DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mbc and Zir

DIOPT Version :9

Sequence 1:	NP_001247267.1	Gene:	mbc / 42817	FlyBaseID:	FBgn0015513	Length:	2008	Species:	Drosophila melanogaster
Sequence 2:	NP_608489.2	Gene:	Zir / 33165	FlyBaseID:	FBgn0031216	Length:	2064	Species:	Drosophila melanogaster

Alignment Length:	1974	Identity:	353/1974 - (17%)
Similarity:	629/1974 - (31%)	Gaps:	664/1974 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   217 LHVNAFVCKFQEDSDLLF---TLFDGETHKPISENYVVKWSRTGIAR---------DTDQIDNNR 269
            :.||....:.:.:.:.:|   .::|.:..:.||||:....:...:.|         |.....::.
  Fly   269 IQVNCLQLRLELEVEPIFASMAIYDAKERQKISENFYFDMNADSLKRMLSSHVQCADISTQSHSA 333

  Fly   270 VLFTDLSKSDLAI------------------------------AKMYLVCYAIRIG--------- 295
            :.......:||.:                              .|...|.|..|:|
  Fly   334 IFEISYPSNDLFLVIRLEKVLQGDINNSVEPYLKEDKDKYREKVKSNAVDYCERLGKYRMPFAWT 398

  Fly   296 -----------SMEFKDSAESKRTSMSIA-----------NSMLNASS--------RKASQLS-- 328
                       :.|.||:..::|.|...|           ||:...||        |||:.:|
  Fly   399 GIYLTNVFNGDNFESKDAGAAERDSFGNACGSSLGTAPSSNSLDRKSSTSSFDQLRRKANDMSGT 463

  Fly   329 VSSSGSSSSNGEYIIRRPFGVACKDLTP--FINKSDDFRG-NIDLP-FIMCEKETL-DGTLRKLI 388
            ::..||.....::          :..:|  |.|..::||. .|.:| |...|.:.: |..|.|::
  Fly   464 LTRRGSLERKEKH----------RSWSPDDFANVVENFRPITITVPSFFKQEADKMKDEDLYKIL 518

  Fly   389 ANKDIGKIDSKMAVTIEVLRGDIK--------QIKEEF-PRLMHTNV-------PVARKMGFPEV 437
            ...   |..|.:....:.:.|.||        :.|... |.|...|.       ||...:.||:.
  Fly   519 PEL---KRPSSVMKKYKCIPGSIKLEISPCVEEAKNALTPELAPINPQSADNVRPVKEILEFPQS 580

  Fly   438 ILPG---DVRNDLYLTICSGEFARIAKTSEKNVEVSVCVANEQGYLMPGVLSIGAGHQPIDEYKS 499
            .:..   ..||.|:::.....|:..| .|.:|:.|.|              .:.||..|.|...:
  Fly   581 AIYNPHYSYRNLLFVSPKELNFSSRA-GSARNIAVRV--------------QLMAGETPKDAVNA 630

  Fly   500 V----------------VYYHDDKPKWQETFKIHVPIEDFKQCHLRFVLKHRSSNEQ----KDRT 544
            :                |.||:..|.:.:..||.:|....:..||.|.:.|.|..::    :...
  Fly   631 IYGKSSCPKFSTEAFTAVNYHNKCPSFYDEIKIALPASIKQHHHLLFTIYHVSCQKKPQDLQPSV 695

  Fly   545 EKPFGLAYVRLMQ-------------------ANGTTITQGQHILAVYKIDHKKYDKTVANCYLE 590
            |.|.|..::.|::                   .|.:.|....|:..:..:|:   .:.|.:..:|
  Fly   696 ETPIGYTWLPLLEDGKLKFGEFNLPVMVESPPENYSFIPPNVHLPGIKWLDN---HRAVFSINVE 757

  Fly   591 LPATVAELQGAKPSIGGLTLLPKDQLSIGVNLCSTKLTQSV-SLLGLLNWSAHKETLEQSLNALS 654
            ....:..|.         :.|.:..|     :|....|::: |.:|..|....   |::.|..:.
  Fly   758 AVTAIHTLD---------SFLDRFFL-----ICEYLDTRNIPSHIGENNIETE---LKKCLLDIE 805

  Fly   655 TVPGEEVVKFLQDILDALFNILVENDH---------PEKYDQLVFMSIIHLIETVSDLKYQHF-- 708
            ....|.:|:.|..:||.|..:||....         ...::.|..:|  .|:..::|.:|..:
  Fly   806 YANREPLVRHLPLVLDKLIELLVVTHKVGGQAMSLGSTVFEVLCLVS--SLLSILNDDQYDQYGR 868

  Fly   709 LSVLDVYIN----------------------ESFSFTLAYTKLMDVLQKNISEAISPKEKSAD-- 749
            .|:|..|::                      |....:.:||...:||..  ..::..||.|.|
  Fly   869 QSLLSTYVHFQCKIPHPFQSKQRLTCSRSTTEDLQLSESYTIYDNVLAS--GRSLDRKELSIDVL 931

  Fly   750 ----GNDLEESPEVRRLYKTTRYLHYVM-----------------KFVIRSRVLYAEMNC-NT-- 790
                ..|:    :||.|::... ||:|:                 :.:::|.:  ..::| ||
  Fly   932 HSMAARDV----QVRLLHEELA-LHWVVASGKAADLAMSNSWFLFELIVKSMI--EHLHCSNTLN 989

  Fly   791 ---------DYMDFATRLQELLRMFIDMIGCPSNLLKSEGALLKNLHIIATDLMQVFEHVRLSIS 846
                     .:.|..:.|..|:.  ..::|..||..|...:|..:|.....|::.:.:. .....
  Fly   990 GPRKHRFPHQFNDDLSTLVHLVT--TKVVGYHSNEPKLAQSLNASLGFFIFDILSIMDR-GFVFG 1051

  Fly   847 IVEILEKFPPRRLTQSKMGCIKDFVETKLFTLPKCRAILLPVFCKHIKDH--------------- 896
            :::...|     :..||...|.|.:..|:        ..|.:.|.|  :|
  Fly  1052 LIKTYTK-----VLISKNASIPDLMNYKI--------DFLRIVCSH--EHFVALNLPFGTSYTMV 1101

  Fly   897 ---------------------LESKEEGDSKTDIWQQE----KNLSKAAKVLGQKKSQLHTCDTT 936
                                 ||.....|...:..||.    ..||..|.|:.....|||
  Fly  1102 TAPCSPTPSTTSSNSQTSCGSLERALHADLSQEFLQQHFLVGLVLSDLAAVMEVPNPQLH----- 1161

  Fly   937 ANKKIAECI-NIMNNILKLLFRSDVGSTHND------IRDIMIILFRTVMKA-----AHALDRDT 989
              .|...|| |:|.:       .|:.:.:::      :..:.|.|...||..     .|.|::|.
  Fly  1162 --GKAIRCIRNLMTS-------HDLDARYSETDARARVAALYIPLLSIVMDCIPQLHQHGLEQDR 1217

  Fly   990 GLVGKFFAIMLGILQRMDAQH---------------------YEYFVKDLH-----QSGELKHFV 1028
                   ...:|.|:.....|                     |.|..:.:.     .|...:|.:
  Fly  1218 -------LQQIGQLEDYQGPHQTITASTINPEVAFAISGSRPYSYLNEQVKNKLPLSSENTRHLL 1275

  Fly  1029 IEILLVFEELVSPHQKAVFPRDWMDMIMHQNTVILGALKHLTVVITDYFLCPFEKQIWSNFFQCS 1093
            :..|.|.:.|    ::.|..|..||:..|:        .|..:...:..|..||..     .|.:
  Fly  1276 VCFLWVLKNL----ERNVLYRWLMDLSPHR--------VHQMLQGVNVCLKTFEYT-----GQKN 1323

  Fly  1094 IAFLVQSPLQ------LNDFNDNKRQIV----FARYRDI--RKDTAMEIRKMWFQLGQHKPKFVP 1146
            :|.|.::..|      ..|..:...:.:    .|||..|  |||.....:..|   .:.:..:..
  Fly  1324 VATLKRTNTQSFRKTGSTDVKEKLEECIRGTNSARYDLINRRKDRNSTEKFRW---RKDQMPYRS 1385

  Fly  1147 QLVEPI------LEMSMIPEKELRQETIPIFFDMMQ-CEYYSSRLEHESYGDT------------ 1192
            |..:.:      ||:|...|..|..|...:..|.:: ..:.::.|.|...|..
  Fly  1386 QYADAVGKSEHELELSHFIEGSLATEVALVLLDTLEIIVHAAANLYHNLLGTVLKVLLHSLSRNQ 1450

  Fly  1193 -----------------KFNN-----------------AHHKG---------------------- 1201
                             ||.|                 ..|.|
  Fly  1451 SVLALQNLFASQRALIFKFPNLLFDDETDICADLCLILLKHCGSLLPGIRSQAAASLYLLMRQNF 1515

  Fly  1202 ----NFSDFKTAMIEKLDILIGAGK--GDAEYKHLFETIMLERCAAHNTLNVDGTAFVQMVTRLM 1260
                ||:..|..:...|..|:|...  .:...:...:|:::   .|.:..::..|:|.:.|   .
  Fly  1516 EIGNNFARVKMQVTMSLSSLVGTSSVFSEQSLRRALKTVLV---YAESDSDLQDTSFPEQV---Q 1574

  Fly  1261 DKLLEYRFIIQD--ESKE------------NRMACTFSLLQFYSEVDLKEMYIRYVNKLCALHME 1311
            |.|.....|:.|  :.||            ||:|     ..:.:..||:   :.::..:...|.|
  Fly  1575 DLLFNLHMILSDTVKMKEYQEDPEMLLDLMNRIA-----KGYQNNPDLR---LTWLENMAKKHRE 1631

  Fly  1312 FENYTEAAFTLKLHTELLRWTDTELSHQLRSYRH------------------------------- 1345
            ..|:||||........|:    :|....|.|.:|
  Fly  1632 RANHTEAAMCYVHAASLV----SEYLSMLESQKHLPVGAVSFQRISPNTLMESAVSDDVLSPGED 1692

  Fly  1346 ----NNCRTHRQLKEALYFEIMEYFDKGKQWECAIDMCRVLA------RQYEEEIFDYLKLAELL 1400
                .|..|...|| ||..|....|.....:|...::.::|.      |.:::....:.||.|..
  Fly  1693 GICLGNHFTETGLK-ALLEEASNSFQVAGMYEAMNEVYKILIPICEANRDFQKLSKVHGKLQEAF 1756

  Fly  1401 NRMALFYEKIIKELRHNSEYFRVCFYGRGFPRFLQNRVYIFRGKEYERHSDFCARMLVQHPQAEL 1465
            ||::....|     |....||||.|||..|.. |..:.:|::.....:..:..:|:...:.:...
  Fly  1757 NRISQLQGK-----RVFGTYFRVGFYGGKFGD-LDQQEFIYKEPTLTKLPEIFSRLQNFYTERFG 1815

  Fly  1466 MQTLEAPGDDIT---NS---DGQYIQVNKVEPIMGQAFNKFNDKIINNEIVKYFTAN-NVQKFQF 1523
            ..::....|..|   ||   |..|||:..|||.    |..:  ::.:.|  .||..| |:::|.:
  Fly  1816 PDSVHIIKDSNTVDINSLDPDKAYIQITYVEPY----FETY--EMRHRE--TYFERNFNIKRFIY 1872

  Fly  1524 SRPFRDSTNGGDRDDVRNLWLERTELRISYPLPGILRWFPVVETNTFKISPLERAVEIMKDTNRD 1588
            :.||  :.||....::......:|.|..:...|.:.....|:......:.|:|.|:|.::....:
  Fly  1873 ATPF--TKNGKAHGELNEQCKRKTILTTANHFPYVKTRIMVISRQQIVLEPIEVAIEDIQKKTLE 1935

  Fly  1589 IRQLVILHKSDETLHINPLSMKLNGIVDPAVMGGFAKYEEAFLTD-------------------- 1633
            :........:|..:    |.|.|.|.:...|..|..:....||::
  Fly  1936 LAAATNQEPADPKI----LQMVLQGCIGTTVNQGPMEMASVFLSNLSDGTTVPTKHQNKLRLCFR 1996

  Fly  1634 -------DYLEQN-----PDDKELVEELK----ELIANQIPLLDL-AIQLHRLRAPDSLKALQEH 1681
                   |.|::|     .|.|:...||:    ..|....|.:.| ::|.|.:     :||
  Fly  1997 EFSKRCADALKKNRNLILSDQKDYQRELERNNDRFIERLTPFITLTSVQNHGV-----VKA---- 2052

  Fly  1682 LERCFADMQQHVEQRYGRKSCDLK 1705
                         ..|..||..||
  Fly  2053 -------------NAYNNKSTPLK 2063

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mbc	NP_001247267.1	SH3_DOCK_AB	14..70	CDD:212805
		DOCK_N	86..435	CDD:292790	56/321 (17%)
		C2_Dock-A	443..633	CDD:176076	40/229 (17%)
		DHR2_DOCK_A	1296..1697	CDD:212570	94/485 (19%)
Zir	NP_608489.2	DUF3398	59..151	CDD:288711
		C2_Dock-C	589..769	CDD:176078	36/206 (17%)
		DHR-2	1549..2037	CDD:284365	104/526 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45452406
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1997
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.740