MAPWRKTDKER--HGVAIYNF-QGSGAQHLTLQIGDVVRIQETCGDWYRGYLIKHKMSQGIFPTS 62

  Fly    66 YIHLCEY---------NIVNGEYCIQRTDIVEEITKVLLEWGSIAKD-YFLTTNPSFPKIRRKMN 120
            :|||.|.         ||:..|     ..:.:|:...|.|||||.|. |..:....|.:::..|.
  Rat    63 FIHLKEVTVEKRRNIENIIPAE-----IPLAQEVATTLWEWGSIWKQLYVASKKERFLQVQSMMY 122

  Fly   121 ELNNNRAALISGNLPLDEVRKVKLLATNQIDTGNKLLGLDMVVRDESGDILDTNAICTTELYEQH 185
            :|...|:.|:||.||.||::::|...|::||.|||:|.||::||||.|:|||.:......|:..|
  Rat   123 DLMEWRSQLLSGTLPKDELKELKQKVTSKIDFGNKILELDLIVRDEDGNILDPDNTSVISLFHAH 187

  Fly   186 MHAVQRIDKANRLSSERGT--------TRTPNKYSHNILLHVNAFVCKFQEDSDLLFTLFDGETH 242
            ..|..:|  ..|:..|...        :|..:..:|::.:.|..|||:..||::|..:|:|....
  Rat   188 EEATHKI--TERIKEETCKDQPDYGIYSRISSSPTHSLYVFVRNFVCRIGEDAELFMSLYDPHKQ 250

  Fly   243 KPISENYVVKWSRTGIARDTDQIDNNRVLFTDLSKSDLAIAKMYLVCYAIRIGSMEFKDSAESKR 307
            ..|||||:|:|...|..::.:.::|.:|:||||...||...|::|:|..:|||.|:.||
  Rat   251 MVISENYLVRWGSKGFPKEIEMLNNLKVVFTDLGNKDLNRDKIFLICQIVRIGKMDLKD------ 309

  Fly   308 TSMSIANSMLNASSRKASQLSVSSSGSSSSNGEYIIRRPFGVACKDLTPFIN---KSDDFRGNID 369
                     :|.  :|.:|            |   :|||||||..|:|..|.   :||:.:.:.
  Rat   310 ---------INV--KKCTQ------------G---LRRPFGVAVMDITDIIKGKAESDEEKQHF- 347

  Fly   370 LPF--IMCEKETLDGTLRKLIANK-DIGKIDSKMAVTIEVLRGDIKQIKEEFPRLMHTNVPVARK 431
            :||  :..|.:.|...|.|:||:| |.|  ...:.||:::|.|||.||::::|.|:.....||||
  Rat   348 IPFHPVSAENDFLHSLLGKVIASKGDSG--GQGLWVTMKMLVGDIIQIRKDYPHLVDRTTVVARK 410

  Fly   432 MGFPEVILPGDVRNDLYLTICSGEFARIAKTSEKNVEVSVCVANEQGYLMPGVLSIGAGHQPIDE 496
            :||||:|:|||||||:|:|:..|:|.:..||:::||||.:||..|.|.::|..:.:|||.:.::|
  Rat   411 LGFPEIIMPGDVRNDIYITLLQGDFDKYTKTTQRNVEVIMCVCTEDGNVLPNAICVGAGDKAMNE 475

  Fly   497 YKSVVYYHDDKPKWQETFKIHVPIEDFKQCHLRFVLKHRSSNEQKDRTEKPFGLAYVRLMQANGT 561
            |.|||||...:|:|.||.|:.|||||.::.||||:.:||||.|.||:.||.|.::||:||:.:||
  Rat   476 YHSVVYYQVKQPRWMETVKVAVPIEDMQRIHLRFMFRHRSSLESKDKGEKNFAMSYVKLMKEDGT 540

  Fly   562 TITQGQHILAVYKIDHKKYDKTVANCYLELPA-------TVAELQGAKPSIGGLTLLPKDQLSIG 619
            |:..|.|.|.|.|.|.||.:.  |:.||.||:       ..|.|..:..|:|||::..:|..||.
  Rat   541 TLQDGYHELVVLKGDSKKMED--ASAYLTLPSYRYHVENKGATLSRSSSSVGGLSVSSRDVFSIS 603

  Fly   620 VNLCSTKLTQSVSLLGLLNWSAHKETLEQSLNALSTVPGEEVVKFLQDILDALFNILVENDHPEK 684
            :.:|||||||:|.|||||.|....:.|:::|..|..|.||||||||||.|||||||::|:....:
  Rat   604 ILVCSTKLTQNVGLLGLLKWRMRPQLLQENLEKLKIVDGEEVVKFLQDTLDALFNIMMEHAQSNE 668

  Fly   685 YDQLVFMSIIHLIETVSDLKYQHFLSVLDVYINESFSFTLAYTKLMDVLQKNISEAISPKEKSAD 749
            ||.|||.::|::|..::|.|:|||.:||:.||.:.||.||||.|||.||:..:       :.|:.
  Rat   669 YDILVFDALIYIIGLIADRKFQHFNTVLEAYIQQHFSATLAYKKLMTVLKTYL-------DTSSR 726

  Fly   750 GNDLEESPEVRRLYKTTRYLHYVMKFVIRSRVLYAEMNCNTDYMDFATRLQELLRMFIDMIGCPS 814
            |...|.      :.:|.:.|.||.||::|||.|::::....:.|:|    :|.:|...:.|   :
  Rat   727 GEQCEP------ILRTLKALEYVFKFIVRSRRLFSQLYEGKEQMEF----EESMRRLFESI---N 778

  Fly   815 NLLKSEG--------ALLKNLHIIATDLMQVFEHVRLSISIVEILEKFPPRRLTQSKMGCIKDFV 871
            ||:||:.        |.||.:..:..|:..||:...||..:.|.....||.:|.:.|:..:.:.|
  Rat   779 NLMKSQHKTTILLQVAALKYIPSVLHDVETVFDAKLLSQLLYEFYTCIPPVKLQKQKVQSMNEIV 843

  Fly   872 ETKLFTLPKCRAILLPVFCKHIKDHLESKEEGDSKTDIWQQEKNLSKAAKVLGQKKSQLHTCDTT 936
            ::.||...:||.|||||..|.:|:.||.:::|        |.:.|.|
  Rat   844 QSNLFKKQECRDILLPVITKELKELLEQRDDG--------QHQALEK------------------ 882

  Fly   937 ANKKIAECINIMNNILKLLFRSDVGSTHNDIRDIMIILFRTVMKAAHALDRDTGLVGKFFAIMLG 1001
                 ..|:.::|:||::|...|...|::.|::||:.|.|||.:....:.||..|:..|.|.|..
  Rat   883 -----KYCVELLNSILEVLSCQDAAFTYDHIQEIMVQLLRTVNRTVITMGRDHSLISHFVACMTA 942

  Fly  1002 ILQRMDAQHYEYFVKDLHQSGELKHFVIEILLVFEELVSPHQKAVFPRDWMDMIMHQNTVILGAL 1066
            ||.:|..|||.::::....|.:|..|::|..::|::|:.   |.|:|.||:.|.|.||.|.|.|:
  Rat   943 ILDQMGDQHYSFYIETFQTSSDLVDFLMETFIMFKDLIG---KNVYPGDWIAMSMVQNRVFLRAI 1004

  Fly  1067 KHLTVVITDYFL--CPFEKQIWSNFFQCSIAFLVQSPLQLNDFNDNKRQIVFARYRDIRKDTAME 1129
            ......:...||  ..||.|:|:|:|..::||:.|..|||..|...|...:..:|.|:|:.....
  Rat  1005 NKFAETMNQKFLEHTSFEFQLWNNYFHLAVAFITQDSLQLEQFTHAKYNKILNKYGDMRRLVGFS 1069

  Fly  1130 IRKMWFQLGQHKPKFVPQLVEPILEMSMIPEKELRQETIPIFFDMMQCEYYSSRLEHESYGDTKF 1194
            ||.||::|||:|..|:|.:|.|||||::|||.|||:.|||||||||.|||
  Rat  1070 IRDMWYKLGQNKICFIPGMVGPILEMTLIPEAELRKATIPIFFDMMLCEY--------------- 1119

  Fly  1195 NNAHHKGNFSDFKTAMIEKLDILIGAGKGDAEYKHLFETIMLERCAAHNTLNVDGTAFVQMVTRL 1259
               ...|.|..|:..:|.|||..:..|:||.:|..|.|:|::|..|.|.|:......||.:|..|
  Rat  1120 ---QRTGAFKKFENEIILKLDHEVEGGRGDEQYMQLLESILMECAAEHPTIAKSVENFVSLVKGL 1181

  Fly  1260 MDKLLEYRFIIQDESKENRMACTFSLLQFYSEVDLKEMYIRYVNKLCALHMEFENYTEAAFTLKL 1324
            ::|||:||.::.||||:|||:||.:||.||.:.:.:||||||:.||..||::.:||||||:||.|
  Rat  1182 LEKLLDYRGVMTDESKDNRMSCTVNLLNFYKDHNREEMYIRYLYKLRDLHLDCDNYTEAAYTLLL 1246

  Fly  1325 HTELLRWTDTELSHQLRSYRHNNCRTHRQLKEALYFEIMEYFDKGKQWECAIDMCRVLARQYEEE 1389
            ||.||:|:|.:.:.|:......:.:|||||||.||..|:.||||||.||.||.:|:.||.|||.|
  Rat  1247 HTWLLKWSDEQCASQVMQTGQQHPQTHRQLKETLYETIIGYFDKGKMWEEAISLCKELAEQYEME 1311

  Fly  1390 IFDYLKLAELLNRMALFYEKIIKELRHNSEYFRVCFYGRGFPRFLQNRVYIFRGKEYERHSDFCA 1454
            :|||..|::.|.:.|.|||.|:|.||...:||.|.:||:|||.||:|:|:|:|||||||..||..
  Rat  1312 VFDYELLSQNLTQQAKFYENIMKILRPKPDYFAVGYYGQGFPSFLRNKVFIYRGKEYERREDFQM 1376

  Fly  1455 RMLVQHPQAELMQTLEAPGDDITNSDGQYIQVNKVEPIMGQAFNKFNDKIINNEIVKYFTANNVQ 1519
            ::|.|.|.||.|.|..|||||:.|:.|||||...|:|::.: ..:|.:|.:.::|:.::.:|.||
  Rat  1377 QLLSQFPNAEKMNTTSAPGDDVKNAPGQYIQCFTVQPVLDE-HPRFKNKPVPDQIINFYKSNYVQ 1440

  Fly  1520 KFQFSRPFRDSTNGGDRDDVRNLWLERTELRISYPLPGILRWFPVVETNTFKISPLERAVEIMKD 1584
            .|.:|||.|..|...: ::..::|:|||....:|.||||||||.||..:...|||||.|:|.|..
  Rat  1441 TFHYSRPVRRGTVDPE-NEFASMWIERTSFLTAYKLPGILRWFEVVHMSQTTISPLENAIETMST 1504

  Fly  1585 TNRDIRQLVILHKSDETLHINPLSMKLNGIVDPAVMGGFAKYEEAFLTDDYLEQNPDDKELVEEL 1649
            .|..|..::..::|||:|.||||||.|||||||||||||||||:||.|::|..::|:|::.:..|
  Rat  1505 ANEKILMMINQYQSDESLPINPLSMLLNGIVDPAVMGGFAKYEKAFFTEEYSREHPEDQDKLSRL 1569

  Fly  1650 KELIANQIPLLDLAIQLHRLRAPDSLKALQEHLERCFADMQQHVEQRYG-RKSCDLKIERDSVVM 1713
            |:|||.|||.|...|::|..|..|:|:...:.:|.||.:::..||:.|| |:..|....|    :
  Rat  1570 KDLIAWQIPFLGAGIKIHEKRVSDNLRPFHDRMEECFKNLKMKVEKEYGVREMPDFDDRR----L 1630

  Fly  1714 RRPNSFLPSLFDGSNNRHSETSMGSSDSGLSKSTFLPRPQTNSIKNPFSGLSFNTRPSLGHSPSI 1778
            .||.|.|.|.     .:.|..|:.|.:|..|                        .||...|.|.
  Rat  1631 GRPRSMLRSY-----RQMSIISLASMNSDCS------------------------TPSKVVSESF 1666

  Fly  1779 KSNKSKDKTPSKRRTKDGKVKEREAHSLSSSQWYTPPLSTITSTPEKEINTSIASLASTSNSSLS 1843
            .......|||        ||:|.             |:|..::.||.::.   .|...|..||:
  Rat  1667 DLESVTPKTP--------KVEEE-------------PISPGSTLPEVKLR---RSKKRTKRSSV- 1706

  Fly  1844 GPKTPDPHVLTEELTPKRPLRSEMEKERRLSRPASIATPTASIKNFPDTRSLSESSNRNSVETTD 1908
                    |..:|   |....||:   :||||.....:.|          :|||.:.
  Rat  1707 --------VFADE---KAAAESEL---KRLSRKHEFMSDT----------NLSEHAT-------- 1739

  Fly  1909 STSEEDIRPPPLPAKARDSTDFTSLSQNMDWTPNGYAMLSTISNTSSMSTTSTLTKTSIT 1968
                       :|.:....:..:..||:|...|   |:..:::....:...||..:.|.|
  Rat  1740 -----------VPTRVSVLSQMSFASQSMPTIP---ALTLSVAGVPGLDEASTSPRLSQT 1785

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mbc	NP_001247267.1	SH3_DOCK_AB	14..70	CDD:212805	25/55 (45%)
		DOCK_N	86..435	CDD:292790	122/363 (34%)
		C2_Dock-A	443..633	CDD:176076	90/196 (46%)
		DHR2_DOCK_A	1296..1697	CDD:212570	197/400 (49%)
Dock2	XP_038943067.1	SH3_DOCK2_A	12..67	CDD:212983	25/55 (45%)
		DOCK_N	71..414	CDD:406558	125/384 (33%)
		C2	422..617	CDD:417471	90/196 (46%)
		DHR2_DOCK2	1200..1620	CDD:212579	207/421 (49%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	200	1.000	Domainoid score	I2939
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D102580at2759
OrthoFinder	1	1.000	-	-		FOG0000433
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100636
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.820